Alternative Evolutionary Pathways in Paspalum Involving Allotetraploidy, Sexuality, and Varied Mating Systems.

The genetic systems of Paspalum species have not been extensively studied. We analyzed the ploidy, reproductive mode, mating system, and fertility of four Paspalum species-Paspalum durifolium, Paspalum ionanthum, Paspalum regnellii, and Paspalum urvillei. An analysis of 378 individuals from 20 populations of northeastern Argentina was conducted. All populations of the four Paspalum species were pure tetraploid and had a sexual and stable reproductive mode. However, some populations of P. durifolium and P. ionanthum showed low levels of apospory. Populations of P. durifolium and P. ionanthum had low seed sets under self-pollination but were fertile under open pollination, showing that self-incompatibility likely caused self-sterility. In contrast, populations of P. regnellii or P. urvillei showed no evidence of apospory, and seed sets in both self- and open pollination conditions were high, suggesting that they are self-compatible due to the absence of pollen-pistil molecular incompatibility mechanisms. The evolutionary origin of the four Paspalum species could explain these differences. This study supplies valuable insights into the genetic systems of Paspalum species, which could have implications for their conservation and management.

Desire for children among male survivors of childhood cancer: A DCCSS LATER study.

BACKGROUND: Knowledge of the desire for children among childhood cancer survivors (CCSs) is scarce. This study evaluated the desire for children in male CCSs in comparison with male siblings. METHODS: A nationwide cohort study was conducted as part of the Dutch Childhood Cancer Survivor Study LATER study: 1317 male CCSs and 407 male sibling controls completed a questionnaire addressing the desire for children. Logistic regression analyses were used to explore the independent association between survivorship status and the desire for children. Furthermore, additional analyses were performed to identify which cancer-related factors were associated with the desire for children in male CCSs. RESULTS: After adjustments for the age at assessment, the percentage of men who had a desire for children was significantly lower among CCSs compared with the siblings (74% vs. 82%; odds ratio [OR], 0.61; 95% CI, 0.46-0.82; p = .001). The association between survivorship status and the desire for children was attenuated after adjustments for marital status, level of education, and employment status (OR, 0.83; 95% CI, 0.61-1.14; p = .250). The percentage of men who had an unfulfilled desire for children remained significantly higher among CCSs compared with the siblings after adjustments for sociodemographic factors (25% vs. 7%; OR, 5.14; 95% CI, 2.48-10.64; p < .001). CONCLUSIONS: The majority of male CCSs have a desire for children. The likelihood of having to deal with an unfulfilled desire for children is 5 times higher among CCSs compared with their siblings. This insight is important for understanding the needs and experienced problems of CCSs regarding family planning and fertility issues.

Chronic Use of Deslorelin in Dogs: Six Cases (2005-2022).

Deslorelin is currently registered for the induction of temporary infertility in male dogs, male cats, male ferrets, and also prepubertal female dogs, but research has shown its usefulness for other conditions requiring chronic treatment. This paper presents six cases of dogs chronically treated with deslorelin for indications such as benign prostatic hyperplasia, control of fertility, abnormal reproductive behavior and urinary incontinence. All animals were in good health during treatment. Treatment duration was 2-9 years. No short-term side effects were observed except for flare-up reactions, which were observed only in 1/4 intact males. Two dogs developed a neoplasia: a spayed bitch treated for urinary incontinence developed a pituitary carcinoma, and an intact male dog implanted for control of fertility developed a bladder carcinoma. While the pituitary carcinoma seems unlikely to be related to deslorelin, the bladder carcinoma could be due to the neutered condition of the dog (which was treated for 9 years) as urinary tract neoplasia is more common in dogs following gonadectomy. Chronic treatment with deslorelin is regarded as safe when an animal is being treated for life. The possibility that a pause in the treatment might be helpful for the animal should be investigated.

Mistimed restricted feeding disrupts circadian rhythms of male mating behavior and female preovulatory LH surges in mice.

In rodents, eating at atypical circadian times, such as during the biological rest phase when feeding is normally minimal, reduces fertility. Prior findings suggest this fertility impairment is due, at least in part, to reduced mating success. However, the physiological and behavioral mechanisms underlying this reproductive suppression are not known. In the present study, we tested the hypothesis that mistimed feeding-induced infertility is due to a disruption in the normal circadian timing of mating behavior and/or the generation of pre-ovulatory luteinizing hormone (LH) surges (estrogen positive feedback). In the first experiment, male+female mouse pairs, acclimated to be food restricted to either the light (mistimed feeding) or dark (control feeding) phase, were scored for mounting frequency and ejaculations over 96 h. Male mounting behavior and ejaculations were distributed much more widely across the day in light-fed mice than in dark-fed controls and fewer light-fed males ejaculated. In the second experiment, the timing of the LH surge, a well characterized circadian event driven by estradiol (E2) and the SCN, was analyzed from serial blood samples taken from ovariectomized and E2-primed female mice that were light-, dark-, or ad-lib-fed. LH concentrations peaked 2 h after lights-off in both dark-fed and ad-lib control females, as expected, but not in light-fed females. Instead, the normally clustered LH surges were distributed widely with high inter-mouse variability in the light-fed group. These data indicate that mistimed feeding disrupts the temporal control of the neural processes underlying both ovulation and mating behavior, contributing to infertility.

Identification of neurohypophysial hormones and the role of VT in the parturition of pregnant seahorses (Hippocampus erectus).

Neurohypophysial hormones regulate the reproductive behavior of teleosts; however, their role in the gestation and parturition of ovoviviparous fishes with male pregnancy (syngnathids) remains to be demonstrated. In the present study, the complementary DNA (cDNA) sequences of arginine vasotocin (VT) and isotocin (IT) from the lined seahorse (Hippocampus erectus) were cloned and identified. We observed that the mature core peptides of seahorse VT and IT were conserved among teleosts. In the phylogenic tree, seahorse VT and IT were clustered independently with teleost VT and IT. The tissue distribution patterns of VT and IT were similar, and both were highly expressed in the brain, gills, and gonads. Interestingly, they were also expressed to some extent in the brood pouch. In situ hybridization revealed that VT and IT messenger RNA (mRNA) signals in the brain were mainly located in the preoptic area region of the hypothalamus. Intraperitoneal administration of the VT core peptide to pregnant seahorses induced premature parturition, stimulated gonadotropin release, increased serum estrogen levels, and decreased prolactin secretion. Moreover, VT injection upregulated the mRNA expression of the membrane estrogen receptor in the brood pouch. In summary, neurohypophysial hormones promote premature parturition by regulating estrogen synthesis through the hypothalamus-pituitary-gonad axis.

Warren Miller y el Modelo TDI-B de toma de decisiones reproductivas: Una revisión teórica / Warren Miller and the T-D-I-B reproductive decision-making model: A theoretical review / Warren Miller e o Modelo T-D-I-B de tomada de decisões reprodutivas: Uma revisão teórica

El presente estudio teórico objetiva sistematizar los aspectos más importantes del modelo Trait-Desires-Intentions-Behaviors (T-D-I-B) de Warren Miller que explica las decisiones reproductivas. Organizamos la información en base a cuatro ejes temáticos: 1) Elementos biográficos de Warren Miller y sus primeras producciones científicas sobre el comportamiento reproductivo; 2) Descripción del modelo T-D-I-B; 3) Definición del modelo diádico donde las estructuras motivacionales de dos socios interactúan a medida que se desarrolla la secuencia de cuatro pasos de cada individuo y; 4) Exposición de la evidencia empírica del modelo T-D-I-B y estudios actuales realizados en Irán, Polonia, Brasil y Perú.

The present theoretical study aims to systematize the most important aspects of Warren Miller's Trait-Desires-Intentions-Behaviors (T-D-I-B) model that explains reproductive decisions. We organize the information based on four thematic axes: 1) Biographical elements of Warren Miller and his first scientific productions on reproductive behavior; 2) Description of the T-D-I-B model; 3) Definition of the dyadic model where the motivational structures of two partners interact as each individual's four-step sequence develops and 4) Exposure of the empirical evidence of the T-D-I-B model and current studies carried out in Iran, Poland, Brazil and Peru.

O presente estudo teórico visa sistematizar os aspectos mais importantes do modelo Traço-Desejo-Intenções-Comportamentos (T-D-I-B) de Warren Miller, que explica as decisões reprodutivas. Organizamos as informações com base em quatro eixos temáticos: 1) Elementos biográficos de Warren Miller e suas primeiras produções científicas sobre comportamento reprodutivo; 2) Descrição do modelo T-D-I-B; 3) Definição do modelo diádico em que as estruturas motivacionais de dois parceiros interagem conforme a sequência de quatro etapas de cada indivíduo se desenvolve; 4) Exposição da evidência empírica do modelo T-D-I-B e estudos atuais realizados no Irã, Polônia, Brasil e Peru.

Lateralization of Courtship Traits Impacts Pentatomid Male Mating Success-Evidence from Field Observations.

Lateralization has been documented in many insect species, but limited information on courtship and mating lateralization in wild conditions is available. We conducted field investigation on the courtship and mating behavior of the neem bug, Halys dentatus, a polyphagous insect mainly infesting Azadirachta indica, with particular attention to lateralization of mating displays. We investigated the presence of population-level behavioral asymmetries during H. dentatus sexual interactions and their influence on male mating success. Two lateralized traits were found: left or right-biased male approaches to the female and left or right-biased male turning displays. Males approaching females from their left side were mainly right-biased in the 180° turning display, and males that approached females from their right side were mainly left-biased. Right-biased males by turning 180° to carry out end-to-end genital contact, performed a lower number of copulation attempts, thus starting copula earlier than left-biased males. Mating success was higher when males approached the left side of females during sexual interactions. A higher number of successful mating interactions was observed in right-biased males when turning 180°. Our results add useful knowledge on the reproductive behavior of H. dentatus in the field, with potential applications for identifying useful benchmarks to monitor the quality of individuals mass-reared for pest control purposes over time.

Influence of octylphenol on gene expression of gonadotropins and their receptors, testicular structure and mating behavior of male Rana chensinensis.

In the present study, responses of the Chinese brown frog (Rana chensinensis) to exposure to different doses and duration of Octyphenol (OP) which degraded from alkylphenol ethoxylates (APEs) were characterized during the adult periods. The effects of OP on growth, development and reproduction and the expression of genes in gonad were investigated. The expression levels of fshß, lhß, fshr and lhr had significant differences as the exposure time increased. The pathological and morphological changes were also observed in the OP treatments. Furthermore, the number of TUNEL positive cells and the TUNEL index was elevated after exposed to OP. Besides that, OP treatment could influence its mating behavior and reduce the fertilization rates. Taken together, these results indicated that OP disrupt sex steroid signaling, normal development of spermatogenesis, courtship behavior of male frogs and decline fertilization rate in R. chensinensis.

Efectos demográficos, clínicos y biológicos de la postergación de la maternidad / Demographic, clinical, and biological effects of delayed maternity

En el presente artículo se analizan los efectos de la postergación de la maternidad en tres ámbitos: i) demográfico, ii) clínico y iii) biológico. Desde luego, la literatura demográfica existente procede fundamentalmente de países con un buen grado de desarrollo, pero se ha realizado un esfuerzo por reunir la mayor cantidad de datos de países en desarrollo. Así se analiza la situación en Europa, EE.UU. y Latinoamérica para finalizar esta sección con la realidad específica en Chile. Desde el punto de vista clínico, se pone especial interés en los cambios que experimenta la probabilidad de embarazo por ciclo (definida como fecundabilidad) y la fertilidad en general. En los aspectos perinatológicos se enfatiza el incremento de frecuencia de la muerte fetal in útero temprana (aborto espontáneo) y tardía con especial mención de algunas patologías (frecuencia del síndrome de Down y otros). Se establece además la frecuencia significativamente mayor de bajo y muy bajo peso de nacimiento, necesidad de hospitalización del recién nacido (morbilidad perinatal) así como el efecto sobre la mortalidad neonatal.Biológicamente la postergación de la maternidad tiene su correlato en la pérdida de reserva ovárica y la disminución de la calidad ovocitaria que involucra un aumento en la incidencia de fallas de fecundación y embriones con bajo potencial de desarrollo y aneuploidías dependientes fundamentalmente de la edad materna. También se hace mención a algunos aspectos del envejecimiento uterino y sus consecuencias en el desarrollo y función placentaria. El enfoque se centra fundamentalmente en la mujer, pero incluye aspectos de la contribución masculina a esta temática.

This article analyzes the effects of the postponement of maternity in three areas: i) demographic, ii) clinical and perinatological and iii) biological. Of course, the existing demographic literature comes primarily from well-developed countries, but an effort has been made to collect as much data from developing countries. The situation in Europe, the U.S. and Latin America is analyzed to end this section with the specific reality in Chile. From the clinical point of view, special interest is placed on changes in the probability of pregnancy by cycle (defined as fecundability) and fertility in general. In the perinatological aspects, the increased frequency of early fetal death (spontaneous abortion) and stillbirth is emphasized, with special mention of some pathologies (frequency of Down syndrome and others). It is also stressed the significant higher frequency of low and very low birth weight, the need newborn hospitalization (perinatal morbidity), as well as the effects on neonatal mortality. Biologically, the postponement of maternity has its correlation in the loss of ovarian reserve and the decrease in oocyte quality that involves an increased incidence of fertilization failure and embryos with low potential for development and aneuploidies, mainly dependent on maternal age. Some aspects of uterine aging and its consequences on placental development and function are also mentioned. The discussion is mainly focused on women, but includes some aspects of the male contribution to this issue

Tributyltin impaired spermatogenesis and reproductive behavior in male zebrafish.

Tributyltin (TBT) was reported to affect sexual behavior and gametogenesis in fish. However, the modes of action involved are largely unclear. In order to elucidate the toxicological mechanisms of TBT in reproduction, zebrafish (Danio rerio) males were exposed to TBT at concentrations of 100 and 500 ng/L for 28 days. After exposure, the sperm count of the treated fish was sharply decreased though the testis weight and gonadosomatic index remained unchanged. Moreover, reduced number of spermatogonia and spermatozoa and increased spermatocytes were observed in TBT-treated fish by histological observation and PCNA-immunostaining. Increased number of apoptotic-positive spermatocytes was also present in TBT-treated fish, indicating an enhanced apoptosis in these cells. Consistent to decreased number of spermatogonia, down-regulated expressions of genes responsible for germ cell proliferation (cyclind1 and pcna) were observed in TBT-treated fish. In contrast, TBT elevated the expressions of genes involved in meiotic entry and maintenance (aldhla2, sycp3 and dmc1) while suppressed the mRNA level of gene responsible for terminus of meiotic entry (cyp26a1), in agreement with arrested meiosis and reduced sperm count. Furthermore, TBT significantly elevated the ratios of bax/bcl-2 and tnfrsf1a/tnfrsf1b in testis, which are markers for intrinsic- and extrinsic-apoptotic pathways, consistent with the enhanced TUNEL positive signals in spermatocytes. Moreover, TBT also significantly affected the parameter of reproductive behaviors in treated fish (reflected by decreased frequency of meeting, visits and time spent in spawning area). Consistently, the expressions of genes responsible for the modulation of reproductive behaviors in brain (such as cyp19a1b, kiss2, gnrh3 and ompb) were significantly down-regulated in treated-fish. Interestingly, disrupted reproductive behaviors of untreated female fish were also observed in the present study. The present study indicated that TBT might affect the reproduction of zebrafish male by disrupting the spermatogenesis and reproductive behavior of the fish.

Norethindrone alters mating behaviors, ovary histology, hormone production and transcriptional expression of steroidogenic genes in zebrafish (Danio rerio).

The impact of progestins (i.e. synthetic forms of progesterone) on aquatic organisms has drawn increasing attention due to their widespread occurrence in the aquatic environments and potential effects on the endocrine system of fish. In this study, the effects of norethindrone (NET, a progestin) on the reproductive behavior, sex hormone production and transcriptional expressions were evaluated by exposing female zebrafish to NET at 0, 3.1, 36.2 and 398.6 ng L-1 for 60 days. Results showed that NET impaired the mating behaviors of female at 36.2 and 398.6 ng L-1 exhibited by males and increased the frequency of atretic follicular cells in the ovary exposed to NET at 398.6 ng L-1. As for sex hormones, plasma testosterone concentration in zebrafish increased, while estradiol concentration decreased. Up-regulation of genes (Npr, Mpra, Mprß, Fshß, Lß, Tshb, Nis and Dio2) was detected in the brain of fish exposed to NET at 398.6 ng L-1. The transcriptional levels of genes (Esr1, Vtg1, Ar, Cyp19a, Cyp11b and Ptgs2) were generally inhibited in the ovary of zebrafish by NET at 398.6 ng L-1. Moreover, the transcripts of genes (Vtg1, Esr1, Ar and Pgr) in the liver were reduced by NET at 36.2 and 398.6 ng L-1. Our findings suggest that NET can potentially diminish the of fish populations not only by damaging their reproductive organs, but also by altering their mating behavior through the changes in the expressions of genes responsible for the production of sex hormones.

Courtship in the male red-sided garter snake is dependent on neural aromatase activity during winter dormancy.

The red-sided garter snake exhibits a dissociated reproductive pattern, mating at a time when their gonads are quiescent and circulating sex steroids, initially reported to be low, have been found to be elevated during the breeding season. However, the only cue identified that initiates courtship behavior and mating in the red-sided garter snake is an extended period of low-temperature dormancy (LTD) followed by exposure to warm temperatures. In this study, we examined a possible association between winter dormancy, sex steroid hormone metabolism, and initiation of reproductive behavior in the male red-sided garter snake. Upon emergence from winter dormancy, courtship behavior was assessed using attractive females as stimuli. Animals receiving implants containing 1,4,6-androstatriene-3,17-dione (ATD), an aromatase inhibiter, showed little or no courtship behavior, while animals implanted with ATD + 17ß estradiol (E2 ) or blank implants exhibited normal courtship. In addition, neurons in the pathways critical in the control of reproductive behavior were examined using the Golgi method. Examination of brains collected upon emergence revealed animals implanted with ATD had a significantly reduced number of dendritic spines compared to controls and animals treated with ATD + E2 . This study provides the first documentation that courtship behavior and mating in the male red-sided garter snake appears to be controlled not by LTD alone, but in conjunction with sex steroid hormones. Moreover, behavioral data suggest that the aromatization of androgens during LTD appears to be critical for the initiation of reproductive behavior in the male red-sided garter snakes.

Gonad development and reproductive hormones of invasive silver carp (Hypophthalmichthys molitrix) in the Illinois River.

Reproduction is a major component of an animal's life history strategy. Species with plasticity in their reproductive biology are likely to be successful as an invasive species, as they can adapt their reproductive effort during various phases of a biological invasion. Silver carp (Hypophthalmicthys molitrix), an invasive cyprinid in North America, display wide variation in reproductive strategies across both their native and introduced ranges, though the specifics of silver carp reproduction in the Illinois River have not been established. We assessed reproductive status using histological and endocrinological methods in silver carp between April and October 2018, with additional histological data from August to October 2017. Here, we show that female silver carp are batch spawners with asynchronous, indeterminate oocyte recruitment, while male silver carp utilize a determinate pattern of spermatogenesis which ceases in the early summer. High plasma testosterone levels in females could be responsible for regulating oocyte development. Our results suggest that silver carp have high spawning activity in the early summer (May-June), but outside of the peak spawning period, female silver carp can maintain spawning-capable status by adjusting rates of gametogenesis and atresia in response to environmental conditions, while males regress their gonads as early as July. The results of this study are compared to reports of silver carp reproduction in other North American rivers as well as in Asia.

Some aspects of the hypothalamic and pituitary development, metamorphosis, and reproductive behavior as studied in amphibians.

In this review article, information about the development of the hypothalamo-hypophyseal axis, endocrine control of metamorphosis, and hormonal and pheromonal involvements in reproductive behavior in some amphibian species is assembled from the works conducted mainly by our research group. The hypothalamic and pituitary development was studied using Bufo embryos and larvae. The primordium of the epithelial hypophysis originates at the anterior neural ridge and migrates underneath the brain to form a Rathke's pouch-like structure. The hypothalamo-hypophyseal axis develops under the influence of thyroid hormone (TH). For the morphological and functional development of the median eminence, which is a key structure in the transport of regulatory hormones to the pituitary, contact of the adenohypophysis with the undeveloped median eminence is necessary. For the development of proopiomelanocortin-producing cells, contact of the pituitary primordium with the infundibulum is required. The significance of avascularization in terms of the function of the intermediate lobe of the pituitary was evidenced with transgenic Xenopus frogs expressing a vascular endothelial growth factor in melanotropes. Metamorphosis progresses via the interaction of TH, adrenal corticosteroids, and prolactin (PRL). We emphasize that PRL has a dual role: modulation of the speed of metamorphic changes and functional development of organs for adult life. A brief description about a novel type of PRL (1B) that was detected was made. A possible reason why the main hypothalamic factor that stimulates the release of thyrotropin is not thyrotropin-releasing hormone, but corticotropin-releasing factor is considered in light of the fact that amphibians are poikilotherms. As regards the reproductive behavior in amphibians, studies were focused on the courtship behavior of the newt, Cynops pyrrhogaster. Male newts exhibit a unique courtship behavior toward sexually developed conspecific females. Hormonal interactions eliciting this behavior and hormonal control of the courtship pheromone secretion are discussed on the basis of our experimental results.

Female Reproductive Behavior.

Reproductive behavior is the behavior related to the production of offspring and includes all aspects from the establishment of mating systems, courtship, sexual behavior, and parturition to the care of young. In this chapter, I outline the hormonal regulation of the estrous cycle, followed by a description of the neural regulation of female sexual behavior. Ovarian hormones play an important role in the induction of ovulation and behavioral estrus, in which they interact closely with several neurotransmitters and neuropeptides to induce sexual behavior. This chapter discusses the latest research on the role of estrogen, progesterone, serotonin, dopamine, noradrenaline, oxytocin, and GABA in female mating behavior. In addition, the most relevant brain areas, such as the preoptic area and the ventromedial nucleus of the hypothalamus, in which these regulations take place, are discussed.

The everlasting outmoded contraceptive method mix in Brazil and its legacy / O mix contraceptivo eternamente obsoleto no Brasil e seu legado / El mix anticonceptivo eternamente obsoleto en Brasil y su legado

Fertility transition occurred in a short period of time in Brazilian the absence of family planning programs, and most noticeable, in a context of illegality in the provision of means of fertility self-regulation. These events did not happen without consequences. Based in the literature and facts registered during that time, the paper first discusses how the resistance to the implementation of family planning programs from the 1960s to the 1980s have contributed to the unbalanced contraceptive method mix in the 1990's. Secondly, the paper will discuss problems around contraceptive data collection in the National Health Survey, and, performing an adjustment of the data, we analyze trends in the use of contraceptive methods from 1986 to 2013, showing that method mix continues to be very concentrated in the same two methods, an even more outdated scheme, with the daily pill exchanging first place with female sterilization. Finally, the paper discusses some fertility characteristics associated with the outdated contraceptive mix, still prevailing at the end of fertility transition, arguing that this could be avoided or minimized if policies and laws are based in reproductive rights of all people only.

A transição da fecundidade ocorreu de maneira rápida no Brasil na ausência de programas de planejamento familiar e, mais impressionante, em um contexto de ilegalidade na provisão dos meios para a autorregulação da fecundidade. Esses eventos não ocorreram sem consequências. Com base na literatura e nos fatos registrados durante esse período, o artigo discute, primeiro, como a resistência à implementação de programas de planejamento familiar nas décadas de 1960 a 1980 contribuiu para o mix contraceptivo obsoleto, já nos anos 1990. Em segundo lugar, abordando os problemas em torno da coleta de dados de contracepção na Pesquisa Nacional de Saúde e fazendo um ajuste nos dados, são analisadas as tendências na prevalência contraceptiva de 1986 a 2013, mostrando que o mix de métodos continua muito concentrado nos mesmos dois métodos, um regime ainda mais obsoleto, com a pílula diária trocando de lugar com a esterilização feminina. Por fim, são discutidas algumas características da fecundidade associadas ao mix contraceptivo obsoleto, que ainda prevalece no final da transição da fecundidade. Argumenta-se que isso poderia ser evitado ou minimizado se políticas e leis fossem baseadas apenas nos direitos reprodutivos de todas as pessoas.

La transición de la fecundidad se dio rápidamente en Brasil en ausencia de programas de planificación familiar y, más sorprendentemente, en un contexto de ilegalidad en la provisión de los medios para la autorregulación de la fecundidad. Esos eventos no ocurrieron sin consecuencias. Con base en la literatura y los hechos registrados durante ese período, el artículo analiza primero cómo la resistencia a la implementación de programas de planificación familiar en los años sesenta a ochenta resultó en el mix de contraceptivos obsoleto de los noventa. En segundo lugar, analizando los problemas relacionados con la recopilación de datos de la Encuesta Nacional de Salud, y ajustándolos, se analizan las tendencias en la prevalencia de los anticonceptivos de 1986 a 2013, lo que demuestra que el mix de métodos sigue estando muy centrado en los mismos dos métodos, un régimen aún más obsoleto, con la píldora diaria intercambiando el primer lugar con la esterilización femenina. Finalmente, se discuten algunas características de fecundidad asociadas con el mix anticonceptivo obsoleto, que aún prevalecen al final de la transición de fecundidad. Se argumenta que esto podría evitarse o minimizarse si las políticas y leyes se basaran en los derechos reproductivos de todas las personas.

Early adolescent childbearing in Colombia: time-trends and consequences / Maternidad prematura adolescente en Colombia: tendencias temporales y consecuencias / Gravidez precoce na adolescência na Colômbia: tendências temporais e consequências

Teenage childbearing has been increasing, especially among girls aged 10 to 14 years, slowing the improvements in public health and propelling social marginalization. The objective of this article is to study adolescent pregnancy in Colombia and suggest possible policy interventions. The study comprises univariate and multivariate analyses that examine trends and correlates of teenage childbirth and related infant mortality in Colombia between 2001-2011 using complete vital statistics. The study compares, by relative risk analysis as well, two groups of teenage mothers, aged 10 to 14 years and 15 to 19 years, with a reference group of mothers aged 20 to 34 years. During the study period, the average of annual birth rates increased 2.6% and 0.8% in mothers aged 10 to 14 years, and 15 to 19 years respectively, whereas it declined at an average rate of 0.2% annually for mothers aged 20 to 35 years. Simultaneously, while the overall rate declined, the infant mortality rate (IMR) of the youngest group was consistently higher during the entire period compared to the IMR of older groups. Compared with the other groups, mothers aged from 10 to 14 were more likely to be unmarried, rural, indigenous or afro-descendant, and have less access to health care. The study demonstrates that early teenage childbirth is a growing challenge at least in Colombia. These mothers are at higher risk of losing their babies while being poor and remaining poor. The study suggests the need for policy that targets appropriate education and health care to poor girls as early as age 10 and even younger.

La maternidad prematura se ha visto incrementada, especialmente entre niñas con edades comprendidas entre los 10 a 14 años, aminorando mejoras en la salud pública y propagando la marginalización social. El objetivo de este artículo es estudiar los embarazos adolescentes en Colombia y sugerir posibles políticas de intervención. El estudio abarca análisis univariados y multivariados que examinan tendencias y correlacionan el parto en la adolescencia y la mortalidad infantil relacionada, en Colombia, durante el periodo de 2001 a 2011, usando estadísticas vitales completas. El estudio compara, también, mediante un análisis de riesgos relativos, a dos grupos de madres adolescentes, con edades de 10 a 14 y edades de 15 a 19 años, con un grupo de referencia, madres con edades de 20 a 34. Durante el período de estudio, la media anual de la tasa de natalidad se incrementó un 2,6% y un 0,8% en madres con edades de 10 a 14 años, y edades de 15 a 19 años, respectivamente, mientras que decreció a una tasa media de 0,2% anualmente en madres con 20-35 años de edad. Simultáneamente, mientras disminuía en general, la tasa de mortalidad infantil (TMI) del grupo más joven fue consistentemente más alta durante todo el período que la TMI de los grupos con mayor edad. Comparadas con otros grupos, las madres con edades entre 10 a 14 años eran más propensas a no estar casadas, ser procedentes del ámbito rural, indígenas o afro-mulatas, y contar con menor acceso a servicios de salud. El estudio demuestra que la maternidad prematura en adolescentes es un desafío creciente, al menos en Colombia. Estas madres tienen un riesgo más alto de perder a sus bebés mientras están en situación de pobreza. El estudio indica la necesidad de políticas que tengan como objetivo una educación apropiada y cuidados de salud, dirigidos a niñas pobres, desde una edad tan temprana como los 10 años o incluso más jóvenes.

A gravidez na adolescência tem crescido, especialmente na faixa etária de 10 a 14 anos, freando avanços na saúde pública e impulsionando a marginalização social. O objetivo deste artigo é estudar a gravidez na adolescência na Colômbia e sugerir possíveis intervenções de políticas públicas. O estudo consiste em análises univariadas e multivariadas que examinam tendências e correlativos da gravidez na adolescência e da mortalidade infantil associada na Colômbia no período de 2001 a 2011 usando estatísticas vitais completas. O estudo compara, também por meio de análise de risco relativo, dois grupos de mães adolescentes, com idade entre 10 e 14 anos e entre 15 e 19 anos, com um grupo de referência, mães com idade entre 20 e 34 anos. Durante o período do estudo, as taxas médias anuais de natalidade aumentaram em 2,6% e 0,8% entre as mães com idade entre 10 e 14 e entre 15 e 19 anos, respectivamente, ao mesmo tempo em que sofreram uma redução, a uma taxa média anual de 0,2%, entre as mães com idade entre 20 e 35 anos. Ao mesmo tempo, a taxa de mortalidade infantil (TMI) do grupo mais jovem foi consistentemente mais alta do que a dos grupos mais velhos, ainda que tenha sofrido uma redução. Quando comparadas aos outros grupos, mães com idade entre 10 e 14 anos tinham maior probabilidade de serem solteiras, indígenas ou Afro-mulatas, viverem em áreas rurais e terem menos acesso a serviços de saúde. Este estudo demonstra que a gravidez precoce na adolescência é um desafio crescente, pelo menos na Colômbia. Essas mães têm risco maior de perderem seus bebês e, simultaneamente, de serem e permanecerem pobres. O estudo sugere a necessidade de políticas dirigidas à educação e serviços de saúde apropriados para meninas pobres a partir dos 10 anos e até mais jovens.

Adaptation to High-Risk Childbearing: A Preliminary Situation-Specific Theory / Adaptación a la maternidad de alto riesgo: una teoría preliminar específica de la situación / Adaptação à maternidade de alto risco: uma teoria preliminar específica da situação

ABSTRACT The purpose of this paper is to present a discussion of a preliminary situation-specific theory of adaptation to high-risk childbearing for expectant and new mothers and fathers. Roy's Adaptation Model guided the design and conduct of the pilot study of correlates of maternal and paternal functional status from which the theory was derived. The conceptual-theoretical-empirical structure for the study is displayed in a diagram. The concepts of the theory-functional status, physical symptoms, physical energy, psychological symptoms, and relationship quality--are identified and defined, and their linkages are identified. Implications for testing and potential use of the theory in nursing practice are discussed.

RESUMEN El propósito de este artículo es presentar una discusión sobre una teoría preliminar específica, de la situación de la adaptación a la maternidad de alto riesgo, para las futuras madres y los nuevos padres. El modelo de adaptación de Roy sirvió de guía para el diseño y la realización del estudio piloto de correlatos del estado funcional materno y paterno del cual se derivó la teoría. La estructura conceptual-teórico-empírica para el estudio se muestra en un diagrama. Se identifican y definen los conceptos de la teoría: estado funcional, síntomas físicos, energía física, síntomas psicológicos y calidad de la relación, y se identifican sus vínculos. Se discuten las implicaciones para las pruebas y el uso potencial de la teoría en la práctica de enfermería.

RESUMO O objetivo deste artigo é apresentar uma discussão de uma teoria preliminar específica da situação de adaptação à maternidade de alto risco para as futuras mães e os novos pais. O modelo de adaptação de Roy serviu como um guia para desenho e implementação do estudo piloto de correlatos do estado funcional materno e paterno do qual a teoria foi derivada. A estrutura conceitual-teórico-empírica para o estudo é mostrada em um diagrama. Os conceitos da teoria são identificados e definidos: estado funcional, sintomas físicos, energia física, sintomas psicológicos e qualidade da relação, e seus elos são identificados. As implicações para o teste e o uso potencial da teoria na prática de enfermagem são discutidas.

Preovulatory progesterone secretion terminates the duration of reproductive behavior during heat in the bitch.

To evaluate the role of preovulatory progesterone on canine sexual behavior and the course of proestrus and estrus, seven bitches in spontaneous cycles were treated with aglepristone for temporary elimination of progesterone action. Aglepristone was administered at the dose 10 mg/kg b.m., two times 24 hours apart, beginning in early proestrus when progesterone concen- tration was ⟨0.5 ng/ml. Seven untreated bitches served as a control group. Reproductive sexual behavior (standing behavior, display vulva, tail deviation) was evaluated according to behavioral score. Cytologic, clinical and vaginoscopic examinations and progesterone measurements were used for the determination of proestrus and estrus and estimation of ovulation time. Although, a similar pattern and magnitude of sexual behavior were observed in both groups, the duration of a total reproductive behavior was significantly extended (28.71 ± 2.06 vs 17.00 ± 2.45, p ⟨0.05) in experimental group; similarly, the length of cytologic estrus (23.86 ± 3.02 vs 11.14 ± 2.41, p ⟨0.05) was prolonged in treated bitches. In contrast, ovulation rate, duration of proestrus did not differ between the groups (p >0.05). We conclude, that during the canine estrus cycle the preovulatory progesterone terminates the duration of reproductive behavior and cytologic estrus.

The use of female estrogenized goats as sexual stimulator of crossbred dairy males subsequently exposed to acyclic goats during two phases of the anestrous season.

This research evaluated the possible influence of exposure of male goats to estrogenized female goats ("female effect") upon males' sexual behavior [appetitive (ASB) & consummatory (CSB)], as well as the induction of reproductive activity of crossbred dairy female goats exposed to such treated males ("male effect") during the early and deep anestrous periods. Crossbred dairy adult male goats (n = 12; 24-48 mo. old) and 80 anovulatory crossbred dairy adult female goats (34-50 mo. old) were used during two experimental periods: March to April and April to May. First, males were separated into four groups (n = 3 each), roughly homogeneous regarding body weight and body condition score and randomly assigned to four experimental groups. The first two groups included males + estrogenized females, then such males were exposed to anestrous females either during March (group 1: three males; 20 females; EFEM-MAR), or during April (group 2: three males; 20 females; EFEM-APR). The second two groups were respective control groups: Males + non-treated-anestrous females, and then such males exposed to acyclic females either during March (group 3: three males; 20 females; CONT-MAR) or April (group 4: three males; 20 females; CONT-APR). Once the male-to-female contact was established, both odor (ODT) and behavior (BEHT) tests (2 d × 2 h) were performed during both anestrous periods. On day 10 after introduction of the males, in both anestrous periods, one ultrasonography scanning ("US") was performed to quantify the presence, number and size of corpus luteum (US-CL) to determine the effectiveness of the "male effect" and indicators of ovarian activity. Then, on day 45 after introduction of the males, a second US was performed to evaluate pregnancy rate (US-PREG). The EFEM-males, regardless of the phase of the anestrous cycle, had an increased (P < 0.05) odor intensity with respect to the control groups. In addition, while an increased (P < 0.05) ASB occurred in the EFEM-males, no CSB differences (P > 0.05) arose when treatments were compared, neither in March-April nor in April-May. The EFEM-males exposed to acyclic goats in March-April (i.e. early anestrous period), promoted not only the largest estrus and ovulatory responses (P < 0.05), but also the largest pregnancy rate (P < 0.05) in these previously anestrus goats, suggesting that in April-May (i.e. profound anestrous), the presence of active males was not enough to completely suppress cyclic reproductive arrest. This study generates interesting out-of-season reproductive outcomes in a goat population with a large proportion of highly seasonal dairy breeds (i.e. Alpine, Saanen and Toggenburg), augmenting the possibility to expand milk production and the economic income of goat producers across the year. Besides, this practice may serve as an interesting reproductive tool to increase the sustainability of marginal goat production systems under semiarid conditions.