RESUMO
Spatial and temporal control over DNA cleavage by photoactivated enediynes can be complemented by additional factors such as the release of internal strain, chelation, pH changes, intramolecular H-bonds, and substituent effects. This review presents design and reactivity of photoactivated enediynes/enynes and analyses the chemical, biological, and photophysical challenges in their applications.
Assuntos
Antibióticos Antineoplásicos/farmacologia , DNA de Neoplasias/efeitos dos fármacos , Enedi-Inos/farmacologia , Neoplasias/tratamento farmacológico , Fotoquimioterapia/métodos , Antibióticos Antineoplásicos/química , Antibióticos Antineoplásicos/efeitos da radiação , Antibióticos Antineoplásicos/uso terapêutico , Ciclização/efeitos da radiação , Dano ao DNA/efeitos dos fármacos , Dano ao DNA/efeitos da radiação , DNA de Neoplasias/química , DNA de Neoplasias/efeitos da radiação , Enedi-Inos/química , Enedi-Inos/efeitos da radiação , Enedi-Inos/uso terapêutico , Humanos , Luz , Lisina/química , Estrutura Molecular , Terapia de Alvo Molecular/métodos , Neoplasias/genéticaRESUMO
Using light to modulate biochemical agents in living organisms has a significant impact on photodynamic therapy and drug release. We demonstrate that a photoresponsive system can reversibly induce paralysis in nematodes as a model for living organisms when two different wavelengths of light are used to toggle the molecular switch between its two structural forms. This example illustrates how photoswitches offer great potential for advancing biomedical technologies.