RESUMO
BACKGROUND: Actinomycosis is a rare, chronic granulomatous disease caused by Gram-positive anaerobic bacteria that colonize the oral cavity. Cervicofacial actinomycosis is the most frequent clinical presentation of actinomycosis, but hematogenous osteomyelitis at distant sites can occur in rare instance in immunocompromised or pediatric patients, only a few cases have been reported in healthy patients. Here we described a new case of distal femur osteomyelitis caused by Actinomyces in an adult patient who was immunocompetent and had no predisposing factors. CASE PRESENTATION: A woman aged 52 years with no history of trauma presented with severe pain, swelling, and increased local heat in the proximal area of the right knee 3 weeks after she first noticed discomfort. Magnetic resonance imaging showed persistent osteomyelitis of the distal metaphysis and diaphysis of the femur with a multifocal intraosseous abscess pocket. An incision and drainage of the abscess were conducted. The tissue culture, fungus culture, acid fast bacillus (AFB) culture, AFB smear, and tuberculosis polymerase chain reaction test results were negative. A pathologic examination confirmed the presence of actinomycosis. The patient was successfully treated with intravenous penicillin G for 8 weeks followed by oral amoxicillin-clavulanate for 6 weeks with repeated surgical debridement and drainage. After a 5-year follow up, the patient had no signs of recurring infection or complications and she had full range of movement in the affected knee. CONCLUSIONS: Although rare, actinomycotic osteomyelitis can occur in healthy people. Furthermore, actinomycotic osteomyelitis is easily misdiagnosed as tuberculosis in areas with a high prevalence of tuberculosis. To detect and identify the bacteria accurately, pathologic examination should be performed as well as culture tests, because the probability for culture confirmation of actinomycosis is quite low. The initial treatment is vital to a successful outcome without ostectomy or amputation.
Assuntos
Actinomyces/isolamento & purificação , Actinomicose/complicações , Antibacterianos/administração & dosagem , Drenagem , Osteomielite/microbiologia , Actinomyces/imunologia , Actinomicose/imunologia , Actinomicose/microbiologia , Actinomicose/terapia , Biópsia , Feminino , Fêmur/diagnóstico por imagem , Fêmur/microbiologia , Fêmur/patologia , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Osteomielite/diagnóstico por imagem , Osteomielite/imunologia , Osteomielite/terapia , Resultado do TratamentoRESUMO
Actinomyces species are part of the commensal flora of the mucous membranes of the oropharynx, gastrointestinal tract and female genital tract. Actinomyces europaeus is a short, nonmotile, facultative anaerobic rod first described in 1997, susceptible in vitro to a wide range of b-lactam antibiotics which are regarded as first choice. In this report we described the case of A. europaeus infection in a young female patient admitted to Intensive Care Unit and the possible damage of vascular endothelium due to a chronic progressive actinomycosis that at first involved neck soft tissue, then cervical lymphnodes, and finally extended to the vascular structure.
Assuntos
Actinomicose/diagnóstico , Linfadenopatia/microbiologia , Doenças do Sistema Nervoso/complicações , Actinomyces/efeitos dos fármacos , Actinomyces/genética , Actinomyces/isolamento & purificação , Actinomicose/tratamento farmacológico , Actinomicose/imunologia , Antibacterianos/uso terapêutico , Encéfalo/diagnóstico por imagem , Endotélio Vascular/microbiologia , Endotélio Vascular/patologia , Feminino , Humanos , Unidades de Terapia Intensiva , Linfonodos/microbiologia , Linfadenopatia/diagnóstico , Linfadenopatia/diagnóstico por imagem , Linfadenopatia/tratamento farmacológico , Doenças do Sistema Nervoso/microbiologia , RNA Ribossômico 16S , Simbiose , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Vasculite/microbiologia , Adulto JovemRESUMO
Although considered a saprophyte, Actinomyces naeslundii can cause invasive infection leading to significant morbidity and mortality. Rarely encountered, bacteremia with this agent occurs in the setting of disrupted mucosal barriers. Previous studies suggest that actinomycosis may be a surrogate marker for poor prognosis in immunocompromised hosts. We report herein a case of a patient with metastatic pancreatic cancer who not only had a prompt resolution of Actinomyces bacteremia and a complete response to chemotherapy, but also remained disease free at 12 months after diagnosis. Our case may suggest that concomitant actinomycosis may not necessarily portend a poor prognosis in all immunocompromised patients.
Assuntos
Actinomyces , Actinomicose , Adenocarcinoma , Ampicilina/administração & dosagem , Antineoplásicos , Neoplasias Pancreáticas , Actinomyces/efeitos dos fármacos , Actinomyces/isolamento & purificação , Actinomyces/patogenicidade , Actinomicose/tratamento farmacológico , Actinomicose/etiologia , Actinomicose/imunologia , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/patologia , Antibacterianos/administração & dosagem , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Antineoplásicos/imunologia , Bacteriemia/tratamento farmacológico , Bacteriemia/microbiologia , Feminino , Humanos , Hospedeiro Imunocomprometido , Pessoa de Meia-Idade , Metástase Neoplásica , Neoplasias Pancreáticas/tratamento farmacológico , Neoplasias Pancreáticas/patologia , Prognóstico , Resultado do TratamentoRESUMO
OBJECTIVES: Actinomycosis is a rare disease favored by disruption of the mucosal barrier. In order to investigate the impact of immunosuppression on outcome we analyzed the most severe cases observed in patients hospitalized in three tertiary care centers. METHODS: We reviewed all cases of proven invasive actinomycosis occurring over a 12-year period (1997 to 2009) in three teaching hospitals in the Paris area. RESULTS: Thirty-three patients (16 male) were identified as having an invasive actinomycosis requiring hospitalization. The diagnosis was made by microbiological identification in 26 patients, pathological examination in eight patients, and by both methods in one. Twenty patients (61%) were immunocompromised. Actinomycosis localization was abdominal or pelvic in 17 patients, thoracic in 11, cervicofacial in three, and neurological in two. Twenty patients (61%) underwent surgery. All strains were susceptible to amoxicillin. All patients were treated with a beta-lactam antibiotic, for a median length of 82 days. Twenty-eight patients (85%) were considered as cured. Overall mortality at hospital discharge was 21% (7/33). Mortality was higher in immunocompromised patients (7/20; 21%) compared to non-immunocompromised patients (0/13) (p=0.027). However, six of seven deaths were directly related to the underlying disease. CONCLUSIONS: Actinomycosis is a cause of severe infection in immunocompromised patients and a surrogate marker of a poor prognosis in this specific population.
Assuntos
Actinomicose/diagnóstico , Hospedeiro Imunocomprometido , Actinomicose/imunologia , Actinomicose/microbiologia , Actinomicose/mortalidade , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , PrognósticoRESUMO
Actinomycosis of the larynx represents an unusual presentation for a common bacterium comprising the oral and oropharyngeal florae. There are few cases reported in the literature of laryngeal actinomycosis occurring primarily in the immunocompromised population. Here, we present a case in a 74-year-old man that occurred in the setting of neutropenia as a result of chemotherapy. Once the diagnosis was made with biopsy of the larynx, the infection was resolved after a prolonged course of penicillin-based therapy.
Assuntos
Actinomicose/imunologia , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Hospedeiro Imunocomprometido , Doenças da Laringe/imunologia , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Actinomicose/diagnóstico , Actinomicose/tratamento farmacológico , Actinomicose/microbiologia , Idoso , Combinação Amoxicilina e Clavulanato de Potássio/administração & dosagem , Antibacterianos/uso terapêutico , Biópsia , Ciprofloxacina/administração & dosagem , Quimioterapia Combinada , Humanos , Doenças da Laringe/diagnóstico , Doenças da Laringe/tratamento farmacológico , Doenças da Laringe/microbiologia , Leucemia Linfocítica Crônica de Células B/imunologia , Masculino , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.
Assuntos
Actinomicose/diagnóstico , Doenças do Esôfago/diagnóstico , Actinomicose/tratamento farmacológico , Actinomicose/imunologia , Adulto , Amoxicilina/uso terapêutico , Antibacterianos/uso terapêutico , Doenças do Esôfago/tratamento farmacológico , Doenças do Esôfago/imunologia , Esofagoscopia , Feminino , Humanos , Imunidade , Penicilina G/uso terapêuticoAssuntos
Actinomicose/microbiologia , Hospedeiro Imunocomprometido , Abscesso Retrofaríngeo/microbiologia , Actinomicose/imunologia , Actinomicose/patologia , Actinomicose/cirurgia , Antibacterianos/administração & dosagem , Dermatomiosite/complicações , Dermatomiosite/tratamento farmacológico , Diagnóstico Diferencial , Doxiciclina/administração & dosagem , Combinação de Medicamentos , Humanos , Injeções Intravenosas , Masculino , Pessoa de Meia-Idade , Ofloxacino/administração & dosagem , Abscesso Retrofaríngeo/imunologia , Abscesso Retrofaríngeo/patologia , Abscesso Retrofaríngeo/cirurgia , Neoplasias Gástricas/complicações , Neoplasias Gástricas/tratamento farmacológicoRESUMO
INTRODUCTION: The development of periapical granulomas is dependent on the host response and involves Th1, Th2, Th17, and Treg-related cytokines. The discovery of new Th9 and Th22 subsets, with important immunomodulatory roles mediated by interleukin (IL)-9 and IL-22, respectively, emphasizes the need for reevaluation of current cytokine paradigms in context of periapical lesions. We investigated the expression of IL-9 and IL-22 in active and stable human granulomas and throughout experimental lesion development in mice. METHODS: Periapical granulomas (N = 83) and control specimens (N = 24) were evaluated regarding the expression of IL-9 and IL-22 via real-time polymerase chain reaction. Experimental periapical lesions were induced in mice (pulp exposure and bacterial inoculation) and the lesions evolution correlation with IL-9 and IL-22 expression kinetics was evaluated. RESULTS: IL-9 and IL-22 mRNA expression was higher in periapical lesions than in control samples; higher levels of IL-9 and IL-22 were observed in inactive than in active lesions. In the experimental lesions model, increasing levels of IL-9 and IL-22 mRNA were detected in the lesions, and inverse correlations were found between IL-9 and IL-22 and the increase of lesion area in the different time point intervals. CONCLUSIONS: Our results suggest that Th9 and Th22 pathways may contribute to human and experimental periapical lesion stability.
Assuntos
Interleucina-9/imunologia , Interleucinas/imunologia , Granuloma Periapical/imunologia , Subpopulações de Linfócitos T/imunologia , Linfócitos T Auxiliares-Indutores/imunologia , Linfócitos T Reguladores/imunologia , Actinomicose/imunologia , Adolescente , Adulto , Animais , Infecções por Bacteroidaceae/imunologia , Exposição da Polpa Dentária/imunologia , Exposição da Polpa Dentária/microbiologia , Modelos Animais de Doenças , Feminino , Infecções por Fusobacterium/imunologia , Fusobacterium nucleatum/imunologia , Humanos , Imunomodulação/imunologia , Masculino , Camundongos , Pessoa de Meia-Idade , Osteoprotegerina/análise , Porphyromonas gingivalis/imunologia , Prevotella nigrescens/imunologia , Ligante RANK/análise , Adulto Jovem , Interleucina 22RESUMO
Actinomyces viscosus has been suggested to be associated with periodontal disease. However, the pathogenicity of this bacterium is not known. In this study, we examined inflammation-inducing activity by A. viscosus. Whole cells and a lipophilic fraction of A. viscosus ATCC19246 induced production of interleukin-8 and tumor necrosis factor alpha from both human oral epithelial cells and human monocytoid cells. This cytokine production was blocked by lipoprotein lipase treatment of the lipophilic fraction. In addition, anti-Toll-like receptor 2 antibody blocked the cytokine production. These results suggest that lipoprotein of A. viscosus triggers inflammatory responses in periodontitis by activation of Toll-like receptor 2.
Assuntos
Actinomyces viscosus/imunologia , Gengiva/imunologia , Lipoproteínas/imunologia , Receptor 2 Toll-Like/imunologia , Actinomyces viscosus/química , Actinomicose/imunologia , Actinomicose/microbiologia , Análise de Variância , Proteínas de Bactérias/imunologia , Citocinas/imunologia , Células Epiteliais/citologia , Células Epiteliais/imunologia , Gengiva/citologia , Doenças da Gengiva/imunologia , Doenças da Gengiva/microbiologia , Células HEK293 , Interações Hospedeiro-Patógeno , Humanos , Inflamação/imunologia , Macrófagos/citologia , Macrófagos/imunologiaAssuntos
Actinomicose/epidemiologia , Dispositivos Intrauterinos/efeitos adversos , Perfuração Uterina/epidemiologia , Perfuração Uterina/etiologia , Actinomicose/imunologia , Doença de Crohn/epidemiologia , Feminino , Humanos , Hospedeiro Imunocomprometido , Pessoa de Meia-Idade , Necrose , Pós-Menopausa , Útero/microbiologia , Útero/patologiaRESUMO
Actinomycosis is an infectious disease that has been known since the late nineteenth century. In the pre-antibiotic era it was thought to be rather common but with increased use of antimicrobial agents its incidence has decreased significantly. The causative agent, most commonly Actinomyces israelii, is part of the commensal bacterial flora. It can infect any tissue, respects no tissue boundaries and can spread throughout the body. The clinical presentation of this illness can be similar to malignant disease and definite diagnosis is sometimes not apparent until after surgery and histologic examination. We report the case of a 71 year old woman who suffered from actinomycosis of the uterus and ovaries due to a forgotten intrauterine contraceptive device that had been in place for over four decades. The disease presentation was consistent with malignant disease and tumor markers, CA 125, CA 19-9 and CEA, measured in blood were elevated. She was treated successfully with total hysterectomy and bilateral salphingo-oophorectomy, as well as penicillin for six months.
Assuntos
Actinomicose/diagnóstico , Dispositivos Intrauterinos/efeitos adversos , Doenças Ovarianas/diagnóstico , Doenças Uterinas/diagnóstico , Actinomicose/tratamento farmacológico , Actinomicose/etiologia , Actinomicose/imunologia , Actinomicose/cirurgia , Idoso , Antibacterianos/uso terapêutico , Antígeno Ca-125/sangue , Antígeno CA-19-9/sangue , Antígeno Carcinoembrionário/sangue , Diagnóstico Diferencial , Feminino , Humanos , Histerectomia , Doenças Ovarianas/tratamento farmacológico , Doenças Ovarianas/etiologia , Doenças Ovarianas/imunologia , Doenças Ovarianas/cirurgia , Ovariectomia , Penicilinas/uso terapêutico , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Doenças Uterinas/tratamento farmacológico , Doenças Uterinas/etiologia , Doenças Uterinas/imunologia , Doenças Uterinas/cirurgiaRESUMO
Salivary proline-rich proteins (PRPs) attach commensal Actinomyces and Streptococcus species to teeth. Here, gel filtration, mass spectrometry and Edman degradation were applied to show the release of a pentapeptide, RGRPQ, from PRP-1 upon proteolysis by Streptococcus gordonii. Moreover, synthetic RGRPQ and derivatives were used to investigate associated innate properties and responsible motifs. The RGRPQ peptide increased 2.5-fold the growth rate of S. gordonii via a Q-dependent sequence motif and selectively stimulated oral colonization of this organism in a rat model in vivo. In contrast, the growth of Streptococcus mutans, implicated in caries, was not affected. While the entire RGRPQ sequence was required to block sucrose-induced pH-decrease by S. gordonii and S. mutans, the N-terminal Arg residue mediated the pH increase (i.e., ammonia production) by S. gordonii alone (which exhibits Arg catabolism to ammonia). Strains of commensal viridans streptococci exhibited PRP degradation and Arg catabolism, whereas cariogenic species did not. The RGRPQ peptide mediated via a differential Q-dependent sequence motif, adhesion inhibition, and desorption of PRP-1-binding strains of A. naeslundii genospecies 2 (5 of 10 strains) but not of S. gordonii (n=5). The inhibitable A. naeslundii strains alone displayed the same binding profile as S. gordonii to hybrid peptides terminating in RGRPQ or GQSPQ, derived from the middle or C-terminal segments of PRP-1. The present findings indicate the presence of a host-bacterium interaction in which a host peptide released by bacterial proteolysis affects key properties in biofilm formation.
Assuntos
Actinomyces/fisiologia , Aderência Bacteriana/fisiologia , Biofilmes , Proliferação de Células , Oligopeptídeos/fisiologia , Streptococcus/fisiologia , Actinomyces/citologia , Actinomyces/metabolismo , Actinomicose/imunologia , Animais , Aderência Bacteriana/imunologia , Biofilmes/crescimento & desenvolvimento , Concentração de Íons de Hidrogênio , Hidrólise , Peptídeos/metabolismo , Domínios Proteicos Ricos em Prolina , Ratos , Ratos Sprague-Dawley , Infecções Estreptocócicas/imunologia , Streptococcus/citologia , Streptococcus/metabolismoAssuntos
Actinomyces/classificação , Actinomicose/diagnóstico , Bacteriemia/diagnóstico , Carcinoma de Células Escamosas/imunologia , Hospedeiro Imunocomprometido , Neoplasias Pulmonares/imunologia , Actinomicose/tratamento farmacológico , Actinomicose/imunologia , Adulto , Antibacterianos/uso terapêutico , Bacteriemia/tratamento farmacológico , Bacteriemia/imunologia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/terapia , Progressão da Doença , Evolução Fatal , Feminino , Humanos , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/terapia , Invasividade Neoplásica/patologia , Estadiamento de Neoplasias , Infecções Oportunistas/diagnóstico , Infecções Oportunistas/tratamento farmacológico , Medição de Risco , Líquido Sinovial/microbiologiaRESUMO
Actinomycosis is caused by gram-positive filamentous organisms of the genus Actinomyces, which may spread through trauma. Most commonly, it is a cervicofacial disease due to dental infection or a thoracic disease secondary to aspiration of foreign bodies. Primary abdominal infection usually follows some form of mucosal disruption. Any organ of the human body may be involved so that a wide range of symptoms may be present. We report a rare form of actinomycosis involving the lung, pleura and colon concomitantly in an immunocompromised patient. A fine needle aspiration from a lung lesion detected the characteristic sulfur granules, and a pleural effusion culture confirmed the diagnosis. Clinical manifestations and treatment are discussed. Actinomycetes are rarely opportunistic agents in immunocompromised patients; thus the disease deserves special attention in those patients.
Assuntos
Actinomicose/diagnóstico , Doenças do Colo/diagnóstico , Hospedeiro Imunocomprometido , Pneumopatias Fúngicas/diagnóstico , Pneumopatias/diagnóstico , Doenças Pleurais/diagnóstico , Actinomicose/imunologia , Idoso , Biópsia por Agulha , Doenças do Colo/imunologia , Diagnóstico Diferencial , Humanos , Pneumopatias/imunologia , Pneumopatias Fúngicas/imunologia , Masculino , Doenças Pleurais/imunologia , Tomógrafos ComputadorizadosRESUMO
A retrospective survey of nocardia and actinomyces infections in five local hospitals was conducted over a 3-year period in El Paso, Texas, a border city, in the southwestern United States. The medical records of 42 patients with suspected nocardiosis or actinomycosis were reviewed. One patient was diagnosed with actinomyces and 12 patients with nocardia. Microbiological data included morphologic characteristics, biochemical profile, and susceptibility testing. Predisposing factors included leukemia, renal insufficiency, renal transplant, and lymphoma. No predisposing factors were found in 67% (n = 8) of patients (including the patient with actinomycosis). Twenty-three percent (n = 3) of patients had disseminated disease without evidence of underlying disease or immunosuppression. The mortality and morbidity of these infections appeared to be low.
Assuntos
Actinomicose/epidemiologia , Actinomicose/imunologia , Hospedeiro Imunocomprometido , Nocardiose/epidemiologia , Nocardiose/imunologia , Actinomicose/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nocardiose/diagnóstico , Texas/epidemiologiaRESUMO
Two distinct cases of maxillary actinomycosis and maxillary candidosis in immunocompetent hosts are reported; These infections are rare and similar to mycotic extramucosal non allergic sinusitis. Microbiology and microscopic examination are mandatory to prompt and successful management. Endoscopic endonasal surgery by middle meatotomy seems to be an adequate treatment for these particular entities.
Assuntos
Infecções por Actinomycetales/diagnóstico , Infecções por Actinomycetales/imunologia , Actinomicose/diagnóstico , Actinomicose/imunologia , Candidíase/diagnóstico , Candidíase/imunologia , Sinusite Maxilar/diagnóstico por imagem , Sinusite Maxilar/microbiologia , Infecções por Actinomycetales/microbiologia , Actinomicose/microbiologia , Adulto , Candidíase/microbiologia , Feminino , Humanos , Tomografia Computadorizada por Raios XRESUMO
Uterine infections are a major reproductive problem in livestock. We conducted two experiments to investigate factors that may modulate uterine responses to infectious bacteria. In Exp. 1, ewes received intrauterine inoculations of either saline or bacteria (75 x 10(7) cfu of Actinomyces pyogenes and 35 x 10(7) cfu of Escherichia coli) on either d 0 or 7 of the estrous cycle. Vena caval samples containing uteroovarian blood were collected twice daily from 12 h before until 6 d after inoculation. Only ewes inoculated with bacteria on d 7 developed infections. Basal (4.8 vs .4 pmol), lipopolysaccharide-stimulated (14.2 vs 6.1 pmol), and concanavalin A-stimulated (65.8 vs 21.6 pmol) blastogenesis (i.e., [3H]thymidine incorporation) of vena caval lymphocytes was greater (P < or = .002) for ewes inoculated with bacteria or saline on d 0 rather than on d 7. The number (per 100 white blood cells) of lymphocytes was greater (41.3 vs 30.8, P < .001) and that of neutrophils was less (42.5 vs 51.6, P < .001) in ewes inoculated on d 0 rather than d 7. Bacteria increased (P < .05) vena caval PGF(2 alpha) but not PGE2 concentrations. In Exp. 2, two protein fractions (molecular weights of > or = 100 kDa and approximately 12.7 kDa) from chromatography of uterine flushings collected on d 0 or 7, or 18 d after ovariectomy on d 0 or 7, modulated phytohemagglutinin-stimulated blastogenesis; the heavier fraction from d 0 had a stimulatory component, but the major effects of the fractions were inhibitory. The differences in immune function and regulation between d 0 and 7 probably explain how the uterus of follicular phase ewes was able to prevent the development of an infection.
Assuntos
Actinomicose/veterinária , Infecções por Escherichia coli/veterinária , Estro/fisiologia , Doenças dos Ovinos/imunologia , Ovinos/fisiologia , Doenças Uterinas/veterinária , Útero/imunologia , Actinomyces/imunologia , Actinomicose/imunologia , Actinomicose/fisiopatologia , Animais , Dinoprosta/sangue , Dinoprostona/sangue , Eosinófilos/citologia , Escherichia coli/imunologia , Infecções por Escherichia coli/imunologia , Infecções por Escherichia coli/fisiopatologia , Estrogênios/sangue , Feminino , Fase Folicular/fisiologia , Fase Luteal/fisiologia , Ativação Linfocitária/fisiologia , Linfócitos/citologia , Linfócitos/efeitos dos fármacos , Linfócitos/metabolismo , Monócitos/citologia , Neutrófilos/citologia , Progesterona/sangue , Ovinos/sangue , Ovinos/imunologia , Doenças dos Ovinos/fisiopatologia , Fatores de Tempo , Doenças Uterinas/imunologia , Doenças Uterinas/fisiopatologia , Útero/metabolismo , Útero/fisiologiaRESUMO
Antibody titres and immunoglobulin concentrations were measured in serum and in uterine and vaginal secretions from five heifers after intrauterine infusion of Actinomyces pyogenes. Infection stimulated an increase in uterine antibody titres of IgG2 and IgA, which approached significance. There was no increase in antibody titres in vaginal secretions or in serum. For each class of immunoglobulin, the ratio of specific antibody to immunoglobulin tended to increase in uterine secretions after infection, whereas no change was detected in the serum. These results indicate that at least a portion of the antibody was derived from local uterine synthesis.
Assuntos
Actinomyces/imunologia , Actinomicose/veterinária , Anticorpos Antibacterianos/biossíntese , Doenças dos Bovinos/imunologia , Doenças dos Genitais Femininos/veterinária , Actinomicose/imunologia , Análise de Variância , Animais , Bovinos , Feminino , Doenças dos Genitais Femininos/imunologia , Imunoglobulina A Secretora/biossíntese , Imunoglobulina G/biossíntese , Imunoglobulina M/biossíntese , Imunoglobulinas/biossíntese , Progesterona/sangue , Irrigação Terapêutica/veterinária , Útero/imunologia , Vagina/imunologiaRESUMO
Abdominal actinomycosis is a rare finding in pediatric patients and its location in the urinary bladder is exceptional. On the other hand, immunodepression can be found in several disorders including that of actinomycosis. The purpose of this study was to report a case of urinary bladder actinomycosis seen in a seven year old girl. No risk factors were found. It was diagnosed as an abdominal tumor which was successfully surgically removed and treated with penicillin. During her recovery, she suffered from a transitory cell-mediated depression of her immune system which later returned to normal once treatment as installed. The pathogenesis of actinomycosis is presented and a review of the literature is cited. Actinomycosis; immunodepression; bladder.