Left Anterior Descending Coronary Artery and Multiple Peripheral Mycotic Aneurysms Due to Mycobacterium Bovis Following Intravesical Bacillus Calmette-Guerin Therapy: A Case Report.

The use of live attenuated intravesicular Bacillus Calmette-Guerin (BCG) therapy is a generally accepted safe and effective method for the treatment of superficial transitional cell carcinoma (TCC) of the bladder. Although rare, < 5% of patient's treated with intravesicular BCG therapy may develop potentially serious complications, including localized infections to the genitourinary tract, mycotic aneurysms and osteomyelitis. We present here a case of a 63-year-old male who developed left coronary and multiple peripheral M. Bovis mycotic aneurysms as a late complication of intravesicular BCG therapy for superficial bladder cancer. The patient initially presented with acute onset pain and swelling in the left knee > 2 years following initial therapy, and initial workup revealed a ruptured saccular aneurysm of the left popliteal artery as well as incidental bilateral common femoral artery aneurysms. Following endovascular treatment and additional workup, the patient was discovered to have additional aneurysms in the right popliteal artery and left anterior descending artery (LAD). Surgical pathology and bacterial cultures obtained from the excised femoral aneurysms and surgical groin wounds were positive for Mycobacterium Bovis, and the patient was initiated on a nine-month antimycobacterial course of isoniazid, rifampin and ethambutol. Including the present case, there has been a total of 32 reported cases of mycotic aneurysms as a complication from intravesicular BCG therapy, which we will review here. The majority of reported cases involve the abdominal aorta; however, this represents the first known reported case of a coronary aneurysm.

Contained rupture of mycotic aneurysm of the left circumflex coronary artery in a child.

Coronary artery aneurysm (CAA) is defined as dilatation of a coronary artery segment to a diameter of more than 1.5-fold normal size. Rupture of CAA is a catastrophic event and may result in sudden death or myocardial infarction. We report this unusual case of contained rupture of the left circumflex CAA.

Successful surgical outcome of infected aneurysmal drug-coated stent endocarditis.

A 52-year-old man developed pyrexia after primary angioplasty following anterior myocardial infarction Noninvasive evaluation revealed staphylococcal septicemia with suspicion of an aneurysm or abscess at the stented segment. Coronary angiography confirmed the presence of a large aneurysm. The infected left anterior descending artery aneurysm was de-roofed and ligated, and a saphenous vein bypass graft was placed, with an excellent outcome.

Mycotic left main coronary artery aneurysm following double-valve replacement for active infective endocarditis.

A 68-year-old man underwent double-valve replacement (DVR) for active infective endocarditis caused by Enterococcus faecalis. Postoperative coronary angiography (CAG) revealed a saccular aneurysm originating from the distal portion of LMCA with severe stenosis at the ostium of the left anterior descending (LAD) artery and left circumflex artery (LCx). Emergent surgical resection with concomitant coronary artery bypass grafting were performed.Mycotic coronary artery aneurysms have a great tendency to rupture, and this may result in cardiac tamponade and sudden death. Early recognition and prompt surgical intervention is mandatory to minimize those fatal complications.

Aneurisma coronariano micótico: relato de dois casos / Mycotic coronary aneurysm: report of two cases / Aneurisma coronario micotico: reporte de dos casos

O número de intervenções percutâneas com implante de stents tem aumentado dramaticamente nos últimos anos, apesar da frequência no uso do dispositivo nos relatos de infecções serem extremamente raros. Neste artigo relatamos dois casos de aneurisma micótico após implante de stents com diferentes apresentações clínicas e evolução.

The number of percutaneous interventions with stent implantation has increased dramatically in recent years, although the frequent use of this device in reports of infections is extremely rare. In this article we report two cases of mycotic aneurysm after implantation of stents with different clinical presentations and outcomes.

El número de intervenciones percutáneas con implantación de stents ha incrementado dramáticamente en los últimos años, a pesar del gran auge del dispositivo los reportes de infecciones son extremadamente raros. En el presente artículo reportamos dos casos de aneurismas micoticos luego de la implantación de stents con presentación y evolución clínicas diferentes.

Infected pseudoaneurysm involving a drug-eluting stent.

Stent infection following percutaneous transluminal coronary angioplasty is rare. We present such a case involving a drug-eluting stent placed in the left anterior descending coronary artery that was managed surgically with removal of the stent with concomitant coronary artery bypass grafting. Early surgical intervention directed at removal of the infected stent, debridement and distal vessel revascularisation is recommended to deal with the infection and prevent myocardial compromise.

Coronary stent infections: a case series.

Stent infection is a rare sequela of coronary stent implantation first reported fifteen years ago. Since that time, much has been learned about this dramatic disease entity by way of case report and review. Nevertheless, clinical experience with regard to the diagnosis and management of coronary artery stent infection remains limited. Here, we report 3 cases of coronary stent infections; 2 with mycotic aneurysms (seen on coronary angiography) that ruptured into an adjacent cardiac chamber, and one with purulent pericarditis. The microbiology as well as the possible mechanisms and risk factors for these infections are discussed.

Infective coronary aneurysms: a complication of percutaneous coronary intervention.

We present the case of a patient who developed infective coronary artery aneurysms after percutaneous coronary artery intervention. We describe the patient's clinical presentation, diagnosis, and treatment, and we review the pertinent medical literature.

Mycotic aneurysm of the right coronary artery.

Mycotic embolism in patients with infective endocarditis is not uncommon, however, mycotic aneurysm of a coronary artery is very rare. We report the case of a 62-year-old woman with mitral valve endocarditis complicated by mycotic aneurysm of the right coronary artery. Mitral valve replacement and resection of the mycotic aneurysm with coronary artery bypass were performed.

Coronary artery bypass graft mycotic aneurysms in a dialysis patient.

Infection is a common problem in dialysis patients and ranks second behind cardiovascular disease as a major cause of death. The major causes of infections, mainly bloodstream infections, often are related to dialysis access. Metastatic infectious complications have been reported frequently in the course of such bacteremias. We report the case of a 79-year-old dialysis patient who was admitted with recurrent catheter-related bacteremia caused by methicillin-resistant Staphylococcus aureus. Echocardiography and a computed tomographic scan of her chest showed multiple coronary artery bypass graft mycotic aneurysms. Despite prompt dialysis catheter removal and antibiotic treatment, she had progressive deterioration of her hemodynamic and mental status and eventually died of profound sepsis. An autopsy confirmed computed tomographic findings, plus extensive suppuration involving the left atrial and ventricular myocardium and upper lobe of the left lung. To our knowledge, this is the first report of coronary artery graft aneurysms complicating infective endocarditis in a dialysis patient.

Successful treatment of a ruptured mycotic coronary artery aneurysm.

Documented mycotic aneurysms of the coronary arteries are unusual, and antemortem identification of such an aneurysm is rare. We present the case of a patient who had successful management of a ruptured mycotic aneurysm of a coronary artery.