The relationship of Candida colonization of the oral and vaginal mucosae of mothers and oral mucosae of their newborns at birth.

OBJECTIVE: Vaginal Candida colonization is common during pregnancy. Vaginal Candida may transmit vertically to the mouth of newborns during labor. The aim of this study was to assess and compare oral Candida colonization between vaginally born newborns and cesarean-born newborns and to investigate the association of the mother's vaginal and oral Candida colonization and the newborn's oral colonization at the time of delivery. STUDY DESIGN: Culture swabs were collected from the oral and vaginal mucosae of 100 pregnant women and from the oral mucosa of their 100 full-term newborns. Fifty (50%) of the mothers gave birth vaginally and the other 50 (50%) by cesarean section. RESULTS: The prevalence of oral and vaginal Candida in pregnant mothers was 49% and 40%, respectively. Oral Candida colonization in newborns was 7%. Oral Candida was isolated from 5 of 50 (10%) in the vaginally born group and from 2 of 50 (4%) in the cesarean-born group (P = .44). In vaginally born group, oral Candida was isolated from 5 of 20 (25%) in those born to mothers with vaginal colonization of Candida, and 0 of 30 (0.0%) in mothers without vaginal colonization of Candida (P = .007). CONCLUSIONS: The mother's vaginal Candida may constitute an important source of oral Candida in the newborns, particularly in those delivered vaginally.

Influência da xerostomia na transmissibilidade de Candida albicans na cavidade bucal de ratos / Effects of xerostomia in the transmissibility of Candida albicans in the oral cavity of rats

A xerostomia produzida pela sialoadenectomia em ratos aumenta a colonizaçäo, permanência e patogenicidade da Candida albicans na cavidade bucal destes animais. O objetivo deste trabalho foi verificar se ratos xerostômicos transmitem Candida albicans para ratos normais com maior intensidade. Foram usados 10 ratos normais e 12 sialoadenectomizados que receberam 12 inoculaçöes semanais contendo 10(8) células de Candida albicans desde 10 até sessenta dias de idade. Após as inoculaçöes, os ratos foram emparelhados com 10 (grupo controle) e 12 (grupo experimental) ratos normais de mesma idade respectivamente. A quantidade de ratos que passaram a apresentar Candida foi maior no grupo experimental três a vinte e oito dias após o emparelhamento, apresentado 83,3 por cento de recuperaçäo após 10,75 por cento após quatorze e dezoito dias, e 100 por cento após vinte e um dias. A transmissibilidade de C. albicans foi mais rápida e acentuada portanto, a partir dos animais sialoadenectomizados