Limited dilute lidocaine anesthesia: A useful technique with many practical applications.

BACKGROUND: Limited dilute lidocaine infiltration facilitates a comfortable procedure and a rapid recovery process following a novel intervention for reduction of cellulite. Infiltration of dilute lidocaine has many other practical applications in dermatologic surgery. OBJECTIVES: This article describes a safe, effective technique for local infiltration of limited volume dilute lidocaine anesthesia in a cellulite reduction procedure. METHODS: The limited dilute lidocaine technique was utilized in studies of a novel device designed to reduce the appearance of cellulite by focal release of fibrous septa in a minimally invasive procedure. No sedation was used. A small (27- to 30-gauge) needle was used to deliver anesthesia to the entry sites. Then, a 20-gauge spinal needle was tunneled under the skin in the superficial plane to manually deliver anesthetic along the advancement pathway of the device and marked cellulite targets. RESULTS: During the initial studies, the mean delivered anesthesia volume was 357.2 ml (range, 250-525 ml) or 18.7 mg/kg (range, 11.1-28.4 mg/kg). The mean anesthesia time was 16 min (range, 8-32 min). The mean number of cellulite depressions treated was 19.8 (range, 11-34). Adverse events were closely monitored, and there were no signs of toxicity in any study patients. There were very low levels of discomfort; all patients reported the procedure was tolerable. This technique facilitates a time-efficient procedure and minimizes weeping of excess fluid during recovery. CONCLUSIONS: When administered with care and skill, the limited dilute anesthesia technique is a safe, effective approach for local anesthesia with many practical applications in dermatologic surgery.

Insights Into the Pathophysiology of Cellulite: A Review.

BACKGROUND: The etiology of cellulite is unclear. Treatment of cellulite has targeted adipose tissue, dermis, and fibrous septae with varying degrees of success and durability of response. OBJECTIVE: Results from clinical trials that target different anatomical aspects of cellulite can provide insights into the underlying pathophysiology of cellulite. MATERIALS AND METHODS: A search of the PubMed database and ClinicalTrials.gov website was conducted to identify clinical trials that have investigated treatments for cellulite. RESULTS: A lack of trial protocol standardization, objective means for quantification of improvement and reported cellulite severity, and short-term follow-up, as well as variation in assessment methods have made comparisons among efficacy studies challenging. However, the lack of durable efficacy and inconsistency seen in clinical results suggest that dermal or adipose tissue changes are not the primary etiologies of cellulite. Clinical studies targeting the collagen-rich fibrous septae in cellulite dimples through mechanical, surgical, or enzymatic approaches suggest that targeting fibrous septae is the strategy most likely to provide durable improvement of skin topography and the appearance of cellulite. CONCLUSION: The etiology of cellulite has not been completely elucidated. However, there is compelling clinical evidence that fibrous septae play a central role in the pathophysiology of cellulite.

Cellulite: Patient Selection and Combination Treatments for Optimal Results-A Review and Our Experience.

BACKGROUND: More than 90% of women have reported concerns of cellulite on their skin. Both commercially advertised creams and topical pharmacological agents have shown limited improvement. Thus far, there has been a paucity of thorough review articles on how to address and treat this condition. OBJECTIVE: To investigate how the etiology and pathogenesis of cellulite can help guide treatment combinations and provide a more algorithmic approach to comprehensively address a condition that affects so many women. MATERIALS AND METHODS: A review of the literature surrounding treatment options for cellulite and the authors' experience in this area are provided. CONCLUSION: This review summarizes available treatment options for cellulite, including topical agents, controlled subcision, energy-based devices, dermal fillers, and new injectable medications. Furthermore, the various ways that these treatments can be combined in an algorithmic and sequential approach based on the degree of volume loss, skin laxity, and excess adiposity associated with cellulite are addressed. These combination therapies for cellulite are supported both in the published literature and the authors' experience to help clinicians tailor a comprehensive treatment plan for the multiple factors that contribute to cellulite. Further clinical trials are needed to compare various devices and techniques for cellulite as well as combination treatments.

Updates on the understanding and treatment of cellulite.

Cellulite is a common dermatologic condition and frequent cause of cosmetic concern among women. This paper aims to update what is known about the pathogenesis of cellulite and reviews targeted treatment modalities that address its underlying components of microvascular dysfunction, endocrine-mediated inflammation, and connective tissue fibrosclerosis.

Evidence-based treatment for gynoid lipodystrophy: A review of the recent literature.

Gynoid lipodystrophy (GLD) is a structural, inflammatory, and biochemical disorder of the subcutaneous tissue causing alterations in the topography of the skin. Commonly known as "cellulite," GLD affects up to 90% of women, practically in all stages of the life cycle, beginning in puberty. It is a clinical condition that considerably affects the patients' quality of life. It is a frequent reason for consultation, although the patients resort to empirical, improvised, nonevidence-based treatments which discourage and can be a source of frustration not only because of the lack of results but also due to the complications derived from those treatments. In this article, a panel of experts from different specialties involved in the management of this clinical skin disorder presents the results of a systematic literature search and of the consensus discussion of the evidence obtained from different treatments currently available. The analysis was divided into topical, systemic, noninvasive, and minimally invasive treatments.

Cellulite: a review of pathogenesis-directed therapy.

Cellulite is a condition that affects the majority of postpubertal women and can negatively impact quality of life. This review discusses several proposed pathophysiologies of cellulite, and examines treatment options that have been utilized, focusing on the etiologic factor targeted by the therapies. This approach aims to help clarify the pathogenesis of cellulite and provide a road map for developing effective treatment paradigms for patients.

Incidencia de celulitis facial odontógena en el territorio de Matanzas / Odontogenic Facial Cellulites incidence in the territory of Matanzas

La Celulitis Facial Odontógena es relativamente frecuente, puede convertirse en un grave riesgo vital cuando el tratamiento no es adecuado. Se realizó un estudio observacional, analítico, transversal desde enero 2006 a diciembre 2008. La muestra incluyó 49 pacientes que acudieron o fueron remitidos a los servicios de urgencias con el diagnóstico de CFO. Los niños y jóvenes resultaron los más afectados, así como el sexo masculino. Los dientes incurables y los restos radiculares constituyeron las causas más frecuentes, la región anatómica prevaleciente fue la cavidad bucal. El 51 por ciento de los casos tuvieron diagnóstico de celulitis leves, siendo necesario el ingreso hospitalario para 25 pacientes, los demás tuvieron tratamiento ambulatorio. Se recomienda diseñar una estrategia de intervención para disminuir la incidencia de CFO en el territorio de Matanzas.

The Odontogenic Facial Cellulites is relatively frequent; when the treatment is not right, it can become a serious risk for life. We carried up an observational, analytic, transversal study from January 2006 to December 2008. The sample included 49 patients assisting or remitted to the Urgent Care Services with a diagnosis of Odontogenic Facial Cellulites. The most affected were children and young people, and the female sex. The most frequent causes were teeth that can not be healed and roots remaining; the prevailing anatomic region was the oral cavity. 51 percent of the cases were diagnosed as mild cellulites, being necessary the hospital staying for 25 patients; the rest received home treatment. It is recommended to design an intervention strategy to diminish the incidence of the Odontogenic Facial Cellulite in the territory of Matanzas.

Complicações orbitárias da rinossinusite aguda: uma nova classificação / Orbital complications of acute rhinosinusitis: a new classification

A rinossinusite é uma doença potencialmente grave, e pode apresentar sérias complicações. As orbitárias são as mais freqüentes, graças às peculiaridades anatômicas desta região, podendo levar à morte em 5 por cento dos casos. Os sintomas variam desde sinais flogísticos periorbitários até proptose do globo ocular, oftalmoplegia e amaurose. OBJETIVOS: Proposição de uma nova classificação para as complicações orbitárias das rinossinusites agudas. MATERIAL E MÉTODO: Revisão de TC e prontuários de 83 pacientes atendidos no Hospital das Clínicas da FMRP-USP, entre os anos de 1995 a 2005, com rinossinusites agudas complicadas. RESULTADOS: Após a revisão das TC e história clínica, foram identificadas em sessenta e seis pacientes, três tipos de complicações orbitárias: celulite orbitária (46,9 por cento), abscesso subperiosteal (40,9 por cento) e abscesso orbitário (12,1 por cento). Dezessete foram considerados como infecções palpebrais, ficando excluídos da nova classificação. CONCLUSÃO: As classificações das complicações orbitárias existentes na atualidade, como a de Chandler, não levam em conta os parâmetros anatômicos da órbita e tornaram-se obsoletas com o advento da TC. Este estudo propõe uma classificação mais concisa e objetiva que ajude a guiar a conduta terapêutica de forma mais linear.

Rhinosinusitis is a severe sickness and may have serious complications. Orbital complications happen more often, due to anatomical particularities and are lethal in 5 percent of patients. They vary from inflammatory signs to proptosis, loss of ocular motility and blindness. AIM: We propose a new classification of acute rhinosinusitis complications. METHODS: A review of 83 patients with CT scan and clinical reports. Patients were evaluated at HCFMRP-USP between 1995 and 2005 and were diagnosed with complicated rhinosinusitis. RESULTS: In sixty-six patients, were identified three types of orbital complications: orbital cellulitis (46. 9 percent), subperiosteal abscess (40. 9 percent) and orbital abscess (12.1 percent). Seventeen were considered as eyelid infections and excluded from this new classification system. CONCLUSIONS: The existing classifications of orbital complications, as Chandler’s, do not consider the orbit’s anatomical characteristics and became obsolete after the development of the CT scan. This study proposes a new, more objective classification to guide the physician in establishing lines of conduct for each case.