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1.
Sci Rep ; 11(1): 19180, 2021 09 28.
Artigo em Inglês | MEDLINE | ID: mdl-34584192

RESUMO

We describe the development and analysis of a new teletherapy modality that, through a novel approach to targeted radiation delivery, has the potential to provide greater conformality than conventional photon-based treatments. The proposed system uses an X-ray lens to reflect photons from a conventional X-ray tube toward a focal spot. The resulting dose distributions have a highly localized peak dose, with lower doses in the converging radiation cone. Physical principles governing the design of this system are presented, along with a series of measurements analyzing various characteristics of the converging beam. The beam was designed to be nearly monoenergetic (~ 59 keV), with an energy bandwidth of approximately 10 keV allowing for treatment energies lower than conventional therapies. The focal spot was measured to be approximately 2.5 cm long and 4 mm wide. Mounting the proposed X-ray delivery system on a robotic arm would allow sub-millimeter accuracy in focal spot positioning, resulting in highly conformal dose distribution via the optimal placement of individual focal spots within the target volume. Aspects of this novel radiation beam are discussed considering their possible clinical application as a treatment approach that takes maximum advantage of the unique properties afforded by converging X-ray beam therapy.


Assuntos
Lentes , Fótons/uso terapêutico , Radioterapia Conformacional/instrumentação , Desenho de Equipamento , Humanos , Método de Monte Carlo , Imagens de Fantasmas , Radiometria , Dosagem Radioterapêutica
2.
Sensors (Basel) ; 20(18)2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32932975

RESUMO

The increase in the urban population is impacting the environment in several ways, including air pollution due to emissions from automobiles and industry. The reduction of air pollution requires reliable and detailed information regarding air pollution levels. Broad deployment of sensors can provide such information that, in turn, can be used for the establishment of mitigating and regulating acts. However, a prerequisite of such a deployment strategy is using highly durable sensors. The sensors must be able to operate for long periods of time under severe conditions such as high humidity, solar radiation, and dust. In recent years, there has been an ongoing effort to ruggedize sensors for industrial applications with an emphasis on elevated temperature, humidity, and pressure. Some of these developments are adapted for urban air sensing applications. However, protection from dust is based on filters that have not been modified in the last few decades. Such filters clog over time, thus requiring frequent replacement. This editorial presents the need for a consumable-free dust removal device that provides consistent performance without affecting the sensing process. A specific solution for removing dust using a cyclone dust separator is presented. The cyclone dust separator is implemented as an add-on module to protect commercially available sensors.

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