RESUMO
BACKGROUND: The use of meshes in hernia surgical repair promoted revolution in the surgical area; however, some difficulties had come, such as a large area of fibrosis, greater postoperative pain and risk of infection. The search for new substances that minimize these effects should be encouraged. Medicinal plants stand out due possible active ingredients that can act on these problems. AIM: To check the copaiba oil influence in the repair of abdominal defects in rats corrected with Vicryl(c) mesh. METHOD: Twenty-four Wistar rats were submitted to an abdominal defect and corrected with Vicryl(c) mesh. They were distributed into two groups: control and copaíba via gavage, administered for seven days after surgery. The analysis of the animals took place on 8, 15 and 22 postoperative days. It analyzed the amount of adhesions and microscopic analysis of the mesh. RESULTS: There was no statistical difference regarding the amount of adhesions. All animals had signs of acute inflammation. In the control group, there were fewer macrophages in animals of the 8th compared to other days and greater amount of necrosis on day 8 than on day 22. In the copaiba group, the number of gigantocytes increased compared to the days analyzed. CONCLUSION: Copaiba oil showed an improvement in the inflammatory response accelerating its beginning; however, did not affect the amount of abdominal adhesions or collagen fibers.
Assuntos
Bálsamos/uso terapêutico , Hérnia Ventral/cirurgia , Herniorrafia/instrumentação , Poliglactina 910 , Telas Cirúrgicas , Animais , Ratos , Ratos WistarRESUMO
In this study, two types of cutaneous-directed nanoparticles are proposed for the co-encapsulation of imiquimod (a drug approved for the treatment of basal cell carcinoma) and copaiba oil (oil that exhibits anti-proliferative properties). Nanostructured copaiba capsules (NCCImq) were prepared using the interfacial deposition method, and nanostructured Brazilian lipids (NBLImq) were prepared by high-pressure homogenization. The formulations exhibited average diameter, zeta potential, pH and drug content of approximately 200nm, -12mV, 6 and 1mgmL(-1), respectively. In addition, the formulations exhibited homogeneity regarding particle size, high encapsulation efficiency and stability. Both nanocarriers controlled imiquimod release, and NBLImq exhibited slower drug release (p < 0.05), likely due to increased interaction of the drug with the solid lipid (cupuaçu seed butter). The in vitro evaluation of the imiquimod-loaded nanocarriers was performed using healthy skin cells (keratinocytes, HaCaT); no alteration was observed, suggesting the biocompatibility of the nanocarriers. In addition, in vitro skin permeation/penetration using pig skin was performed, and NCCImq led to increased drug retention in the skin layers and reduced amounts of drug found in the receiver solution. Thus, NCCImq is considered the most promising nanoformulation for the treatment of skin carcinoma.
Assuntos
Aminoquinolinas/administração & dosagem , Bálsamos/administração & dosagem , Nanocápsulas/administração & dosagem , Neoplasias Cutâneas/tratamento farmacológico , Aminoquinolinas/farmacocinética , Aminoquinolinas/uso terapêutico , Animais , Bálsamos/farmacocinética , Bálsamos/uso terapêutico , Linhagem Celular , Feminino , Humanos , Imiquimode , Queratinócitos/efeitos dos fármacos , Queratinócitos/metabolismo , Tamanho da Partícula , Pele/metabolismo , SuínosRESUMO
Background:The use of meshes in hernia surgical repair promoted revolution in the surgical area; however, some difficulties had come, such as a large area of fibrosis, greater postoperative pain and risk of infection. The search for new substances that minimize these effects should be encouraged. Medicinal plants stand out due possible active ingredients that can act on these problems.Aim:To check the copaiba oil influence in the repair of abdominal defects in rats corrected with Vicryl(c) mesh. Method:Twenty-four Wistar rats were submitted to an abdominal defect and corrected with Vicryl(c) mesh. They were distributed into two groups: control and copaíba via gavage, administered for seven days after surgery. The analysis of the animals took place on 8, 15 and 22 postoperative days. It analyzed the amount of adhesions and microscopic analysis of the mesh.Results:There was no statistical difference regarding the amount of adhesions. All animals had signs of acute inflammation. In the control group, there were fewer macrophages in animals of the 8th compared to other days and greater amount of necrosis on day 8 than on day 22. In the copaiba group, the number of gigantocytes increased compared to the days analyzed.Conclusion:Copaiba oil showed an improvement in the inflammatory response accelerating its beginning; however, did not affect the amount of abdominal adhesions or collagen fibers.
Racional:A utilização de telas nas herniorrafias foi grande revolução na área cirúrgica; contudo, elas trouxeram algumas dificuldades, como grande área de fibrose, maior dor pós-operatória e risco de infecção. A busca por novas substâncias que minimizem esses efeitos deve ser estimulada. As plantas medicinais se destacam por apresentaram conjunto de princípios ativos que podem atuar em todos esses problemas.Objetivo:Verificar se o óleo de copaíba influência no reparo de defeitos abdominais em ratos corrigidos com tela de Vicryl®.Método:Vinte e quatro ratas Wistar foram submetidas a um defeito abdominal e corrigidos com tela de Vicryl®. Elas foram distribuídas em dois grupos: controle e copaíba via gavagem, administrada durante sete dias após a operação. A análise dos animais ocorreu nos dias 8, 15 e 22 de pós-operatório. Foi analisada a quantidade de aderências e feita análise microscópica da tela.Resultados:Não houve diferença estatística em relação à quantidade de aderências. Todos os animais tiveram sinais de inflamação aguda. No grupo controle, houve menor quantidade de macrófagos nos animais do dia 8 em relação aos demais dias e maior quantidade de necrose no dia 8 do que no dia 22. No grupo copaíba, o número de gigantócitos aumentou em relação aos dias analisados.Conclusão:O óleo de copaíba mostrou melhora na resposta inflamatória acelerando o seu início; contudo, não interferiu na quantidade de aderências abdominais ou fibras colágenas.
Assuntos
Animais , Ratos , Bálsamos/uso terapêutico , Hérnia Ventral/cirurgia , Herniorrafia/instrumentação , Telas Cirúrgicas , Ratos WistarRESUMO
PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; CONTROL GROUP: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized. RESULTS: All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05) CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.
Assuntos
Bálsamos/administração & dosagem , Sepse/tratamento farmacológico , Animais , Bálsamos/uso terapêutico , Ceco/cirurgia , Injeções Subcutâneas/métodos , Intubação Gastrointestinal/métodos , Ligadura , Pulmão/patologia , Masculino , Camundongos , Modelos Animais , Necrose/patologia , Doenças Peritoneais/tratamento farmacológico , Punções , Distribuição Aleatória , Análise de Sobrevida , Fatores de TempoRESUMO
PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized. RESULTS: All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05) CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage. .
Assuntos
Animais , Masculino , Camundongos , Bálsamos/administração & dosagem , Sepse/tratamento farmacológico , Bálsamos/uso terapêutico , Ceco/cirurgia , Injeções Subcutâneas/métodos , Intubação Gastrointestinal/métodos , Ligadura , Pulmão/patologia , Modelos Animais , Necrose/patologia , Punções , Doenças Peritoneais/tratamento farmacológico , Distribuição Aleatória , Análise de Sobrevida , Fatores de TempoRESUMO
PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.
Assuntos
Antineoplásicos Fitogênicos/uso terapêutico , Bálsamos/uso terapêutico , Carcinoma 256 de Walker/tratamento farmacológico , Colo do Útero/efeitos dos fármacos , Animais , Carcinoma 256 de Walker/imunologia , Carcinoma 256 de Walker/patologia , Colo do Útero/imunologia , Colo do Útero/patologia , Feminino , Imuno-Histoquímica , Distribuição Aleatória , Ratos , Ratos Wistar , Reprodutibilidade dos Testes , Fatores de Tempo , Resultado do TratamentoRESUMO
PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.
Assuntos
Animais , Feminino , Ratos , Antineoplásicos Fitogênicos/uso terapêutico , Bálsamos/uso terapêutico , /tratamento farmacológico , Colo do Útero/efeitos dos fármacos , /imunologia , /patologia , Colo do Útero/imunologia , Colo do Útero/patologia , Imuno-Histoquímica , Distribuição Aleatória , Ratos Wistar , Reprodutibilidade dos Testes , Fatores de Tempo , Resultado do TratamentoRESUMO
Los quistes dentígeros son quistes odontogénicos que rodean la corona de un diente incluido o retenido, comúnmente asociados a terceros molares inferiores y que no se han diagnosticado a tiempo. Pueden alcanzar grandes tamaños, son los segundos quistes en orden de frecuencia, siendo el quiste radicular el primero. Se presenta el caso de una paciente de sexo femenino con un quiste dentígero gigante en maxilar inferior, el cual fue tratado con técnica de cicatrización por segunda intención, preconizada por Finochietto-Yoel, sin relleno óseo, ni placa de titanio, con una técnica de enucleación y curetaje conservadora, sólo con la utilización de gasa iodoformada embebida en una solución quirúrgica de 50 por ciento de eugenol, 25 por ciento de bálsamo de Perú y 25 por ciento de bálsamo de Canadá.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Cisto Dentígero/cirurgia , Cisto Dentígero/diagnóstico , Cisto Dentígero , Bálsamos/uso terapêutico , Diagnóstico Diferencial , Procedimentos Cirúrgicos Bucais/métodos , Cisto Dentígero/etiologiaRESUMO
Purpose: To verify the copaiba balsam (Copaifera officinalis) effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats. Methods: Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC). On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2x10(6) concentration) was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba balsam to the GCop group. On the 12th day, euthanasia was performed and the tumor was grafted, being weighted and verified its volume. The data were submitted to statistical analysis with ANOVA test. Results: It was observed that copaiba balsam presented a negative inhibitory potential of 70 percent. Conclusion: The copaiba balsam stimulated the tumor growth.
Objetivo: Verificar o efeito do óleo de copaíba da espécie Copaifera officinalis no carcinoma de Walker 256 inoculado em vagina e colo de útero de ratas. Métodos: Foram utilizadas 18 ratas da linhagem Wistar, pesando entre 180-250g, distribuídas em dois grupos (CCop, GC). No 1º dia de experimento, em ambos os grupos foi inoculado 0,3ml de tumor de Walker 256 na concentração de 2x10(6); no 3º dia após essa inoculação, foi iniciada a administração de água destilada na dose de 4,8 ml/kg ao GC, e copaíba na dose de 4,8 ml/kg ao GCop. No 12º dia foi realizada a eutanásia das ratas e ressecado o tumor, sendo este pesado e averiguado seu volume. Os dados obtidos foram submetidos à análise estatística pelo método ANOVA. Resultados: Observou-se que o óleo de copaíba apresentou um potencial inibitório negativo de 70 por cento. Conclusão: O óleo de copaíba estimulou o crescimento tumoral.
Assuntos
Animais , Feminino , Ratos , Antineoplásicos Fitogênicos/uso terapêutico , Bálsamos/uso terapêutico , /tratamento farmacológico , Fitoterapia , Neoplasias do Colo do Útero/tratamento farmacológico , Neoplasias Vaginais/tratamento farmacológico , /patologia , Ensaios de Seleção de Medicamentos Antitumorais/métodos , Ratos Wistar , Neoplasias do Colo do Útero/patologia , Neoplasias Vaginais/patologiaRESUMO
PURPOSE: To verify the copaiba balsam (Copaifera officinalis) effect on Walker 256 carcinoma inoculated into vagina and uterine cervix of rats. METHODS: Eighteen female Wistar rats weighing between 180-250g were used, distributed into 2 groups (GCop, GC). On the 1st day of the experiment, 0.3 ml of Walker 256 carcinoma (2x10(6) concentration) was inoculated in both groups; on the 3rd day of the experiment, it was given 4.8 ml/kg of distilled water to the GC group, and 4.8 ml/kg of copaiba balsam to the GCop group. On the 12th day, euthanasia was performed and the tumor was grafted, being weighted and verified its volume. The data were submitted to statistical analysis with ANOVA test. RESULTS: It was observed that copaiba balsam presented a negative inhibitory potential of 70%. CONCLUSION: The copaiba balsam stimulated the tumor growth.
Assuntos
Antineoplásicos Fitogênicos/uso terapêutico , Bálsamos/uso terapêutico , Carcinoma 256 de Walker/tratamento farmacológico , Fitoterapia , Neoplasias do Colo do Útero/tratamento farmacológico , Neoplasias Vaginais/tratamento farmacológico , Animais , Carcinoma 256 de Walker/patologia , Ensaios de Seleção de Medicamentos Antitumorais/métodos , Feminino , Ratos , Ratos Wistar , Neoplasias do Colo do Útero/patologia , Neoplasias Vaginais/patologiaRESUMO
Heparin-induced thrombocytopenia syndrome is a serious, potentially life-threatening adverse reaction to the use of heparin anticoagulation therapy that can result in significant skin damage and organ morbidity. A case study design is used to describe the innovative use of a topical wound treatment (trypsin-balsam of Peru-castor oil ointment) on bullous lesions related to the effects of this syndrome. An elderly, morbidly obese woman was treated for 2 weeks with twice-daily applications of the product along with non-adherent oil emulsion dressings. Oozing decreased substantially within a few days and open blisters closed within 1 week. After 2 weeks of therapy, the bullous skin reaction was fully resolved with no recurrence. The results of this case study suggest that this topical product may have had a positive effect on the bullous lesions and should be considered for use in other similar significant integumentary reactions.
Assuntos
Anticoagulantes/efeitos adversos , Bálsamos/uso terapêutico , Vesícula , Óleo de Rícino/uso terapêutico , Heparina/efeitos adversos , Trombocitopenia , Tripsina/uso terapêutico , Administração Cutânea , Idoso , Bálsamos/química , Bandagens , Vesícula/induzido quimicamente , Vesícula/prevenção & controle , Óleo de Rícino/química , Química Farmacêutica , Combinação de Medicamentos , Feminino , Humanos , Enfermeiros Clínicos , Avaliação em Enfermagem , Obesidade Mórbida/complicações , Pomadas , Higiene da Pele/métodos , Higiene da Pele/enfermagem , Síndrome , Trombocitopenia/induzido quimicamente , Trombocitopenia/prevenção & controle , Resultado do Tratamento , Tripsina/química , CicatrizaçãoRESUMO
La cicatrización del alvéolo dental posextracción es un proceso fisiológico multifactoraial. El procedimiento quirúrgico como tal, presenta una serie de cambios que en un momento dado pueden afectar el proceso reparativo local. Se presenta una revisión de la literatura de la evolución normal de la odontectomía, así como de las posibles complicaciones con su tratamiento específico
Assuntos
Humanos , Bálsamos/uso terapêutico , Bismuto , Alvéolo Seco , Iodoformium , Osteotomia , Regeneração Óssea/fisiologiaRESUMO
Copaifera langsdorffii oleo-resin (CLOR) is a reputed herbal medicine used to combat gastrointestinal functional disorders. Our previous studies show that CLOR prevents gastric ulceration and promotes wound healing. This study examined the effects of CLOR on intestinal damage associated with mesenteric ischemia/reperfusion in rat. Wistar albino rats were divided into four groups of six in each. Group 1: Sham operated, Group 2: Vehicle + 45 min of ischemia followed by 60 min reperfusion (I/R), Groups 3 and 4: I/R + CLOR (200 and 400 mg /kg, p.o., respectively). All treatments were given 24 h, 12 h and 2 h before I/R. Animals were sacrificed at the end of reperfusion period and ileal tissue samples were obtained for biochemical analysis. Myeloperoxidase (MPO), an index of polymorphonuclear leukocytes; malondialdehyde (MDA), an end product of lipoperoxidation; catalase (CAT), an antioxidant enzyme; reduced glutathione (GSH), a key antioxidant; and nitrite, a marker of nitric oxide (NO) production were determined in ileum homogenates. The results show that I/R produces a significant increase in MDA content, MPO, and CAT activities with a significant decrease in GSH and an elevation in nitrite production, as compared to sham control. CLOR treatment caused significant attenuations in I/R-associated increases of MPO, MDA and CAT activities and on nitrite level. Besides, CLOR could effectively prevent the I/R-associated depletion of GSH. The data indicate that the oleo-resin has a protective action against I/R-induced intestinal tissue damage, which appeared to be, at least in part, due to an antioxidant and anti-lipid peroxidation mechanism.
Assuntos
Bálsamos/uso terapêutico , Íleo/fisiopatologia , Traumatismo por Reperfusão/tratamento farmacológico , Análise de Variância , Animais , Catalase/metabolismo , Glutationa/metabolismo , Íleo/metabolismo , Masculino , Malondialdeído/metabolismo , Nitritos/metabolismo , Peroxidase/metabolismo , Ratos , Ratos WistarRESUMO
The oleo-resin from Copaifera langsdorffii (Leguminosae) was evaluated in rats on acetic acid-induced colitis. Rats were pretreated orally (15 and 2 h) or rectally (2 h) before the induction of colitis with copaiba oleo-resin (200 and 400 mg/kg) or vehicle (1 ml, 2% Tween 80). Colitis was induced by intracolonic instillation of a 2 ml of 4% (v/v) acetic acid solution and 24 h later, the colonic mucosal damage was analyzed for the severity of macroscopic colonic damage, myeloperoxidase (MPO) activity, and malondialdehyde levels. A significant reduction in gross damage score and in wet weight/length ratio of colonic tissue were evident in test substance-pretreated animals as compared to vehicle or oleo-resin alone-treated controls. This effect was confirmed biochemically by a reduction in colonic myeloperoxidase activity, the marker of neutrophilic infiltration, and by a marked decrease in malondialdehyde level, an indicator of lipoperoxidation. Furthermore, microscopical examination revealed the diminution of inflammatory cell infiltration, and submucosal edema in the colon segments of rats treated with copaiba oleo-resin. The data indicate the protective effect of copaiba oleo-resin in the animal model of acute colitis possibly through an antioxidant and or anti-lipoperoxidative mechanism.
Assuntos
Ácido Acético/toxicidade , Bálsamos/uso terapêutico , Colite/tratamento farmacológico , Fabaceae , Animais , Bálsamos/isolamento & purificação , Colite/induzido quimicamente , Colite/patologia , Masculino , Casca de Planta , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/uso terapêutico , Ratos , Ratos WistarRESUMO
Skin graft donor sites are partial-thickness wounds that are commonly managed with gauze-type dressings. As such, they often cause more pain and difficulty in healing than the graft-recipient site. A retrospective study was conducted to ascertain the effects of using a castor oil-balsam of Peru-trypsin containing ointment on skin graft donor sites in 36 consecutive patients (16 female, 20 male). All donor sites were epithelialized after 11 days (range 6 to 11 days, mean 8 days) and no wound complications were observed. Given these healing results and product ease of use, this particular formulation has become the facilities' current treatment of choice and further study is indicated and warranted.
Assuntos
Bálsamos/uso terapêutico , Óleo de Rícino/uso terapêutico , Higiene da Pele/métodos , Transplante de Pele , Tripsina/uso terapêutico , Cicatrização/efeitos dos fármacos , Administração Cutânea , Adulto , Idoso , Idoso de 80 Anos ou mais , Bálsamos/farmacologia , Bandagens , Óleo de Rícino/farmacologia , Combinação de Medicamentos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pomadas , Cuidados Pós-Operatórios/métodos , Estudos Retrospectivos , Transplante de Pele/efeitos adversos , Resultado do Tratamento , Tripsina/farmacologiaRESUMO
The wound healing activity of oleo-resin from Copaifera langsdorffii Desf. (Leguminaceae) bark was evaluated in rats on experimental wounds. The oleo-resin was tested by monitoring wound contraction in excised wounds and by measuring tensile strength in healing incision wounds. The topical application of oleo-resin at a concentration of 4% accelerated wound contraction in open wounds. The mean values of wound contraction in oleo-resin treated rats on day 9 was 84.05% +/- 2.37% as against 51.29% +/- 9.54% seen in controls and the difference was statistically significant (p < 0.05). No significant differences in the rates of wound contraction were observed on days 12, 15, 18 and 21. Also, the tensile strength in healing incised wounds was found to be significantly higher in the group of animals treated with 4% oleo-resin on day 5 but not on days 7 and 12 (controls: 35.95 +/- 7.44 g/cm; oleo-resin: 71.48 +/- 5.77 g/cm; p < 0.05). These results indicate the beneficial effect of C. langsdorffii oleo-resin on wound healing and justify its traditional use for the treatment of wounds.
Assuntos
Bálsamos/farmacologia , Fabaceae , Fitoterapia , Cicatrização/efeitos dos fármacos , Administração Cutânea , Animais , Bálsamos/administração & dosagem , Bálsamos/uso terapêutico , Masculino , Ratos , Ratos Wistar , Resistência à Tração/efeitos dos fármacos , Cicatrização/fisiologiaRESUMO
We studied the effects of Biopin ointment containing pine resin and used for the therapy of burns, wounds, and purulent and inflammatory diseases on the cell composition of wounds and histochemical changes in the granulation tissue during the therapy of extensive third-degree burns. The preparation stimulated the nonspecific immune response, normalized hemodynamics in damaged regions, and stimulated cell proliferation in the squamous epithelium.
Assuntos
Anti-Infecciosos/uso terapêutico , Queimaduras/patologia , Tecido de Granulação/patologia , Resinas Vegetais/uso terapêutico , Antibacterianos/uso terapêutico , Bálsamos/uso terapêutico , Queimaduras/tratamento farmacológico , Divisão Celular/efeitos dos fármacos , Células Epiteliais/efeitos dos fármacos , Tecido de Granulação/efeitos dos fármacos , Hemodinâmica/efeitos dos fármacos , Humanos , Sistema Imunitário/efeitos dos fármacos , Pomadas , Compostos OrgânicosRESUMO
Os autores fazem uma análise crítica quanto aos aspectos terapêutico, toxicológico, ético e farmacológico do óleo de copaíba
Assuntos
Animais , Ratos , Plantas Medicinais/uso terapêutico , Anti-Inflamatórios/farmacologia , Bálsamos/uso terapêutico , Óleos de Plantas/farmacologiaRESUMO
Se estudia la efectividad del propoleo para irrigar zonas intervenidas quirurgicamente en pacientes con distintas afecciones bucales. En las ulceras bucales, la disminucion del dolor y la cicatrizacion fue mas rapida que en el grupo donde se aplico el balsamo de Chostakovski. Se concluye que las propiedades antimicrobianas, hemostaticas y antiinflamatorias del propoleo favorecieron una recuperacion mas rapida y mejor de los tejidos en el posoperatorio de los pacientes intervenidos quirurgicamente, que en aquellos del grupo control. Asimismo, se obtuvo una regresion mas rapida de los sintomas dolorosos y una mejor curacion de las ulceras al comparar los resultados en ambos grupos