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Environ Sci Pollut Res Int ; 31(22): 32998-33010, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38671268

RESUMO

We investigated the larvicidal activity of the essential oil (EO) from Tetradenia riparia and its majority compound fenchone for controlling Culex quinquefasciatus larvae, focusing on reactive oxygen and nitrogen species (RONS), catalase (CAT), glutathione S-transferase (GST), acetylcholinesterase (AChE) activities, and total thiol content as oxidative stress indicators. Moreover, the lethal effect of EO and fenchone was evaluated against Anisops bouvieri, Diplonychus indicus, Danio rerio, and Paracheirodon axelrodi. The EO and fenchone (5 to 25 µg/mL) showed larvicidal activity (LC50 from 16.05 to 18.94 µg/mL), followed by an overproduction of RONS, and changes in the activity of CAT, GST, AChE, and total thiol content. The Kaplan-Meier followed by Log-rank (Mantel-Cox) analyses showed a 100% survival rate for A. bouvieri, D. indicus, D. rerio, and P. axelrodi when exposed to EO and fenchone (262.6 and 302.60 µg/mL), while α-cypermethrin (0.25 µg/mL) was extremely toxic to these non-target animals, causing 100% of death. These findings emphasize that the EO from T. riparia and fenchone serve as suitable larvicides for controlling C. quinquefasciatus larvae, without imposing lethal effects on the non-target animals investigated.


Assuntos
Culex , Lamiaceae , Larva , Óleos Voláteis , Estresse Oxidativo , Animais , Óleos Voláteis/farmacologia , Óleos Voláteis/química , Culex/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Larva/efeitos dos fármacos , Lamiaceae/química , Inseticidas , Canfanos , Norbornanos
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