RESUMO
CASE DESCRIPTION: A 7-year-old 42-kg (92.4-lb) sexually intact nulliparous female Italian Mastiff was examined because of a history of vaginal prolapse during diestrus. CLINICAL FINDINGS: A physical examination revealed vaginal fold prolapse. Abdominal ultrasonography revealed an enlarged uterus with hypoechogenic content, corpora lutea in the ovaries, and a cyst in the right ovary. Hematologic abnormalities included leukocytosis, neutrophilia, mild anemia, and low Hct. Progesterone and estradiol concentrations were 9.36 ng/mL and 30.42 pg/mL, respectively, in serum and 72.72 ng/mL and 792 pg/mL, respectively, in the ovarian cystic fluid. TREATMENT AND OUTCOME: Ovariohysterectomy was performed; the prolapsed tissue was repositioned by external manipulation and maintained in situ by temporary apposition of the vulvar lips with a retention suture. Anatomic and histologic examinations of the excised tissues revealed pyometra and papillary cystadenocarcinoma in the right ovary. The vaginal hyperplasia completely regressed at 35 days after surgery; 5 months after surgery, the dog's general condition was considered good. CLINICAL RELEVANCE: Findings in this case were indicative of a hormonally active ovarian papillary cystadenocarcinoma in a female dog in diestrus. Hormone production by the cystadenocarcinoma was the predisposing factor that induced pyometra, mucosal hyperplasia, and vaginal fold prolapse in the dog. On the basis of these concurrent disorders, ovariohysterectomy was an appropriate treatment.
Assuntos
Cistadenocarcinoma Papilar/veterinária , Doenças do Cão/etiologia , Neoplasias Ovarianas/veterinária , Piometra/veterinária , Prolapso Uterino/veterinária , Animais , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/metabolismo , Cistadenocarcinoma Papilar/patologia , Doenças do Cão/patologia , Doenças do Cão/cirurgia , Cães , Estradiol/metabolismo , Feminino , Histerectomia/veterinária , Neoplasias Ovarianas/complicações , Neoplasias Ovarianas/metabolismo , Neoplasias Ovarianas/patologia , Ovariectomia/veterinária , Progesterona/metabolismo , Piometra/complicações , Piometra/cirurgia , Prolapso Uterino/etiologia , Prolapso Uterino/cirurgiaRESUMO
OBJECTIVES: Preoperative hematologic parameters: thrombocytosis, leukocytosis and anemia have been demonstrated to be independent poor prognostic factors in ovarian and endometrial cancers. However, little is known about their relation to uterine serous papillary carcinoma (USPC). We evaluated several preoperative hematologic parameters and their association with clinicopathologic features, disease progression and overall survival in USPC patients. STUDY DESIGN: This was a retrospective cohort study reviewing charts of all patients with a histologic pure USPC at two gynecologic oncology centers from January 2000 through July 2012. All patients had comprehensive hematologic tests prior to primary surgical treatment and were exposed to the same adjuvant treatment protocol. RESULTS: The study included 56 patients, mean age at diagnosis 69.4±15. Six (11%) had platelet count above 400000 10(6)/L, of them four (66%) were dead at the end of follow up (HR=1.4, p=0.48; CI 95% 0.5-4.3). The mean hemoglobin level was 12.3g/dl, fibrinogen 437.5mg/dL and lymphocytes 2013/µL. None of these parameters was significantly associated with 5 year survival. Leukocyte and neutrophil levels were adversely associated with survival. Of 15 patients with leukocytosis >10000/µL, 67% were dead at the end of follow up (HR=3.98, p=0.003; CI 95% 1.6-9.8). Of the 27 with neutrophils above 65%, 14 (52%) were dead at the end of follow up (HR=3.1; p=0.015; CI 95% 1.2-7.8). CONCLUSIONS: In patients with USPC, leukocytosis and neutrophilia are associated with aggressive tumor biology, and may predict a lower 5 year survival.
Assuntos
Anemia/sangue , Cistadenocarcinoma Papilar/sangue , Cistadenocarcinoma Seroso/sangue , Leucocitose/sangue , Trombocitose/sangue , Neoplasias Uterinas/sangue , Idoso , Idoso de 80 Anos ou mais , Anemia/complicações , Anemia/diagnóstico , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/diagnóstico , Cistadenocarcinoma Seroso/complicações , Cistadenocarcinoma Seroso/diagnóstico , Feminino , Humanos , Contagem de Leucócitos , Leucocitose/complicações , Leucocitose/diagnóstico , Pessoa de Meia-Idade , Contagem de Plaquetas , Prognóstico , Estudos Retrospectivos , Trombocitose/complicações , Trombocitose/diagnóstico , Neoplasias Uterinas/complicações , Neoplasias Uterinas/diagnósticoRESUMO
Nodular histiocytic aggregate (NHA) of the omentum is a rare benign proliferative process composed predominantly of histiocytes with scattered mesothelial cells. NHA is a differential diagnosis for neoplasms or metastatic tumors in cancer patients. To further clarify this clinical pitfall issue, the authors investigated surgical samples of the greater omentum from 96 patients with gastrointestinal malignancies and 53 patients with gynecologic neoplasms. Visible NHA of greater omentum was identified in 3 patients with ovarian neoplasms (borderline mucinous cystadenoma, low-grade papillary serous cystadenocarcinoma, and juvenile granulosa-cell tumor) but in none of the patients with gastrointestinal malignancies. Similar lesion was also identified on the cell blocks from peritoneal washings in 1 of the 3 patients. Grossly, the lesions formed small yellow-red nodules on the greater omentum, and the NHA lesion was also found diffusely on the surface of the appendix and fallopian tubes in 2 of the 3 patients. Histological study showed that typical NHA changes over an inflammatory background, which may indicate that NHA is a consequence of a chronic inflammatory process of omentum. The predominant infiltration of T lymphocytes in the NHA lesions indicates that the aggregation of histiocytes may be related to the activation of T-cell immunity. This report has first demonstrated visible NHA in the greater omentum of patients with ovarian malignancies, and awareness of this entity should be brought to clinicians to avoid misdiagnosis.
Assuntos
Cistadenocarcinoma/diagnóstico , Cistadenoma Mucinoso/diagnóstico , Tumor de Células da Granulosa/diagnóstico , Histiocitose/diagnóstico , Omento/patologia , Neoplasias Ovarianas/diagnóstico , Doenças Peritoneais/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Cistadenocarcinoma/complicações , Cistadenocarcinoma/cirurgia , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/diagnóstico , Cistadenocarcinoma Papilar/cirurgia , Cistadenocarcinoma Seroso/complicações , Cistadenocarcinoma Seroso/diagnóstico , Cistadenocarcinoma Seroso/cirurgia , Cistadenoma Mucinoso/complicações , Cistadenoma Mucinoso/cirurgia , Diagnóstico Diferencial , Feminino , Tumor de Células da Granulosa/complicações , Tumor de Células da Granulosa/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Omento/cirurgia , Neoplasias Ovarianas/complicações , Neoplasias Ovarianas/cirurgia , Doenças Peritoneais/complicações , Doenças Peritoneais/cirurgia , Lavagem Peritoneal , Neoplasias Gástricas/complicações , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/cirurgia , Adulto JovemRESUMO
A young woman with polycystic ovary syndrome and congenital cervical hypoplasia conceived with clomifen citrate treatment after placement of a transabdominal cervico-isthmic cerclage. Her pregnancy successfully reached term and cesarean section was performed to preserve the cerclage for the next pregnancy; when the ovaries were explored an irregular structure was detected on the left ovary. A wedge biopsy was done and the pathological assessment of the specimen was borderline micropapillary serous tumor of the ovary. The patient wanted to preserve her fertility, therefore a fertility-sparing staging surgery was performed six months after the cesarean section. There was no residual tumor in the left ovary, but there was a borderline tumor in the right ovarian biopsy specimen (frozen section was negative). Two months after staging surgery the patient conceived with IVF and delivered twins at the 33rd week of pregnancy with cesarean section. At her second cesarean section the right ovary and abdomen appeared normal on inspection, but the cerclage tape was in the endocervical canal and was thus removed. To our knowledge this is the second reported case of transabdominal cerclage tape migration into the endocervical canal. The patient is clinically disease-free 18 months after her second cesarean section. The clinical findings, treatment modalities, management and prognosis are discussed together with a literature review of a patient with a serous borderline ovarian tumor and congenital cervical hypoplasia.
Assuntos
Colo do Útero/anormalidades , Cistadenocarcinoma Papilar/diagnóstico , Neoplasias Ovarianas/diagnóstico , Complicações Neoplásicas na Gravidez/diagnóstico , Adulto , Cerclagem Cervical/métodos , Colo do Útero/patologia , Cesárea , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/cirurgia , Feminino , Humanos , Neoplasias Ovarianas/complicações , Neoplasias Ovarianas/cirurgia , Síndrome do Ovário Policístico/complicações , Gravidez , Complicações Neoplásicas na Gravidez/cirurgia , Resultado da Gravidez , Gravidez Múltipla , Indução de RemissãoAssuntos
Adenoma/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Cistadenocarcinoma Papilar/diagnóstico , Nevo Sebáceo de Jadassohn/complicações , Neoplasias Cutâneas/diagnóstico , Adenoma/complicações , Adenoma/patologia , Carcinoma de Células Escamosas/complicações , Carcinoma de Células Escamosas/patologia , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/patologia , Histocitoquímica , Humanos , Masculino , Microscopia , Pessoa de Meia-Idade , Nevo Sebáceo de Jadassohn/patologia , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/patologiaAssuntos
Cistadenocarcinoma Papilar/patologia , Neoplasias Pancreáticas/patologia , Pseudocisto Pancreático/patologia , Neoplasias Cutâneas/patologia , Biópsia , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/diagnóstico por imagem , Feminino , Humanos , Pessoa de Meia-Idade , Invasividade Neoplásica , Neoplasias Pancreáticas/complicações , Neoplasias Pancreáticas/diagnóstico por imagem , Pseudocisto Pancreático/complicações , Pseudocisto Pancreático/diagnóstico por imagem , Neoplasias Cutâneas/complicações , Tomografia Computadorizada por Raios XRESUMO
Endometrial carcinoma is the most common gynecologic cancer in the United States. Uterine papillary serous carcinoma comprises approximately 5-10% of endometrial carcinomas. This aggressive carcinoma typically occurs in older women, characteristically arising on atrophic endometrium. This frequently is associated with early extrauterine spread and, infrequently, with peritoneal dissemination. We present a case of acute gastric outlet obstruction secondary to papillary serous adenocarcinoma of the endometrium with diffuse peritoneal psammomatous implants.
Assuntos
Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Seroso/complicações , Neoplasias do Endométrio/complicações , Obstrução da Saída Gástrica/etiologia , Abdome Agudo/diagnóstico por imagem , Idoso , Meios de Contraste , Cistadenocarcinoma Papilar/diagnóstico por imagem , Cistadenocarcinoma Seroso/diagnóstico por imagem , Diagnóstico Diferencial , Neoplasias do Endométrio/diagnóstico por imagem , Feminino , Obstrução da Saída Gástrica/diagnóstico por imagem , Humanos , Tomografia Computadorizada por Raios XAssuntos
Cistadenocarcinoma Papilar/veterinária , Doença da Mama Fibrocística/veterinária , Glândulas Mamárias Animais/patologia , Neoplasias Mamárias Animais/patologia , Animais , Secreções Corporais , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/patologia , Feminino , Doença da Mama Fibrocística/complicações , Doença da Mama Fibrocística/patologia , Hiperplasia/complicações , Hiperplasia/patologia , Hiperplasia/veterinária , Hipertrofia/veterinária , Glândulas Mamárias Animais/metabolismo , Neoplasias Mamárias Animais/complicações , CoelhosRESUMO
OBJECTIVE: To describe the cytomorphology of psammocarcinomas in peritoneal washings, including ThinPrep (Cytyc Corporation/Hologic, Marlborough, Massachusetts, U.S.A.)-processed material, in a series of patients. STUDY DESIGN: A retrospective, 19-year search was performed for cases of peritoneal washings in which psammomatous calcifications were reported. All clinical findings as well as cytospin, ThinPrep and cell block slides from peritoneal washings in patients with psammocarcinoma were reviewed. RESULTS: A total of 37 cases were identified with peritoneal washings containing psammomatous calcifications, 4 (11%) of which were associated with psammocarcinoma. Psammocarcinomas occurred in patients of average age 52 years (range, 39-68) and were of either peritoneal (n = 3) or ovarian (n = 1) origin. In these psammocarcinomas, peritoneal washings were bloody, were of moderate to high cellularity and contained many papillary serous cell groups. Tumor cells had high nuclear:cytoplasmic ratios, irregular nuclei, prominent nucleoli and variable hyperchromasia. Laminated psammomatous calcifications were abundant in 3 cases (> 80 bodies per cytologic slide and cell block) and of variable size (up to 150 microm), occurring both alone and in clusters associated with atypical epithelial cell groups. CONCLUSION: The characteristic cytologic finding of low grade epithelial atypia in papillary cell groups accompanied by numerous psammoma bodies is very distinctive of psammocarcinoma and closely resembles the striking histopathologic findings seen in this rare subset of serous carcinomas.
Assuntos
Cistadenocarcinoma Papilar/patologia , Cistadenocarcinoma Seroso/patologia , Neoplasias Ovarianas/patologia , Lavagem Peritoneal/métodos , Neoplasias Peritoneais/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Calcinose/etiologia , Calcinose/patologia , Núcleo Celular/patologia , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Seroso/complicações , Feminino , Humanos , Histerectomia , Pessoa de Meia-Idade , Omento/patologia , Omento/cirurgia , Neoplasias Ovarianas/complicações , Neoplasias Ovarianas/cirurgia , Neoplasias Peritoneais/complicações , Neoplasias Peritoneais/cirurgia , Estudos Retrospectivos , Adulto JovemRESUMO
A major diagnostic challenge to the evaluation of an incomplete intestinal obstruction is to distinguish between infectious and malignant etiologies. We present a case of an elderly woman complaining of abdominal pain accompanied with nausea and vomiting, and failure to pass gas or stools. Anti-tuberculosis drugs were used to relieve her abdominal pain, and a needle biopsy of the peritoneal cavity showed evidence of primary papillary serous carcinoma of the peritoneum (PSCP). This is a rare description of tuberculosis in the setting of PSCP. This report illustrates the potential complex nature of malignancies, and emphasizes the need to consider coexistence of malignancy and infection in patients, especially in those with risk factors for malignancy who fail with antibiotic therapy.
Assuntos
Cistadenocarcinoma Papilar/complicações , Neoplasias Peritoneais/complicações , Peritonite Tuberculosa/complicações , Antituberculosos/uso terapêutico , Cistadenocarcinoma Papilar/patologia , Diagnóstico Diferencial , Feminino , Humanos , Falência Hepática/etiologia , Pessoa de Meia-Idade , Neoplasias Peritoneais/patologia , Peritonite Tuberculosa/tratamento farmacológico , Peritonite Tuberculosa/patologia , Insuficiência Renal/etiologia , Teste TuberculínicoAssuntos
Cistadenocarcinoma Papilar/complicações , Degeneração Paraneoplásica Cerebelar/etiologia , Neoplasias do Colo do Útero/complicações , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Cistadenocarcinoma Papilar/diagnóstico , Cistadenocarcinoma Papilar/tratamento farmacológico , Evolução Fatal , Feminino , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Degeneração Paraneoplásica Cerebelar/tratamento farmacológico , Degeneração Paraneoplásica Cerebelar/patologia , Tomografia Computadorizada por Raios X , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/tratamento farmacológicoAssuntos
Tamponamento Cardíaco/etiologia , Cistadenocarcinoma Papilar/secundário , Neoplasias do Mediastino/secundário , Neoplasias Ovarianas/patologia , Pericárdio , Idoso , Antineoplásicos/uso terapêutico , Biópsia , Tamponamento Cardíaco/cirurgia , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/terapia , Diagnóstico Diferencial , Evolução Fatal , Feminino , Humanos , Neoplasias do Mediastino/complicações , Neoplasias do Mediastino/tratamento farmacológico , Neoplasias Ovarianas/complicações , Neoplasias Ovarianas/cirurgia , Ovariectomia , PericardiocenteseRESUMO
An asymptomatic thirty-eight-year-old female developed recurrent DVT at the latter end of her first pregnancy and in the puerperium. Blood tests revealed a moderately elevated ANF (1:640) with a speckled pattern, hyperglobulinemia, and antibodies to thyroid tissues. Two months postpartum, following neurological disturbances she was found to have a patent foramen ovale and had developed paradoxical emboli to the brain causing multiple arterial occlusions. However, she also had cerebral venous occlusions as well as deep venous thromboses and pulmonary emboli, indicating a generalised prothrombotic state. Abdominal ultrasound examination revealed the presence of tumour which, on surgical removal, proved to be an ovarian carcinoma. The only antiphospholipid antibodies detectable were antibodies to mitochondria Type M5 in moderately elevated titres.
Assuntos
Síndrome Antifosfolipídica/complicações , Autoanticorpos/sangue , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Seroso/complicações , Mitocôndrias/imunologia , Neoplasias Ovarianas/complicações , Trombose Venosa/complicações , Adulto , Feminino , Humanos , Embolia Intracraniana/complicações , Gravidez , Complicações na Gravidez , RecidivaAssuntos
Antineoplásicos/uso terapêutico , Carboplatina/uso terapêutico , Cistadenocarcinoma Papilar/tratamento farmacológico , Fasciite/etiologia , Mãos , Neoplasias Ovarianas/tratamento farmacológico , Síndromes Paraneoplásicas , Idoso , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Carboplatina/administração & dosagem , Carboplatina/efeitos adversos , Cistadenocarcinoma Papilar/complicações , Fasciite/induzido quimicamente , Feminino , Humanos , Neoplasias Ovarianas/complicações , Prednisona/administração & dosagem , Prednisona/uso terapêutico , Fatores de TempoAssuntos
Abscesso/complicações , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Seroso/complicações , Infecções por Escherichia coli/complicações , Doenças das Tubas Uterinas/complicações , Doenças Ovarianas/complicações , Neoplasias Ovarianas/complicações , Pós-Menopausa , Idoso , Feminino , Humanos , Ruptura EspontâneaAssuntos
Cistadenocarcinoma Papilar/patologia , Cistadenocarcinoma Seroso/patologia , Neoplasias Ovarianas/patologia , Quimioterapia Adjuvante , Cistadenocarcinoma Papilar/complicações , Cistadenocarcinoma Papilar/tratamento farmacológico , Cistadenocarcinoma Papilar/cirurgia , Cistadenocarcinoma Seroso/complicações , Cistadenocarcinoma Seroso/tratamento farmacológico , Cistadenocarcinoma Seroso/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias Ovarianas/complicações , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/cirurgia , Ovário/diagnóstico por imagem , Ovário/patologia , Pós-Menopausa , Radiografia , Hemorragia Uterina/etiologiaRESUMO
BACKGROUND: Nephrotic syndrome (NS) is rarely associated with ovarian tumor. Only five cases of NS with pathologic diagnosis have been reported in patients with ovarian tumors. However, the association between minimal change disease (MCD) and ovarian tumor has not been previously reported. CASE: A 55-year-old woman presented with abdominal mass and edema. Radiologic studies revealed a 10 x 10 x 11 cm-sized mass and multiple enlarged lymph nodes, suggesting a malignant ovarian tumor. Urinalysis showed heavy proteinuria (4+) with decreased serum albumin and increased cholesterol levels, suggesting NS. She underwent operation and renal biopsy. Histopathology of the mass and the kidney revealed papillary serous carcinoma of the ovary and MCD, respectively. Oral prednisolone and adjuvant chemotherapy resulted in remission of NS. CONCLUSION: We herein report a case of MCD associated with ovarian carcinoma.