RESUMO
Laryngeal leishmaniasis is an unusual form of the disease. We report the case of a patient who consulted for dysphonia and dysphagia in a context of asthenia and weight loss. The patient had lesions that were suggestive of laryngeal cancer but were revealed to be leishmaniasis by histopathology examination and polymerase chain reaction. Treatment with amphotericin B and miltefosine permitted complete resolution of the lesions and no recurrence during the 18-month follow-up period.
Assuntos
Transtornos de Deglutição , Disfonia , Laringe , Leishmaniose , Idoso , Anfotericina B/uso terapêutico , Antiprotozoários/uso terapêutico , Transtornos de Deglutição/etiologia , Transtornos de Deglutição/parasitologia , Diagnóstico Diferencial , Disfonia/etiologia , Disfonia/parasitologia , Humanos , Neoplasias Laríngeas/diagnóstico , Laringe/parasitologia , Laringe/patologia , Leishmaniose/complicações , Leishmaniose/diagnóstico , Leishmaniose/tratamento farmacológico , Leishmaniose/patologia , Masculino , Fosforilcolina/análogos & derivados , Fosforilcolina/uso terapêuticoAssuntos
Disfonia/diagnóstico , Disfonia/parasitologia , Leishmania infantum , Leishmaniose Mucocutânea/diagnóstico , Idoso , Progressão da Doença , Disfonia/patologia , Doenças Endêmicas , França/epidemiologia , Humanos , Leishmania infantum/fisiologia , Leishmaniose Mucocutânea/parasitologia , Leishmaniose Visceral/epidemiologia , Masculino , FumantesRESUMO
We present a case of a man in his late 60s, who had spent 3-4â months of the year in rural Spain, presenting with intermittent hoarseness of voice. He had a background of asthma and bronchiectasis, and was taking inhaled corticosteroids. His dysphonia was initially managed as bronchiectasis with little improvement. Bronchoscopy revealed a cystic lesion on his left vocal fold, and tissue biopsy revealed Leishmania amastigotes. This confirmed a diagnosis of laryngeal leishmaniasis. We propose that this is likely secondary to his inhaled corticosteroid therapy. The infection was treated with a 30-day course of miltefosine, and at most recent follow-up the patient was deemed free from leishmanial infection.