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Adv Mater ; 32(11): e1907365, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32022975

RESUMO

Tumor-lymph node (LN) metastasis is the dominant prognostic factor for tumor staging and therapeutic decision-making. However, concurrently visualizing metastasis and performing imaging-guided lymph node surgery is challenging. Here, a multiplexed-near-infrared-II (NIR-II) in vivo imaging system using nonoverlapping NIR-II probes with markedly suppressed photon scattering and zero-autofluorescence is reported, which enables visualization of the metastatic tumor and the tumor metastatic proximal LNs resection. A bright and tumor-seeking donor-acceptor-donor (D-A-D) dye, IR-FD, is screened for primary/metastatic tumor imaging in the NIR-IIa (1100-1300 nm) window. This optimized D-A-D dye exhibits greatly improved quantum yield of organic D-A-D fluorophores in aqueous solutions (≈6.0%) and good in vivo performance. Ultrabright PbS/CdS core/shell quantum dots (QDs) with dense polymer coating are used to visualize cancer-invaded sentinel LNs in the NIR-IIb (>1500 nm) window. Compared to clinically used indocyanine green, the QDs show superior brightness and photostability (no obvious bleaching even after continuous laser irradiation for 5 h); thus, only a picomolar dose is required for sentinel LNs detection. This combination of dual-NIR-II image-guided surgery can be performed under bright light, adding to its convenience and appeal in clinical use.


Assuntos
Corantes Fluorescentes/química , Metástase Linfática/diagnóstico por imagem , Imagem Óptica/métodos , Pontos Quânticos/química , Linfonodo Sentinela/diagnóstico por imagem , Animais , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Compostos de Cádmio/química , Linhagem Celular Tumoral , Feminino , Chumbo/química , Metástase Linfática/terapia , Camundongos , Polímeros/química , Compostos de Selênio/química , Linfonodo Sentinela/cirurgia , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Cirurgia Assistida por Computador/métodos
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