Assuntos
Neoplasias da Mama/patologia , Cisto Epidérmico/patologia , Tumor Filoide/diagnóstico , Neoplasias Vulvares/patologia , Adulto , Diagnóstico Diferencial , Cisto Epidérmico/diagnóstico , Cisto Epidérmico/cirurgia , Cisto Epidérmico/ultraestrutura , Feminino , Humanos , Tumor Filoide/patologiaRESUMO
Chordoid glioma (CG) is a World Health Organization classified grade II tumor located exclusively in the region of anterior third ventricle. Association of CG with other lesions is extremely rare. We report a case of CG in a 45-year-old male coexisting with an epidermoid cyst in the third ventricle. Ultrastructural examination of the CG revealed microvilli, junctional complexes, and intermediate filaments within the cytoplasm suggesting origin from specialized ependyma. The association of the 2 lesions appears coincidental as convincing evidence for a common histogenesis was not found.
Assuntos
Encefalopatias/complicações , Neoplasias do Ventrículo Cerebral/complicações , Cisto Epidérmico/complicações , Glioma/complicações , Terceiro Ventrículo/patologia , Biomarcadores Tumorais/análise , Encefalopatias/patologia , Neoplasias do Ventrículo Cerebral/patologia , Neoplasias do Ventrículo Cerebral/ultraestrutura , Cisto Epidérmico/patologia , Cisto Epidérmico/ultraestrutura , Glioma/patologia , Glioma/ultraestrutura , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Terceiro Ventrículo/ultraestruturaAssuntos
Encefalopatias/patologia , Encefalopatias/fisiopatologia , Tronco Encefálico/patologia , Cisto Epidérmico/fisiopatologia , Riso , Adulto , Cisto Epidérmico/patologia , Cisto Epidérmico/ultraestrutura , Feminino , Humanos , Imageamento por Ressonância Magnética , Microscopia Eletrônica de Transmissão e VarreduraRESUMO
Cutaneous ciliated cyst is an exceedingly rare, benign lesion most commonly found in the dermis or subcutis of the lower extremities of young female patients in their second and third decades. The pathogenesis of the cyst is unknown. We report a cutaneous ciliated cyst in the lower extremity of a 13-year-old female patient. On histologic examination, clusters of eccrine sweat glands were observed adjacent to the cyst. Upon comparison of the immunohistochemical profile of the cutaneous ciliated cyst and the eccrine sweat glands, they appeared almost completely unrelated. The histologic, immunohistochemical, and ultrastructural findings of this case and the literature provide evidence in favor of the Mullerian heterotopia theory.
Assuntos
Coristoma/patologia , Cisto Epidérmico/ultraestrutura , Tubas Uterinas , Ductos Paramesonéfricos/ultraestrutura , Dermatopatias/patologia , Adolescente , Biomarcadores/análise , Cílios/ultraestrutura , Glândulas Écrinas/metabolismo , Glândulas Écrinas/patologia , Cisto Epidérmico/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Perna (Membro)/patologia , Microscopia Eletrônica de TransmissãoRESUMO
Los quistes epidermoides son lesiones dermatológicas comunes pero poco frecuentes en la boca. En este artículo se presentan dos casos excepcionales de quistes epidermoides localizados intrabucalmente, en el que se discuten sus características clínicas e histopatológicas, su comportamiento y su manejo. Debido a lo inusual de estos casos, se enfatiza sobre la necesidad de informar su presencia en la cavidad bucal para su análisis y profundización en el estudio de estas alteraciones.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Cisto Epidérmico/diagnóstico , Cisto Epidérmico/etiologia , Cisto Epidérmico/patologia , Diagnóstico Diferencial , México/epidemiologia , Prognóstico , Cisto Epidérmico/cirurgia , Cisto Epidérmico/ultraestruturaRESUMO
OBJECTIVE: The classic sonographic description of an epidermoid cyst is a mass with a target or onion ring appearance of alternating rings of hyperechogenicity and hypoechogenicity. This study presents a pathologic-sonographic assessment of classic and nonclassic appearances of an epidermoid cyst of the testis and reports the possible similarity between a classic epidermoid cyst and a teratoma on sonography. METHODS: We reviewed the sonographic and histologic features of 8 testicular tumors that either had a classic onion ring pattern or were found at pathologic examination to be epidermoid cysts but did not have the classic sonographic pattern. RESULTS: Three epidermoid cysts had a typical onion ring appearance. Histologic sections of these tumors revealed a squamous epithelial layer lining the cyst and multiple concentric laminated layers of keratin. Two tumors did not have a typical sonographic appearance of epidermoid cysts but were found to be epidermoid cysts at pathologic examination. One was homogeneously hypoechoic, and the other had irregular cystic and solid components, but neither had a target or onion ring appearance. Histologically, both of these tumors consisted of cystic cavities lined by squamous epithelium and contained desquamated keratinized epithelium. Notably, 3 other tumors pathologically diagnosed as teratomas had a sonographic appearance of classic epidermoid cysts. These tumors contained layers of keratin, but the cyst was lined by both squamous cells (ectodermal origin) and cylindrical epithelium (endodermal origin), thereby precluding the diagnosis of epidermoid cysts. CONCLUSIONS: There is considerable overlapping of the sonographic appearances of teratomas and epidermoid cysts of the testis. Although the onion ring appearance of an intratesticular tumor is suggestive of an epidermoid cyst, this appearance may also be found in cases of a teratoma. Whereas the former condition can be treated by local enucleation, the latter requires radical orchiectomy.
Assuntos
Cisto Epidérmico/ultraestrutura , Teratoma/diagnóstico por imagem , Neoplasias Testiculares/diagnóstico por imagem , Adulto , Cisto Epidérmico/patologia , Humanos , Masculino , Reprodutibilidade dos Testes , Teratoma/patologia , Neoplasias Testiculares/patologia , UltrassonografiaRESUMO
BACKGROUND: Syringocystadenoma papilliferum (SCAP) and verrucous cyst are two uncommon benign tumors. The simultaneous occurrence of the two lesions has not been reported before. METHODS: We report four cases of the simultaneous occurrence of the two rare lesions as so-called collision lesions with a review of the literature. CONCLUSION: The relationship of SCAP with viral infection needs further investigation.
Assuntos
Adenoma de Glândula Sudorípara/patologia , Cisto Epidérmico/patologia , Infecções por Papillomavirus/patologia , Dermatopatias/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Adenoma de Glândula Sudorípara/virologia , Idoso , Diagnóstico Diferencial , Cisto Epidérmico/ultraestrutura , Cisto Epidérmico/virologia , Feminino , Humanos , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Papillomaviridae/ultraestrutura , Reação em Cadeia da Polimerase , Dermatopatias/virologia , Neoplasias das Glândulas Sudoríparas/virologia , Infecções Tumorais por Vírus/patologia , Verrugas/patologiaRESUMO
Two trichilemmal cysts (TC) on the scalps of two Japanese women were examined at the electron microscopic level. The ultrastructural characteristics of the TC included an abrupt transition from nucleate to anucleate cells, a few oval, small, keratohyaline granules mixed with increasing numbers of tonofibrils from the peripheral layer towards the center, spherical particles with lipid droplets, desmosomal structures in keratinized cells, and the interdigitation of keratin in the uppermost keratinizing cells. The keratinization pattern of the TC was unique in that typical soft or hard keratinization processes did not occur. Trichilemmal keratinization is observed in the trichilemmal sacs that surround the lower ends of catagen or telogen hairs, as well as in the outer root sheaths in the follicular isthmus of anagen hairs. Comparison of the ultrastructure of these two known types of trichilemmal keratinization with the keratinization pattern of the TC in our patients indicates that TC may differentiate into, or originate from, the proliferation of the outer root sheath in the follicular isthmus of anagen hairs.
Assuntos
Cisto Epidérmico/etiologia , Adulto , Membrana Basal/ultraestrutura , Derme/patologia , Cisto Epidérmico/patologia , Cisto Epidérmico/ultraestrutura , Feminino , Humanos , Microscopia Eletrônica , Pessoa de Meia-Idade , Pele/patologia , Pele/ultraestruturaRESUMO
Introducción. El quiste epidermoide gigante de bazo es poco frecuente y su etiología es desconocida. El objetivo del presente estudio es informar el caso clínico de una adolescente a la cual se le diagnosticó quiste epidermoide gigante de bazo. Caso clínico. Femenino de 13 años de edad, la cual acudió al hospital por presentar un tumor abdominal. El ultrasonido mostró una masa sólida e hipoecoica de 20.5 x 24 x 14.5 cm en el cuadrante superior izquierdo del abdomén. En la tomografía computada de abdomen se observó un tumor quístico de bazo de 21.8 x 20.4 x 14 cm. Se le realizó esplenectomía total y el estudio histopatológico reportó epitelio plano poliestratificado. Conclusiones. El quiste epidermoide gigante de bazo es una causa poco frecuente de esplenomegalia en el niño
Assuntos
Humanos , Feminino , Adolescente , Cisto Epidérmico/cirurgia , Cisto Epidérmico/ultraestrutura , Baço , Baço/patologia , Esplenomegalia/etiologiaRESUMO
Epidermolysis bullosa (EB) pruriginosa is a rare clinical subset of dystrophic EB, characterized by marked itching and presence of prurigo-like or lichenoid features. In order to further delineate the phenotype and understand the pathogenesis of this disorder, the clinical, histological and ultrastructural findings of a 19-year-old patient presenting a typical form of EB pruriginosa are described. The prevalence of papular itchy lichenoid lesions, signs of scratching and paucity of blisters at the time of clinical examination may result in incorrect diagnosis and treatment. Microscopic studies of the lesions show the typical findings of dystrophic EB associated with an unusually high density of collagen bundles and absence of elastic fibres in the upper dermis. Itching lichenoid lesions of EB pruriginosa could represent an abnormal dermal reactivity of some patients to their inherited bullous disorder.
Assuntos
Epidermólise Bolhosa Distrófica/patologia , Erupções Liquenoides/patologia , Prurigo/patologia , Adulto , Vesícula/patologia , Cicatriz/patologia , Colágeno/ultraestrutura , Tecido Elástico/patologia , Tecido Elástico/ultraestrutura , Cisto Epidérmico/patologia , Cisto Epidérmico/ultraestrutura , Epidermólise Bolhosa Distrófica/etiologia , Feminino , Humanos , Erupções Liquenoides/etiologia , Doenças da Unha/patologia , Fenótipo , Prevalência , Prurigo/etiologia , Prurido , Pele/patologia , Pele/ultraestruturaRESUMO
A 19-year-old woman with a cutaneous ciliated cyst on her buttock is reported. Histological, histochemical, and electron microscopic studies revealed ciliated cells, mucinous cells showing merocrine secretion, and areas of squamous metaplasia in the cyst wall. This is the first case of cutaneous ciliated cyst that contained non-ciliated mucinous cells as a component.
Assuntos
Cisto Epidérmico/patologia , Dermatopatias/patologia , Adulto , Cílios/ultraestrutura , Cisto Epidérmico/ultraestrutura , Feminino , Humanos , Microscopia EletrônicaRESUMO
BACKGROUND: The Bazex-Dupré-Christol syndrome is characterized by follicular atrophoderma, congenital hypotrichosis, and basal cell neoformations that include basal cell carcinomas and basal cell nevi. OBSERVATIONS: We describe a large family in which 20 persons across four generations present with typical features of the Bazex-Dupré-Christol syndrome. However, the clinical picture in this family differs with regard to gender and age. Male subjects have a uniformly severe disease, whereas female subjects exhibit a range of severity of the syndrome. The most striking difference between male and female subjects is provided by hypotrichosis. In male subjects, hypotrichosis is diffuse and affects all scalp hairs. On the other hand, female subjects do not have hypotrichosis, but normal hairs are intermingled with abnormal hairs. In infancy and childhood, multiple milia are present, whereas in adults only a few milia are observed. CONCLUSIONS: The family pedigree seems to be consistent with an X-linked inheritance, since male-to-male transmission does not occur. Moreover, further evidence of an X-linked dominant mode of inheritance could be derived from the observation of gender differences that can be attributed to the lyonization phenomenon in female subjects. From a clinical and morphologic point of view, the Bazex-Dupré-Christol syndrome seems to be a disorder of the hair follicle.
Assuntos
Carcinoma Basocelular/ultraestrutura , Cabelo/ultraestrutura , Hipotricose/patologia , Neoplasias Cutâneas/ultraestrutura , Adulto , Atrofia , Criança , Cisto Epidérmico/ultraestrutura , Feminino , Humanos , Hipotricose/congênito , Lactente , Masculino , Pessoa de Meia-Idade , SíndromeRESUMO
Se presenta un caso de síndrome de Birt-Hogg-Dubé(SBHD)compuesto por fibrofoliculomas, tricodiscomas y acrocordones múltiples en un hombre de 56 años, con datos familiares(padre) de lesiones similares y sin lesiones sistémicas. Se revé el diagnóstico diferencial entre fibrofoliculoma y fibroma perifolicular, así como la literatura sobre este infrecuente síndrome
Assuntos
Doenças do Cabelo/patologia , Diagnóstico Diferencial , Fibroma/classificação , Fibroma/patologia , Doenças do Cabelo/diagnóstico , Cisto Epidérmico/ultraestrutura , Esclerose Tuberosa/diagnósticoRESUMO
An adnexal tumor on the scalp of a 74-year-old woman is described. Histologically, the tumor was composed of cystic structures showing typical trichilemmal keratinization. The tumor cells in the cyst walls often formed duct-like or squamous eddy-like structures and occasionally showed vacuolation or poroma-like change. Ultrastructurally, some tumor cells showed differentiation either toward the acrosyringium or sebaceous cells. From these findings, the present tumor is considered to differentiate toward various parts of the hair follicle including infundibulo-isthmus epithelium, apocrine acrosyringium, and sebaceous cells.
Assuntos
Cisto Epidérmico/patologia , Couro Cabeludo/patologia , Neoplasias Cutâneas/patologia , Adenoma , Idoso , Glândulas Apócrinas , Diferenciação Celular , Divisão Celular , Cisto Epidérmico/ultraestrutura , Feminino , Humanos , Microscopia Eletrônica , Couro Cabeludo/ultraestrutura , Neoplasias das Glândulas Sebáceas , Neoplasias Cutâneas/ultraestruturaRESUMO
The clinical and pathological features of 4 cases of pilomatricoma associated with epidermoid cysts, are described. None of the cases showed features of Gardner's syndrome.
Assuntos
Cisto Epidérmico/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Cutâneas/patologia , Adolescente , Adulto , Criança , Cisto Epidérmico/ultraestrutura , Feminino , Humanos , Masculino , Recidiva Local de NeoplasiaRESUMO
A cotton rat was inoculated orally with oocysts of Caryospora bigenetica from the feces of a rattlesnake. Sixteen days later the rat was euthanized, and portions of the scrotum, foot pad and muzzle were processed for histological sections and transmission electron microscopy. Sporozoites within caryocysts had typical coccidian features such as an anterior and posterior refractile body, centrally located nucleus, micronemes, rhoptries, a conoid, a micropore near the anterior refractile body, a posterior pore, amylopectin granules, lipid bodies, a Golgi-like body, a mitochondrion and subpellicular microtubules. The infected host cell was spherical and surrounded by a fibrous wall-like covering, 0.35-1.00 microns thick. This outer covering, when viewed in stained histological sections, was periodic acid-Schiff (PAS)-positive.
Assuntos
Coccídios/ultraestrutura , Coccidiose/parasitologia , Cisto Epidérmico/parasitologia , Animais , Arvicolinae , Coccidiose/patologia , Cisto Epidérmico/ultraestrutura , MasculinoRESUMO
O cisto epidermóide é uma lesäo benigna responsável por aproximadamente 1 por cento de todos os tumores testiculares. Ele näo pode ser diferenciado de outros tumores testiculares com base unicamente em aspectos clínicos. Apresentamos um caso de cisto epidermóide e fazemos uma breve revisäo da literatura mundial sobre o assunto
Assuntos
Adulto , Humanos , Masculino , Cisto Epidérmico/ultraestrutura , Neoplasias Testiculares/ultraestrutura , Microscopia EletrônicaRESUMO
The formation of structures resembling hair matrices is the least common form of follicular differentiation and only occurs with any frequency in pilomatricoma. Rarely, follicular cysts and both benign and malignant adnexal tumors can show areas of pilomatricoma-like change, or hair matrix differentiation. Examples of focal hair matrix differentiation in a follicular cyst, a cutaneous mixed tumor, and an adnexal carcinoma are presented. Each of these cases also demonstrates the presence of limited differentiation toward structures of the inner root sheath.
Assuntos
Cisto Epidérmico/ultraestrutura , Cisto Folicular/ultraestrutura , Cabelo/ultraestrutura , Neoplasias Cutâneas/ultraestrutura , Adulto , Idoso , Cisto Epidérmico/epidemiologia , Cisto Folicular/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/epidemiologiaRESUMO
A trabecular (Merkel cell) carcinoma arising in the wall of an epidermal cyst in a 58-year-old white male metastasized, 17 months after local excision, to an inguinal lymph node. Ultrastructural studies showed polygonal tumor cells with typical dense-core granules. Although squamous-cell carcinoma and other malignant neoplasms have been reported rarely to have arisen in epidermal cysts, a literature search failed to find a precedent for the present case.