Constituição psíquica e linguística de um sujeito com transtorno do espectro do autismo imerso em uma família vulnerável pela imigração no pós-guerra / Psychic and linguistic constitution of a subject with autism spectrum disorder immersed in a family vulnerable by post-war immigration / Constitución psíquica y lingüística de un sujeto con trastorno del espectro autismo inmerso en una familia vulnerable por inmigración de posguerra

Introdução: este artigo apresenta a constituição psíquica e linguística de um jovem autista, proveniente de uma família de imigrantes em situação de pós-guerra, em que entram em questão temas como o luto, a constituição psíquica transgeracional, e a presença de angústias no processo de desenvolvimento da criança em uma situação singular que é a presença do autismo. Objetivo: analisar os efeitos singulares da imigração e multiculturalismo em um caso de autismo e sua evolução terapêutica. Método: estudo de caso longitudinal, que utilizou diário clínico e filmagens de sessões com observações do desenvolvimento de Rafael, desde os dezoito meses até a idade adulta. Como abordagem terapêutica e análise dos resultados, foram utilizados aportes da constituição psíquica da teoria psicanalítica, e sobre o desenvolvimento linguístico em uma perspectiva enunciativa. Resultados: O multiculturalismo acarretava um desafio maior ao processo de aquisição da linguagem por parte da criança com autismo, enquanto o silêncio consequente da dor do luto, presente nos adultos, dificultava a troca verbal e atrasava sua constituição psíquica. O autismo, por sua vez, apresentou-se como transtornos qualitativos na comunicação, necessitando maior investimento por parte de seus cuidadores para que a aquisição da linguagem se desse, pois o paciente precisou ser fisgado para a nossa cultura. Conclusão: Diante de todo esse quadro, o caso clínico demonstra a importância do suporte terapêutico à família e do investimento contínuo na subjetivação, considerando e valorizando os diferentes códigos culturais que compõem o núcleo familiar. (AU)

Introduction: this article presents the psychic and linguistic constitution of an autistic young man, from a post-war immigrant family, in which themes such as mourning, the transgenerational psychic constitution, and the presence of anxieties in the process come into question of the child development in a unique situation that is the presence of autism. Objective: to analyze the unique effects of immigration and multiculturalism in a case of autism and its therapeutic evolution. Method: longitudinal case study, which used a clinical diary and footage of sessions with observations of the development of R. from eighteen months to adulthood. As a therapeutic approach and analysis of results, contributions from the psychic constitution of psychoanalytic theory, and on linguistic development in an enunciative perspective, were used. Results: Multiculturalism posed a greater challenge to the process of language acquisition by the child with autism, while the consequent silence of the pain of grief, present in adults, hindered verbal exchange and delayed their psychic constitution. Autism, in turn, presented itself as qualitative disorders in communication, requiring greater investment on the part of its caregivers for the acquisition of language to take place, as it needed to be hooked for our culture. Conclusion: Given this situation, this clinical case demonstrates the importance of therapeutic support to the family and the continuous investment in subjectivity, considering and valuing the different cultural codes that make up the family nucleus. (AU)

Introducción: este artículo presenta la constitución psíquica y lingüística de un joven autista, proveniente de una familia inmigrante de posguerra, en la que se cuestionan temas como el luto, la constitución psíquica transgeneracional y la presencia de ansiedades en el proceso del desarrollo del niño en una situación única que es la presencia del autismo. Objetivo: analizar los efectos singulares de la inmigración y la multiculturalidad en un caso de autismo y su evolución terapéutica. Método: estudio de caso longitudinal, que utilizó un diario clínico y metraje de sesiones con observaciones del desarrollo de R. desde los dieciocho meses hasta la edad adulta. Como abordaje terapéutico y análisis de resultados se utilizaron aportes desde la constitución psíquica de la teoría psicoanalítica y sobre el desarrollo lingüístico en perspectiva enunciativa. Resultados: El multiculturalismo supuso un mayor desafío al proceso de adquisición del lenguaje por parte del niño con autismo, mientras que el consiguiente silencio del dolor del duelo, presente en los adultos, dificultó el intercambio verbal y retrasó su constitución psíquica. El autismo, a su vez, se presentó como un trastorno cualitativo en la comunicación, requiriendo una mayor inversión por parte de sus cuidadores para que se produjera la adquisición del lenguaje, pues necesitaba engancharse a nuestra cultura. Conclusión: Ante esta situación, este caso clínico demuestra la importancia del apoyo terapéutico a la familia y la continua inversión en la subjetividad, considerando y valorando los diferentes códigos culturales que conforman el núcleo familiar. (AU)

Expectativas de mães e cuidadoras sobre participação em um programa de prevenção à violência / Expectations of mothers/caregivers regarding the participation in a violence prevention program / Expectativas de madres/cuidadoras sobre la participación en un programa de prevención de la violencia

O presente estudo qualitativo objetivou compreender as expectativas de mães e cuidadoras sobre a sua participação no Programa ACT para Educar Crianças em Ambientes Seguros na versão remota, no período da pandemia de covid-19. Também visou identificar a percepção das participantes sobre educar uma criança em um ambiente seguro. Foram realizadas entrevistas semiestruturadas on-line com doze mães e cuidadoras, antes da participação no Programa ACT. Os resultados indicaram diferentes expectativas sobre a participação no Programa ACT, entre elas: adquirir novos conhecimentos, aprimorar as habilidades parentais, trocar experiências, receber auxílio no momento da pandemia de covid-19 e possibilitar para a criança um desenvolvimento saudável. Na percepção das mães e cuidadoras, a versão remota do Programa ACT apresenta aspectos positivos; entre eles, a participação de pais e cuidadores que não residem na cidade em que é oferecida a intervenção. No entanto, apontaram como fatores negativos a ausência do contato físico e as interrupções que podem acontecer a partir das falhas de internet. Para as mães e cuidadoras, educar a criança em um ambiente seguro estava relacionado a promover os direitos estabelecidos no Estatuto da Criança e do Adolescente (ECA), como educação, saúde, lazer, cuidado, afeto, assim como protegê-la de situações de violência. Considera-se que as expectativas das participantes estavam alinhadas aos objetivos do Programa ACT. Torna-se prioritário oferecer programas de prevenção à violência aos pais e cuidadores, em especial em momentos adversos como o da pandemia de covid-19, a fim de promover o desenvolvimento e a saúde das crianças, assim como prevenir situações de violação de direitos.(AU)

This qualitative study aims to understand the expectations of mothers and caregivers about participating in the ACT Raising Safe Kids Program in its remote version, during the COVID-19 pandemic period. It also aims to identify the participants' perception of raising a child in a safe environment. Semi-structured on-line interviews were conducted with 12 mothers/caregivers, prior to participation in the ACT Program. The results indicated different expectations regarding the participation in the ACT Program, for example: acquiring new knowledge, improving parenting skills, exchanging experiences, receiving support during the COVID-19 pandemic, and enabling the child to have a healthy development. In the perception of mothers and caregivers, the remote version of the ACT Program has positive aspects, such as the participation of parents and caregivers who do not live in the city where the intervention is offered. However, they pointed out as negative factors absence of physical contact and interruptions due to internet failures. For the mothers/caregivers, educating children in a safe environment was related to promoting the rights established by the Brazilian Child and Adolescent Statute, namely education, health, leisure, care, affection, as well as protecting them from situations of violence. The expectations of the participants were aligned with the objectives of the ACT Program. Offering violence prevention programs to parents and caregivers is a priority, especially in adverse moments such as the COVID-19 pandemic, in order to promote the development and health of children, as well as prevent situations of violation of rights.(AU)

Este estudio cualitativo pretendió comprender las expectativas de madres y cuidadoras sobre la participación en el Programa de ACT para Educar a Niños en Ambientes Seguros en la versión remota, en el periodo de la pandemia de la COVID-19. También se propuso identificar la percepción de las participantes sobre educar a un niño en un ambiente seguro. Se llevaron a cabo entrevistas semiestructuradas en línea con 12 madres/cuidadoras, antes de la participación en el Programa ACT. Los resultados señalaron diferentes expectativas con la participación del Programa de ACT, entre ellas: adquirir nuevos conocimientos, perfeccionar las habilidades parentales, intercambiar experiencias, recibir auxilio en el momento de la pandemia de la COVID-19 y posibilitar al niño un desarrollo saludable. En la percepción de las madres y cuidadoras, la versión remota del Programa de ACT presenta aspectos positivos, como la participación de padres y cuidadores que no residen en la ciudad donde es ofrecida la intervención. Sin embargo, señalaron como factores negativos la ausencia del contacto físico y las interrupciones, que pueden ocurrir por fallas en Internet. Para las madres/cuidadoras, educar al niño en un ambiente seguro estaba relacionado a promover los derechos establecidos en el Estatuto del Niño y del Adolescente de Brasil, como educación, salud, ocio, cuidado, afecto, así como protegerlo de situaciones de violencia. Se considera que las expectativas de las participantes estaban alineadas con los objetivos del Programa de ACT. Es prioritario ofrecer programas de prevención a la violencia a los padres y cuidadores, en especial en momentos adversos como el de la pandemia de la COVID-19, con el fin de promover el desarrollo y la salud de los niños, así como prevenir situaciones de vulneración de derechos.(AU)

Prevenção do suicídio: esquecimento do ser e era da técnica / Suicide prevention: forgetfulness of being and technical era / Prevención del suicidio: olvido del ser y la era de la técnica

Martin Heidegger, em sua ontologia, destaca uma característica específica da atualidade que atravessa o comportamento humano, na filosofia, na ciência ou no senso comum: o esquecimento do ser. O filósofo diferencia a época atual das demais épocas históricas. O horizonte histórico contemporâneo se desvela por meio do desafio e da exploração, da tentativa de controle e domínio dos acontecimentos, ao modo da disponibilidade e em função da produtividade. O filósofo esclarece que todo esse desenraizamento do homem atual está atrelado ao esquecimento daquilo que é o mais essencial, qual seja, a existência. A questão que norteia este estudo é apurar, por meio das referências de Heidegger e dos estudos sobre suicídio, o quanto a interpretação da morte voluntária nos dias atuais está atravessada por tal esquecimento. Pretendemos investigar o quanto as ações de prevenção desenvolvidas pela suicidologia se encontram atravessadas por tal esquecimento do ser do homem e, dessa forma, acabam por estabelecer relações entre ser e ente em uma consequente redução ao ente como invariante e atemporal. O caminho para investigar a questão iniciará por abordar, em maiores detalhes, a analítica existencial, a questão da técnica e o movimento de esquecimento do ser apontados por Heidegger a fim de problematizar as perspectivas científicas atuais sobre o suicídio em sua prevenção para, então, estabelecer uma compreensão fenomenológica e existencial sobre o referido fenômeno.(AU)

Martin Heidegger, in his ontology, highlights a specific characteristic of the present moment that crosses human behavior, in philosophy, science, or common sense: the forgetfulness of being. The philosopher differentiates the current age from other historical ages. The contemporary historical horizon is unveiled by the challenge and the exploration, from the attempt to control and dominate events, to the mode of standing reserve and in terms of productivity. The philosopher clarifies that all this uprooting of the current man is linked to the forgetfulness of what is the most essential, namely, the existence itself. The question that guides this study is to investigate, via Heidegger's references and studies on suicide, to what extent the interpretation of voluntary death today is crossed by such forgetfulness. We intend to investigate to what extent the prevention actions developed by suicidology are crossed by such forgetfulness of the human's being and, in this way, they end up establishing relationships between being and entity in a consequent reduction to entity as an invariant and timeless. The path to investigate the issue will start by addressing, in greater detail, the existential analytics, the question concerning technique and the movement of forgetting the being pointed out by Heidegger to problematize the current scientific perspectives on suicide and its prevention to, then, propose a phenomenological and existential understanding about the referred phenomenon.(AU)

Martin Heidegger en su ontología destaca una característica específica del presente que atraviesa el comportamiento humano, ya sea en la filosofía, la ciencia o el sentido común: el olvido del ser. El filósofo diferencia la época actual de otras épocas históricas. El horizonte histórico contemporáneo se devela el desafío y la exploración, el intento de controlar y dominar los eventos, en la modalidad de disponibilidad y en términos de productividad. Y así aclara que todo este desarraigo del hombre actual está involucrado en el olvido de lo más esencial, que es la existencia misma. A partir de las referencias a Heidegger y de los estudios sobre el suicidio, este estudio busca saber hasta qué punto la interpretación de la muerte voluntaria hoy está atravesada por este olvido. Pretendemos investigar en qué medida las acciones de prevención desarrolladas por la suicidología se encuentran atravesadas por el olvido del ser del hombre y, de esta manera, terminan por establecer relaciones entre el ser y el ente, en una consecuente reducción al ente como invariante y atemporal. Para investigar el tema se abordará inicialmente, con mayor detalle, la analítica existencial, la cuestión de la técnica y el movimiento del olvido del ser señalado por Heidegger para problematizar las perspectivas científicas actuales sobre el suicidio y su prevención y, luego, proponer una comprensión fenomenológica y existencial sobre el referido fenómeno.(AU)

Psicologia, Conselho Federal de Psicologia e covid-19: enfrentamento às desigualdades psicossociais no Brasil / Psychology, FCP, and covid-19: facing the psychosocial inequalities in Brazil / Psicología, Consejo Federal de Psicología y covid-19: enfrentando las desigualdades psicosociales en Brasil

A pandemia da covid-19 impôs transformações no cotidiano mundial, em âmbito micro e macroestrutural. Seu impacto psicológico desestabiliza e evidencia desigualdades e vulnerabilidades psicossociais brasileiras. Configura-se como um estudo de perspectiva crítica, com base na Psicologia Sócio-histórica, com o objetivo de mapear os posicionamentos da Psicologia, vindos de diferentes campos, diante das ações de saúde mental. Para tanto, utiliza-se o site do Conselho Federal de Psicologia para a análise de 62 documentos, que resultaram em dois eixos de produção crítica: 1) a relação da Psicologia com o Conselho Federal de Psicologia; e 2) da Psicologia com a sociedade. Revela-se o abismo social entre segmentos da sociedade brasileira; formas de exclusão da população carcerária; violência doméstica contra as mulheres e as crianças; dificuldades de acesso a estratégias sociais, na educação e na saúde, e de superação dos impasses acirrados com a infecção global pelo novo coronavírus. Conclui-se que a diversidade de públicos, temáticas, áreas de atuação e referenciais teóricos materializa um compromisso crítico e científico da Psicologia.(AU)

The COVID-19 pandemic imposed transformations in the world daily life, at the micro and macrostructural levels. Its psychological impact destabilizes and highlights Brazilian inequalities and psychosocial vulnerabilities. This is a critical perspective study, based in socio-historical Psychology, aiming to map the positions of Psychology, from different fields, in the face of mental health actions. To this end, the Federal Council of Psychology website is utilized to analyze 62 documents, which resulted in two axes of critical production: 1) the relation between Psychology and the Federal Council of Psychology; and 2) Psychology with society. They reveal the social gap between segments of Brazilian society; ways of excluding prison po7pulation; domestic violence against women and children; and difficulties in accessing social strategies, in education and health, and in overcoming impasses aggravated by the global infection by the new coronavirus. In conclusion, the diversity of public, themes, areas of professional performance, and theoretical references materialize Psychology's critical and scientific commitment.(AU)

La pandemia del COVID-19 provocó transformaciones globales en lo cotidiano a nivel micro y macroestructural. Su impacto psicológico desestabiliza y destaca las desigualdades y vulnerabilidades psicosociales en Brasil. Esta es una investigación en la perspectiva crítica, basada en la psicología sociohistórica, con el objetivo de mapear las posiciones de la Psicología, procedentes de diferentes campos, frente a las acciones de salud mental. Para este fin, se utiliza el sitio web del Consejo Federal de Psicología para el análisis de 62 documentos, lo que resultó en dos ejes de producción crítica: 1) la relación de la Psicología con el Consejo Federal de Psicología; y 2) de la Psicología con la sociedad. Se revelan la brecha social entre los segmentos de la sociedad brasileña; las formas de exclusión de la población carcelaria; la violencia doméstica contra las mujeres y los niños; y las dificultades para acceder a las estrategias sociales, en la educación y la salud, para superar los impasses agravados por la infección global por el nuevo coronavirus. Se concluye que la diversidad de públicos, temáticas, áreas de actividad y referentes teóricos materializa un compromiso crítico y científico de la Psicología.(AU)

Understanding the impact of complicated grief on combat related posttraumatic stress disorder, guilt, suicide, and functional impairment in a clinical trial of post-9/11 service members and veterans.

BACKGROUND: Complicated grief (CG) is a bereavement-specific syndrome distinct from but commonly comorbid with posttraumatic stress disorder (PTSD). While bereavement is common among military personnel (Simon et al., 2018), there is little research on the impact of CG comorbidity on PTSD treatment outcomes. METHODS: To evaluate the impact of comorbid CG on PTSD treatment outcomes we analyzed data from a randomized trial comparing prolonged exposure, sertraline, and their combination in veterans with a primary diagnosis of combat-related PTSD (n = 194). Assessment of PTSD, trauma-related guilt, functional impairment, and suicidal ideation and behavior occurred at baseline and weeks 6, 12, and 24 during the 24-week trial. RESULTS: CG was associated with lower PTSD treatment response (odds ratio (OR) = 0.29, 95% confidence interval (CI) [0.12, 0.69], p = 0.005) and remission (OR = 0.28, 95% CI [0.11, 0.71], p = 0.007). Those with CG had greater severity of PTSD (p = 0.005) and trauma-related guilt (<0.001) at baseline and endpoint. In addition, those with CG were more likely to experience suicidal ideation during the study (CG: 35%, 14/40 vs. no CG 15%, 20/130; OR = 3.01, 95% CI [1.29, 7.02], p = 0.011). CONCLUSIONS: Comorbid CG is associated with elevated PTSD severity and independently associated with poorer endpoint treatment outcomes in veterans with combat-related PTSD, suggesting that screening and additional intervention for CG may be needed.

Trauma: um estudo sobre a inibição generalizada (ou econômica) / Trauma: a study on generalized (or economic) inhibition / Trauma: un estudio sobre la inhibición generalizada (o económica) / Traumatisme: une étude sur l'inhibition généralisée (ou économique)

Freud descreveu, em seu trabalho "Inibição, sintoma e angústia" (1926/2014b), duas formas de inibição da ação: uma relacionada à evitação da reatualização de conflitos psíquicos, da instauração de um novo ato de recalcamento e da emissão de angústia-sinal (inibição específica); outra conexa a situações de empobrecimento de energia disponível no eu (inibição generalizada). Os autores do presente artigo buscam aprofundar a descrição do mecanismo metapsicológico do segundo tipo de inibição - ao qual propõem a designação alternativa de "inibição econômica" -, baseando-se, para isso, no modelo de trauma desenvolvido por Freud em "Além do princípio do prazer" (1920/2010c). Essa forma de inibição é uma medida emergencial do eu cuja finalidade é alterar o gerenciamento de energia em favor de tarefas psíquicas prioritárias, que demandam elevado custo energético para sua realização.

In the work "Inhibition, Symptom and Anguish" (1926/2014b), Freud described two forms of action inhibition: one related to the avoidance of the re-actualization of psychic conflicts, the establishment of a new act of repression and the emission of signal anguish ( specific inhibition); another related to situations of energy depletion available in the self (generalized inhibition). The authors of this paper seek to deepen the description of the meta-psychological mechanism of the second type of inhibition - which they propose the alternative designation of "economic inhibition" - based on Freud's trauma model in "Beyond the Principle of pleasure" (1920/2010c). This form of inhibition is an emergency measure of the self whose purpose is to alter energy management in favor of priority psychic tasks that demand a high energy cost to accomplish.

Freud describió, en su trabajo "Inhibición, síntoma y angustia" (1926/2014b), dos formas de inhibición de la acción: una relacionada a la evitación de la reactualización de conflictos psíquicos, de la implantación de un nuevo acto de represión y de la emisión de señal de angustia (inhibición específica); otra en conexión con situaciones de empobrecimiento de energía disponible en el yo (inhibición generalizada). Los autores de este trabajo buscan profundizar la descripción del mecanismo metapsicológico del segundo tipo de inhibición - a lo cual proponen la designación alternativa de "inhibición económica"-, basándose, para eso, en el modelo de trauma desarrollado por Freud en "Más allá del principio del placer" (1920/2010c). Esta forma de inhibición es una medida de emergencia del yo cuya finalidad es alterar la gestión de energía en favor de tareas psíquicas prioritarias, que demandan elevado coste energético para su realización.

Freud a décrit dans son œuvre "Inhibition, Symptôme et Angoisse" (1926/2014b) deux catégories de l'inhibition de l'action: une liée à éviter réactualiser les conflits psychiques, de l'instauration d'un nouveau acte de répression et de l'émission de l'angoisse-signe (inhibition spécifique); l'autre liée aux situations appauvrissement de l'énergie disponible en soi (inhibition généralisée). Les auteurs du présent article cherchent approfondir la description du mécanisme métapsychologie du second type d'inhibition - auquel ils proposent la désignation alternative « inhibition économique ¼. À cause de cela, ils se son basés dans le modèle de traumatisme développé par Freud dans «Au delà du principe de plaisir ¼ (1920/2010c). Cette forme d'inhibition est une mesure d'urgence chez le soi dont le but est de modifier la gestion de l'énergie en faveur de tâches psychiques prioritaires, lesquelles nécessitent un coût énergétique élevé.

Gulf War Illnesses are autoimmune conditions caused by the direct effect of the nerve gas prophylaxis drug (pyridostigmine bromide) on anergic immune system lymphocytes.

Immune system dysregulation in 1991 Gulf War Veterans was caused in part by the nerve gas prophylactic drug pyridostigmine bromide (PB) by direct agonist activation of muscarinic receptors on anergic B and T lymphocytes, leading to multiple types of autoimmune illnesses, and this effect may have been potentiated by combat stress.

Hermann Oppenheim, a pioneer of modern German neurology / Hermann Oppenheim, um pioneiro da moderna neurologia alemã

Hermann Oppenheim (1858-1919) was a leading fgure of the modern German neurology. In spite of the antisemitic ofcial policy, besides his complex personality, he had achieved widespread recognition of his professional qualifcation that attracted neurologists from all around the world to his private clinic. However, he did not held prominent positions at University milieu, in spite of being the main assistant to Karl Westphal (1833­1890) at the Charité-Hospital, in Berlin. Oppenheim was the author of an encyclopedic book of neurology titled "Lehrbuch der Nervenkrankheiten für Ärzte und Studierende" ("Textbook of Nervous Diseases for Doctors and Students"), frst ed., 1894. He also published signifcant works on several disorders, including "traumatic neurosis" (1889) that was criticized by Jean-Martin Charcot (1825­1893), among others. He was clinically responsible for the frst successful removal of brain tumors, including pineal tumor. He coined the term "dystonia musculorum deformans", and he led to several other achievements such as amyotonia congenita ("Oppenheim's disease"), besides Oppenheim's reflex.

Hermann Oppenheim (1858-1919) foi uma fgura importante da moderna neurologia alemã. Apesar da política ofcial anti-semita, além de sua personalidade complexa, ele alcançou amplo reconhecimento de sua qualifcação profssional que atraiu neurologistas de todo o mundo para sua clínica particular. No entanto, ele não ocupou posições de destaque no meio universitário, apesar de ser o principal assistente de Karl Westphal (1833-1890) no Charité-Hospital, em Berlim. Oppenheim foi o autor de um livro enciclopédico de neurologia intitulado "Lehrbuch der Nervenkrankheiten für Ärzte und Studierende" ("Livro Didático de Doenças Nervosas para Médicos e Alunos"), editado em 1894. Ele também publicou trabalhos signifcativos sobre vários distúrbios, incluindo "neurose traumática" ( 1889) que foi criticado por Jean-Martin Charcot (1825­1893), entre outros. Ele foi clinicamente responsável pela primeira remoção bem sucedida de tumores cerebrais, incluindo o tumor pineal. Ele cunhou o termo "distonia musculorumdeformans" e levou a outras várias conquistas como a amiotonia congênita ("doença de Oppenheim"), além do reflexo de Oppenheim.

Relations of combat stress and posttraumatic stress disorder to 24-h plasma and cerebrospinal fluid interleukin-6 levels and circadian rhythmicity.

BACKGROUND: Acute and chronic stress can lead to a dysregulation of the immune response. Growing evidence suggests peripheral immune dysregulation and low-grade systemic inflammation in posttraumatic stress disorder (PTSD), with numerous reports of elevated plasma interleukin-6 (IL-6) levels. However, only a few studies have assessed IL-6 levels in the cerebrospinal fluid (CSF). Most of those have used single time-point measurements, and thus cannot take circadian level variability and CSF-plasma IL-6 correlations into account. METHODS: This study used time-matched, sequential 24-h plasma and CSF measurements to investigate the effects of combat stress and PTSD on physiologic levels and biorhythmicity of IL-6 in 35 male study volunteers, divided in 3 groups: (PTSD = 12, combat controls, CC = 12, and non-deployed healthy controls, HC = 11). RESULTS: Our findings show no differences in diurnal mean concentrations of plasma and CSF IL-6 across the three comparison groups. However, a significantly blunted circadian rhythm of plasma IL-6 across 24 h was observed in all combat-zone deployed participants, with or without PTSD, in comparison to HC. CSF IL-6 rhythmicity was unaffected by combat deployment or PTSD. CONCLUSIONS: Although no significant group differences in mean IL-6 concentration in either CSF or plasma over a 24-h timeframe was observed, we provide first evidence for a disrupted peripheral IL-6 circadian rhythm as a sequel of combat deployment, with this disruption occurring in both PTSD and CC groups. The plasma IL-6 circadian blunting remains to be replicated and its cause elucidated in future research.

Terapias de conversão: histórico da (des)patologização das homossexualidades e embates jurídicos contemporâneos / Conversion therapies: a history of the (de)pathologization of homosexuality and contemporary legal conflicts / Terapias de conversión: histórico de la (des)patologización de las homosexualidades y los enfrentamientos legales contemporáneos

O presente artigo analisa alguns elementos concernentes ao embate atual no campo legal brasileiro em relação às "terapias de conversão". É apresentado inicialmente um breve panorama da patologização das sexualidades dissidentes para, em seguida, descrever tal processo em relação às homossexualidades em específico. Na sequência, é feita uma descrição e análise histórica das terapias de reversão da orientação sexual, em especial nos EUA e no Brasil, seguida da discussão sobre as "terapias de conversão", de base religiosa, e do enfrentamento de seus proponentes com os conselhos profissionais nestes mesmos países. Ao final, são analisados aspectos concernentes aos discursos presentes em Ação Popular recente contra a Resolução no 001/1999, do CFP, apontando-se alguns elementos para se pensar estratégias de enfrentamento da disseminação destas terapias. Dentre eles, destacam-se: a necessidade de desconstrução do argumento da liberdade individual, utilizado pelos defensores destas terapias; a problematização do uso da "ciência" como argumento central pelos conselhos de classe nesse embate jurídico, uma vez que tais práticas foram sustentadas historicamente por argumentos "científicos" de sua época; e a necessidade do debate se centralizar nas questões éticas que envolvem tais práticas a partir do conceito de laicidade, tendo em vista que os discursos jurídicos e científicos se mostraram em muitos momentos históricos inseparáveis das concepções de base religiosa.(AU)

The present article analyzes some elements concerning the current clash in the Brazilian legal field in relation to "conversion therapies". A brief overview of the pathologization of dissident sexualities is presented initially and then this process is described especially in relation to homosexuality. After this, the paper presents a description and historical analysis of sexual orientation reversion therapies, especially in the USA and Brazil, followed by the discussion of religiously based "conversion therapies" and the confrontation of their proponents with professional counseling in these countries. Finally, aspects related to the discourses present in the recent Popular Action against Resolution 001/1999 of the CFP are analyzed, pointing out some elements for the analysis of the coping strategies of the dissemination of these therapies. Among them, the following stand out: the need to deconstruct the arguments of individual freedom used by proponents of these therapies; the problematization of the use of "science" as central argument by the class councils in this juridical attack, since such practices were supported historically by "scientific" arguments of its time; and the need to focus on the ethical issues surrounding such practices, based on the concept of secularity, given that legal and scientific discourses have been shown in many historical moments inseparable from conceptions of religious basis.(AU)

El presente artículo analiza algunos elementos relacionados con el choque actual en el campo legal brasileño con respecto a las "terapias de conversión". Se presenta una breve descripción de la patologización de las sexualidades disidentes, y luego se describe en relación con homosexualidades específicas. A continuación, se presenta una descripción histórica y un análisis de las terapias de inversión de la orientación sexual, particularmente en EE. UU. y en Brasil, seguida de una discusión sobre las "terapias de conversión" basadas en la religión y la confrontación de sus defensores con los consejos profesionales en estos mismos países. Al final, se analizan aspectos relacionados con los discursos presentes en la reciente Acción Popular contra la Resolución 001/1999, del CFP señalando algunos elementos para pensar en estrategias para hacer frente a la difusión de estas terapias. Entre ellos, destacan los siguientes: la necesidad de desconstrucción del argumento de la libertad individual, utilizado por los defensores de estas terapias; la problematización del uso de la "ciencia" como argumento central por parte de los consejos de clase en este choque legal, ya que tales prácticas fueron históricamente apoyadas por argumentos "científicos" de su tiempo; y la necesidad del debate para centrarse en los problemas éticos que rodean a tales prácticas desde el concepto de secularismo, dado que los discursos legales y científicos se han mostrado en muchos momentos históricos inseparables de concepciones basadas en la religión.(AU)

Creative Minds in the Aftermath of the Great War: Four Neurologically Wounded Artists.

Many artists were involved in the First World War. Some of them were mobilized, like millions of soldiers, others enlisted to fight on the battlefield. The stories of writers who returned neurologically wounded from the war, such as Guillaume Apollinaire (1880-1918) or Blaise Cendrars (1887-1961), are well-known. The cases of painters and sculptors who suffered from First World War neurological wounds are scarce. Nevertheless, their injuries led to intense modifications of artistic practice. We detail four examples of artists whose creative mind was impacted by their First World War neurological wounds or diseases. The painter Jean-Julien Lemordant (1878-1968), who suffered from blindness after his injury, stopped his artistic work and became an icon of Franco-American friendship. The sculptor Maurice Prost (1894-1967), suffering from a neuroma due to the loss of his arm, built a special device to continue his work as a wildlife artist. The painter Georges Braque (1882-1963) was trepanned but carried on with his cubist work without ever mentioning the conflict. Conversely, the painter Fernand Léger (1881-1955), who suffered from a war neurosis, produced a significant war testimony through drawings and letters.

Specialized Palliative and Hospice Care and the Importance of Mourning Our Nation's Veterans.

One aspect of palliative medicine that has been underexplored is the perspective of veterans either facing critical life-limiting illness or at the end of life. The needs of veterans differ not only because military culture affects how veterans cope with their illness but also because exposure-related factors (combat and environmental) differ between military branches. In this paper, we describe two cases involving end-of-life care for veterans with combat trauma and describe individualized approaches to their care.

Childhood trauma, combat trauma, and substance use in National Guard and reserve soldiers.

BACKGROUND: The goal of this work was to examine associations among childhood trauma, combat trauma, and substance use (alcohol problems, frequent heavy drinking [FHD], current cigarette smoking, and current/lifetime drug use) and the interaction effects of childhood trauma and combat exposure on those associations among National Guard/reserve soldiers. METHODS: Participants (N = 248) completed an electronic survey asking questions about their military experiences, physical and mental health, and substance use. Childhood trauma and combat exposure were examined jointly in regression models, controlling for age, marital satisfaction, and number of deployments. RESULTS: Childhood trauma was associated with current drug use (trend level, odds ratio [OR] = 1.44, 95% confidence interval [CI]: 0.97, 2.14; P = .072) in the main effect model; however, there was not a significant interaction with combat. Combat exposure had a significant interaction with childhood trauma on alcohol problems (b = -0.56, 95% CI: -1.12, -0.01; P = .048), FHD (b = -0.27, 95% CI: -0.47, -0.08; P = .007), and lifetime drug use (OR = 1.78, 95% CI: 1.04, 3.04; P = .035). There were no associations with either of the trauma measures and current cigarette smoking. CONCLUSIONS: These results demonstrate that childhood and combat trauma have differential effects on alcohol use, such that combat trauma may not add to the effect on alcohol use in those with greater child maltreatment but may contribute to greater alcohol use among those with low child maltreatment. As expected, childhood and combat trauma had synergistic effects on lifetime drug use. Screening for multiple types of trauma prior to enlistment and/or deployment may help to identify at-risk individuals and allow time for early intervention to prevent future adverse outcomes.

Correlation between interferon γ and interleukin 6 with PTSD and resilience.

Posttraumatic Stress Disorder (PTSD) is a debilitating psychiatric disorder with decreased general health prognosis and increased mortality. Inflammation has been hypothesised to be a link between PTSD and the most common co-morbid medical disorders. However, the relationship between inflammation and PTSD is not clear. Individual inflammatory markers have shown variable associations with PTSD. This study investigates the correlations between serum cytokines, PTSD and resilience in a cohort of Caucasian Vietnam combat veterans (n = 299). After correction for multiple testing, PTSD severity was correlated with small but significant decreases in interleukin 6 and interferon γ (p = 0.004, p = 0.013, respectively) whereas resilience was correlated with increased levels of interleukin 6 and interferon γ (p = 0.023; p = 0.007, respectively). Analyses of sub-symptoms of PTSD revealed that mood and arousal symptoms showed the most significant effect on interleukin 6 and interferon γ. More research is needed to further elucidate the mechanisms underlying the relationship between cytokine levels, PTSD sub-symptoms and trauma outcomes to improve the knowledge base of differences in trauma response and the biological system.

Combat, Posttraumatic Stress Disorder, and Smoking Trajectory in a Cohort of Male Australian Army Vietnam Veterans.

Background: Whether trauma exposure itself or consequent posttraumatic stress disorder (PTSD) is primarily responsible for smoking and failure to quit remains unclear. Methods: A cohort of male Australian Vietnam veterans (N = 388) was interviewed twice, 22 and 36 years after their return to Australia using standardized psychiatric diagnostic and health interviews and assessment of combat exposure. The smoking trajectory over time revealed a spectrum of outcomes (never smoked, early quitters, late quitters, and continuing smokers). Analysis used multivariate statistics to assess the relative contributions of combat trauma exposure and PTSD while controlling for potential confounders. Results: The trajectory of smoking over time revealed that 21.9% of veterans had never smoked, 45.1% had quit smoking by the time of wave 1, 16.2% were current smokers at wave 1 who had quit by the time of wave 2, 2.8% were late adopters who were current smokers, and 13.9% were continuing smokers. Smoking was associated in single-predictor models with demographics, intelligence, combat exposure, PTSD symptom clusters and diagnosis, and alcohol disorders. Multivariate analysis revealed that PTSD, combat, and intelligence were related to the smoking spectrum but, after adding demographics and other Axis I psychiatric diagnoses, only combat remained significant. No PTSD symptom cluster uniquely predicted smoking status. Conclusions: The results suggest that trauma exposure in the form of military combat may be a more robust predictor of smoking status over time than PTSD. It may be stress itself, rather than poststress disorder, that is more germane to smoking and failure to quit. Implications: Exposure to traumatic stress and development of PTSD have been implicated separately in the maintenance of smoking. This longitudinal cohort study of smoking in war veterans up to three decades postwar enabled evaluation of traumatic stress exposure in combat and the course of PTSD in smoking and quitting while controlling for intelligence, background disadvantage, and other psychiatric conditions. Combat rather than PTSD emerged as more significant to smoking status, suggesting that it may be the traumatic stress itself rather than the development of a poststress disorder that is more germane to smoking in war veterans.

Cuidado de enfermería en salud mental a personas con trastorno por estrés postraumático, asociado al combate / Nursing care in mental health for people with post-traumatic stress disorder, associated with combat

Introducción: Los lectores de este documento se darán cuenta desde la primera página que la intención no es otra que la de informar, describir y proponer una estrategia de cuidado terapéutico desde enfermería en salud mental para personas con Trastorno por estrés postraumático (TEPT), cuadro clínico que adquieren los individuos que se han visto expuestos a traumas de forma directa o indirecta (Corzo & Bohórquez, 2009). Justificación: La experiencia como enfermero de servicio hospitalario en psiquiatría, mientras se cumple la práctica de atención a pacientes con trastorno psiquiátrico dentro de un equipo interdisciplinar, conduce a observar la situación de las personas con TEPT asociado al combate en crisis y procesos de recuperación, este mismo hecho es una de las grandes motivaciones para la elaboración de la presente propuesta como un aporte para el cuidado de enfermería, que favorecerá la recuperación, para que soportado en el conocimiento que transmite la disciplina y el conocimiento empírico, proponga y genere estrategias de atención guiadas al abordaje integral de las necesidades de este perfil de pacientes. Objetivo: Aportar una propuesta de cuidado de enfermería para personas con TEPT (TEPT), asociado al combate. Metodología: Comienza haciendo una revisión bibliográfica en busca de hallazgos que muestre evidencia científica sobre estrategias de intervención desde enfermería para personas diagnosticadas con TEPT Se percibe la necesidad de plantear una posible forma de intervención a la persona con diagnóstico psiquiátrico y que la propuesta sea liderada por el profesional de enfermería, se reúnen criterios de significancia y pertinencia disciplinar porque es un paso hacia la apertura de áreas de intervención respaldada conceptual y teóricamente, además con sistema de registro que facilita la determinación del impacto en un campo de acción donde está presente enfermería, hay un déficit de propuestas e información en las publicaciones consultadas; Esta propuesta es una forma de intervención que puede ser utilizada por el profesional de enfermería, sin necesidad de tener especialidad académica en el área, recurso que se instaura debido a la notoria dificultad de contar con profesionales especializados en el área de salud mental y psiquiatría. Conclusiones: En este trabajo se propone una estrategia de intervención desde enfermería enmarcada en el Modelo de Relaciones Interpersonales de Hildegard Peplau, partiendo desde un diagnóstico NANDA de enfermería que es el de Síndrome Postraumático, se complementa con una intervención de asesoramiento en el proceso de restablecimiento de la salud mental mediante un tratamiento de ayuda interactiva centrado en las necesidades y sentimientos del paciente para fomentar o apoyar la capacidad de resolver problemas y las relaciones interpersonales, utilizando como medio de interacción la técnica de remotivación, haciendo uso de los resultados de la valoración con taxonomía NOC, en el dominio de estrés. Recomendaciones: Queda la invitación para que esta idea se aplique a la vida real por cualquier enfermero, para que se dé un paso más adelante con la utilización en la práctica, para poder identificar impacto, generar resultados, crear instrumentos y hacer seguimiento; esta propuesta no debe quedarse en el papel, o en trabajo escrito porque se desaprovecharía una oportunidad de comenzar a materializar lo que se escribe con lo que se hace.

Introduction: Readers of this document realize from the first page that they have no intention other than to inform, present and propose a strategy of therapeutic care of mental illness in people with Post Traumatic Stress Disorder (PTSD). to individuals who have been exposed to trauma directly or indirectly (Corzo and Bohórquez, 2009). Justification: The experience as a hospital service nurse in psychiatry, while the practice of caring for patients with psychiatric disorder within an interdisciplinary team is carried out, leads to a process of the situation of people with PTSD associated with combat in crisis and processes of Recovery. this same fact is one of the great motivations for the development of the present proposal as a support for nursing care, which will favor recovery, so that supported by the knowledge that transmits the discipline and empirical knowledge, propose and generate strategies of guided attention to the integral approach of the needs of this patient profile. Objective: To provide a care proposal for people with PTSD (PTSD), associated with combat. Methodology: a bibliographic review is sought in search of findings that provide scientific evidence on intervention strategies for people diagnosed with PTSD. The need to consider a possible form of intervention for the person with a psychiatric diagnosis is perceived and the proposal is led by the professional of nursing, criteria of significance and disciplinary relevance because it is a step towards the opening of intervention areas theoretically and theoretically supported, in addition to a registration system that facilitates the determination of the impact in a field of action where nursing is present, there is a deficit of proposals and information in the publications consulted; This is a form of intervention that can be used by the nursing professional, the need to have an academic specialty in the area, the resource that was established in the notification of difficulty to have specialized services in the area of mental health and psychiatry. Conclusions: This paper presents a nursing intervention strategy framed in Hildegard Peplau's Interpersonal Relationship Model, starting from a NANDA nursing diagnosis that is Post-Traumatic Syndrome, complemented by an advisory intervention in the process of re-establishing mental health through a treatment of interactive help with the needs and feelings of the patient to encourage or support the ability to solve problems and interpersonal relationships, using as a means of interaction the technique of remotivation, making use of the results of the assessment with taxonomy NOC, in the stress domain. Recommendations: The invitation remains for this idea to be applied to real life for any other person, so that it can be taken a step further with the use in practice, to be able to identify the impact, generate results, create instruments and follow up; This proposal should not remain on paper, or in written work because it was disapproved an opportunity to begin to materialize what is written with what is done.

Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity.

Inflammation is reported in post-traumatic stress disorder (PTSD). Few studies have investigated circulating blood cells that may contribute to inflammation. We assessed circulating platelets, white blood cells (WBC) and red blood cells (RBC) in PTSD and assessed their relationship to inflammation and symptom severity. One-hundred and sixty-three male combat-exposed veterans (82 PTSD, 81 non-PTSD) had blood assessed for platelets, WBC, and RBC. Data were correlated with symptom severity and inflammation. All cell counts were significantly elevated in PTSD. There were small mediation effects of BMI and smoking on these relationships. After adjusting for these, the differences in WBC and RBC remained significant, while platelet count was at trend level. In all subjects, all of the cell counts correlated significantly with inflammation. Platelet count correlated with inflammation only in the PTSD subjects. Platelet count, but none of the other cell counts, was directly correlated with PTSD severity ratings in the PTSD group. Combat PTSD is associated with elevations in RBC, WBC, and platelets. Dysregulation of all three major lineages of hematopoietic cells in PTSD, as well as their significant correlation with inflammation, suggest clinical significance of these changes.

The relationship between the First World War and neurology: 100 years of "Shell Shock" / A relação entre a Primeira Guerra Mundial e a neurologia: 100 anos do "Shell Shock"

ABSTRACT The First World War was a global war, beginning on 28 July 1914, until 11 November 1918. Soon after the beginning of the war, there was an “epidemic” of neurological conversion symptoms. Soldiers on both sides started to present in large numbers with neurological symptoms, such as dizziness, tremor, paraplegia, tinnitus, amnesia, weakness, headache and mutism of psychosomatic origin. This condition was known as shell shock, or “war neurosis”. Because medically unexplained symptoms remain a major challenge, and considering the close relationship of symptoms described in shell shock with clinical neurology, we should study their history in order to improve future care.

RESUMO A Primeira Guerra Mundial foi uma guerra global, iniciada em 28 de julho de 1914, até 11 de novembro de 1918. Logo após o início da guerra, exatamente há 100 anos, houve uma “epidemia” de sintomas neurológicos conversivos. Soldados de ambos os lados começaram a apresentar com frequência sintomas neurológicos, tais como: tontura, tremor, paraplegia, zumbido, amnésia, fraqueza, cefaleia e mutismo de origem psicossomática. Esta condição ficou conhecida como shell shock, ou “neurose de guerra”. Como muitos sintomas e doenças inexplicadas continuam sendo um grande desafio, e considerando a estreita relação dos sintomas descritos no shell shock com a neurologia clínica, torna-se importante estudar essa parte da história com o objetivo de entendermos e melhorarmos os cuidados aos pacientes.