RESUMO
This case report describes a rare epitrichial sweat gland ductal carcinoma in a 14-year-old horse and is the first report of multiple carcinomas of this type in horses. Although several tumours developed, mostly on the distal extremities, over a 2-year period, the horse remained otherwise healthy. Topical treatment with imiquimod was successful for many of them.
Assuntos
Adenoma de Glândula Sudorípara/veterinária , Doenças dos Cavalos/diagnóstico , Neoplasias Primárias Múltiplas/veterinária , Neoplasias das Glândulas Sudoríparas/veterinária , Adenoma de Glândula Sudorípara/diagnóstico , Administração Cutânea , Aminoquinolinas/administração & dosagem , Aminoquinolinas/uso terapêutico , Animais , Antineoplásicos/administração & dosagem , Antineoplásicos/uso terapêutico , Diagnóstico Diferencial , Doenças dos Cavalos/tratamento farmacológico , Doenças dos Cavalos/patologia , Cavalos , Imiquimode , Masculino , Neoplasias Primárias Múltiplas/diagnóstico , Neoplasias das Glândulas Sudoríparas/diagnósticoRESUMO
A cutaneous mass at the base of the retroauricular region of a 4-year-old, female Golden Retriever was examined pathologically. Histologically, the mass formed multiple nodules consisting of a proliferation of large clear cells with abundant cytoplasm. Mitotic figures among the neoplastic cells were very sparse. The large clear cells were intensely positive for cytokeratins (AE1/AE4, cytokeratin 8 and 18) and moderately positive for lysozyme and contained periodic acid-Schiff-positive granules in the cytoplasm. In addition, small flat cells lined the islands of neoplastic large clear cells, and these were strongly positive for alpha-smooth muscle actin and vimentin, and some were positive for cytokeratin (AE1/AE4), suggesting they were myoepithelial cells. No local recurrence or metastasis has been recognized during the 18 months since surgical excision. On the basis of these findings, the present tumor was diagnosed as apocrine sweat gland adenoma, clear cell variant. There have been few previous reports of canine apocrine adenomas showing a clear cell morphology.