A History of Flexible Gastrointestinal Endoscopy.

Surgeons have been involved, since the beginning, in the development and evolution of endoscopy. They have been instrumental in developing new methods and have been actively involved in most of the therapeutic applications. The continued evolution of endoscopic technique is inevitable and will involve the integration of new technology with innovative thinking.

Biomedical optics centers: forty years of multidisciplinary clinical translation for improving human health.

Despite widespread government and public interest, there are significant barriers to translating basic science discoveries into clinical practice. Biophotonics and biomedical optics technologies can be used to overcome many of these hurdles, due, in part, to offering new portable, bedside, and accessible devices. The current JBO special issue highlights promising activities and examples of translational biophotonics from leading laboratories around the world. We identify common essential features of successful clinical translation by examining the origins and activities of three major international academic affiliated centers with beginnings traceable to the mid-late 1970s: The Wellman Center for Photomedicine (Mass General Hospital, USA), the Beckman Laser Institute and Medical Clinic (University of California, Irvine, USA), and the Medical Laser Center Lübeck at the University of Lübeck, Germany. Major factors driving the success of these programs include visionary founders and leadership, multidisciplinary research and training activities in light-based therapies and diagnostics, diverse funding portfolios, and a thriving entrepreneurial culture that tolerates risk. We provide a brief review of how these three programs emerged and highlight critical phases and lessons learned. Based on these observations, we identify pathways for encouraging the growth and formation of similar programs in order to more rapidly and effectively expand the impact of biophotonics and biomedical optics on human health.

Ibn al-Haytham (965-1039 AD), the original portrayal of the modern theory of vision.

Abu ՙAli al-Hasan ibn al-Hasan ibn al-Haytham, known in the West as Alhazen, was an Arab-Islamic scholar who helped develop the science of ophthalmology during the medieval era. He was the first to reject firmly the extramission theory of vision, which was prevalent during his time, and suggested that the eyes are the source of the light rays responsible for vision. Ibn al-Haytham in his book entitled Kitab al-Manazir (Book of Optics) explained vision based on light emanating from objects. In this study we review Ibn al-Haytham's life and introduce his major contribution to the field of ophthalmology, his theory of vision.

[Effects of physics on development of optometry in the United States from the late 19th to the mid 20th century].

In this paper, it was studied how physics affected development of optometry in the United States, from aspects of formation and academization of optometry. It was also revealed that history of optometry was analogous to history of engineering. Optics in the 19th century was divided into electromagnetic study of light and visual optics. Development of the visual optics promoted professionalization of ophthalmology that had already started in the 18th century. The visual optics also stimulated formation of optometry and optometrists body in the late 19th century of the United States. The American optometrists body were originated from opticians who had studied visual optics. Publication of several English academic textbooks on visual optics induced appearance of educated opticians (and jewelers). They acquired a right to do the eye examination in the early 20th century after C. F. Prentice's trial in 1897, evolving into optometrists. The opticians could be considered as craftsmen, and they were divided into (dispensing) opticians and optometrists. Such history of American optometrists body is analogous to that of engineers body in the viewpoints of craftsmen origin and separation from craftsmen. Engineers were also originated from educated craftsmen, but were separated from craftsmen when engineering was built up. Education system and academization of optometry was strongly influenced by physics, too. When college education of optometry started at American universities, it was not belonged to medical school but to physics department. Physics and optics were of great importance in curriculum, and early faculty members were mostly physicists. Optometry was academized in the 1920s by the college education, standardization of curriculum, and formation of the American Academy of Optometry. This is also analogous to history of engineering, which was academized by natural sciences, especially by mathematics and physics. The reason why optometry was academized not by medicine but by physics is because ophthalmologists did not have conciliatory attitudes to optometry education. Optometry became independent of physics from the 1930s to the 1940s. Optometric researches concentrated on binocular vision that is not included to discipline of physics, and faculty members who majored in optometry increased, so that optometry departments and graduate schools were established around 1940. Such independence from natural sciences after academization also resembles history of engineering. On the contrary, history of optometry was different from history of ophthalmology in several aspects. Ophthalmology had already been formed in the 18th century before development of visual optics, and was not academized by visual optics. Ophthalmologists body were not originated from craftsmen, and were not separated from craftsmen. History of optometry in the United States from the late 19th to the mid 20th century is analogous to history of engineering rather than history of medicine, though optometry is a medical discipline.

"Through the looking glass": optical physics, issues, and the evolution of neuroendoscopy.

Although the concept of endoscopy has existed for centuries, a practical, working neuroendoscopic system did not emerge until last century, as a result of numerous contributions and refinements in optical technology, illumination sources, and instrumentation. Modern neuroendoscopy would not be a flourishing field, as it is today, without the dedication, innovation, and implementation of emerging technology by key contributors including Maximilian Nitze, Walter Dandy, and Harold Hopkins. Despite several inherent and unique limitations, neuroendoscopic surgery is now performed for a variety of intraventricular, skull base, and spinal operations. In this review, the history of neuroendoscopy, key players who envisioned how the inner workings of the human body could be visualized "through the looking glass," and current state and future potential for neuroendoscopic surgery are discussed. Future directions of neuroendoscopic surgery will likely be guided by further miniaturization in camera and optical technology, innovations in surgical instrumentation design, the introduction of robotics, multi-port minimally invasive surgery, and an enhanced ability to perform bimanual microdissection.

The multifaceted career of Louis Borsch.

John Louis Borsch Jr, MD (1873-1929), was an ophthalmologist from Philadelphia who spent most of his career in France. During his lifetime he was probably best known as the inventor of the first fused bifocal lens, which was marketed very successfully as the Kryptok lens. He may be better known today for performing cataract surgery on Mary Cassatt (1844-1926), the American Impressionist artist, and on James Joyce (1882-1941), the Irish author. Little known, but remarkable, is his thesis for his second medical degree, Le Traitement Chirurgical de l'Astigmie (The Surgical Treatment of Astigmatism).

The rainbow: from ancient Greece to modern optics.

We provide a historical perspective on the rainbow, with a review of early research and observations regarding the rainbow's origin and a discussion of some of the major contributors to our current understanding of what the rainbow represents. An overview of the various types of rainbows is undertaken. We conclude with a discussion of the rainbow's link to refraction, light, the visual system, and perception.

75th Anniversary of the Stiles-Crawford Effect(s): a celebratory special symposium, October 23, 2008; Rochester, New York.

There are rather few articles which, so-to-speak, serve to change the landscape in a scientific field. One of those was the discovery of the "directional sensitivity of the retina" by Walter Stanley Stiles and Brian Hewson Crawford (first reported in 1933). Subsequently, their findings were subdivided by Hansen into two logical components, "the Stiles-Crawford Effects of the First and Second Kinds, (SCE- 1 and SCE-2)." The former (SCE-1) dealt with aspects of their research which addressed alterations in perceived brightness of a visual stimulus; the second (SCE-2) was associated with the perceived hue and saturation of these visual stimuli. These discoveries arose out of a failed attempt by W.S. Stiles and B.H. Crawford to measure properly the areas of the entrance pupils of their experimental subjects as part of a research program which addressed problems of glare, e.g., disability glare, in illuminating engineering. Their research was conducted at the National Physical Laboratory (NPL), which is located in Teddington, Middlesex, England. These two fine scientists properly deduced the reason for the failure of their experimental design, and they effectively described and defined a new feature of the visual system which was largely ascribed to the retina. In time, it was realized that this phenomenon was associated in large measure with the waveguide/fiber-optics properties of photoreceptors, and that this was a feature shared by virtually all vertebrate species. This paper is divided into two parts. In the first part, Enoch describes, as best he can, the culture and working conditions at NPL during 1959/60 when he served as a post-doctoral fellow with W.S. Stiles. And in the second part of this paper, the authors describe the findings of W.S. Stiles and B.H. Crawford at the time of their discovery. Today, we celebrate the 75th Anniversary of that research. The organizing committee for this program (alphabetically) is David Atchison, Jay M. Enoch, Vasudevan Lakshminarayanan, and Pieter Walraven. Our group of speakers today will follow with discussions of aspects of subsequent work which has evolved from the initial discoveries made by the late W.S. Stiles and B.H. Crawford.

Johannes Vermeer y Anthon van Leeuwenhoek: El arte y la ciencia de Delft unidos en su máxima expresión en el siglo de oro holandés / Johannes Vermeer and Anthon van Leeuwenhoek: Delft Art and Science together during the golden Dutch century

Johannes Vermeer and Anthon van Leeuwenhoek are among the greatest geniuses in Art and Science respectively. During the seventeenth century, they achieved innovative advances. Vermeer, in painting, created a new intímate view of people specially women, developing the treatment of light and details. Leeuwenhoek, friend of Vermeer, influenced him in the use of the obscure camera in his works. In spite of having no formal academic education, he made extremely relevant discoveries with the use of microscope. He showed for first time human spermatozoids, red blood cells, brain, nerve and muscle structures and described many living animals. These two brilliant contemporary Dutch men made a great contribution to our civilization.

Anatomy of the eye from the view of Ibn Al-Haitham (965-1039). The founder of modern optics.

Ibn Al-Haitham (known as Alhazen in Latin [965 Basra, Iraq-1039, Cairo, Egypt]) was a scientist who played an important role in the middle age Islam world. He wrote many books and novels, but only 90 of them are known. His main book Kitab al-Manazir was translated into Western languages in the late twelfth century, and in the early thirteenth century. In this book, he formulated many hypotheses on optical science. The book, which is also known as Optic treasure (opticae thesaurus), affected many famous Western scientists. He became an authority until the seventeenth century in the Eastern and Western countries. Roger Bacon (1212-1294), who made radical changes in the Western optical traditions, reconfirmed Ibn Al-Haitham's findings. Ibn al-Haitham began his book Kitab al-Manazir with the anatomy and physiology of the eye. He specifically described cornea, humor aqueous, lens, and corpus vitreum. He examined the effect of light on seeing. He caused changes in the prevailing ideas of his age, and suggested that light came from objects, not from the eye. He provided information regarding the optic nerve, retina, iris, and conjunctiva. He showed the system of the eye as a dioptric, and the relations between the parts of the eye. It is understood that he mastered all knowledge on the structure of the eye in his century. The best proof of this is the eye picture that he drew.

The Sämisch case and the Müllers of Wiesbaden.

PURPOSE: There are significant inconsistencies in accounts in textbooks of the fitting in 1887 of a device resembling a scleral contact lens. The aim of this study was to establish the facts of this case and to provide an overview of the subsequent clinical performance of blown scleral shells and lenses. METHODS: A literature search was conducted that included the original report published in 1910 of the fitting of the patient. The dimensions and back vertex power of a blown scleral shell were measured. RESULTS: In 1887, the right eye of a patient with lagophthalmic keratitis as a sequel to cancerous destruction of the lower eyelid was fitted with a protective blown scleral shell. His left eye was effectively blind. The referring ophthalmologist was Professor Theodor Sämisch of Bonn and the fitting was undertaken by the firm of F Ad Müller & Söhne of Wiesbaden, Germany. With periodical replacement, a shell was worn for at least 21 years. Müller scleral shells were principally fitted in keratoconus providing markedly improved visual acuities and wearing times of up to 14 h a day. There were instances of continuous wear. CONCLUSIONS: Failure to consult original sources is responsible for errors in descriptions of the Sämisch case that is of historical importance because it represents both the first use of a therapeutic contact shell and the first instance of continuous wear. Blown scleral shells and lenses played an important part in the optical correction of keratoconus and the management of other ocular conditions during the first quarter of the 20th century.

Ibn al-Haitham--father of optics and describer of vision theory.

Among famous Arabic doctor belongs also Ibn Al-Haitam (known in the west as Alhazen) which is considered to be the greatest Muslim doctor and one of the greatest researches of optics for all times. Al Haitam is born in city Basra and immigrated to Egypt during reign of Caliph Al Hakim. He is quoted as excellent astronomer, mathematician and doctor as well as one of the best commentators of the Galen and Aristotle's work. He is the first medical scholar who teaches that light "does not originates from the eye but on opposite enters the eye", and in that manner corrects the wrong opinion of the Greeks about the nature of vision. According to this scholar retina is the center of vision and the impressions that it receives are transferred to the brain by the optical nerve, in order that brain afterwards create visual image in the symmetrical relationship for both retinas. Al-Haitam was the most important researcher of optics in Islam. He was convinced that the adequate theory of vision must combine Euclid and Ptolemy "mathematical" approach and "physical doctrine of the naturalists. The result of his reflections in the paper "Optics", supported by the experimental approach, is the new theory of vision, much richer and perfected than any before. He thought that light and color, two physical features that exist independently from the observed subject, in strait lines originates from the each point of visible object. Al Haitam concludes that what we perceive is actually the object which is on a certain distance from the eye and which have certain shape and size, and vision itself is the result of intervention by the visual material received by the brain and stored information's from previous experiences. Reception hypothesis (intromission) Al-Haitam exposed to mathematical testing, and then incorporated into already developed perception theory, which is still not completely explored by historians. In his experiments he used "dark chambers", trying to confirm the features of light, such as expansion in straight lines, reflexion and refraction of the light beams. Basic stand point which he supported was that the vision is the result of impression which light leaves on the sight sense, he supported it based on the experience that the eye "retains an image" or has pain when looking into bright light. Theory of vision by Haitam Optics, written in Egypt during the first half of XI century, overmatches Galen, Euclid and Ptolemy ones.