1.
Ann Neurol
; 92(6): 985-991, 2022 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36094107
RESUMO
This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means of real-time quaking-induced conversion, a highly sensitive and specific technique capable of detecting and amplifying misfolded aggregated forms of α-synuclein in the cerebrospinal fluid. Seven patients were positive and they did not differ from negative cases, except for a more frequent L-dopa responsiveness and gait characterized by a wider base. The two groups did not differ in terms of response rate to tap test or shunt surgery, although step length and gait velocity improved by a lesser extent in positive cases. ANN NEUROL 2022;92:985-991.
Assuntos
Hidrocefalia de Pressão Normal , Sinucleinopatias , Humanos , alfa-Sinucleína/líquido cefalorraquidiano , Hidrocefalia de Pressão Normal/diagnóstico , Hidrocefalia de Pressão Normal/cirurgia , Marcha
2.
Arq. neuropsiquiatr
; 79(1): 88-88, Jan. 2021. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1153135