Analysis of the Complexity of Palliative Care for Cancer Patients.

INTRODUCTION: The Spanish National Health System has defined complexity as a set of factors of increased difficulty that require the intervention of a palliative care team. Palliative care aims to improve the quality of life of patients with chronic terminal illnesses. This study aims to describe the degree of complexity of cancer patients in palliative care, to determine which elements of complexity are most prevalent and to determine which other hospital clinical factors are associated with the level of complexity. METHODS: This study is a descriptive, observational, and cross-sectional analysis that included patients diagnosed with advanced oncological pathology undergoing palliative treatment who were admitted to the Medical Oncology ward of the Miguel Servet University Hospital between March and April 2023. RESULT: A total of 100 patients were selected for the study. According to the IDC-Pal, 68% of patients were classified as highly complex, 26% of patients were complex and only 6% of patients were classified as non-complex. The presence of pain (P < .001), nausea and vomiting (P = .027), depression (P = .033) and functional status (P = .011) were statistically independent predictors of high complexity. DISCUSSION: This study has shown that a high proportion of hospitalized palliative care cancer patients have high complexity, suggesting a good matching of healthcare resources to patient complexity. Four factors related to complexity have been identified, namely pain, nausea and vomiting, depression and a bedridden functional state. The presence of any of the 4 factors could help healthcare professionals to identify patients for early specialized palliative care.

Spanish Clinical Guidelines on Vascular Access for Haemodialysis. / Guía Clínica Española del Acceso Vascular para Hemodiálisis.

Vascular access for haemodialysis is key in renal patients both due to its associated morbidity and mortality and due to its impact on quality of life. The process, from the creation and maintenance of vascular access to the treatment of its complications, represents a challenge when it comes to decision-making, due to the complexity of the existing disease and the diversity of the specialities involved. With a view to finding a common approach, the Spanish Multidisciplinary Group on Vascular Access (GEMAV), which includes experts from the five scientific societies involved (nephrology [S.E.N.], vascular surgery [SEACV], vascular and interventional radiology [SERAM-SERVEI], infectious diseases [SEIMC] and nephrology nursing [SEDEN]), along with the methodological support of the Cochrane Center, has updated the Guidelines on Vascular Access for Haemodialysis, published in 2005. These guidelines maintain a similar structure, in that they review the evidence without compromising the educational aspects. However, on one hand, they provide an update to methodology development following the guidelines of the GRADE system in order to translate this systematic review of evidence into recommendations that facilitate decision-making in routine clinical practice, and, on the other hand, the guidelines establish quality indicators which make it possible to monitor the quality of healthcare.

Cómo planificar, diseñar y organizar un centro de cirugía ambulatoria / How to plan, design and organize an ambulatory surgery center

Los centros de cirugía ambulatoria han contribuido al progreso de esta cirugía y se caracterizan por ser eficientes, productivos, rentables y generar alta satisfacción. Construir un centro de cirugía ambulatoria requiere constituir un equipo multidisciplinario encargado de desarrollar un proyecto que evalúe la viabilidad económica, seleccione el tipo de centro a construir, determine el tamaño y el diseño del centro y defina la dotación de personal; con esta información se realiza la evaluación económica final que decide la factibilidad de construir el centro. Organizar el inicio de actividades y el funcionamiento de este servicio requiere determinar horarios, modalidad de trabajo, flujos de circulación y funciones del personal, a través de protocolos que definan, describan y coordinen todos los procesos clínicos y administrativos involucrados desde la indicación de la cirugía hasta el alta del paciente. La eficiencia del pabellón quirúrgico es determinante en el funcionamiento de un centro de cirugía ambulatoria. Varios factores contribuyen a la eficiencia de pabellón, y el más crítico de estos es el tiempo entre cirugías o tiempo de recambio de pacientes, el cual es factible de optimizar. La cirugía ambulatoria es una modalidad de trabajo quirúrgico que requiere un servicio clínico propio, adecuadamente planificado, diseñado y organizado para lograr sus objetivos y ventajas.

Ambulatory surgery centers have contributed to the progress of ambulatory surgery and they are characterized by its efficiency, productivity and to produce high satisfaction. To build an outpatient surgery center a multidisciplinary team should be responsible to develop a project that to assess the economic viability, to select the type of center, to determine the size and the design of center and to set de staffing; with this information the final economic evaluation that decide the feasibility to build the center must be performed. To organize the launch activities and the operation of this service requires determining schedules, working mode, traffic flows and staff functions through protocols that to define, to describe and to coordinate all clinic and administrative process involved from the surgery indication to the patient discharge. The operating room efficiency is determining factor in the ambulatory surgery center functioning. Several factors contribute to the operating room efficiency, the most critical of which is the time between surgical procedures o turnover time and this time is feasible to optimize. Ambulatory surgery is a mode of surgical work requiring its own clinical service properly planned, designed and organized to achieve its objectives and advantages.

Dexmedetomidine pharmacokinetics in the obese.

PURPOSE: This study aims to characterize the influence of body weight and composition on the pharmacokinetics of dexmedetomidine. METHODS: Twenty obese patients and 20 non-obese patients scheduled for elective laparoscopic surgery were given dexmedetomidine infusion schemes. Venous blood samples were taken during and after dexmedetomidine administration. Population pharmacokinetic modeling was undertaken to investigate fat free mass (FFM) and normal fat mass (NFM) as size descriptors of volumes and clearances using non-linear mixed effects modeling. NFM partitions total body weight into FFM and fat mass calculated from total body weight (TBW) minus FFM. The relative influence of fat mass compared to FFM is described by the fraction of fat mass that makes fat equivalent to FFM (Ffat). RESULTS: Theory-based allometric scaling using FFM best described weight and body composition differences in clearances and volumes A negative effect of fat mass of with an exponential parameter of -0.00541/kg (95 % CI -0.0118 to -0.00246) was estimated for clearance which indicates increased fat mass is associated with impairment of clearance. CONCLUSIONS: The use of theory-based allometry with predictions of fat free mass has been able to separate the influences of weight and body composition and indicates that size-normalized clearance of dexmedetomidine is impaired in patients who are obese.

Effect of acute arterial hypertension on morphine requirements and postsurgical pain.

STUDY OBJECTIVE: The study objective was to establish the impact of acute hypertension on morphine's requirements after laparoscopic cholecystectomy. DESIGN: The design was a randomized, simple blinded study. SETTING: The settings were operating room, postoperative recovery area, and first postoperative day. PATIENTS: There were 50 patients, American Society of Anesthesiologists I-II, aged 18-50 years, undergoing elective laparoscopic cholecystectomy with general anesthesia. INTERVENTIONS: Anesthetic management was standardized using propofol for induction, isoflurane for bispectral index (BIS) ranging between 40 and 60, and remifentanil maintained at a constant rate of 0.4 µg kg per minute throughout surgery in all patients. Once intubated, patients were randomly allocated to 1 of 2 groups: hypertensive group: systolic arterial blood pressure was maintained with phenylephrine infusion 20%-30% over baseline; control group: systolic arterial blood pressure was maintained 20%-30% below baseline. All surgical incisions were infiltrated with bupivacaine 0.5%, and every patient received ketorolac 60 mg intravenous. Patient-controlled analgesia with morphine intravenous was used for postoperative analgesia. MEASUREMENTS: Pain visual analogue scale scores, arterial blood pressure, and hyperalgesia were assessed at recovery room every 15 minutes during the first 2 postoperative hours and then at 6, 12, and 24 postoperative hours. Cumulative morphine consumption was registered at 2 and 24 postoperative hours. MAIN RESULTS: The cumulative morphine consumption in the control group was around 18 mg compared with 6 mg in the hypertensive group (P = .019). During the first 75 minutes after surgery, the control group had higher visual analogue scale score pain compared with hypertensive group (P = .005). CONCLUSIONS: The intraoperative acute generation of mild hypertension with phenylephrine reduced postoperative morphine consumption and pain scores after laparoscopic cholecystectomy.

Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.

BACKGROUND: Obesity is associated with important physiologic changes that can potentially affect the pharmacokinetic (PK) and pharmacodynamic (PD) profile of anesthetic drugs. We designed this study to assess the predictive performance of 5 currently available propofol PK models in morbidly obese patients and to characterize the Bispectral Index (BIS) response in this population. METHODS: Twenty obese patients (body mass index >35 kg/m), aged 20 to 60 years, scheduled for laparoscopic bariatric surgery, were studied. Anesthesia was administered using propofol by target-controlled infusion and remifentanil by manually controlled infusion. BIS data and propofol infusion schemes were recorded. Arterial blood samples to measure propofol were collected during induction, maintenance, and the first 2 postoperative hours. Median performance errors (MDPEs) and median absolute performance errors (MDAPEs) were calculated to measure model performance. A PKPD model was developed using NONMEM to characterize the propofol concentration-BIS dynamic relationship in the presence of remifentanil. RESULTS: We studied 20 obese adults (mean weight: 106 kg, range: 85-141 kg; mean age: 33.7 years, range: 21-53 years; mean body mass index: 41.4 kg/m, range: 35-52 kg/m). We obtained 294 arterial samples and analyzed 1431 measured BIS values. When total body weight (TBW) was used as input of patient weight, the Eleveld allometric model showed the best (P < 0.0001) performance with MDPE = 18.2% and MDAPE = 27.5%. The 5 tested PK models, however, showed a tendency to underestimate propofol concentrations. The use of an adjusted body weight with the Schnider and Marsh models improved the performance of both models achieving the lowest predictive errors (MDPE = <10% and MDAPE = <25%; all P < 0.0001). A 3-compartment PK model linked to a sigmoidal inhibitory Emax PD model by a first-order rate constant (ke0) adequately described the propofol concentration-BIS data. A lag time parameter of 0.44 minutes (SE = 0.04 minutes) to account for the delay in BIS response improved the fit. A simulated effect-site target of 3.2 µg/mL (SE = 0.17 µg/mL) was estimated to obtain BIS of 50, in the presence of remifentanil, for a typical patient in our study. CONCLUSIONS: The Eleveld allometric PK model proved to be superior to all other tested models using TBW. All models, however, showed a trend to underestimate propofol concentrations. The use of adjusted body weight instead of TBW with the traditional Schnider and Marsh models markedly improved their performance achieving the lowest predictive errors of all tested models. Our results suggest no relevant effect of obesity on both the time profile of BIS response and the propofol concentration-BIS relationship.

Prevalence of abdominal aortic aneurysm is still high in certain areas of southern Europe.

BACKGROUND: Ultrasound screening of abdominal aortic aneurysm (AAA) has proved to reduce mortality from AAA rupture and has been implemented in several countries. Recent reports show a decreasing prevalence of AAA in Western countries. We report the results from a screening program among 65-year-old men in a defined area in the North of Spain. METHODS: We invited the 1,413 men born in 1943 and registered in the health area under our care to participate in the study. We registered their medical history and cardiovascular risk factors and we performed an abdominal ultrasound scan. We diagnosed an AAA when the infrarenal aortic diameter was ≥3 cm. We performed univariate and multivariate analysis to assess independent factors associated with the development of an AAA, using logistic regression. RESULTS: The participation rate was 70.8%. The prevalence of active smoking, hypertension, diabetes, and hypercholesterolemia was 19.6%, 52.1%, 25.7%, and 76.9%, respectively. Including 3 previously known and repaired AAAs, the total prevalence of AAA was 4.7% (n=37). The mean diameter of the AAA was 35.7±7.9 mm (range, 30-62 mm). Multivariate analysis confirmed the independent impact of active smoking (Exp[B], 3.47 [95% confidence interval {CI}: 1.67-7.22]), hypertension (Exp[B], 2.43 [95% CI: 1.08-5.45]), and peripheral arterial disease (Exp[B], 3.00 [95% CI: 1.16-7.80]) on the incidence of AAA. CONCLUSIONS: The prevalence of AAA remains high in the studied area in the North of Spain. The potential benefit of lowering smoking rates has not been observed yet. The current international recommendations of screening for 65-year-old men are still applicable in our population.