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1.
J Hand Surg Asian Pac Vol ; 28(2): 149-155, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37120311

RESUMO

Background: The aim of this study was to evaluate the impact of variant factors on finger replantation and revascularisation after traumatic amputation, which also included duty shift and the level of main operator. Methods: To determine the prognostic factors for the survival rate of finger replantation and revascularisation after traumatic finger amputation, we retrospectively reviewed the cases of finger replantation conducted from January 2001 to December 2017. Data collected consisted of the basic information of the patients, trauma-related factors, details of the operation and treatment outcomes. Descriptive statistics and data analysis was performed to assess outcomes. Results: In total, 150 patients with 198 replanted digits were enrolled in this study. The median age of the participants was 42.5 years, and 132 (88%) patients were men. The overall successful replantation rate was 86.4%. Seventy-three (36.9%) digits had Yamano type 1 injury; 110 (55.6%), Yamano type 2 injury and 15 (7.6%), Yamano type 3 injury. In total, 73 (36.9%) digits were completely amputated and 125 (63.1%) were not. Half of the replantation procedures (101, 51.0%) were performed during night shift (16:00-00:00), 69 (34.8%) during day shift (08:00-16:00) and 28 (14.1%) during graveyard shift (00:00-08:00). Multivariate logistic regression demonstrated that the trauma mechanism and type of amputation (complete vs. incomplete) significantly affect the survival rate of replantation. Conclusions: The trauma mechanism and type of amputation (complete vs. incomplete) significantly affect the survival rate of replantation. Other factors including duty shift and the level of operator did not reach statistically significance. Further studies must be conducted to validate the results of the current study. Level of Evidence: Level III (Prognostic).


Assuntos
Amputação Traumática , Traumatismos dos Dedos , Masculino , Humanos , Adulto , Feminino , Estudos Retrospectivos , Prognóstico , Amputação Traumática/cirurgia , Amputação Traumática/etiologia , Reimplante/métodos , Traumatismos dos Dedos/cirurgia , Traumatismos dos Dedos/etiologia , Amputação Cirúrgica
2.
Clin Orthop Relat Res ; 481(8): 1583-1594, 2023 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-36795073

RESUMO

BACKGROUND: Ensuring the patency of repaired vessels is pivotal in improving the success rate of digit replantation. There is no consensus on how to best approach postoperative treatment for digit replantation. The influence of postoperative treatment on the risk of failure of revascularization or replantation remains unclear. QUESTIONS/PURPOSES: (1) Is there an increased risk of postoperative infection with early discontinuation of antibiotic prophylaxis? (2) How are anxiety and depression affected by a treatment protocol consisting of prolonged antibiotic prophylaxis and administration of antithrombotic and antispasmodic drugs and by the failure of a revascularization or replantation procedure? (3) Are there differences in the risk of revascularization or replantation failure based on the number of anastomosed arteries and veins? (4) What factors are associated with failure of revascularization or replantation? METHODS: This retrospective study was conducted between July 1, 2018, and March 31, 2022. Initially, 1045 patients were identified. One hundred two patients chose revision of amputation. In all, 556 were excluded because of contraindications. We included all patients in whom the anatomic structures of the amputated part of the digit were well preserved, and those with an ischemia time for the amputated part that did not exceed 6 hours. Patients in good health without any other serious associated injuries or systemic diseases and those without a history of smoking were eligible for inclusion. The patients underwent procedures that were performed or supervised by one of four study surgeons. Patients were treated with antibiotic prophylaxis (1 week); patients treated with antithrombotic and antispasmodic drugs were categorized into the prolonged antibiotic prophylaxis group. The remaining patients treated with antibiotic prophylaxis for less than 48 hours and no antithrombotic and no antispasmodic drugs were categorized into the nonprolonged antibiotic prophylaxis group. Postoperative follow-up was for a minimum of 1 month. Based on the inclusion criteria, 387 participants with 465 digits were selected for an analysis of postoperative infection. Twenty-five participants with a postoperative infection (six digits) and other complications (19 digits) were excluded from the next stage of the study, in which we assessed factors associated with the risk of failure of revascularization or replantation. A total of 362 participants with 440 digits were examined, including the postoperative survival rate, variation in Hospital Anxiety and Depression Scale scores, the association between the survival rate and Hospital Anxiety and Depression Scale scores, and the survival rate based on the number of anastomosed vessels. Postoperative infection was defined as swelling, erythema, pain, purulent discharge, or a positive bacterial culture result. Patients were followed for 1 month. The differences in anxiety and depression scores between the two treatment groups and the differences in anxiety and depression scores based on failure of revascularization or replantation were determined. The difference in the risk of revascularization or replantation failure based on the number of anastomosed arteries and veins was assessed. Except for statistically significant variables (injury type and procedure), we thought that the number of arteries, number of veins, Tamai level, treatment protocol, and surgeons would be important. A multivariable logistic regression analysis was used to perform an adjusted analysis of risk factors such as postoperative protocol, injury type, procedure, number of arteries, number of veins, Tamai level, and surgeon. RESULTS: Postoperative infection did not appear to increase without prolonged use of antibiotic prophylaxis beyond 48 hours (1% [3 of 327] versus 2% [3 of 138]; OR 2.4 [95% confidence interval (CI) 0.5 to 12.0]; p = 0.37). Intervention with antithrombotic and antispasmodic therapy increased the Hospital Anxiety and Depression Scale scores for anxiety (11.2 ± 3.0 versus 6.7 ± 2.9, mean difference 4.5 [95% CI 4.0 to 5.2]; p < 0.01) and depression (7.9 ± 3.2 versus 5.2 ± 2.7, mean difference 2.7 [95% CI 2.1 to 3.4]; p < 0.01). In the analysis based on the failure of revascularization or replantation, the Hospital Anxiety and Depression Scale scores for anxiety (11.4 ± 4.4 versus 9.7 ± 3.5, mean difference 1.7 [95% CI 0.6 to 2.8]; p < 0.01) and depression (8.5 ± 4.6 versus 7.0 ± 3.1, mean difference 1.5 [95% CI 0.5 to 2.5]; p < 0.01) were higher in the failed revascularization or replantation group than in the successful revascularization or replantation group. There was no increase in the artery-related risk of failure (one versus two anastomosed arteries: 91% versus 89%, OR 1.3 [95% CI 0.6 to 2.6]; p = 0.53). For patients with anastomosed veins, a similar outcome was observed for the two vein-related risk of failure (two versus one anastomosed vein: 90% versus 89%, OR 1.0 [95% CI 0.2 to 3.8]; p = 0.95) and three vein-related risk of failure (three versus one vein anastomosed: 96% versus 89%, OR 0.4 [95% CI 0.1 to 2.4]; p = 0.29). Factors associated with failure of revascularization or replantation included the mechanism of injury (crush: OR 4.2 [95% CI 1.6 to 11.2]; p < 0.01, avulsion: OR 10.2 [95% CI 3.4 to 30.7]; p < 0.01). Revascularization had a lower risk of failure than replantation (OR 0.4 [95% CI 0.2 to 1.0]; p = 0.04). Treatment with a protocol of prolonged antibiotics, antithrombotics, and antispasmodics was not associated with a lower risk of failure (OR 1.2 [95% CI 0.6 to 2.3]; p = 0.63). CONCLUSION: With proper wound debridement and patency of repaired vessels, prolonged use of antibiotic prophylaxis and regular antithrombotic and antispasmodic treatment may not be necessary for successful digit replantation. However, it may be associated with higher Hospital Anxiety and Depression Scale scores. Postoperative mental status is associated with digit survival. Well-repaired vessels, instead of the number of anastomosed vessels, could be critical to survival and decrease the influence of risk factors. Further research on consensus guidelines that compare postoperative treatment and the surgeon's level of expertise after digit replantation should be conducted at multiple institutions. LEVEL OF EVIDENCE: Level III, therapeutic study.


Assuntos
Amputação Traumática , Traumatismos dos Dedos , Humanos , Amputação Traumática/etiologia , Estudos Retrospectivos , Antibioticoprofilaxia , Reimplante/efeitos adversos , Reimplante/métodos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Amputação Cirúrgica
3.
Plast Reconstr Surg ; 152(1): 117-123, 2023 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-36735820

RESUMO

BACKGROUND: Digital necrosis (DN) is a serious complication after replantation. However, predisposing factors, as reported less, remain controversial. The purpose of this study was to explore risk factors of necrosis after single-digit replantation by means of a retrospective study. METHODS: Patients who underwent single-digit replantations in our hospital between June of 2014 and October of 2020 were included. The authors regarded DN as the failure group and digital survival as the success group. The factors were conducted by univariate and multivariate analysis. RESULTS: The survival rate in our study was 78.8% (745 of 946). The results of univariate analysis showed that there were significant differences in the levels of D-dimer (first), menstrual cycle, injury level, and starting and finishing time of surgery between different groups. In multivariate analysis, age, injury level, duration of surgery, and D-dimer (first) were identified as the risk factors for DN in the entire and male population. In addition, regarding male patients, ischemia time was also found to be a risk factor for DN. In terms of female patients, the menstrual period and menopause were related to DN. CONCLUSIONS: Many factors, including age, ischemia time, injury level, menstrual period, menopause, and duration of surgery, were related to DN after digital replantation. D-dimer (first) was first found as a predicted factor for DN. In addition, these results also showed that the starting and ending times of surgery were associated with DN by univariate analysis. Preoperative measures should be taken to lower the incidence of DN. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III.


Assuntos
Amputação Traumática , Traumatismos dos Dedos , Humanos , Masculino , Feminino , Estudos Retrospectivos , Amputação Traumática/cirurgia , Amputação Traumática/etiologia , Traumatismos dos Dedos/cirurgia , Reimplante/métodos , Necrose/etiologia , Isquemia/etiologia
4.
Ghana Med J ; 56(1): 51-54, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35919783

RESUMO

Amputation of the penis is a rare and devastating injury. The etiologies vary from accidental, self-inflicted to attacks due to sexual jealousy and revenge. In the present era of microvascular surgery, replantation is the standard care. However, replantation of the penis comes with its own set of difficulties and complications. Knowledge of the anatomy and prior knowledge of the possible complications makes the surgeon aware of the course of events after a replantation. It helps in devising strategies to overcome these challenges methodically. We present a case of penile replant with the complications that we encountered, and the measures are taken to counter them on our way to a successful outcome. Funding: No external funding.


Assuntos
Amputação Traumática , Amputação Cirúrgica , Amputação Traumática/etiologia , Amputação Traumática/cirurgia , Humanos , Masculino , Microcirurgia , Pênis/lesões , Pênis/cirurgia , Reimplante
5.
Plast Reconstr Surg ; 148(3): 382e-388e, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34432687

RESUMO

BACKGROUND: This study investigated patient-reported outcomes after surgical treatment of rodeo thumb amputation to guide clinical decision-making. METHODS: A retrospective review was performed for rodeo thumb amputations from 2009 to 2019. Patient-reported outcomes were collected and compared by injury level, age, and treatment. Two-sided t test was used to compare continuous variables, and Pearson chi-square test was used to compare categorical data. RESULTS: The study included 37 patients. Patients with interphalangeal injuries treated with replantation had Quick Disabilities of the Arm, Shoulder and Hand questionnaire scores similar to those treated with amputation (1 versus 8; p = 0.07). There was no significant difference in percentage of patients with similar or better roping ability after treatment (40 percent versus 79 percent; p = 0.26), and similar percentages were satisfied (80 percent versus 71 percent; p = 1.00). Patients with metacarpophalangeal injuries treated with replantation and those treated with amputation had similar questionnaire scores (7 versus 10; p = 0.47). Both groups had similar roping ability after treatment (67 percent versus 56 percent; p = 1.00), and there was no statistically significant difference in satisfaction (79 percent versus 44 percent; p = 0.34). Pediatric patients had questionnaire scores similar to those of adults (6 versus 8; p = 0.42). A significantly higher percentage of pediatric patients had similar roping ability following injury than adults (100 percent versus 54 percent; p = 0.02). Most patients in both groups were satisfied (89 percent versus 61 percent; p = 0.22). CONCLUSIONS: For both interphalangeal and metacarpophalangeal injuries, patient-reported outcomes were similar regardless of treatment. Children were able to return to roping and perform at a similar or higher level at a greater rate than adults, but had similar questionnaire scores and satisfaction.


Assuntos
Amputação Traumática/cirurgia , Traumatismos em Atletas/cirurgia , Reimplante/estatística & dados numéricos , Polegar/lesões , Adolescente , Adulto , Fatores Etários , Idoso , Amputação Traumática/etiologia , Traumatismos em Atletas/etiologia , Criança , Tomada de Decisão Clínica , Humanos , Masculino , Pessoa de Meia-Idade , Medidas de Resultados Relatados pelo Paciente , Estudos Retrospectivos , Polegar/cirurgia , Adulto Jovem
6.
Ann Plast Surg ; 86(6S Suppl 5): S599-S602, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-34100819

RESUMO

BACKGROUND: Upper-extremity amputations can be devastating injuries that lead to lifelong disabilities. The purpose of our study was to review national data and identify populations at risk and injury patterns that could be targeted with prevention strategies. METHODS: Data from the National Electronic Injury Surveillance System between years 2012 and 2018 were reviewed. Injuries affecting the upper extremity resulting in amputation were included. Patient demographics, anatomical location, mechanism of injury, level of care provided, and setting of injury were recorded. Descriptive was recorded and tabulated for each category. RESULTS: There were 4,766 patients identified with amputations to the upper extremity from 2012 to 2018. The following categories are listed below: age in years, sex, race, anatomical location of injury, most common mechanisms of injury, disposition of patient, environmental location. CONCLUSIONS: Our data show that male children younger than 10 years are at the high risk for finger amputations. In addition, the majority of these injuries occur in the home. This suggests that safety prevention in the home is a significant area in need of improvement. We recommend further research in areas of home safety and injury prevention to decrease the risk of the devastating injuries.


Assuntos
Amputação Traumática , Amputação Cirúrgica , Amputação Traumática/epidemiologia , Amputação Traumática/etiologia , Amputação Traumática/cirurgia , Criança , Eletrônica , Humanos , Masculino , Estudos Retrospectivos , Extremidade Superior/cirurgia
7.
J Hand Surg Asian Pac Vol ; 26(1): 36-40, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33559580

RESUMO

Background: Angle grinders are a handheld power tool used for grinding and polishing stone, metal, and concrete. Some people, however, use them with a circular saw blade attachment for cutting wood and consequently, suffer injuries. We aimed to investigate the underlying cause and mechanisms of injuries caused by cutting wood with an angle grinder. Methods: We conducted a retrospective study using medical records from our trauma center and identified 15 patients treated for angle grinder injury between 2017 and 2018. Moreover, we contacted the National Consumer Affairs Center of Japan for further information about angle grinder injuries. Results: Nine of the 15 patients used angle grinders improperly, of which only three patients were aware of the risk of injury. The details of the nine patients were as follows: the types of injuries: complete finger amputation (n = 2), partial finger amputation (n = 1), tendon injury with phalangeal fracture (n = 5), and tendon injury alone, (n = 1); the causes of accidents: kickback (n = 7) and glove entanglement (n = 2); and the accident situations: on-the-job (n = 5) and do-it-yourself (n = 4). Conclusions: The primary cause of angle grinder injury caused by cutting wood was a lack of user knowledge that an angle grinder cannot be used as a cutting tool. Appropriate feedback from hand surgeons are necessary to urge manufacturers to take safety measures.


Assuntos
Amputação Traumática/etiologia , Traumatismos dos Dedos/etiologia , Falanges dos Dedos da Mão/lesões , Fraturas Ósseas/etiologia , Traumatismos dos Tendões/etiologia , Acidentes/estatística & dados numéricos , Adulto , Idoso , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Centros de Traumatologia , Madeira , Adulto Jovem
8.
J Plast Reconstr Aesthet Surg ; 73(11): 1995-2000, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32948497

RESUMO

PURPOSE: Replantation of multidigit amputations is difficult to perform due to severe damage to the digits, prolonged operative time, and ischemia. This study aimed to report the clinical results of multidigit replantation. METHODS: A retrospective case series of 34 digits belonging to 12 consecutive patients who underwent multidigit replantation was conducted. Patients with injury in at least one or more amputated fingers proximal to the insertion of the flexor digitorum superficialis tendon were included. The mean follow-up duration was 18.1 months. The number of amputated digits, mechanism and zone of injury, survival rate, and clinical outcomes, including the range of motion, grip strength, and sensory recovery, at the final follow-up were reviewed and analyzed. RESULTS: The mean number of amputated digits per patient was 2.8. Complete survival was achieved in 27 of 31 digits (87.1%). The mean final percentage of total active motion of injured digits was 47.0%, and the mean percentage of grip strength was 45.9% of the contralateral uninjured side. The comparison between patients with two and three amputated digits showed that there was no significant difference in both survival rates and functional outcomes. CONCLUSIONS: The results showed that both the survival rates and functional outcomes of multidigit replantation were as good as those of single-digit replantation, and there was no significant difference for outcomes between patients with two and three amputated digits. These results suggested that all multidigit replantations should be performed regardless of the number of injured digits or amputation zones.


Assuntos
Amputação Traumática , Traumatismos dos Dedos/cirurgia , Procedimentos de Cirurgia Plástica , Complicações Pós-Operatórias , Recuperação de Função Fisiológica , Reimplante , Amputação Traumática/etiologia , Amputação Traumática/cirurgia , Feminino , Articulações dos Dedos/fisiopatologia , Força da Mão , Humanos , Masculino , Microcirurgia/efeitos adversos , Microcirurgia/métodos , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/fisiopatologia , Amplitude de Movimento Articular , Procedimentos de Cirurgia Plástica/efeitos adversos , Procedimentos de Cirurgia Plástica/métodos , Reimplante/efeitos adversos , Reimplante/métodos , Estudos Retrospectivos , Índices de Gravidade do Trauma
9.
Pan Afr Med J ; 36: 13, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32774590

RESUMO

A 15-years-old boy was admitted in our hospital emergency unit with complaints of injured and hemorrhagic penile glans after donkey bites. The accident occurred during domestic activity with the animal when the boy attempted to guide the donkey. After thorough physical examination, the patient presented a penile glans amputation. Tetanic prophylaxis was started. The patient benefited from hemostatic suturing, stump regularization and penile glans reconstructive surgery and there was no complication. Functional and cosmetic results were satisfactory with good quality of micturition after six months' follow-up.


Assuntos
Amputação Traumática/etiologia , Mordeduras e Picadas/complicações , Pênis/lesões , Procedimentos de Cirurgia Plástica/métodos , Adolescente , Amputação Traumática/cirurgia , Animais , Burkina Faso , Equidae , Seguimentos , Humanos , Masculino , Pênis/cirurgia
11.
Hand (N Y) ; 15(6): 831-836, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-30880517

RESUMO

Background: Firework injuries to the hand can be devastating due to the explosive and ballistic nature of these devices. The aim of this study was to describe the injury and treatment characteristics of patients requiring surgery for firework-related hand injuries and to investigate which factors are associated with an increased utilization of health care resources. Methods: A retrospective chart review of patients undergoing surgery for firework-related hand injuries at two American College of Surgeons level I trauma centers between 2005 and 2016 was performed. Twenty cases were identified. These patients were evaluated for demographics, injury characteristics, number and types of surgical interventions, length of stay, and utilization of health care resources. Bivariate analyses were performed to investigate which factors were associated with increased consumption of health care resources. Results: Injuries ranged from digital nerve injuries to traumatic amputation. Patients underwent a median of 3 surgical operations. More than half the patients underwent flap or skin graft coverage of a soft tissue defect. The median length of hospital stay was 7 days. Factors found to be associated with an increased utilization of surgical and hospital resources included a first web space injury, thumb fracture, and traumatic amputation of any digit. Conclusions: The morbidity inflicted by firework injuries to individual patients is substantial. Patients with severe injuries undergo a median of three surgical operations and have a long duration of initial hospital stay. Knowing which factors are associated with an increased utilization of resources can help prognosticate these preventable injuries.


Assuntos
Amputação Traumática/etiologia , Traumatismos por Explosões/cirurgia , Traumatismos da Mão/etiologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Centros de Traumatologia/estatística & dados numéricos , Amputação Traumática/epidemiologia , Amputação Traumática/cirurgia , Traumatismos por Explosões/patologia , Traumatismos da Mão/epidemiologia , Traumatismos da Mão/cirurgia , Humanos , Estudos Retrospectivos
13.
J Foot Ankle Surg ; 59(3): 629-631, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31848041

RESUMO

We present the case of a 21-year-old male with 12 months' follow-up after reimplantation of a completely extruded first metatarsal. The patient had a motorcycle accident involving his right foot and ankle, with multiple lesser metatarsal fractures, lateral malleolus fracture, and a total first metatarsal extrusion (without fracture) through a large dorso-medial forefoot wound. The extruded bone was recovered at the site of the motor vehicle accident and was transported to the hospital with the patient. Before the reimplantation surgery was undertaken, the first metatarsal was immersed in a chlorhexidine solution for 20 minutes and then washed in an antibiotic solution. Metatarsal fixation was performed with Kirschner wires; the lateral malleolus fracture was fixed with plate and screws. An external fixator was then applied. Throughout the 12-month follow-up period, there was no evidence of infection. At the present time, this case suggests that, after antiseptic cleansing and prompt surgery, extruded first metatarsal reimplantation is possible with a reasonable degree of clinical success.


Assuntos
Amputação Traumática/cirurgia , Fixação Interna de Fraturas , Ossos do Metatarso/lesões , Reimplante , Amputação Traumática/diagnóstico por imagem , Amputação Traumática/etiologia , Humanos , Masculino , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
14.
BMC Pediatr ; 19(1): 175, 2019 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-31153365

RESUMO

BACKGROUND: Circumcision is considered to be a procedure with minimal morbidity but may be associated with catastrophic complications in inexpert hands. CASE PRESENTATION: We presented a 9-year-old boy with a past medical history of circumcision at the age of one year with Plastibell clamp who was referred with severe chronic penile injury due to neglected plastibell string. After string removal under a loupe magnification (4×), we saw a deep circular injury at distal penile shaft which led to painless glandular autoamputation 45 days later. The patient was managed conservatively with daily urethral self-dilation until future reconstructive surgery. CONCLUSION: This complication emphasized the importance of the follow-up visit by a physician for any probable string remnant.


Assuntos
Amputação Traumática/etiologia , Circuncisão Masculina/efeitos adversos , Pênis/lesões , Complicações Pós-Operatórias/etiologia , Suturas/efeitos adversos , Criança , Circuncisão Masculina/instrumentação , Dilatação/métodos , Humanos , Masculino , Fotografação , Fatores de Tempo , Uretra , Cateterismo Urinário
16.
Clin Orthop Relat Res ; 477(3): 644-654, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30601320

RESUMO

BACKGROUND: Although use of nonsteroidal antiinflammatory drugs and low-dose irradiation has demonstrated efficacy in preventing heterotopic ossification (HO) after THA and surgical treatment of acetabular fractures, these modalities have not been assessed after traumatic blast amputations where HO is a common complication that can arise in the residual limb. QUESTIONS/PURPOSES: The purpose of this study was to investigate the effectiveness of indomethacin and irradiation in preventing HO induced by high-energy blast trauma in a rat model. METHODS: Thirty-six Sprague-Dawley rats underwent hind limb blast amputation with a submerged explosive under water followed by irrigation and primary wound closure. One group (n = 12) received oral indomethacin for 10 days starting on postoperative Day 1. Another group (n = 12) received a single dose of 8 Gy irradiation to the residual limb on postoperative Day 3. A control group (n = 12) did not receive either. Wound healing and clinical course were monitored in all animals until euthanasia at 24 weeks. Serial radiographs were taken immediately postoperatively, at 10 days, and every 4 weeks thereafter to monitor the time course of ectopic bone formation until euthanasia. Five independent graders evaluated the 24-week radiographs to quantitatively assess severity and qualitatively assess the pattern of HO using a modified Potter scale from 0 to 3. Assessment of grading reproducibility yielded a Fleiss statistic of 0.41 and 0.37 for severity and type, respectively. By extrapolation from human clinical trials, a minimum clinically important difference in HO severity was empirically determined to be two full grades or progression of absolute grade to the most severe. RESULTS: We found no differences in mean HO severity scores among the three study groups (indomethacin 0.90 ± 0.46 [95% confidence interval {CI}, 0.60-1.19]; radiation 1.34 ± 0.59 [95% CI, 0.95-1.74]; control 0.95 ± 0.55 [95% CI, 0.60-1.30]; p = 0.100). For qualitative HO type scores, the radiation group had a higher HO type than both indomethacin and controls, but indomethacin was no different than controls (indomethacin 1.08 ± 0.66 [95% CI, 0.67-1.50]; radiation 1.89 ± 0.76 [95% CI, 1.38-2.40]; control 1.10 ± 0.62 [95% CI, 0.70-1.50]; p = 0.013). The lower bound of the 95% CI on mean severity in the indomethacin group and the upper bound of the radiation group barely spanned a full grade and involved only numeric grades < 2, suggesting that even if a small difference in severity could be detected, it would be less than our a priori-defined minimum clinically important difference and any differences that might be present are unlikely to be clinically meaningful. CONCLUSIONS: This work unexpectedly demonstrated that, compared with controls, indomethacin and irradiation provide no effective prophylaxis against HO in the residual limb after high-energy blast amputation in a rat model. Such an observation is contrary to the civilian experience and may be potentially explained by either a different pathogenesis for blast-induced HO or a stimulus that overwhelms conventional regimens used to prevent HO in the civilian population. CLINICAL RELEVANCE: HO in the residual limb after high-energy traumatic blast amputation will likely require novel approaches for prevention and management.


Assuntos
Amputação Traumática/terapia , Anti-Inflamatórios não Esteroides/farmacologia , Traumatismos por Explosões/terapia , Indometacina/farmacologia , Ossificação Heterotópica/prevenção & controle , Doses de Radiação , Amputação Traumática/etiologia , Animais , Traumatismos por Explosões/etiologia , Modelos Animais de Doenças , Masculino , Ossificação Heterotópica/diagnóstico por imagem , Ossificação Heterotópica/etiologia , Ratos Sprague-Dawley , Fatores de Tempo , Cicatrização/efeitos dos fármacos , Cicatrização/efeitos da radiação
17.
Can J Surg ; 61(6): S203-S207, 2018 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-30418007

RESUMO

Background: We have previously reported a higher than expected rate of upper-extremity amputation (UEA) in victims of an antipersonnel improvised explosive device (AP-IED) compared with a similar cohort injured by antipersonnel mines (APM). The goal of this study was to describe the rate, severity and impact of UAE caused by an AP-IED. Methods: We analyzed a prospective database of 100 consecutive dismounted AP-IED victims with pattern 1 injuries to compare the outcomes of the cohort with UEA to that without. Results: We found that UEA (8 above elbow, 19 below elbow, 1 through elbow, 3 hand, 15 digit(s)) was much more prevalent with AP-IED than with APM (40% v. 6%, p < 0.001). In addition, UEA was associated with a higher rate of multiple amputations (39 [98%] v. 32 [53%], p < 0.001), bilateral lower-extremity amputation (LEA; 33 [82.5%] v. 30 [53.3%], p = 0.003) and facial injury (8 [20%] v. 4 [6.4%], p = 0.044), but not with pelvic disruption (10 [25%]), genitoperineal mutilation (19 [48%]), eye injury (6 [15%]), or skull fracture (6 [15%]). The fatality rate was higher in patients with UEA than in those without (12 [30%] v. 7 [12%], p = 0.022). Conclusion: Upper-extremity amputation is more prevalent with AP-IED than APM. Presence of UEA is associated with more severe injury and increased risk of death in AP-IED victims. Upper-limb injury has significant consequences for rehabilitation from LEA, which universally accompanies UEA in AP-IED victims. Upper-extremity injury should be amenable to prevention by innovative personal protective equipment designed to protect the flexed elbow.


Contexte: Nous avons déjà fait état d'un taux plus élevé que prévu d'amputations des membres supérieurs (AMS) chez les victimes d'engins explosifs artisanaux (EEA) comparativement à une cohorte similaire blessée par des mines antipersonnel (MAP). L'objectif de cette étude est de décrire le taux, la gravité et l'impact des AMS causées par des EEA. Méthodes: Nous avons analysé une base de données prospective de 100 victimes consécutives d'EEA alors qu'elles se trouvaient hors de leur véhicule et présentant des blessures de type 1 afin de comparer les résultats des cohortes ayant subi ou non des AMS. Résultats: Nous avons constaté que l'AMS (8 au-dessus du coude, 19 sous le coude, 1 au niveau du coude, 3 mains et 15 doigts) était beaucoup plus prévalente avec les EEA qu'avec les MAP (40 % c. 6 %, p < 0,001). De plus, l'AMS a été associée à un taux plus élevé d'amputations multiples (39 [98 %] c. 32 [53 %], p < 0,001), d'amputations bilatérales des membres inférieurs (AMI) (33 [82,5 %] c. 30 [53,3 %], p = 0,003) et de blessures au visage (8 [20 %] c. 4 [6,4 %], p = 0,044), mais non de blessures au bassin (10 [25%]), de mutilations génitopérinéales (19 [48 %]), de blessures oculaires (6 [15 %]), ou de fractures du crâne (6 [15 %]). Le taux de létalité a été plus élevé chez les patients ayant subi une AMS que chez ceux qui n'en ont pas subi (12 [30 %] c. 7 [12 %], p = 0,022). Conclusion: L'amputation des membres supérieurs est plus prévalente avec les EEA qu'avec les MAP. L'AMS est associée à des blessures plus graves et à un risque plus grand de décès chez les victimes d'un EEA. Les blessures aux membres supérieurs ont de graves conséquences sur la réadaptation nécessaire après l'AMI, qui accompagne presque toujours l'AMS chez les victimes d'un EEA. Les blessures aux membres supérieurs devraient pouvoir être évitées grâce à de l'équipement de protection individuelle novateur conçu pour protéger le coude fléchi.


Assuntos
Amputação Traumática/epidemiologia , Traumatismos do Braço/epidemiologia , Traumatismos por Explosões/epidemiologia , Substâncias Explosivas/efeitos adversos , Lesões Relacionadas à Guerra/epidemiologia , Adolescente , Adulto , Campanha Afegã de 2001- , Amputação Traumática/etiologia , Traumatismos do Braço/etiologia , Traumatismos por Explosões/etiologia , Criança , Humanos , Masculino , Prevalência , Estudos Prospectivos , Lesões Relacionadas à Guerra/etiologia , Adulto Jovem
18.
Ann Plast Surg ; 81(1): 106-112, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29762453

RESUMO

BACKGROUND: Pediatric dog bite injuries account for 1% of emergency department visits per year and represent an underrecognized and underreported public health problem. Reconstructive surgery is frequently utilized, and in the most extreme injuries, microvascular replantation may be considered. We sought to systematically review the available literature on microvascular replantation after facial dog bite injuries in children, with particular attention to perioperative morbidity and long-term follow-up. METHODS: We reviewed a case of microvascular replantation after a facial dog bite injury in a child from our own institution and conducted a systematic literature search to identify other similar reports. Clinical variables were collected from the reported cases, and descriptive statistics were calculated. A management algorithm was developed from the reviewed published experience. RESULTS: We report the youngest child to date in the literature to undergo replantation after a facial dog bite injury. Nineteen other cases were found involving children aged 18 months to 17 years, with follow-up ranging from 2 weeks to 28 years. Anastomosis techniques varied considerably and included both an artery and vein in only 9 (47%) of 19 cases. Venous congestion was nearly universal, and multimodal techniques were used until native venous outflow was reestablished. Blood transfusion was common, but intensive care unit utilization was not frequently reported. Long-term outcomes were excellent, with growth of the replanted part and recovery of function; however, minor revision procedures were common. CONCLUSIONS: Microvascular replantation following facial dog bite amputation injuries in the pediatric population is the ultimate step in the reconstructive ladder. Strong consideration should be given to microvascular exploration with involvement of large or whole segments of the lip, nose, or ear; however, parents should be counseled extensively regarding the known morbidity of replantation surgery. With meticulous surgical technique and careful postoperative care, replantation after facial dog bite amputation injuries may successfully achieve dramatic and lasting results for pediatric patients.


Assuntos
Amputação Traumática/cirurgia , Mordeduras e Picadas/cirurgia , Traumatismos Faciais/cirurgia , Reimplante/métodos , Adolescente , Algoritmos , Amputação Traumática/etiologia , Animais , Mordeduras e Picadas/complicações , Criança , Pré-Escolar , Cães , Traumatismos Faciais/etiologia , Feminino , Humanos , Masculino , Procedimentos de Cirurgia Plástica/métodos , Lesões dos Tecidos Moles/cirurgia , Cicatrização
20.
J Pediatr Rehabil Med ; 9(4): 265-269, 2016 11 30.
Artigo em Inglês | MEDLINE | ID: mdl-27935565

RESUMO

PURPOSE: To determine the demographic pattern, level, mechanism of traumatic amputation in children and adolescent age group and to compare findings with other studies. METHODS: Patients aged less than 18 years with traumatic amputation attending Department of Physical Medicine and Rehabilitation, King George's Medical University, Lucknow, India between July 2013 and January 2016 were enrolled and their demographic characteristics were analyzed. RESULTS: Fifty-three patients were included aged less than 18 years when injured. Mean age of the population studied was 9.89 ± 4.13 with male to females ratio of 3:2. Majority (69.81%) of traumatic amputations involved lower limb. Most common level was unilateral transtibial (35.85%), followed by transfemoral (16.98%). In upper limb, most common type was transradial. RTA followed by train accidents was most common mechanism of traumatic amputation. 8 patients needed revision surgery. 52.8% patients of acquired amputations complained of phantom sensation and 37.74% phantom pain. CONCLUSIONS: This study aims to visualize the current scenario and the data generated could be possibly helpful in planning policies and programs at institutional as well as at higher levels for prevention, treatment and distribution of resource to the young amputee population, to ensure their better health care and also opportunities in life.


Assuntos
Amputação Traumática/epidemiologia , Adolescente , Amputação Traumática/diagnóstico , Amputação Traumática/etiologia , Amputação Traumática/cirurgia , Criança , Pré-Escolar , Feminino , Humanos , Índia/epidemiologia , Lactente , Recém-Nascido , Masculino , Estudos Prospectivos , Centros de Atenção Terciária , Resultado do Tratamento
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