Quantifying imbalanced classification methods for leukemia detection.

Uncontrolled proliferation of B-lymphoblast cells is a common characterization of Acute Lymphoblastic Leukemia (ALL). B-lymphoblasts are found in large numbers in peripheral blood in malignant cases. Early detection of the cell in bone marrow is essential as the disease progresses rapidly if left untreated. However, automated classification of the cell is challenging, owing to its fine-grained variability with B-lymphoid precursor cells and imbalanced data points. Deep learning algorithms demonstrate potential for such fine-grained classification as well as suffer from the imbalanced class problem. In this paper, we explore different deep learning-based State-Of-The-Art (SOTA) approaches to tackle imbalanced classification problems. Our experiment includes input, GAN (Generative Adversarial Networks), and loss-based methods to mitigate the issue of imbalanced class on the challenging C-NMC and ALLIDB-2 dataset for leukemia detection. We have shown empirical evidence that loss-based methods outperform GAN-based and input-based methods in imbalanced classification scenarios.

Knowledge distillation approach towards melanoma detection.

Melanoma is regarded as the most threatening among all skin cancers. There is a pressing need to build systems which can aid in the early detection of melanoma and enable timely treatment to patients. Recent methods are geared towards machine learning based systems where the task is posed as image recognition, tag dermoscopic images of skin lesions as melanoma or non-melanoma. Even though these methods show promising results in terms of accuracy, they are computationally quite expensive to train, that questions the ability of these models to be deployable in a clinical setting or memory constraint devices. To address this issue, we focus on building simple and performant models having few layers, less than ten compared to hundreds. As well as with fewer learnable parameters, 0.26 million (M) compared to 42.5 M using knowledge distillation with the goal to detect melanoma from dermoscopic images. First, we train a teacher model using a ResNet-50 to detect melanoma. Using the teacher model, we train the student model known as Distilled Student Network (DSNet) which has around 0.26 M parameters using knowledge distillation achieving an accuracy of 91.7%. We compare against ImageNet pre-trained models such MobileNet, VGG-16, Inception-V3, EfficientNet-B0, ResNet-50 and ResNet-101. We find that our approach works well in terms of inference runtime compared to other pre-trained models, 2.57 s compared to 14.55 s. We find that DSNet (0.26 M parameters), which is 15 times smaller, consistently performs better than EfficientNet-B0 (4 M parameters) in both melanoma and non-melanoma detection across Precision, Recall and F1 scores.

MoNuSAC2020: A Multi-Organ Nuclei Segmentation and Classification Challenge.

Detecting various types of cells in and around the tumor matrix holds a special significance in characterizing the tumor micro-environment for cancer prognostication and research. Automating the tasks of detecting, segmenting, and classifying nuclei can free up the pathologists' time for higher value tasks and reduce errors due to fatigue and subjectivity. To encourage the computer vision research community to develop and test algorithms for these tasks, we prepared a large and diverse dataset of nucleus boundary annotations and class labels. The dataset has over 46,000 nuclei from 37 hospitals, 71 patients, four organs, and four nucleus types. We also organized a challenge around this dataset as a satellite event at the International Symposium on Biomedical Imaging (ISBI) in April 2020. The challenge saw a wide participation from across the world, and the top methods were able to match inter-human concordance for the challenge metric. In this paper, we summarize the dataset and the key findings of the challenge, including the commonalities and differences between the methods developed by various participants. We have released the MoNuSAC2020 dataset to the public.

Melanoma detection using adversarial training and deep transfer learning.

Skin lesion datasets consist predominantly of normal samples with only a small percentage of abnormal ones, giving rise to the class imbalance problem. Also, skin lesion images are largely similar in overall appearance owing to the low inter-class variability. In this paper, we propose a two-stage framework for automatic classification of skin lesion images using adversarial training and transfer learning toward melanoma detection. In the first stage, we leverage the inter-class variation of the data distribution for the task of conditional image synthesis by learning the inter-class mapping and synthesizing under-represented class samples from the over-represented ones using unpaired image-to-image translation. In the second stage, we train a deep convolutional neural network for skin lesion classification using the original training set combined with the newly synthesized under-represented class samples. The training of this classifier is carried out by minimizing the focal loss function, which assists the model in learning from hard examples, while down-weighting the easy ones. Experiments conducted on a dermatology image benchmark demonstrate the superiority of our proposed approach over several standard baseline methods, achieving significant performance improvements. Interestingly, we show through feature visualization and analysis that our method leads to context based lesion assessment that can reach an expert dermatologist level.