Universidad latinoamericana y el derecho social a la salud / The Latin-American University and the Social Right to Health

Este artículo se presenta en la sección de Conferencias Magistrales por ser el texto de una conferencia dictada en la IV Conferencia Internacional Educación Médica en el Siglo xxi durante la IV Convención Internacional de Salud, La Habana, octubre de 2022. Se ha mantenido su carácter de discurso oral. Se aborda el tema universidad latinoamericana y el derecho social a la salud, al considerar la relevancia de la salud en el desarrollo social y económico de la población y al tomar en cuenta la importancia de formar recursos humanos comprometidos con la salud como un derecho social, un bien público y una responsabilidad del Estado. Esto permite analizar críticamente el espacio de la salud pública y la formación de los recursos humanos en el siglo xx y el inicio del siglo xxi para aportar a la demanda de una nueva dimensión estratégica que responda, de forma comprometida, a las necesidades y prioridades de salud de nuestras poblaciones(AU)

This article is presented in the Keynote Lectures section because it is the text of a lecture given at the IV International Conference on Medical Education in the 21st Century during the IV International Health Convention, Havana, October 2022. It has been kept as an oral text. The topic on the Latin-American university and the social right to health is addressed, considering the relevance of health in the social and economic development of the population, as well as taking into account the importance of training human resources committed to health as a social right, a public good, and a responsibility of the State. This allows to analyze critically the public health space and the training of human resources in the twentieth century and the beginning of the twenty-first century, in order to contribute to the demand for a new strategic dimension that responds, in a committed manner, to the health needs and priorities of our populations(AU)

Fatores sociodemográficos e via de parto: revisão sistemática / Sociodemographic factors and type of delivery: systematic review / Factores sociodemográficos y tipo de parto: revisión sistemática

Objetivo: identificar os fatores sociodemográficos associados à via de parto. Método: trata-se de revisão sistemática com busca nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde, PubMed e Cochrane em maio de 2021. O protocolo do estudo foi registrado na PROSPERO sob o nº CRD42021257340. Os artigos selecionados foram posteriormente analisados pelos sistemas Joanna Briggs Institute e Sistema Grading of Recommendations Assessment, Development and Evaluation. Resultados: mulheres com maior nível socioeconômico, maior nível de escolaridade, com idade acima de 35 anos e parto em instituições privadas possuem maior chance de realizar cesariana comparado ao parto vaginal. A qualidade da evidência para variável de prestador hospitalar foi baixa, para idade e escolaridade materna a qualidade é moderada e classe econômica a qualidade é alta. Conclusões: os fatores sociodemográficos contribuem para o aumento da taxa de cesárea e reforçam o cenário encontrado na literatura.

Objective: to identify the sociodemographic factors associated with the mode of delivery. Method: this is a systematic review with a search in the Latin American and Caribbean Literature on Health Sciences, PubMed and Cochrane databases in May 2021. The study protocol was registered with PROSPERO under number CRD42021257340. The selected articles were analyzed by the Joanna Briggs Institute and the Grading System of Recommendations Assessment, Development and Evaluation systems. Results:women with a higher socioeconomic level, higher education, aged over 35 years and private institutions have a greater chance of having a cesarean section compared to the vaginal level. The quality of quality of quality for the service provider variable was low and the quality of maternal schooling is low and the quality of economic class is high. Conclusion: Sociodemographic conclusions in the literature.

Objetivo: identificar los factores sociodemográficos asociados a la modalidad de parto. Método: se trata de una revisión sistemática con búsqueda en las bases de datos Literatura Latinoamericana y del Caribe en Ciencias de la Salud, PubMed y Cochrane en mayo de 2021. El protocolo de estudio fue registrado en PROSPERO con el número CRD42021257340. Los artículos seleccionados fueron analizados por el Instituto Joanna Briggs y los sistemas Grading System of Recommendations Assessment, Development and Evaluation. Resultados: las mujeres con mayor nivel socioeconómico, educación superior, mayores de 35 años e instituciones privadas tienen mayor probabilidad de tener una cesárea en comparación con el nivel vaginal. La calidad de calidad de calidad para la variable proveedor de servicios fue baja y la calidad de escolaridad materna es baja y la calidad de clase económica es alta.

Change in the pattern of frailty among socially vulnerable older adults over a 36-month period and associated factors: a follow-up study / Mudança do padrão de fragilidade entre idosos socialmente vulneráveis no período de 36 meses e fatores associados: um estudo de seguimento

OBJECTIVE: To investigate changes in the frailty levels of older adults in a context of high social vulnerability. METHODS: We conducted a prospective cohort study. Data were collected from 2 surveys conducted in 2015 and 2018. The frailty phenotype and sociodemographic and health characterization instruments were used. Descriptive statistical analysis was performed, including non-parametric tests, test for equality of proportions, and multivariate multinomial logistic regression. The use of the database was authorized, and the research was approved by the Ethics Committee. RESULTS: In 2015, 346 community-dwelling older adults participated in the study. After 36 months, a final sample of 223 participants was obtained. In 2015, the prevalence of non-frail, pre-frail, and frail older adults was 13.0%, 56.5%, and 30.5%, respectively. In 2018, 22.9% were non-frail, 56.0% were pre-frail, and 21.1% were frail. Higher education and better quality of life reduced the likelihood of becoming pre-frail and frail, respectively. CONCLUSION: There was a change in the pattern of frailty among socially vulnerable older adults over a 36-month period.

OBJETIVO: Verificar alterações nos níveis de fragilidade de pessoas idosas em contexto de alta vulnerabilidade social. METODOLOGIA: Trata-se de um estudo de coorte prospectivo. Foram coletados dados de dois inquéritos realizados em 2015 e 2018. Utilizou-se o Fenótipo de Fragilidade e instrumentos de caracterização sociodemográfica e de saúde. Análises estatísticas descritivas foram realizadas, incluindo testes não-paramétricos, teste de igualdade de proporções e regressão logística multinomial multivariada. O uso do banco de dados foi autorizado, e a pesquisa foi aprovada pelo Comitê de Ética. RESULTADOS: Em 2015, 346 idosos comunitários participaram do estudo. Após o período de 36 meses, obteve-se uma amostra final de 223 participantes. Em 2015, a prevalência de não frágeis, pré-frágeis e frágeis foi de 13,0, 56,5 e 30,5%, respectivamente. Em 2018, 22,9% eram não frágeis, 56,0% pré-frágeis e 21,1% frágeis. Maior escolaridade e qualidade de vida diminuíram a probabilidade de se tornar pré-frágil e frágil, respectivamente. CONCLUSÃO: Observou-se uma mudança do padrão de fragilidade entre idosos socialmente vulneráveis no período de 36 meses.

Trends in Cardiovascular Risk Factors in US Adults by Race and Ethnicity and Socioeconomic Status, 1999-2018.

Importance: After decades of decline, the US cardiovascular disease mortality rate flattened after 2010, and racial and ethnic differences in cardiovascular disease mortality persisted. Objective: To examine 20-year trends in cardiovascular risk factors in the US population by race and ethnicity and by socioeconomic status. Design, Setting, and Participants: A total of 50 571 participants aged 20 years or older from the 1999-2018 National Health and Nutrition Examination Surveys, a series of cross-sectional surveys in nationally representative samples of the US population, were included. Exposures: Calendar year, race and ethnicity, education, and family income. Main Outcomes and Measures: Age- and sex-adjusted means or proportions of cardiovascular risk factors and estimated 10-year risk of atherosclerotic cardiovascular disease were calculated for each of 10 two-year cycles. Results: The mean age of participants ranged from 49.0 to 51.8 years and the proportion of women from 48.2% to 51.3% in the surveys. From 1999-2000 to 2017-2018, age- and sex-adjusted mean body mass index increased from 28.0 (95% CI, 27.5-28.5) to 29.8 (95% CI, 29.2-30.4); mean hemoglobin A1c increased from 5.4% (95% CI, 5.3%-5.5%) to 5.7% (95% CI, 5.6%-5.7%) (both P < .001 for linear trends). Mean serum total cholesterol decreased from 203.3 mg/dL (95% CI, 200.9-205.8 mg/dL) to 188.5 mg/dL (95% CI, 185.2-191.9 mg/dL); prevalence of smoking decreased from 24.8% (95% CI, 21.8%-27.7%) to 18.1% (95% CI, 15.4%-20.8%) (both P < .001 for linear trends). Mean systolic blood pressure decreased from 123.5 mm Hg (95% CI, 122.2-124.8 mm Hg) in 1999-2000 to 120.5 mm Hg (95% CI, 119.6-121.3 mm Hg) in 2009-2010, then increased to 122.8 mm Hg (95% CI, 121.7-123.8 mm Hg) in 2017-2018 (P < .001 for nonlinear trend). Age- and sex-adjusted 10-year atherosclerotic cardiovascular disease risk decreased from 7.6% (95% CI, 6.9%-8.2%) in 1999-2000 to 6.5% (95% CI, 6.1%-6.8%) in 2011-2012, then did not significantly change. Age- and sex-adjusted body mass index, systolic blood pressure, and hemoglobin A1c were consistently higher, while total cholesterol was lower in non-Hispanic Black participants compared with non-Hispanic White participants (all P < .001 for group differences). Individuals with college or higher education or high family income had consistently lower levels of cardiovascular risk factors. The mean age- and sex-adjusted 10-year risk of atherosclerotic cardiovascular disease was significantly higher in non-Hispanic Black participants compared with non-Hispanic White participants (difference, 1.4% [95% CI, 1.0%-1.7%] in 1999-2008 and 2.0% [95% CI, 1.7%-2.4%] in 2009-2018]). This difference was attenuated (-0.3% [95% CI, -0.6% to 0.1%] in 1999-2008 and 0.7% [95% CI, 0.3%-1.0%] in 2009-2018) after further adjusting for education, income, home ownership, employment, health insurance, and access to health care. Conclusions and Relevance: In this serial cross-sectional survey study that estimated US trends in cardiovascular risk factors from 1999 through 2018, differences in cardiovascular risk factors persisted between Black and White participants; the difference may have been moderated by social determinants of health.

Epidemiology, risk factors, social determinants of health, and current management for non-alcoholic fatty liver disease in sub-Saharan Africa.

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease globally and is estimated to affect approximately 25% of the world's population. Data about the prevalence and incidence of NAFLD in Africa are scarce, but the prevalence is estimated to be 13·5% for the general population. This is likely to be an underestimate considering the increasing burden of non-communicable diseases, particularly the rising prevalence of obesity and type 2 diabetes, driven by the overlapping challenges of food insecurity, nutritional transition, and associated increased consumption of calorie-dense foods. Establishing the true prevalence of NAFLD, raising public awareness around the risk factors behind the increase in NAFLD, and proactively addressing all components of metabolic syndrome will be important to combat this silent epidemic, which will have long-term health-care costs and economic consequences for the region.

Sociodemographic index and global trends in prostate cancer: 1990-2017.

BACKGROUND: Considered globally, prostate cancer is a disease of the aging male that increases in prevalence with exposure to screening and diagnostic testing, and which requires a population with the health and longevity to encounter it. The Global Burden of Disease (GBD) dataset is an aggregation of worldwide registries and health data systems that reports global and regional assessment of disease impact. METHODS: Using the GBD database, 1171 worldwide registries and health registration systems from 1990 to 2016 were aggregated for prostate cancer disease codes and outcomes. Disease-Adjusted Life Years (DALYs) were calculated and segregated by sociodemographic index (SDI) quintile, and compared to other urologic diseases and tuberculosis (TB). RESULTS: Prostate cancer exerts a burden of disease that is vastly higher in the top quintile of SDI. The three lowest SDI quintiles represent the majority of global population but are currently less impacted by prostate cancer. Conversely, TB has its highest impact on the lowest SDI levels, although these rates are declining. CONCLUSIONS: As a global disease, prostate cancer predominantly affects high SDI men who enjoy a longer life expectancy in which to suffer from this disease and a greater exposure to screening and diagnosis. As lower SDI men are elevated in health and income, reallocation of DALYs will occur, and a greater burden of prostate cancer can be expected. These epidemiologic trends have great implications for the allocation of resources, as the population of men affected by prostate cancer outpaces urologic workforce growth.

Health disparities: Intracellular consequences of social determinants of health.

Health disparities exist dependent on socioeconomic status, living conditions, race/ethnicity, diet, and exposures to environmental pollutants. Herein, the various exposures contributing to a person's exposome are collectively considered social determinants of health (SDOH), and the SDOH-exposome impacts health more than health care. This review discusses the extent of evidence of the physiologic consequences of these exposures at the intracellular level. We consider how the SDOH-exposome, which captures how individuals live, work and age, induces cell processes that modulate a conceptual "redox rheostat." Like an electrical resistor, the SDOH-exposome, along with genetic predisposition and age, regulate reductive and oxidative (redox) stress circuits and thereby stimulate inflammation. Regardless of the source of the SDOH-exposome that induces chronic inflammation and immunosenescence, the outcome influences cardiometabolic diseases, cancers, infections, sepsis, neurodegeneration and autoimmune diseases. The endogenous redox rheostat is connected with regulatory molecules such as NAD+/NADH and SIRT1 that drive redox pathways. In addition to these intracellular and mitochondrial processes, we discuss how the SDOH-exposome can influence the balance between metabolism and regulation of immune responsiveness involving the two main molecular drivers of inflammation, the NLRP3 inflammasome and NF-κB induction. Mitochondrial and inflammasome activities play key roles in mediating defenses against pathogens and controlling inflammation before diverse cell death pathways are induced. Specifically, pyroptosis, cell death by inflammation, is intimately associated with common disease outcomes that are influenced by the SDOH-exposome. Redox influences on immunometabolism including protein cysteines and ion fluxes are discussed regarding health outcomes. In summary, this review presents a translational research perspective, with evidence from in vitro and in vivo models as well as clinical and epidemiological studies, to outline the intracellular consequences of the SDOH-exposome that drive health disparities in patients and populations. The relevance of this conceptual and theoretical model considering the SARS-CoV-2 pandemic are highlighted. Finally, the case of asthma is presented as a chronic condition that is modified by adverse SDOH exposures and is manifested through the dysregulation of immune cell redox regulatory processes we highlight in this review.

The effect of smoking on cumulative damage in systemic lupus erythematosus: An incident cohort study.

OBJECTIVES: To investigate the relationship between smoking history and pack-year exposure on the rate of end-organ damage in systemic lupus erythematosus (SLE). METHODS: The SLE incident cohort included patients who met American College of Rheumatology (ACR) 1997 or SLE International Collaborating Clinics (SLICC) 2012 SLE criteria and had rheumatology encounters at a US academic institution (2008-16). The primary outcome was median time to SLICC/ACR damage index (SLICC/ACR-DI) increase or death. Main explanatory variables were smoking status and pack-years. Covariates included age, sex, race, ethnicity, receipt of Medicaid, neighborhood area deprivation index, and baseline SLE damage. Damage increase-free survival was evaluated by smoking status and pack-years using Kaplan-Meier and Cox proportional hazards methods. RESULTS: Patients of Black race and Medicaid recipients were more commonly current smokers (p's < 0.05). Former smokers were older and more likely to have late-onset SLE (54% versus 33% of never and 29% of current smokers, p = 0.001). Median time to SLICC/ACR-DI increase or death was earlier in current or former compared to never smokers (4.5 and 3.4 versus 9.0 yrs; p = 0.002). In multivariable models, the rate of damage accumulation was twice as fast in current smokers (HR 2.18; 1.33, 3.57) and smokers with a >10 pack-year history (HR 2.35; 1.15, 3.64) versus never smokers. CONCLUSIONS: In this incident SLE cohort, past or current smoking predicted new SLE damage 4-5 years earlier. After adjustment, current smokers and patients with a pack-year history of >10 years accumulated damage at twice the rate of never smokers.

Association Between Social Determinants of Health and Postoperative Outcomes in Patients Undergoing Single-Level Lumbar Fusions: A Matched Analysis.

STUDY DESIGN: Retrospective cohort. OBJECTIVE: The aim of this study was to analyze association between social determinants of health (SDH) disparity on postoperative complication rates, and 30-day and 90-day all-cause readmission in patients undergoing single-level lumbar fusions. SUMMARY OF BACKGROUND DATA: Decreasing postoperative complication rates is of great interest to surgeons and healthcare systems. Postoperative complications are associated with poor convalescence, inferior patient reported outcomes measures, and increased health care resource utilization. Better understanding of the association between Social Determinants of Health (SDH) on postoperative outcomes maybe helpful to decrease postoperative complication rates. METHODS: MARINER 2020, an all-payer claims database, was utilized to identify patients undergoing single-level lumbar fusions between 2010 and 2018. The primary outcomes were the rates of any postoperative complication, symptomatic pseudarthrosis, need for revision surgery, or 30-day and 90-day all-cause readmission. RESULTS: The exact matched population analyzed in this study contained 16,560 patients (8280 [50.0%] patients undergoing single-level lumbar fusion with an SDH disparity; 8280 [50.0%] patients undergoing single-level lumbar fusion without a disparity). Both patient groups were balanced at baseline. The rate of symptomatic pseudarthrosis (1.0% vs. 0.6%, P < 0.05) or any postoperative complication (16.3% vs. 10.4%, P < 0.05) in the matched analysis was higher in the disparity group. The presence of a disparity was associated with 70% increased odds of developing any complication (OR 1.7, 95% CI 1.53-1.84) or symptomatic pseudarthrosis (OR 1.7, 95% CI 1.17-2.37). Unadjusted and adjusted sensitivity analyses yielded similar results as the primary analysis. CONCLUSION: Social Determinants of Health affect outcomes in spine surgery patients and are associated with an increased risk of developing postoperative complications following lumbar spine fusion.Level of Evidence: 3.

Quantifying the collective influence of social determinants of health using conditional and cluster modeling.

OBJECTIVES: Our objective was to analyze the collective effect of social determinants of health (SDoH) on lumbar spine surgery outcomes utilizing two different statistical methods of combining variables. METHODS: This observational study analyzed data from the Quality Outcomes Database, a nationwide United States spine registry. Race/ethnicity, educational attainment, employment status, insurance payer, and gender were predictors of interest. We built two models to assess the collective influence of SDoH on outcomes following lumbar spine surgery-a stepwise model using each number of SDoH conditions present (0 of 5, 1 of 5, 2 of 5, etc) and a clustered subgroup model. Logistic regression analyses adjusted for age, multimorbidity, surgical indication, type of lumbar spine surgery, and surgical approach were performed to identify the odds of failing to demonstrate clinically meaningful improvements in disability, back pain, leg pain, quality of life, and patient satisfaction at 3- and 12-months following lumbar spine surgery. RESULTS: Stepwise modeling outperformed individual SDoH when 4 of 5 SDoH were present. Cluster modeling revealed 4 distinct subgroups. Disparities between the younger, minority, lower socioeconomic status and the younger, white, higher socioeconomic status subgroups were substantially wider compared to individual SDoH. DISCUSSION: Collective and cluster modeling of SDoH better predicted failure to demonstrate clinically meaningful improvements than individual SDoH in this cohort. Viewing social factors in aggregate rather than individually may offer more precise estimates of the impact of SDoH on outcomes.

Lifestyle-Related Determinants of Obesity Among Omani Children.

OBJECTIVES: This study aimed to examine the relationship between body mass index (BMI) z-scores and lifestyle-related factors including nutrition, physical activity, screen time and time spent sleeping in 6-10-year-old Omani children. METHODS: This cross-sectional study included mother-child dyads that were recruited from five provinces in Oman. Children's BMI measurements and questionnaires on nutrition intake, physical activity, screen time and time spent sleeping and a single-day dietary recall were collected. RESULTS: A total of 197 dyads were included in this study. The children's mean age was 7.7 ± 1.6 years and 53% were female. In this study, 17.4% of the children were classified as overweight or obese. No significant relationship was found between the children's BMI z-scores and nutrition intake, moderate-to-vigorous physical activity time or screen time (P ≥0.05). Increased time spent sleeping at night was positively associated with childhood obesity (P <0.05). CONCLUSION: The relationship between obesity and caloric intake, physical activity and screen time among children younger than 10 years seems to be moderated by certain factors that need to be investigated. Qualitative studies and questionnaires that are culturally sensitive are therefore needed.

Impact of Multiple Social Determinants of Health on Incident Stroke.

BACKGROUND AND PURPOSE: Social determinants of health (SDOH) have been previously associated with incident stroke. Although SDOH often cluster within individuals, few studies have examined associations between incident stroke and multiple SDOH within the same individual. The objective was to determine the individual and cumulative effects of SDOH on incident stroke. METHODS: This study included 27 813 participants from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study, a national, representative, prospective cohort of black and white adults aged ≥45 years. SDOH was the primary exposure. The main outcome was expert adjudicated incident stroke. Cox proportional hazards models examined associations between incident stroke and SDOH, individually and as a count of SDOH, adjusting for potential confounders. RESULTS: The mean age was 64.7 years (SD 9.4) at baseline; 55.4% were women and 40.4% were blacks. Over a median follow-up of 9.5 years (IQR, 6.0-11.5), we observed 1470 incident stroke events. Of 10 candidate SDOH, 7 were associated with stroke (P<0.10): race, education, income, zip code poverty, health insurance, social isolation, and residence in one of the 10 lowest ranked states for public health infrastructure. A significant age interaction resulted in stratification at 75 years. In fully adjusted models, among individuals <75 years, risk of stroke rose as the number of SDOH increased (hazard ratio for one SDOH, 1.26 [95% CI, 1.02-1.55]; 2 SDOH hazard ratio, 1.38 [95% CI, 1.12-1.71]; and ≥3 SDOH hazard ratio, 1.51 [95% CI, 1.21-1.89]) compared with those without any SDOH. Among those ≥75 years, none of the observed effects reached statistical significance. CONCLUSIONS: Incremental increases in the number of SDOH were independently associated with higher incident stroke risk in adults aged <75 years, with no statistically significant effects observed in individuals ≥75 years. Targeting individuals with multiple SDOH may help reduce risk of stroke among vulnerable populations.

Risk Factors for Heart Failure: 20-Year Population-Based Trends by Sex, Socioeconomic Status, and Ethnicity.

BACKGROUND: There are multiple risk factors for heart failure, but contemporary temporal trends according to sex, socioeconomic status, and ethnicity are unknown. METHODS: Using a national UK general practice database linked to hospitalizations (1998-2017), 108 638 incident heart failure patients were identified. Differences in risk factors among patient groups adjusted for sociodemographic factors and age-adjusted temporal trends were investigated using logistic and linear regression. RESULTS: Over time, a 5.3 year (95% CI, 5.2-5.5) age difference between men and women remained. Women had higher blood pressure, body mass index, and cholesterol than men (P<0.0001). Ischemic heart disease prevalence increased for all to 2006 before reducing in women by 0.5% per annum, reaching 42.7% (95% CI, 41.7-43.6), but not in men, remaining at 57.7% (95% CI, 56.9-58.6; interaction P=0.002). Diabetes mellitus prevalence increased more in men than in women (interaction P<0.0001). Age between the most deprived (74.6 years [95% CI, 74.1-75.1]) and most affluent (79.9 [95% CI, 79.6-80.2]) diverged (interaction P<0.0001), generating a 5-year gap. The most deprived had significantly higher annual increases in comorbidity numbers (+0.14 versus +0.11), body mass index (+0.14 versus +0.11 kg/m2), and lower smoking reductions (-1.2% versus -1.7%) than the most affluent. Ethnicity trend differences were insignificant, but South Asians were overall 6 years and the black group 9 years younger than whites. South Asians had more ischemic heart disease (+16.5% [95% CI, 14.3-18.6]), hypertension (+12.5% [95% CI, 10.5-14.3]), and diabetes mellitus (+24.3% [95% CI, 22.0-26.6]), and the black group had more hypertension (+12.3% [95% CI, 9.7-14.8]) and diabetes mellitus (+13.1% [95% CI, 10.1-16.0]) but lower ischemic heart disease (-10.6% [95% CI, -13.6 to -7.6]) than the white group. CONCLUSIONS: Population groups show distinct risk factor trend differences, indicating the need for contemporary tailored prevention programs.

Association of the Robert Wood Johnson Foundations' social determinants of health and Medicare hospitalisations for ischaemic strokes: a cross-sectional data analysis.

Objective: Social determinants of health (SDH) have previously demonstrated to be important risk factors in determining health outcomes. To document whether the SDH are associated with hospitalisations for ischaemic stroke. Methods: This cross-sectional study examines data from fiscal year 2015. Patients from the national Medicare 100% Inpatient Limited Dataset were linked with SDH measures from the Robert Wood Johnson Foundation (RWJF) County Health Rankings. Medicare patients were included in the study group if they had either an admitting or primary diagnosis of ischaemic stroke. Counties without RWJF data were excluded from the study. Ischaemic strokes were compared with all other hospitalisations associated with characteristics of the SDH measures and benchmarked to above or below their respective national median. Estimates were performed with nested logistic regression. Results: Approximately 256 766 Medicare patients had ischaemic stroke hospitalisations compared with all other Medicare patients (n=6 386 180) without ischaemic stroke hospitalisations while 30 853 patients were excluded due to residence in US territories. Significant factors included air pollution exceeding the national median (OR 1.06; 95% CI 1.05 to 1.07), per cent of children in single parent households exceeding the national median, (OR 1.02; 95% CI 1.01 to 1.03), violent crime rates exceeding the national median, (OR 1.02; 95% CI 1.01 to 1.03) and per cent smoking exceeding the national median, (OR 1.02; 95% CI 1.01 to 1.03). Conclusions: When cross-sectional SDH are benchmarked to national median for ischaemic stroke hospitalisations and compared with all-cause hospitalisations, the effects remain significant. Further research on the longitudinal effects of the SDH and cardiovascular health, particularly disease-specific outcomes, is needed.

Tendencia del bajo peso al nacer en recién nacidos a término y su relación con la pobreza y el desarrollo municipal en Colombia. 2000-2014 / Tendency of low birth weight in full-term newborns and its relationship with poverty and municipal development in Colombia. 2000-2014

El objetivo del estudio fue describir las prevalencias de bajo peso al nacer a término y las desigualdades socio-geográficas entre los municipios y regiones de Colombia. Se realizó un estudio ecológico longitudinal a partir de los registros de estadísticas vitales del Departamento Administrativo Nacional de Estadística (DANE) de 1096 municipios de Colombia entre los años 2000 y 2014. La población de estudio fueron 7.514.492 nacidos vivos a término, de partos de único feto de madres entre 15 a 45 años. Se ajustó un modelo jerárquico bayesiano para la estimación de riesgos relativos suavizados y sus intervalos de credibilidad (95%). Como resultados se encontró que la prevalencia de bajo peso al nacer en Colombia fue de 2,28 (2,26-2,29), con una tendencia a la reducción pasando de 2,80 en el 2000 a 1.79 en el 2014. Se observaron desigualdades territoriales, en donde los municipios más pobres y menos desarrollados mostraron mayores riesgos de bajo peso al nacer a término, tendencia que se mantuvo a lo largo del periodo analizado. En conclusión, existe una tendencia a la disminución de bajo peso al nacer a término en Colombia, para cada una de sus regiones y un gradiente social negativo.

The objective of the study was to describe the prevalence of term low birth weight and the relationship with sociogeographical inequalities between the municipalities and regions of Colombia. A longitudinal ecological study was carried out based on the vital statistics records of the National Administrative Department of Statistics (DANE) of 1096 Colombian municipalities between 2000 and 2014. The study population was 7,514,492 live births at term, from deliveries to mothers between 15 and 45 years old. A Bayesian hierarchical model was adjusted for the estimation of smoothed relative risks and their credibility intervals (95%). The prevalence of term low birth weight in Colombia was 2.28 (2.26-2.29), with a tendency to decrease from 2.80 in 2000 to 1.79 in 2014. Territorial inequalities were observed, where poorer and less developed municipalities showed greater risks of term low birth weight, a trend that was maintained throughout the period analyzed. In conclusion, term low birth weight is decreasing in Colombia overall and in each of its regions, with a negative social gradient.

Race and socioeconomic differences associated with endovascular peripheral vascular interventions for newly diagnosed claudication.

BACKGROUND: Despite guidelines cautioning against the use of endovascular peripheral vascular interventions (PVI) for claudication, more than 1.3 million PVI procedures are performed annually in the United States. We aimed to describe national rates of PVI for claudication, and identify patient and county-level risk factors associated with a high rate of PVI. METHODS: We used the Medicare claims database to identify all Medicare beneficiaries with a new diagnosis of claudication between January 2015 and June 2017. A hierarchical logistic regression model accounting for patient age, sex, comorbidities; county region and setting; and a patient race-county median income interaction was used to assess the associations of race and income with a high PVI rate. RESULTS: We identified 1,201,234 patients with a new diagnosis of claudication for analysis. Of these, 15,227 (1.27%) underwent a PVI. Based on hierarchical logistic regression accounting for patient and county-level factors, black patients residing in low-income counties had a significantly higher odds of undergoing PVI than their white counterparts (odds ratio [OR], 1.30; 95% confidence interval [CI], 1.20-1.40), whereas the odds of PVI for black versus white patients was similar in high-income counties (OR, 1.06; 95% CI, 0.99-1.14). PVI rates were higher for low versus high-income counties in both the black (OR, 1.46; 95% CI, 1.31-1.64) and white (OR, 1.19; 95% CI, 1.12-1.27) groups. There were no significant associations of Hispanic, Asian, North American native, or other races with PVI in either low- or high-income counties after risk adjustment (all P ≥ .09). CONCLUSIONS: In the Medicare population, the mean rate of PVI of 12.7 per 1000 claudication patients varies significantly based on race and income. Our data suggest there are racial and socioeconomic differences in the treatment of claudication across the United States.

Black Race as a Social Determinant of Health and Outcomes After Lumbar Spinal Fusion Surgery: A Multistate Analysis, 2007 to 2014.

STUDY DESIGN: A retrospective analysis of patient hospitalization and discharge records. OBJECTIVE: To examine the association between race and inpatient postoperative complications following lumbar spinal fusion surgery. SUMMARY OF BACKGROUND DATA: Racial disparities in healthcare have been demonstrated across a range of surgical procedures. Previous research has identified race as a social determinant of health that impacts outcomes after lumbar spinal fusion surgery. However, these studies are limited in that they are outdated, contain data from a single institution, analyze small limited samples, and report limited outcomes. Our study aims to expand and update the literature examining the association between race and inpatient postoperative complications following lumbar spine surgery. METHODS: We analyzed 267,976 patient discharge records for inpatient lumbar spine surgery using data from the Healthcare Cost and Utilization Project's State Inpatient Databases for California, Florida, New York, Maryland, and Kentucky from 2007 through 2014. We used unadjusted bivariate analysis, adjusted multivariable, and stratified analysis to compare patient demographics, present-on-admission comorbidities, hospital characteristics, and complications by categories of race/ethnicity. RESULTS: Black patients were 8% and 14% more likely than white patients to experience spine surgery specific complications (adjusted odds ratios [aOR]: 1.08, 95% confidence interval [CI]: 1.03-1.13) and general postoperative complications (aOR: 1.14, 95% CI: 1.07-1.20), respectively. Black patients, compared with white patients, also had increased adjusted odds of 30-day readmissions (aOR: 1.13, 95% CI: 1.07-1.20), 90-day readmissions (aOR: 1.07, 95% CI: 1.02-1.13), longer length of stay (LOS) (adjusted Incidence Rate Ratio: 1.15, 95% CI: 1.14-1.16), and higher total charges (adjusted Incidence Rate Ratio: 1.08, 95% CI: 1.07-1.09). CONCLUSION: Our findings demonstrate that black patients, as compared with white patients, are more likely to have postoperative complications, longer postoperative lengths of stay, higher total hospital charges, and increased odds of 30- and 90-day readmissions following lumbar spinal fusion surgery. LEVEL OF EVIDENCE: 4.

Tendência das iniquidades sociais nas notificações de violência sexual no Brasil entre 2010 e 2014 / Trend of social iniquities in reports of sexual violence in Brazil between 2010 and 2014

RESUMO: Introdução: A violência sexual tem despontado no cenário da saúde com as mudanças nos perfis epidemiológicos das populações. Metodologia: Estudo ecológico com 5.565 municípios brasileiros entre 2010 e 2014. Realizou-se análise descritiva das variáveis (taxa populacional de notificação de violência sexual, renda domiciliar per capita e índice de desenvolvimento humano - IDH) e suas estratificações por quintil. Para explorar os fatores associados às mudanças nas desigualdades sociais na taxa de notificação de violência sexual, foram adotados o coeficiente angular de desigualdade e o índice relativo de desigualdade. Construiu-se equiplot para o desfecho em cada variável independente. Resultados: A taxa média de notificações de violência sexual no Brasil foi de 4,38 notificações/100 mil habitantes para o período. Houve incremento na taxa de violência e melhoria nas condições socioeconômicas. Observou-se maior taxa de notificações no quintil com melhores condições de vida, bem como aumento na desigualdade da taxa de notificações de violência sexual em função da renda domiciliar e do IDH. Diversos fatores parecem influenciar o aumento das notificações de violência sexual no país. Entre eles, destacam-se a melhoria nas condições de vida da população e a maior sensibilidade moral à violência, contudo ainda há disparidade de notificações entre os municípios de acordo com sua condição socioeconômica. Conclusão: A falta de políticas públicas de equidade social em saúde tem interferido nas notificações de violência sexual no país e ampliado as iniquidades em saúde.

ABSTRACT: Introduction: Sexual violence has emerged in the health field with changes in the epidemiological profiles of populations. Methodology: An ecological study with 5,565 Brazilian municipalities between 2010 and 2014. A descriptive analysis of the variables (Population rate of sexual violence reporting, household income per capita and HDI) and their stratification by quintile was performed. In order to explore the factors associated with changes in social inequalities regarding the rate of reporting of sexual violence, the Slope Index of Inequality and Relative Index of Inequality were adopted. An Equiplot was constructed for the outcome on each independent variable. Results: The mean rate of reports of sexual violence in Brazil was 4.38 reports/100,000 inhabitants for the period. There was an increase in the rate of sexual violence and improvement in socioeconomic conditions. There was a higher rate of reporting in the quintile with better living conditions. An increase in the inequality of the rate of sexual violence as a function of household income and the HDI was observed. Several factors seem to influence the increase of reports of sexual violence in the country, among them the improvement in the living conditions of the population and greater moral sensitivity to violence. However, there is still a disparity in reporting among municipalities according to their socioeconomic status. Conclusion: The lack of public policies on social equity in health has interfered with reports of sexual violence in the country and has widened health inequities.

Determinantes sociales del consumo de alcohol en adolescentes del Colegio Daniel Córdova de Cuenca: estudio transversal, 2016 / Social determinants of alcohol consumption in adolescents from Daniel Cordova High School in Cuenca: cross sectional study, 2016

Introduction: the alcohol consumption in adolescence is frequent and it is associated with social determinants. The objective of the study was to determine the prevalence of alcohol consumption in adolescents of the Daniel Córdova High School in Cuenca - Ecuador and its association with some social determinants.Methods: it is a cross-sectional study, with a sample of 218 adolescents. A questionnaire for demo-graphic variables, family structure and migration was used to determine the prevalence of alcohol consumption, the diagnostic criteria of the DSM5 was used to identify the family functioning of the FF-SIL Test and for the lifestyle the FANTASTIC test was applied. The PR was obtained with its confidence intervals to control if the social determinants were a risk or protection factor for the alcohol consumption, and the statistical significance was determined with values of p <0.05.Results: the prevalence of alcohol consumption was 42.2%; a total of 56% of the students come from a "nuclear home", the 55% have a migrant relative, 39% have a good lifestyle and 50% be-long to families qualified as moderately functional. There is a statistically significant association with the fact of having a migrant family member, having a bad lifestyle and belonging to a reconstituted and dysfunctional family.Conclusion: the prevalence of alcohol consumption is higher than those reported in other studies carried out in Cuenca city high schools; It is associated with similar social determinants globally.(AU).

Introducción: el consumo de alcohol en la adolescencia es frecuente y se encuentra asociado a determinantes sociales. El objetivo de nuestro estudio fue determinar la prevalencia de consumo de alcohol en los adoles-centes del colegio "Daniel Córdova" de Cuenca ­ Ecuador y su asociación con algunos determinantes sociales.Métodos: estudio transversal, en una muestra de 218 adolescentes. Se usó un cuestionario para las variables demográficas, estructura familiar y migración; para determinar la prevalencia de consumo de alcohol se usó los criterios diagnósticos del DSM5, para identificar el funcionamiento fa-miliar el Test FF-SIL y para el estilo de vida el test FANTASTIC. Se obtuvo la RP con sus intervalos de confianza para determinar si los determinantes sociales fueron factor de riesgo o de protección para el consumo de alcohol y la significancia estadística se determinó con valores de p<0.05. Resultados: la prevalencia del consumo de alcohol fue del 42.2 %; el 56% de los estudiantes provienen de un "hogar nuclear", el 55% tienen algún fa-miliar migrante, el 39% tienen un buen estilo de vida y el 50% pertenecen a familias calificadas como moderadamente funcionales y existe asociación estadísticamente significativa con el hecho de tener un familiar migrante, poseer un mal estilo de vida y pertenecer a una familia reconstituida y disfuncional. Conclusión: la prevalencia del consumo de alcohol es mayor que los re-portados en otros estudios realizados en colegios de la ciudad de Cuenca y se asocia con determinantes sociales similares a nivel global.(AU).

Social determinants of health and vulnerabilities to sexually transmitted infections in adolescents / Determinantes sociales de la salud y vulnerabilidades a las infecciones sexualmente transmisibles en adolescentes / Determinantes sociais de saúde e vulnerabilidades às infecções sexualmente transmissíveis em adolescentes

ABSTRACT Objective: To verify the association between social determinants of health and the vulnerability of adolescents to Sexually Transmitted Infections (STIs). Method: Cross-sectional study, performed with 287 students aged 11 to 17 years, in the outskirts of Fortaleza, Ceará, Brazil, from August do September 2016. Two instruments were used, one destined to social determinants of health and another to investigating the vulnerability to STIs. The magnitude of associations was expressed through odds ratio and interval of confidence, considering a 5% significance level. This research was approved by the Research Ethics Committee of the Federal University of Ceará. Results: 212 (73.9%) adolescents were considered more vulnerable, with a score ≥ 4. The intermediate social determinant "housing (home ownership)" obtained significant association with with the vulnerability to STIs (p of 0.022; CI 1.1 to 3.3; OR 1.9). Conclusion: The intermediate social determinant "type of housing" influences the vulnerability to STAs.

RESUMEN Objetivo: Comprobar si hay una asociación entre los determinantes sociales de la salud y la vulnerabilidad de los adolescentes a las Infecciones Sexualmente Transmisibles (IST). Método: Estudio transversal, realizado de agosto a septiembre de 2016 con 287 estudiantes de 11 a 17 años, en la periferia de Fortaleza, Ceará, Brasil. Se utilizaron dos instrumentos: el primer estaba destinado a los determinantes sociales de la salud y segundo al estudio de la vulnerabilidad a las IST. La magnitud de las asociaciones se calculó mediante la razón de posibilidades e intervalo de confianza, considerando el nivel de significancia del 5%. La investigación fue aprobada por el Comité de Ética de la Universidad Federal de Ceará. Resultados: Se consideraron más vulnerables a 212 (un 73,9%) adolescentes, con una calificación ≥ 4 puntuaciones. El determinante social intermedio "vivienda (casa propia)" obtuvo una asociación significativa con la vulnerabilidad a las IST (p de 0,022; IC 1,1 a 3,3; OR 1,9). Conclusión: El determinante social intermedio "tipo de vivienda" influye en la vulnerabilidad a las IST.

RESUMO Objetivo: Verificar a associação entre os determinantes sociais de saúde e a vulnerabilidade dos adolescentes às Infecções Sexualmente Transmissíveis (ISTs). Método: Estudo transversal, realizado com 287 escolares de 11 a 17 anos, na periferia de Fortaleza, Ceará, Brasil, de agosto a setembro de 2016. Foram utilizados dois instrumentos, um destinado aos determinantes sociais de saúde e o outro à investigação da vulnerabilidade às ISTs. A magnitude das associações foi expressa através da razão de chances e intervalo de confiança, considerando-se nível de significância de 5%. A pesquisa foi aprovada pelo Comitê de Ética da Universidade Federal do Ceará. Resultados: 212 (73,9%) adolescentes foram considerados mais vulneráveis, com uma pontuação ≥ 4 escores. O determinante social intermediário "moradia (casa própria)" obteve associação significativa com a vulnerabilidade às ISTs (p de 0,022; IC 1,1 a 3,3; OR 1,9). Conclusão: O determinante social intermediário "tipo de moradia" influencia na vulnerabilidade às ISTs.