Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 430
Filtrar
1.
Sci Rep ; 14(1): 22279, 2024 09 27.
Artigo em Inglês | MEDLINE | ID: mdl-39333283

RESUMO

Integrating artificial limbs as part of one's body involves complex neuroplastic changes resulting from various sensory inputs. While somatosensory feedback is crucial, plastic processes that enable embodiment remain unknown. We investigated this using somatosensory evoked fields (SEFs) in the primary somatosensory cortex (S1) following the Rubber Hand Illusion (RHI), known to quickly induce artificial limb embodiment. During electrical stimulation of the little finger and thumb, 19 adults underwent neuromagnetic recordings before and after the RHI. We found early SEF displacement, including an illusion-brain correlation between extent of embodiment and specific changes to the first cortical response at 20 ms in Area 3b, within S1. Furthermore, we observed a posteriorly directed displacement at 35 ms towards Area 1, known to be important for visual integration during touch perception. That this second displacement was unrelated to extent of embodiment implies a functional distinction between neuroplastic changes of these components and areas. The earlier shift in Area 3b may shape extent of limb ownership, while subsequent displacement into Area 1 may relate to early visual-tactile integration that initiates embodiment. Here we provide evidence for multiple neuroplastic processes in S1-lasting beyond the illusion-supporting integration of artificial limbs like prostheses within the body representation.


Assuntos
Potenciais Somatossensoriais Evocados , Córtex Somatossensorial , Humanos , Córtex Somatossensorial/fisiologia , Feminino , Masculino , Adulto , Potenciais Somatossensoriais Evocados/fisiologia , Ilusões/fisiologia , Plasticidade Neuronal/fisiologia , Adulto Jovem , Percepção do Tato/fisiologia , Estimulação Elétrica , Magnetoencefalografia , Dedos/fisiologia , Membros Artificiais , Mãos/fisiologia
2.
Sensors (Basel) ; 24(8)2024 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-38676202

RESUMO

Haptic hands and grippers, designed to enable skillful object manipulation, are pivotal for high-precision interaction with environments. These technologies are particularly vital in fields such as minimally invasive surgery, where they enhance surgical accuracy and tactile feedback: in the development of advanced prosthetic limbs, offering users improved functionality and a more natural sense of touch, and within industrial automation and manufacturing, they contribute to more efficient, safe, and flexible production processes. This paper presents the development of a two-finger robotic hand that employs simple yet precise strategies to manipulate objects without damaging or dropping them. Our innovative approach fused force-sensitive resistor (FSR) sensors with the average current of servomotors to enhance both the speed and accuracy of grasping. Therefore, we aim to create a grasping mechanism that is more dexterous than grippers and less complex than robotic hands. To achieve this goal, we designed a two-finger robotic hand with two degrees of freedom on each finger; an FSR was integrated into each fingertip to enable object categorization and the detection of the initial contact. Subsequently, servomotor currents were monitored continuously to implement impedance control and maintain the grasp of objects in a wide range of stiffness. The proposed hand categorized objects' stiffness upon initial contact and exerted accurate force by fusing FSR and the motor currents. An experimental test was conducted using a Yale-CMU-Berkeley (YCB) object set consisted of a foam ball, an empty soda can, an apple, a glass cup, a plastic cup, and a small milk packet. The robotic hand successfully picked up these objects from a table and sat them down without inflicting any damage or dropping them midway. Our results represent a significant step forward in developing haptic robotic hands with advanced object perception and manipulation capabilities.


Assuntos
Dedos , Força da Mão , Robótica , Tato , Robótica/métodos , Robótica/instrumentação , Humanos , Dedos/fisiologia , Tato/fisiologia , Força da Mão/fisiologia , Impedância Elétrica , Mãos/fisiologia , Desenho de Equipamento
3.
Bioinspir Biomim ; 19(3)2024 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-38579732

RESUMO

In the field of robotic hands, finger force coordination is usually achieved by complex mechanical structures and control systems. This study presents the design of a novel transmission system inspired from the physiological concept of force synergies, aiming to simplify the control of multifingered robotic hands. To this end, we collected human finger force data during six isometric grasping tasks, and force synergies (i.e. the synergy weightings and the corresponding activation coefficients) were extracted from the concatenated force data to explore their potential for force modulation. We then implemented two force synergies with a cable-driven transmission mechanism consisting of two spring-loaded sliders and five V-shaped bars. Specifically, we used fixed synergy weightings to determine the stiffness of the compression springs, and the displacements of sliders were determined by time-varying activation coefficients. The derived transmission system was then used to drive a five-finger robotic hand named SYN hand. We also designed a motion encoder to selectively activate desired fingers, making it possible for two motors to empower a variety of hand postures. Experiments on the prototype demonstrate successful grasp of a wide range of objects in everyday life, and the finger force distribution of SYN hand can approximate that of human hand during six typical tasks. To our best knowledge, this study shows the first attempt to mechanically implement force synergies for finger force modulation in a robotic hand. In comparison to state-of-the-art robotic hands with similar functionality, the proposed hand can distribute humanlike force ratios on the fingers by simple position control, rather than resorting to additional force sensors or complex control strategies. The outcome of this study may provide alternatives for the design of novel anthropomorphic robotic hands, and thus show application prospects in the field of hand prostheses and exoskeletons.


Assuntos
Procedimentos Cirúrgicos Robóticos , Robótica , Humanos , Mãos/fisiologia , Dedos/fisiologia , Força da Mão
4.
Sensors (Basel) ; 24(5)2024 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-38474915

RESUMO

This work investigates a new sensing technology for use in robotic human-machine interface (HMI) applications. The proposed method uses near E-field sensing to measure small changes in the limb surface topography due to muscle actuation over time. The sensors introduced in this work provide a non-contact, low-computational-cost, and low-noise method for sensing muscle activity. By evaluating the key sensor characteristics, such as accuracy, hysteresis, and resolution, the performance of this sensor is validated. Then, to understand the potential performance in intention detection, the unmodified digital output of the sensor is analysed against movements of the hand and fingers. This is done to demonstrate the worst-case scenario and to show that the sensor provides highly targeted and relevant data on muscle activation before any further processing. Finally, a convolutional neural network is used to perform joint angle prediction over nine degrees of freedom, achieving high-level regression performance with an RMSE value of less than six degrees for thumb and wrist movements and 11 degrees for finger movements. This work demonstrates the promising performance of this novel approach to sensing for use in human-machine interfaces.


Assuntos
Procedimentos Cirúrgicos Robóticos , Humanos , Mãos/fisiologia , Dedos/fisiologia , Punho/fisiologia , Polegar
5.
IEEE Trans Haptics ; 17(3): 471-482, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38329871

RESUMO

A lightweight haptic display that does not interfere with the user's natural movement is required for an immersive haptic experience. This study proposes a lightweight, powerful, and responsive passive haptic actuator driven by airborne focused ultrasound. This 6.2 g completely plastic passive device amplifies an applied ultrasound radiation force by a factor of 35 using a simple lever mechanism, presenting an amplified force of 0.7 N to the user's finger pad. 2-30 Hz vibration can also be presented. Since the radiation force is presented at the speed of sound, the amplified force is presented at high speed even with the high amplification rate of a lever, achieving such strong force and vibration presentation. Physical measurements showed that the amplified force was 0.7 N for the 20.48 mN input radiation force, and the amplitude of the presented vibration was over 0.1 N at 2-30 Hz. A psychophysical experiment showed that the vibration and force were perceivable with a device output level of -7.7 dB. In the future, we will explore methodologies around device design to present desired tactile sensations.


Assuntos
Desenho de Equipamento , Percepção do Tato , Vibração , Humanos , Percepção do Tato/fisiologia , Adulto , Tato , Ondas Ultrassônicas , Adulto Jovem , Masculino , Feminino , Dedos/fisiologia , Interface Usuário-Computador , Estimulação Física , Psicofísica
6.
J Neural Eng ; 21(2)2024 03 12.
Artigo em Inglês | MEDLINE | ID: mdl-38417152

RESUMO

Objective.The study aims to characterize movements with different sensory goals, by contrasting the neural activity involved in processing proprioceptive and visuo-motor information. To accomplish this, we have developed a new methodology that utilizes the irregularity of the instantaneous gamma frequency parameter for characterization.Approach.In this study, eight essential tremor patients undergoing an awake deep brain stimulation implantation surgery repetitively touched the clinician's finger (forward visually-guided/FV movement) and then one's own chin (backward proprioceptively-guided/BP movement). Neural electrocorticographic recordings from the motor (M1), somatosensory (S1), and posterior parietal cortex (PPC) were obtained and band-pass filtered in the gamma range (30-80 Hz). The irregularity of the inter-event intervals (IEI; inverse of instantaneous gamma frequency) were examined as: (1) auto-information of the IEI time series and (2) correlation between the amplitude and its proceeding IEI. We further explored the network connectivity after segmenting the FV and BP movements by periods of accelerating and decelerating forces, and applying the IEI parameter to transfer entropy methods.Main results.Conceptualizing that the irregularity in IEI reflects active new information processing, we found the highest irregularity in M1 during BP movement, highest in PPC during FV movement, and the lowest during rest at all sites. Also, connectivity was the strongest from S1 to M1 and from S1 to PPC during FV movement with accelerating force and weakest during rest.Significance. We introduce a novel methodology that utilize the instantaneous gamma frequency (i.e. IEI) parameter in characterizing goal-oriented movements with different sensory goals, and demonstrate its use to inform the directional connectivity within the motor cortical network. This method successfully characterizes different movement types, while providing interpretations to the sensory-motor integration processes.


Assuntos
Dedos , Lobo Parietal , Humanos , Dedos/fisiologia , Propriocepção/fisiologia , Movimento/fisiologia , Eletrocorticografia
7.
Artigo em Inglês | MEDLINE | ID: mdl-38032787

RESUMO

Wearing robotic gloves has become increasingly crucial for hand rehabilitation in stroke patients. However, traditional robotic gloves can exert additional pressure on the hand, such as prolonged use leading to poor blood circulation and muscle stiffness. To address these concerns, this work analyzes the finger kinematic model based on computerized tomography (CT) images of human hands, and designs a low-pressure robotic glove that conforms to finger kinematic characteristics. Firstly, physiological data on finger joint flexion and extension were collected through CT scans. The equivalent rotation centers of finger joints were obtained using the SURF and RANSAC algorithms. Furthermore, the trajectory of finger joint end and the correlation equation of finger joint motion were fitted, and a comprehensive finger kinematic model was established. Based on this finger kinematic model, a novel under-actuated exoskeleton mechanism was designed using a human-machine integration approach. The novel robotic glove fully aligns with the equivalent rotation centers and natural motion trajectories of the fingers, exerting minimal and evenly distributed dynamic pressure on the fingers, with a theoretical static pressure value of zero. Experiments involving gripping everyday objects demonstrated that the novel robotic glove significantly reduces the overall pressure on the fingers during grasping compared to the pneumatic glove and the traditional exoskeleton robotic glove. It is suitable for long-term use by stroke patients for rehabilitation training.


Assuntos
Procedimentos Cirúrgicos Robóticos , Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral , Humanos , Articulações dos Dedos , Fenômenos Biomecânicos , Mãos/fisiologia , Dedos/fisiologia , Tomografia Computadorizada por Raios X , Rotação
8.
Comput Biol Med ; 162: 107139, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37301095

RESUMO

BACKGROUND: Manual dexterity is a fundamental motor skill that allows us to perform complex daily tasks. Neuromuscular injuries, however, can lead to the loss of hand dexterity. Although numerous advanced assistive robotic hands have been developed, we still lack dexterous and continuous control of multiple degrees of freedom in real-time. In this study, we developed an efficient and robust neural decoding approach that can continuously decode intended finger dynamic movements for real-time control of a prosthetic hand. METHODS: High-density electromyogram (HD-EMG) signals were obtained from the extrinsic finger flexor and extensor muscles, while participants performed either single-finger or multi-finger flexion-extension movements. We implemented a deep learning-based neural network approach to learn the mapping from HD-EMG features to finger-specific population motoneuron firing frequency (i.e., neural-drive signals). The neural-drive signals reflected motor commands specific to individual fingers. The predicted neural-drive signals were then used to continuously control the fingers (index, middle, and ring) of a prosthetic hand in real-time. RESULTS: Our developed neural-drive decoder could consistently and accurately predict joint angles with significantly lower prediction errors across single-finger and multi-finger tasks, compared with a deep learning model directly trained on finger force signals and the conventional EMG-amplitude estimate. The decoder performance was stable over time and was robust to variations of the EMG signals. The decoder also demonstrated a substantially better finger separation with minimal predicted error of joint angle in the unintended fingers. CONCLUSIONS: This neural decoding technique offers a novel and efficient neural-machine interface that can consistently predict robotic finger kinematics with high accuracy, which can enable dexterous control of assistive robotic hands.


Assuntos
Procedimentos Cirúrgicos Robóticos , Humanos , Fenômenos Biomecânicos , Mãos/fisiologia , Dedos/fisiologia , Eletromiografia/métodos , Movimento/fisiologia
9.
Hand Surg Rehabil ; 42(5): 424-429, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-37353200

RESUMO

OBJECTIVES: The effect of metacarpophalangeal joint position and finger joint movement speed on lumbrical muscle activity remains unproven and was examined in this study. MATERIAL AND METHODS: Twenty-four healthy adults performed flexion-extension movements of the index finger in different metacarpophalangeal joint positions (extension or flexion) and movement speeds (60, 120, 240, and 360 beats per minute). The activities of the first lumbrical, first dorsal interosseous, and extensor digitorum muscles were evaluated using surface electromyography, and compared with those during finger joint extension. RESULTS: The metacarpophalangeal joint positions affected only lumbrical muscle activity, which was greater during extension. Further, finger movement speed affected the lumbrical and extensor digitorum muscle activities, which increased with increasing movement speeds. CONCLUSION: The present study suggests that position and movement speed can influence the lumbrical muscle activity during metacarpophalangeal joint extension. These findings may help expound lumbrical function and develop suitable strategies for inducing lumbrical muscle activity.


Assuntos
Articulações dos Dedos , Músculo Esquelético , Adulto , Humanos , Articulações dos Dedos/fisiologia , Músculo Esquelético/fisiologia , Dedos/fisiologia , Mãos , Articulação Metacarpofalângica/fisiologia
10.
Biol Cybern ; 117(3): 221-247, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-37222800

RESUMO

In a partially impaired anthropomorphic hand, maintaining the movement coordination of the robotic digits with the central nervous system (CNS) and natural digits is crucial for robust performance. A challenge in the control perspective of movement coordination of a human hand is finding methods robust to the disturbances in a well-posed control problem of a biomechanical model. We use visco-elastic dynamics in the human palm frame of reference to explore the biomechanics of movement coordination to solve this control problem. Our biomechanical model incorporates the time delay due to actuation force, parametric uncertainty, exogenous disturbances, and sensory noise to constitute a 21-degree of freedom model. A mixed [Formula: see text]-synthesis controller, considering the real parametric uncertainty, represents the CNS in the control paradigm. We consider the robotic finger's flexion movement when perturbed from the initial equilibrium. The controller provides feedback force at the joints to regulate the robotic finger movement. The index finger follows a reference trajectory of the joint angular position profile and stabilizes at a flexion angle of 1 rad/s at a time of 1 s. The main control objective is to keep the angular displacement of the finger joint constant when a disturbance force acts. We simulate the modeling scheme in MATLAB/ Simulink. The results demonstrate that our controller scheme is robust against the worst-case disturbance and achieves the desired performance value. Developing a biologically inspired neurophysiological controller with robust performance has many applications, including assistive rehabilitation devices, hand movement disorder diagnosis, and robotic manipulators.


Assuntos
Procedimentos Cirúrgicos Robóticos , Robótica , Humanos , Mãos/fisiologia , Dedos/fisiologia , Movimento/fisiologia
11.
Soft Robot ; 10(3): 624-635, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-36576497

RESUMO

Haptic displays act on the user's body to stimulate the sense of touch and enrich applications from gaming and computer-aided design to rehabilitation and remote surgery. However, when crafted from typical rigid robotic components, they tend to be heavy, bulky, and expensive, while sleeker designs often struggle to create clear haptic cues. This article introduces a lightweight wearable silicone finger sheath that can deliver salient and rich vibrotactile cues using electromagnetic actuation. We fabricate the sheath on a ferromagnetic mandrel with a process based on dip molding, a robust fabrication method that is rarely used in soft robotics but is suitable for commercial production. A miniature rare-earth magnet embedded within the silicone layers at the center of the finger pad is driven to vibrate by the application of alternating current to a nearby air-coil. Experiments are conducted to determine the amplitude of the magnetic force and the frequency response function for the displacement amplitude of the magnet perpendicular to the skin. In addition, high-fidelity finite element analyses of the finger wearing the device are performed to investigate the trends observed in the measurements. The experimental and simulated results show consistent dynamic behavior from 10 to 1000 Hz, with the displacement decreasing after about 300 Hz. These results match the detection threshold profile obtained in a psychophysical study performed by 17 users, where more current was needed only at the highest frequency. A cue identification experiment and a demonstration in virtual reality validate the feasibility of this approach to fingertip haptics.


Assuntos
Sinais (Psicologia) , Imãs , Desenho de Equipamento , Dedos/fisiologia , Silicones
12.
Sci Rep ; 12(1): 22267, 2022 12 23.
Artigo em Inglês | MEDLINE | ID: mdl-36564388

RESUMO

Stability of timing and force production in repetitive movements characterizes skillful motor behaviors such as surgery and playing musical instruments. However, even trained individuals such as musicians undergo further extensive training for the improvement of these skills. Previous studies that investigated the lower extremity movements such as jumping and sprinting demonstrated enhancement of the maximum force and rate of force development immediately after the plyometric exercises. However, it remains unknown whether the plyometric exercises enhance the stability of timing and force production of the dexterous finger movements in trained individuals. Here we address this issue by examining the effects of plyometric exercise specialized for finger movements on piano performance. We compared the training-related changes in the piano-key motion and several physiological features of the finger muscles (e.g., electromyography, rate of force development, and muscle temperature) by well-trained pianists. The conditioning demonstrated a decrease of the variation in timing and velocity of successive keystrokes, along with a concomitant increase in the rate of force development of the four fingers, but not the thumb, although there was no change in the finger muscular activities through the activity. By contrast, such a conditioning effect was not evident following a conventional repetitive piano practice. In addition, a significant increase in the forearm muscle temperature was observed specifically through performing the plyometric exercise with the fingers, implying its association with improved performance. These results indicate effectiveness of the plyometric exercises for improvement of strength, precision, and physiological efficiency of the finger movements even in expert pianists, which implicates that ways of practicing play a key role in enhancing experts' expertise.


Assuntos
Destreza Motora , Música , Humanos , Destreza Motora/fisiologia , Fenômenos Biomecânicos/fisiologia , Dedos/fisiologia , Polegar , Movimento/fisiologia
13.
Hand Surg Rehabil ; 41(1): 152-154, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34543764

RESUMO

Paradoxical extension was first described, and termed "lumbrical-plus" finger, by Parkes in 1970. It is characterized by extension of the interphalangeal joints when flexing the fingers. The It is most common in the middle finger. Treatment involves lumbrical muscle release or a flexor digitorum profundus graft of appropriate length. A search of the literature found no reports of results of conservative management. The present case report describes a novel conservative technique for lumbrical-plus deformity.


Assuntos
Dedos , Músculo Esquelético , Dedos/fisiologia , Humanos
14.
Arch Orthop Trauma Surg ; 141(6): 1073-1080, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33550452

RESUMO

INTRODUCTION: Biomechanical evaluation of the viscoelastic properties tissue deformation, stiffness, and maximum breaking load of the human A2 pulley. We hypothesized that the A2 pulleys of index, middle, and ring fingers exhibit no difference regarding the aforementioned biomechanical parameters. METHODS: Forty-one A2 pulleys of 14 upper extremities (8 body donors) were assessed. Cyclic and load-to-failure testing were performed. The biomechanical parameters tissue deformation during cyclic and load-to-failure testing, stiffness, and maximum breaking load were determined. RESULTS: No significant differences between the fingers could be detected regarding the biomechanical parameters. A significant negative correlation could be detected between stiffness and deformation of the pulley. Significant positive correlations could be identified between stiffness and maximum breaking load and between maximum breaking load and deformation of the pulleys. CONCLUSIONS: Assessment of the viscoelastic properties of the A2 finger pulley promotes precise diagnosis of pulley lesions and will help to optimize treatment.


Assuntos
Fenômenos Biomecânicos/fisiologia , Elasticidade/fisiologia , Dedos/fisiologia , Tendões/fisiologia , Humanos , Viscosidade
15.
J Dev Orig Health Dis ; 12(6): 859-864, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-33472723

RESUMO

The ratio of length between the second (index) and fourth (ring) fingers (digit ratio or 2D:4D) is frequently employed as a retrospective marker of prenatal sex hormone exposure. Lutchmaya et al. (2004) reported that the ratio of testosterone (T) to estradiol (E) present in second-trimester amniotic fluid was negatively correlated with digit ratios for the right hand (but not the left hand) in a sample of 29 children at 2-year follow-up. This observation is frequently cited as evidence for the measure's validity but has not been replicated. We therefore present the findings of another study of amniotic T and E that did not find evidence for these effects at 4½-year follow-up. The confidence intervals were large, the direction of correlations observed was generally erratic, and the overall findings question the premise that second-trimester sex hormones affect the development of digit length ratios in humans.


Assuntos
Líquido Amniótico/química , Razão Digital , Estradiol/análise , Dedos/fisiologia , Testosterona/análise , Adulto , Líquido Amniótico/metabolismo , Feminino , Humanos , Masculino , Estudos Retrospectivos , Caracteres Sexuais
16.
Pan Afr Med J ; 36: 141, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32849996

RESUMO

Radial nerve is a frequently injured nerve. Radial nerve palsy result from direct trauma, neuropathies, and fracture over the humerus, malignant tumor and neuritis. A case of 26-year male is presented in this report who had a road traffic accident resulting in injury over the right shoulder, wrist joint and diagnosed of radial nerve palsy, consequently was operated with soft tissue reconstruction with tendon transfers which resulted into pain over wrist joint and loss of extensors muscle function of the wrist joint, which led to difficulty in performing activities of daily living. Surgical history and rehabilitation is mentioned in the case report. We report that there were significant improvements in muscle strength, range of motion, relief from pain, and exceptional improvements in the patient´s functional independence with physiotherapy interventions post-operative tendon transfers.


Assuntos
Nervo Radial/lesões , Nervo Radial/cirurgia , Neuropatia Radial/reabilitação , Neuropatia Radial/cirurgia , Transferência Tendinosa/reabilitação , Adulto , Dedos/fisiologia , Humanos , Índia , Masculino , Modalidades de Fisioterapia , Cuidados Pós-Operatórios/métodos , Período Pós-Operatório , Nervo Radial/fisiopatologia , Neuropatia Radial/fisiopatologia , Amplitude de Movimento Articular , Transferência Tendinosa/métodos , Punho/fisiologia , Articulação do Punho/fisiologia
17.
World Neurosurg ; 140: 303-307, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32428719

RESUMO

BACKGROUND: Malformations of cortical development (MCDs) often result in mental retardation, intractable epilepsy, neurodevelopmental delay, and contralateral hemiparesis. We describe herein a rare patient with MCD who had developed normally in spite of diffuse hemispheric anomaly of the brain. CASE DESCRIPTION: We report a left-handed 20-year-old healthy man. A magnetic resonance image scan revealed congenital left cerebral hemispheric dysplasia and deficit of the normal anatomical primary motor cortices although he was normally developed without hemiparesis nor aphasia. Diffusion tensor tractography showed unusual fiber radiation from the left cerebral peduncle to the much more rostral and lateral cerebral cortices compared with normal anatomy. Right finger flexion-extension task showed activation in that area on functional magnetic resonance imaging. CONCLUSIONS: Even in a congenital hemispheric dysplasia, the contralateral fine finger movement may still depend on the dysplastic hemisphere. On the other hand, speech and the other gross movements including leg, foot, and arm can be compensated with the ipsilateral normal cerebral cortices.


Assuntos
Dedos/fisiologia , Lateralidade Funcional/fisiologia , Córtex Motor/fisiopatologia , Movimento/fisiologia , Imagem de Tensor de Difusão , Humanos , Imageamento por Ressonância Magnética , Masculino , Córtex Motor/diagnóstico por imagem , Adulto Jovem
18.
Sci Rep ; 10(1): 6341, 2020 04 14.
Artigo em Inglês | MEDLINE | ID: mdl-32286380

RESUMO

The ratio between the length of second and fourth digits (2D:4D) is a putative biomarker for prenatal testosterone and estrogen exposure. The aim of the study was to examine the association between 2D:4D and women's general and reproductive health. This analysis was conducted within a prospective pregnancy cohort study. The study population included 187 women. 2D:4D was measured directly in both hands using a digital caliper. Multivariable linear and logistic models were used to study the associations between digit ratio and the studied health characteristics. Mean age of the participants was 30.7 ± 4.9 years. The mean age at menarche was 12.9 ± 1.4 years. Right hand 2D:4D mean ± SD was 0.965 ± 0.03. Left hand 2D:4D mean ± SD was 0.956 ± 0.03. An association was found between right 2D:4D and age at menarche, with older age in women with 2D:4D ≥ mean versus 2D:4D < mean (13.2 ± 1.5 and 12.8 ± 1.3 respectively, b = 0.48, 95%CI:0.06-0.91) while controlling for ethnicity. Higher 2D:4D was also associated with heavier menses bleeding and dysmenorrhea. There is an association between 2D:4D and sub optimal reproductive characteristics, including later age at menarche, heavier menses bleeding and dysmenorrhea. These findings support the association between the intrauterine period and reproductive characteristics. Further studies are required to support our findings.


Assuntos
Dedos/fisiologia , Menarca/fisiologia , Reprodução/fisiologia , Adolescente , Adulto , Idoso , Antropometria/métodos , Criança , Estudos de Coortes , Estrogênios/sangue , Feminino , Dedos/anatomia & histologia , Humanos , Menarca/sangue , Gravidez , Estudos Prospectivos , Reprodução/genética , Testosterona/sangue
19.
JAMA Netw Open ; 3(4): e202064, 2020 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-32242908

RESUMO

Importance: Atrial fibrillation (AF) affects more than 6 million people in the United States; however, much AF remains undiagnosed. Given that more than 265 million people in the United States own smartphones (>80% of the population), smartphone applications have been proposed for detecting AF, but the accuracy of these applications remains unclear. Objective: To determine the accuracy of smartphone camera applications that diagnose AF. Data Sources and Study Selection: MEDLINE and Embase were searched until January 2019 for studies that assessed the accuracy of any smartphone applications that use the smartphone's camera to measure the amplitude and frequency of the user's fingertip pulse to diagnose AF. Data Extraction and Synthesis: Bivariate random-effects meta-analyses were constructed to synthesize data. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) of Diagnostic Test Accuracy Studies reporting guideline. Main Outcomes and Measures: Sensitivity and specificity were measured with bivariate random-effects meta-analysis. To simulate the use of these applications as a screening tool, the positive predictive value (PPV) and negative predictive value (NPV) for different population groups (ie, age ≥65 years and age ≥65 years with hypertension) were modeled. Lastly, the association of methodological limitations with outcomes were analyzed with sensitivity analyses and metaregressions. Results: A total of 10 primary diagnostic accuracy studies, with 3852 participants and 4 applications, were included. The oldest studies were published in 2016 (2 studies [20.0%]), while most studies (4 [40.0%]) were published in 2018. The applications analyzed the pulsewave signal for a mean (range) of 2 (1-5) minutes. The meta-analyzed sensitivity and specificity for all applications combined were 94.2% (95% CI, 92.2%-95.7%) and 95.8% (95% CI, 92.4%-97.7%), respectively. The PPV for smartphone camera applications detecting AF in an asymptomatic population aged 65 years and older was between 19.3% (95% CI, 19.2%-19.4%) and 37.5% (95% CI, 37.4%-37.6%), and the NPV was between 99.8% (95% CI, 99.83%-99.84%) and 99.9% (95% CI, 99.94%-99.95%). The PPV and NPV increased for individuals aged 65 years and older with hypertension (PPV, 20.5% [95% CI, 20.4%-20.6%] to 39.2% [95% CI, 39.1%-39.3%]; NPV, 99.8% [95% CI, 99.8%-99.8%] to 99.9% [95% CI, 99.9%-99.9%]). There were methodological limitations in a number of studies that did not appear to be associated with diagnostic performance, but this could not be definitively excluded given the sparsity of the data. Conclusions and Relevance: In this study, all smartphone camera applications had relatively high sensitivity and specificity. The modeled NPV was high for all analyses, but the PPV was modest, suggesting that using these applications in an asymptomatic population may generate a higher number of false-positive than true-positive results. Future research should address the accuracy of these applications when screening other high-risk population groups, their ability to help monitor chronic AF, and, ultimately, their associations with patient-important outcomes.


Assuntos
Fibrilação Atrial/diagnóstico , Confiabilidade dos Dados , Determinação da Frequência Cardíaca/instrumentação , Smartphone/instrumentação , Adulto , Idoso , Idoso de 80 Anos ou mais , Fibrilação Atrial/epidemiologia , Coleta de Dados/métodos , Feminino , Dedos/fisiologia , Humanos , Hipertensão/epidemiologia , Hipertensão/fisiopatologia , Masculino , Programas de Rastreamento/métodos , Pessoa de Meia-Idade , Aplicativos Móveis/estatística & dados numéricos , Valor Preditivo dos Testes , Sensibilidade e Especificidade , Estados Unidos/epidemiologia
20.
J Orthop Surg Res ; 15(1): 121, 2020 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-32238189

RESUMO

BACKGROUND: Flexor digitorum superficialis (FDS) muscle provides dynamic stabilization and medial elbow support for ulnar collateral ligament (UCL). The FDS contraction significantly affects the medial joint distance (MJD) through grip contraction. However, it remains unclear whether FDS activity alone contributes to medial elbow stability, or together with the activation of the flexor digitorum profundus during grip contraction, and which finger's FDS is the main contributor to elbow stability. We investigated the resistive effects of isolated FDS contraction in individual fingers against valgus stress in the elbow joint using stress ultrasonography (US). METHODS: We investigated 17 healthy males (mean age, 27 ± 5 years). Valgus stress US was performed using the Telos device, with the elbow at 30° flexion. MJD was measured for each arm during 3 separate conditions: at rest (unloaded), under valgus load (50 N) (loaded), and under valgus load with FDS contracted in individual fingers (loaded-contracted). RESULTS: MJD was significantly longer when loaded (5.4 ± 0.4 mm) than unloaded (4.1 ± 0.2 mm, P = 0.007) or loaded-contracted (4.6 ± 0.3 mm, P = 0.003) for each finger. When loaded-contracted, MJD differed statistically between the index and ring fingers (P = 0.03) and between the middle and ring fingers (P = 0.04). However, the difference between the index and middle fingers was not statistically significant (P = 0.08). CONCLUSIONS: Individual FDS contraction, particularly of the index and middle fingers, contributes most to stabilization against valgus stress. Thus, injury care programs should incorporate FDS exercises of these fingers.


Assuntos
Ligamento Colateral Ulnar/fisiologia , Articulação do Cotovelo/fisiologia , Dedos/fisiologia , Força da Mão/fisiologia , Contração Muscular/fisiologia , Músculo Esquelético/fisiologia , Adulto , Ligamento Colateral Ulnar/diagnóstico por imagem , Articulação do Cotovelo/diagnóstico por imagem , Feminino , Dedos/diagnóstico por imagem , Humanos , Masculino , Músculo Esquelético/diagnóstico por imagem , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA