A method to predict space radiation biological effectiveness for non-cancer effects following intense Solar Particle Events.

In addition to the continuous exposure to cosmic rays, astronauts in space are occasionally exposed to Solar Particle Events (SPE), which involve less energetic particles but can deliver much higher doses. The latter can exceed several Gy in a few hours for the most intense SPEs, for which non-stochastic effects are thus a major concern. To identify adequate shielding conditions that would allow respecting the dose limits established by the various space agencies, the absorbed dose in the considered organ/tissue must be multiplied by the corresponding Relative Biological Effectiveness (RBE), which is a complex quantity depending on several factors including particle type and energy, considered biological effect, level of effect (and thus absorbed dose), etc. While in several studies only the particle-type dependence of RBE is taken into account, in this work we developed and applied a new approach where, thanks to an interface between the FLUKA Monte Carlo transport code and the BIANCA biophysical model, the RBE dependence on particle energy and absorbed dose was also considered. Furthermore, we included in the considered SPE spectra primary particles heavier than protons, which in many studies are neglected. This approach was then applied to the October 2003 SPE (the most intense SPE of solar cycle 23, also known as "Halloween event") and the January 2005 event, which was characterized by a lower fluence but a harder spectrum, i.e., with higher-energy particles. The calculation outcomes were then discussed and compared with the current dose limits established for skin and blood forming organs in case of 30-days missions. This work showed that the BIANCA model, if interfaced to a radiation transport code, can be used to calculate the RBE values associated to Solar Particle Events. More generally, this work emphasizes the importance of taking into account the RBE dependence on particle energy and dose when calculating equivalent doses.

Cancer and circulatory disease risks for the largest solar particle events in the space age.

In this paper we use the NASA Space Cancer Risk (NSCR version 2022) model to predict cancer and circulatory disease risks using energy spectra representing the largest SPE's observed in the space age. Because tissue dose-rates behind shielding for large SPE's lead to low dose-rates (<0.2 Gy/h) we consider the integrated risk for several historical periods of high solar activity, including July-November, 1960 events and August-October 1989 events along with the February 1956 and August 1972 events. The galactic cosmic ray (GCR) contribution to risks is considered in predictions. Results for these largest historical events show risk of exposure induced death (REID) are mitigated to < 1.2 % with a 95 % confidence interval with passive radiation shielding of 20 g/cm2 aluminum, while larger amounts would support the application of the ALARA principle. Annual GCR risks are predicted to surpass the risks from large SPEs by ∼30 g/cm2 of aluminum shielding.

Ground-based passive generation of Solar Particle Event spectra: Planning and manufacturing of a 3D-printed modulator.

The generation of space radiation on Earth is essential to study and predict the effects of radiation on space travelers, electronics, or materials during future long-term space missions. Next to the heavy ions of the galactic cosmic rays, solar particle events play a major role concerning the radiation risk in space, which consist of intermediate-energy protons with broad spectra and energies up to a few hundred MeV. This work describes an approach for the ground-based generation of solar particle events. As a proof of principle, a passive beam modulator with a specific funnel-shaped periodic structure was designed and is used to convert a monoenergetic proton beam into a spectral proton energy distribution, mimicking a solar particle event from August 1972, which is known as one of the strongest recorded SPE events. The required proton beam of 220 MeV can be generated at many existing particle accelerators at research or particle therapy facilities. The planning, manufacturing and testing of the modulator is described step by step. Its correct manufacturing and the characteristics of the solar particle event simulator are tested experimentally and by means of Monte Carlo simulations. Future modulators will follow the same concept with minor adjustments such as a larger lateral extension. As of now, the presented beam modulator is available to the research community to conduct experiments at GSI for exposure under solar particle event conditions. In addition, researchers can use and apply the described concept to design and print their individualized modulator to reproduce any desired solar particle event spectrum or request the presented modulator geometry from the authors.

Observation of the radiation environment and solar energetic particle events in Mars orbit in May 2018- June 2022.

The dosimeter Liulin-MO for measuring the radiation environment onboard the ExoMars Trace Gas Orbiter (TGO) is a module of the Fine Resolution Epithermal Neutron Detector (FREND). Here we present results from measurements of the charged particle fluxes, dose rates and estimation of dose equivalent rates at ExoMars TGO Mars science orbit, provided by Liulin-MO from May 2018 to June 2022. The period of measurements covers the declining and minimum phases of the solar activity in 24th solar cycle and the rising phase of the 25th cycle. Compared are the radiation values of the galactic cosmic rays (GCR) obtained during the different phases of the solar activity. The highest values of the dose rate and flux from GCR are registered from March to August 2020. At the minimum of 24th and transition to 25th solar cycle the dose rate from GCR is 15.9 ± 1.6 µGy h-1, particle flux is 3.3 ± 0.17 cm-2s-1, dose equivalent rate is 72.3 ± 14.4 µSv h-1. Since September 2020 the dose rate and flux of GCR decrease. Particular attention is drawn to the observation of the solar energetic particle (SEP) events in July, September and October 2021, February and March 2022 as well as their effects on the radiation environment on TGO during the corresponding periods. The SEP event during15-19 February 2022 is the most powerful event observed in our data. The SEP dose during this event is 13.8 ± 1.4 mGy (in Si), the SEP dose equivalent is 21.9 ± 4.4 mSv. SEP events recorded in Mars orbit are related to coronal mass ejections (CME) observed by SOHO and STEREO A coronagraphs. Compared are the time profiles of the count rates measured by Liulin-MO, the neutron detectors of FREND and neutron detectors of the High Energy Neutron Detector (HEND) aboard Mars Odyssey during 15-19 February 2022 event. The data obtained is important for the knowledge of the radiation environment around Mars, regarding future manned and robotic flights to the planet. The data for SEP events in Mars orbit during July 2021-March 2022 contribute to the details on the solar activity at a time when Mars is on the opposite side of the Sun from Earth.

Active radiation measurements over one solar cycle with two DOSTEL instruments in the Columbus laboratory of the International Space Station.

Two DOSimetry TELescopes (DOSTELs) have been measuring the radiation environment in the Columbus module of the International Space Station (ISS) since 2009 in the frame of the DOSIS and DOSIS 3D projects. Both instruments have measured the charged particle flux rate and dose rates in a telescope geometry of two planar silicon detectors. The radiation environment in the ISS orbit is mostly composed by galactic cosmic radiation (GCR) and its secondary radiation and protons from the inner radiation belt in the South Atlantic Anomaly (SAA) with sporadic contributions of solar energetic particles at high latitudes. The data presented in this work cover two solar activity minima and corresponding GCR intensity maxima in 2009 and 2020 and the solar activity maximum and corresponding GCR intensity minimum in 2014/2015. Average dose rates measured in the Columbus laboratory in the ISS orbit from GCR and SAA are presented separately. The data is analyzed with respect to the effective magnetic shielding and grouped into different cut-off rigidity intervals. Using only measurements in magnetically unshielded regions at low cut-off rigidity and applying a factor for the geometrical shielding of the Earth, absorbed dose rates and dose equivalent rates in near-Earth interplanetary space are estimated for the years 2009 to 2022.

Radiation measurements in the International Space Station, Columbus module, in 2020-2022 with the LIDAL detector.

The Light Ion Detector for ALTEA (LIDAL) is a new instrument designed to measure flux, energy spectra and Time of Flight of ions in a space habitat. It was installed in the International Space Station (Columbus) on January 19, 2020 and it is still operating. This paper presents the results of LIDAL measurements in the first 17 months of operation (01/2020-05/2022). Particle flux, dose rate, Time of Flight and spectra are presented and studied in the three ISS orthogonal directions and in the different geomagnetic regions (high latitude, low latitude, and South Atlantic Anomaly, SAA). The results are consistent with previous measurements. Dose rates range between 1.8 nGy/s and 2.4 nGy/s, flux between 0.21 particles/(sr cm2 s) and 0.32 particles/(sr cm2 s) as measured across time and directions during the full orbit. These data offer insights concerning the radiation measurements in the ISS and demonstrate the capabilities of LIDAL as a unique tool for the measurement of space radiation in space habitats, also providing novel information relevant to assess radiation risks for astronauts.

About 4-Day Rhythm of Proliferative Activity of L-929 Cells in Culture Correlates with the Intensity of Secondary Cosmic Radiation Fluctuations.

The dynamics of proliferative activity of the L-929 cell culture of mouse fibroblast-like cells in the phase of logarithmic growth was compared with some heliogeophysical parameters (Ap and ULF indexes of geomagnetic activity, vertical component of the interplanetary magnetic field, and intensity of fluctuations of secondary cosmic radiation estimated by the neutron monitoring near the Earth's surface). Among the considered heliogeophysical parameters, only the magnitude of fluctuations of minute-to-minute changes in the neutron monitor indicator reliably and negatively correlates with the rate of cell culture reproduction. Considering that the amplitude of secondary cosmic fluctuations is about 5%, which is 0.1% of the total ray flux, and proliferative activity varies in the range of 30-50%, the probability of a direct biotrophic effect of this physical factor is extremely low. It seems likely that proliferative activity of L-929 cell culture is directly affected by another environmental factor, the marker of which is the intensity of neutron counting rate fluctuations.

Extensive study of radiation dose on human body at aviation altitude through Monte Carlo simulation.

The diverse near-Earth radiation environment due to cosmic rays and solar radiation has direct impact on human civilization. In the present and upcoming era of increasing air transfer, it is important to have precise idea of radiation dose effects on human body during air travel. Here, we calculate the radiation dose on the human body at the aviation altitude, also considering the shielding effect of the aircraft structure, using Monte Carlo simulation technique based on Geant4 toolkit. We consider proper 3D mathematical model of the atmosphere and geomagnetic field, updated profile of the incoming particle flux due to cosmic rays and appropriate physics processes. We use quasi-realistic computational phantoms to replicate the human body (male/female) for the effective dose calculation and develop a simplified mathematical model of the aircraft (taking Boeing 777-200LR as reference) for the shielding study. We simulate the radiation environment at the flying altitude (at 10 km and considering geomagnetic latitude in the range of 45-50°), as well as at various locations inside the fuselage of the aircraft. Then, we calculate the dose rates in the different organs for both male and female phantoms, based on latest recommendations of International Commission on Radio logical Protection. This calculation shows that the sex-averaged effective dose rate in human phantom is 5.46 µSv/h, whereas, if we calculate weighted sum of equivalent dose contributions separately in female and male body: total weighted sum of equivalent dose rate received by the female phantom is 5.72 µSv/h and that by the male phantom is 5.20 µSv/h. From the simulation, we also calculate the numerous cosmogenic radionuclides produced inside the phantoms through activation or spallation processes which may induce long-term biological effects.

A new type of ground-based simulator of radiation field inside a spacecraft in deep space.

The problem of full-scale ground-based modeling of cosmic radiation on heavy-ion accelerators for space radiobiology is very urgent. A new type of space radiation simulator at the 56Fe ion beam with energy 1 GeV/n is proposed. The simulator uses rotating converters consisting of segmented targets with varying thicknesses. When a flat uniform field of primary 56Fe ions is used, this design ensures the uniformity of the fields of all secondary particles behind the targets. The proposed setup with four replaceable converters makes it possible to simulate not only the distribution of linear energy transfers of cosmic radiation but also reproduce continuous energy spectra of all charged fragments of the projectile ion from protons to Co. The results of simulation of the internal radiation field inside the habitable module of a spacecraft with a shell of 15 g/cm2 Al, generated by particles of galactic cosmic rays in the solar activity range from 0 to 190 Wolf numbers, are presented.

Consequences of space radiation on the brain and cardiovascular system.

Staying longer in outer space will inevitably increase the health risks of astronauts due to the exposures to galactic cosmic rays and solar particle events. Exposure may pose a significant hazard to space flight crews not only during the mission but also later, when slow-developing adverse effects could finally become apparent. The body of literature examining ground-based outcomes in response to high-energy charged-particle radiation suggests differential effects in response to different particles and energies. Numerous animal and cellular models have repeatedly demonstrated the negative effects of high-energy charged-particle on the brain and cognitive function. However, research on the role of space radiation in potentiating cardiovascular dysfunction is still in its early stages. This review summarizes the available data from studies using ground-based animal models to evaluate the response of the brain and heart to the high-energy charged particles of GCR and SPE, addresses potential sex differences in these effects, and aims to highlight gaps in the current literature for future study.

The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.

Both microgravity and radiation exposure in the spaceflight environment have been identified as hazards to astronaut health and performance. Substantial study has been focused on understanding the biology and risks associated with prolonged exposure to microgravity, and the hazards presented by radiation from galactic cosmic rays (GCR) and solar particle events (SPEs) outside of low earth orbit (LEO). To date, the majority of the ground-based analogues (e.g., rodent or cell culture studies) that investigate the biology of and risks associated with spaceflight hazards will focus on an individual hazard in isolation. However, astronauts will face these challenges simultaneously Combined hazard studies are necessary for understanding the risks astronauts face as they travel outside of LEO, and are also critical for countermeasure development. The focus of this review is to describe biologic and functional outcomes from ground-based analogue models for microgravity and radiation, specifically highlighting the combined effects of radiation and reduced weight-bearing from rodent ground-based tail suspension via hind limb unloading (HLU) and partial weight-bearing (PWB) models, although in vitro and spaceflight results are discussed as appropriate. The review focuses on the skeletal, ocular, central nervous system (CNS), cardiovascular, and stem cells responses.

Observations of neutron radiation environment during Odyssey cruise to Mars.

In April 2001, Mars Odyssey spacecraft with the High Energy Neutron Detector (HEND) onboard was launched to Mars. HEND/Odyssey was switched on measurement mode for most of transit to Mars to monitor variations of spacecraft background and solar activity. Although HEND/Odyssey was originally designed to measure Martian neutron albedo and to search for Martian subsurface water/water ice, its measurements during cruise phase to Mars are applicable to evaluate spacecraft ambient radiation background. The biological impact of the neutron component of this radiation background should be understood, as it must be taken into account in planning future human missions to Mars. We have modeled the spacecraft neutron spectral density and compared it with HEND measurements to estimate neutron dose equivalent rates during Odyssey cruise phase, which occurred during the maximum period of solar cycle 23. We find that the Odyssey ambient neutron environment during May - September 2001 yields 10.6 ± 2.0 µSv per day in the energy range from 0 to 15 MeV, and about 29 µSv per day when extrapolated to the 0-1000 MeV energy range during solar quiet time (intervals without Solar Particle Events, SPEs). We have also extrapolated HEND/Odyssey measurements to different periods of solar cycle and find that during solar minimum (maximum of GCR flux), the neutron dose equivalent rate during cruise to Mars could be as high as 52 µSv per day with the same shielding. These values are in good agreement with results reported for a similar measurement made with an instrument aboard the Mars Science Laboratory during its cruise to Mars in 2011-2012.

Spaceflight medical countermeasures: a strategic approach for mitigating effects from solar particle events.

NASA was recently charged with returning humans to the lunar surface within the next five years. This will require preparation for spaceflight missions of longer distance and duration than ever performed in the past. Protecting the crew and mission from the hazards associated with spaceflight will be a priority. One of the primary hazards to address is the challenging radiation environment. Space is unforgiving when it comes to radiation. There is galactic cosmic radiation (GCR) that is pervasive in space and the possibility of solar particle events (SPE) that release high energy particles from the sun that can result in high doses of radiation to the crew if unprotected. NASA has been preparing and evaluating several means of ensuring that crew health is not compromised during these missions. Physical shielding, space weather monitoring, and more recently storm shelters are all possible means of protecting crew during a SPE. Medical countermeasures have not been necessary for operations in low Earth orbit; however, future human exploration missions should consider including therapies onboard to address radiation-induced health effects. While the likelihood of experiencing a significant SPE is very low, serious adverse health effects or even death could occur if no medical countermeasures were available. Having a Food and Drug Administration (FDA) approved medical countermeasure on board that could mitigate acute radiation-induced hematopoietic syndrome due to a SPE could provide life saving measures for the crew. This paper discusses the mitigation strategies that can be implemented for Artemis missions and identifies numerous areas of research for future improvements.

A Comprehensive Approach for Estimating Collective and Average Effective Doses of Galactic Cosmic Radiation Received by Pilots.

This study proposes a feasible and comprehensive approach for estimating collective and average effective doses of galactic cosmic radiation received by pilots on the basis of data in publicly available civil aviation annual statistical reports. Large uncertainties are associated with the estimation of these quantities because the radiation environment at aviation altitudes is complex, and a large number of flights operated by various air carriers is involved. A best estimate can be obtained through this approach because it considers all passenger, cargo, and charter flights operated during a long period of time instead of subjectively selecting some representative flights for dose evaluation. The approach becomes feasible and practical with the aid of a special feature called automatic batch analysis in the NTHU Flight Dose Calculator. There are two international airlines in Taiwan: China Airlines and EVA Air. As a demonstration, the collective effective dose received by the 2,513 pilots from the two airlines in 2018 was estimated to be 4,947 person-mSv, and the average effective dose per pilot was 1.97 mSv. These estimates were considered representative because they were based on all 151,526 flight segments operated that year. The assessment of the annual effective doses received by pilots in Taiwan from 2006 to 2018 was performed. The results varied in the range of 1.70-2.97 mSv because of variations in solar activity and operational flight routes. A regression model that can effectively reproduce the derived average effective dose rates on board aircraft was obtained for future application in aircrew dosimetry.

Recent progress in space weather research for cosmic radiation dosimetry.

The radiation environment in space is a complex mixture of particles of solar and galactic origin with a broad range of energies. In astronaut dose estimation, three sources must be considered: galactic cosmic radiation, trapped particles, and solar energetic particles (SEPs). The astronaut dose due to SEP exposure during a space mission is more difficult to estimate than the other components because the occurrence of a large solar particle event cannot be predicted by the current space weather research. Thus, several models have been proposed to estimate the worst-case scenario and/or the probability of the integral SEP fluence during a particular space mission, considering the confidence level, solar activity, and duration of the mission. In addition, recent investigations of the cosmogenic nuclide concentrations in tree rings and ice cores have revealed that the sun can cause solar particle events much larger than the largest event recorded in the modern solar observations. If such an extreme event occurs during a mission to deep space, astronauts may suffer from radiation doses in excess of the threshold value for some tissue reactions (0.5 Gy) and their career limit (0.6-1.2 Sv). This article reviews the recent progress made in space weather research that is useful for cosmic radiation dosimetry.

ASSESSING RADIATION EXPOSURE INSIDE THE EARTH'S ATMOSPHERE.

The study of the particle showers created inside the Earth's atmosphere due to interactions of cosmic rays of solar and galactic origin is of great importance for the determination of the radiation impact on technological and biological systems. DYASTIMA is a Geant4-based software application that simulates the evolution of secondary particle cascades inside the atmosphere of Earth. DYASTIMA-R is a new feature especially created for assessing the exposure of flight-personnel and frequent flyers to cosmic radiation by performing calculations of radiobiological quantities, such as dose and equivalent dose rates for several air-flight scenarios. In this work, the validation of DYASTIMA/DYASTIMA-R, according to internationally accepted ICRP and ICRU standards, is discussed. Initial results for radiobiological quantities for several air-flight scenarios are also included. The results for specific scenarios calculated by DYASTIMA/DYASTIMA-R are provided as a federated product through the European Space Agency Space Situational Awareness Space Weather Service Centre Network.

Potential benefit of retrospective use of neutron monitors in improving ionising radiation exposure assessment on international flights: issues raised by neutron passive dosimeter measurements and EPCARD simulations during sudden changes in solar activity.

Since air transport became more accessible, more and more people have been exposed to ionising radiation of cosmic origin. Measuring the neutron dose equivalent is a good approximation of total ambient dose equivalent, as neutrons carry about 50 % of the dose at flight altitudes. The aim of our study was to compare our measurements of the neutron component of secondary cosmic radiation dose, taken with passive dosimeters, with the data obtained from a simulation generated by EPCARD software, which is common in assessing flight crew exposure to ionising radiation. We observed deviations (both above and below) from the expected proportion of the neutron component (between 40 and 80 %), which pointed to certain issues with actual passive dosimeter measurement and the EPCARD simulation. The main limitation of the dosimeter are large uncertainties in high energy neutron response, which may result in underestimation of neutron dose equivalent. The main drawback of the software simulation is monthly averaging of solar potential in calculations, which can neglect sporadic high energy events. Since airlines worldwide almost exclusively use software (due to costs and convenience) to estimate the dose received by their crew, it is advisable to retrospectively recalculate the dose taking into account neutron monitor readings when solar activity changes.

The associations of geomagnetic storms, fast solar wind, and stream interaction regions with cardiovascular characteristic in patients with acute coronary syndrome.

It is shown the statistical associations between space weather pattern and humans' cardiovascular system. We investigated the association between space weather events and cardiovascular characteristics of 4076 randomly selected patients with acute coronary syndrome (ACS) who were admitted for inpatient treatment in Kaunas city, Lithuania during 2000-2005. We hypothesized that days of the space weather events, 1-3 days after, and the period between two events, named as intersection days (1-3 days after the event, which coincided with 1-3 days before the event), might be associated with patients' cardiovascular characteristics. The multivariate logistic regression was applied, and the patients' risk was evaluated by odds ratio (OR), adjusting for age, sex, smoking status, the day of the week, and seasonality. During the intersection days of geomagnetic storms (GS), the risk of ACS increases in obese patients (OR=1.72, p = 0.008). The risk of ventricular fibrillation during admission was associated with stream interaction region (SIR) with a lag of 0-3 days (OR=1.44, p = 0.049) The risk of ACS in patients with chronic atrial fibrillation was associated with fast solar wind (FSW) (≥600 km/s) (lag 0-3 days, OR=1.39, p = 0.030) and with days of solar proton event (lag 0-3) going in conjunction with SIR (lag 0-3) (OR=2.06, p = 0.021). During days which were not assigned as GS with a lag of (-3 to 3) days, FSW (lag 0-3) was associated with the risk of ACS in patients with renal disease (OR=1.71, p = 0.008) and days of SIR - with the risk in patients with pulmonary disease (OR=1.53, p = 0.021). A SIR event, days between two space weather events, and FSW without GS may be associated with a risk to human health.

Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights.

As more exploration spaceflights are planned to travel beyond the protective Earth magnetosphere to deep space destinations, acute health risks due to possible high radiation doses during severe Solar Particle Events (SPEs) are of greater concern to mission planners and management teams. It is expected that some degree of Acute Radiation Syndromes (ARS) symptoms may be observed, but the specific list of health risks that are relevant to exploration missions has been ambiguous and debatable in the past. This mini-review gives a brief summary of the features of radiation exposure if astronauts encounter severe SPEs beyond Low Earth Orbit (LEO), the evidence of ARS radiobiological studies at exposure levels close to recommended limits, and the shortcomings of previous dose projection approaches for ARS risk assessment. Some ARS biomathematical models, particularly those pertinent to the dose ranges that severe SPEs beyond LEO could generate, are reviewed and evaluated, focusing on their capability to predict the incidence of performance incapacitation and time-phased health effects with subsequent medical care recommendations. Using onboard active dosimeter input for estimating organ doses and likely clinical outcomes for SPEs in real time, a new strategy for ARS assessment and mitigation is described to cope with the potential threats of severe SPEs for planned deep space missions.