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1.
J Radiol Prot ; 44(2)2024 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-38834051

RESUMO

The measurement of linear energy transfer (LET) is crucial for the evaluation of the radiation effect in heavy ion therapy. As two detectors which are convenient to implant into the phantom, the performance of CR-39 and thermoluminescence detector (TLD) for LET measurement was compared by experiment and simulation in this study. The results confirmed the applicability of both detectors for LET measurements, but also revealed that the CR-39 detector would lead to potential overestimation of dose-averaged LET compared with the simulation by PHITS, while the TLD would have a large uncertainty measuring ions with LET larger than 20 keVµm-1. The results of this study were expected to improve the detection method of LET for therapeutic carbon beam and would finally be benefit to the quality assurance of heavy ion radiotherapy.


Assuntos
Radioterapia com Íons Pesados , Transferência Linear de Energia , Dosimetria Termoluminescente , Dosimetria Termoluminescente/instrumentação , Imagens de Fantasmas , Carbono , Desenho de Equipamento , Polietilenoglicóis
2.
Appl Radiat Isot ; 174: 109771, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34048992

RESUMO

Present study concerns the key thermoluminescence (TL) properties of photonic crystal fibres (PCFs), seeking development of alternatively structured TL materials that are able to offer a advantages over existing passive dosimeters. In terms of their internal structure and light guiding properties the PCFs, collapsed and structured, differ significantly from that of conventional optical fibres. To investigate the dosimetric parameters of the PCFs use was made of a linear accelerator producing a 6 MV photon beam, delivering doses ranging from 0.5 Gy to 8 Gy. The parameters studied included TL response, linearity index, glow curves, relative sensitivity and TL signal fading, the results being compared against those obtained using TLD-100 chips. At 4 Gy photon dose the Ge-doped collapsed PCFs were found to provide a response 27 × that of structured PCF, also giving a TL yield similar to that of standard TLD-100 chips. Over post-irradiation periods of 15 and 30 days collapsed PCF TL signal fading were 8% and 17% respectively, with corresponding values of 37% and 64% for the structured PCF. Trapping parameters including the order of kinetics (b), activation energy (E) and frequency factor (s-1) were assessed with Chen's peak shape method. Lifetime of trapping centre was found to be (2.36 E+03) s and (9.03 E +01) s regarding the collapsed and structured PCF respectively with 6 Gy of photon beam. For the Ge-doped collapsed PCF, the high TL yield, sensitivity and low fading provide the basis of a highly promising system of TLD for radiotherapy applications.


Assuntos
Fótons , Dosagem Radioterapêutica , Dosimetria Termoluminescente/instrumentação , Cristalização , Germânio/química
3.
PLoS One ; 15(12): e0241550, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33378398

RESUMO

For x- and gamma- irradiations delivering entrance doses from 2- up to 1000 Gy to commercial 1.0 mm thick borosilicate glass microscope slides, study has been made of their thermoluminescence yield. With an effective atomic number of 10.6 (approximating bone equivalence), photon energy dependency is apparent in the low x-ray energy range, with interplay between the photoelectric effect and attenuation. As an example, over the examined dose range, at 120 kVp the photon sensitivity has been found to be some 5× that of 60Co gamma irradiations, also with repeatability to within ~1%. The glow-curves, taking the form of a single prominent broad peak, have been deconvolved yielding at best fit a total of five peaks, the associated activation energies and frequency factors also being obtained. The results indicate borosilicate glass slides to offer promising performance as a low-cost passive radiation dosimeter, with utility for both radiotherapy and industrial applications.


Assuntos
Compostos de Boro/química , Fótons , Dosímetros de Radiação , Silicatos/efeitos da radiação , Dosimetria Termoluminescente/instrumentação , Compostos de Boro/efeitos da radiação , Relação Dose-Resposta à Radiação , Raios gama , Humanos , Doses de Radiação , Silicatos/química , Dosimetria Termoluminescente/métodos , Raios X
4.
Appl Radiat Isot ; 160: 109132, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32351224

RESUMO

As a result of the various evolving needs, thermoluminescence dosimetry is constantly under development, with applications intended in environmental and personal radiation monitoring through to the sensing of radiotherapy and radiation processing doses. In radiotherapy dosimetry challenges include small-field profile evaluation, encompassing the fine beams of radiosurgery, evaluations confronting the steep dose gradients of electronic brachytherapy and the high dose rates of FLASH radiotherapy. Current work concerns the thermoluminescent dosimetric properties of commercial low-cost borosilicate glass in the form of thin (sub-mm to a few mm) plates, use being made of microscope cover-slips irradiated using clinical external-beam radiotherapy facilities as well as through use of 60Co gamma irradiators. In using megavoltage photons and MeV electrons, characterization of the dosimetric response has been made for cover-slips of thicknesses up to 4 mm. Reproducibility to within +/5% has been obtained. In particular, for doses up to 10 Gy, the borosilicate cover-slips have been demonstrated to have considerable potential for use in high spatial resolution radiotherapy dosimetry, down to 0.13 mm in present work, with a coefficient of determination in respect of linearity of >0.99 for the thinner cover-slips. Results are also presented for 0.13- and 1.00-mm thick cover slips irradiated to 60Co gamma-ray doses, initially in the range 5- to 25 Gy, subsequently extended to 5 kGy-25 kGy, again providing linear response.


Assuntos
Vidro , Microscopia/instrumentação , Dosimetria Termoluminescente/instrumentação
5.
Phys Med ; 69: 127-133, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31901837

RESUMO

In the last few years there has been an increasing interest in the measurement of the absorbed dose from radionuclides, with special attention devoted to molecular radiotherapy treatments. In particular, the determination of the absorbed dose from beta emitting radionuclides in liquid solution poses a number of issues when dose measurements are performed using thermoluminescent dosimeters (TLD). Finite volume effect, i.e. the exclusion of radioactivity from the volume occupied by the TLD is one of these. Furthermore, TLDs need to be encapsulated into some kind of waterproof envelope that unavoidably contributes to beta particle attenuation during the measurement. The purpose of this study is twofold: I) to measure the absorbed dose to water, Dw, using LiF:Mg,Cu,P chips inside a PMMA cylindrical phantom filled with a homogenous 90YCl3 aqueous solution II) to assess the uncertainty budget related to Dw measurements. To this purpose, six cylindrical PMMA phantoms were manufactured at ENEA. Each phantom can host a waterproof PMMA stick containing 3 TLD chips encapsulated by a polystyrene envelope. The cylindrical phantoms were manufactured so that the radioactive liquid environment surrounds the whole stick. Finally, Dw measurements were compared with Monte Carlo (MC) calculations. The measurement of absorbed dose to water from 90YCl3 radionuclide solution using LiF:Mg,Cu,P TLDs turned out to be a viable technique, provided that all necessary correction factors are applied. Using this method, a relative combined standard uncertainty in the range 3.1-3.7% was obtained on each Dw measurement. The major source of uncertainty was shown to be TLDs calibration, with associated uncertainties in the range 0.7-2.2%. Comparison of measured and MC-calculated absorbed dose per emitted beta particle provided good results, with the two quantities being in the ratio 1.08.


Assuntos
Cobre/química , Fluoretos/química , Compostos de Lítio/química , Magnésio/química , Fósforo/química , Dosimetria Termoluminescente/instrumentação , Dosimetria Termoluminescente/métodos , Radioisótopos de Ítrio , Algoritmos , Calibragem , Humanos , Método de Monte Carlo , Imagens de Fantasmas , Dosímetros de Radiação , Radioisótopos , Radiometria , Reprodutibilidade dos Testes , Água/química
6.
Phys Med Biol ; 65(1): 015008, 2020 01 10.
Artigo em Inglês | MEDLINE | ID: mdl-31569080

RESUMO

Changes in the relative biological effectiveness (RBE) of the radiation-induced cell killing of human salivary glands (HSG) were assessed along the Bragg peak of a 60 MeV clinical proton beam by means of coupling biophysical models with the results of Monte Carlo radiation transport simulations and experimental measurements with luminescent detectors. The fluence- and dose-mean unrestricted proton LET were determined along the Bragg peak using a recently developed methodology based on the combination of the response of 7LiF:Mg,Ti (MTS-7) and 7LiF:Mg,Cu,P (MCP-7) thermoluminescent detectors. The experimentally assessed LET values were compared with the results of radiation transport simulations using the Monte Carlo code PHITS, showing a good agreement. The cell survival probabilities and RBE were then calculated using the linear-quadratic model with the linear term derived using a phenomenological LET-based model (Carabe A et al 2012 Phys. Med. Biol. 57 1159) in combination with the experimentally-assessed or PHITS-simulated dose mean proton LET values. To the same aim, PHITS simulated microdosimetric spectra were used as input to the modified microdosimetric kinetic model (modified MKM, (Kase et al 2006 Radiat. Res. 166 629-38)). The RBE values calculated with the three aforementioned approaches were compared and found to be in very good agreement between each other, proving that by using dedicated pairs of thermoluminescent detectors it is possible to determine ionization density quantities of therapeutic proton beams which can be applied to predict the local value of the RBE.


Assuntos
Morte Celular , Simulação por Computador , Modelos Estatísticos , Prótons , Glândulas Salivares/patologia , Dosimetria Termoluminescente/instrumentação , Células Cultivadas , Relação Dose-Resposta à Radiação , Humanos , Cinética , Método de Monte Carlo , Eficiência Biológica Relativa , Glândulas Salivares/efeitos da radiação
7.
Z Med Phys ; 30(2): 142-147, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31818650

RESUMO

Ruthenium-106 ophthalmic applicators have proven to be effective when using beta emitters in brachytherapy. For dose calculations , typically, the dosimetric reference data given by the manufacturer are used. An additional check of the applicators is usually not provided. However, the medical physicist is responsible for correct dosimetry in the clinic; therefore dosimetric verification is desirable. Despite the fact that the use of beta-ray emitting sealed brachytherapy sources is a safe treatment method, errors can occur (Kaulich et al., 2004). Hence, a method for absolute dose measurements based on the use of thin layer MCP-N-thermoluminescence detectors (TLD Poland, Krakow, Poland) is described in this study. A custom-made polymethyl methacrylate (PMMA)- based phantom was developed for this study. The surface of the phantom was designed to fit with spherical shells of ruthenium-106 ophthalmic applicators (e.g. applicator type CCA, CCB and CIA by Eckert & Ziegler BEBIG GmbH, Berlin, Germany) studied in this work. To verify the reference data from the source certificates, absolute point dose values were measured at different phantom depths with the thermoluminescence detectors and compared to the certificate values. Calibrations of the thermoluminescence detectors were performed in a water phantom with a 6 MV CLINAC (Artiste, Siemens Medical, Erlangen, Germany) before. A comparison with scintillator measurement results given by the manufacturer in the applicator certificate shows the measurement series of absolute dose using MCP-N thin layer detectors being in good accordance with the values of the applicator certificate. The dose values calculated with the source certificate can be confirmed with a maximum deviation of 6.5%. Further, it can be shown that compared to TLD-100, the use of MCP-N thermoluminescence detectors is an advantage, when calibrating with 6 MV photons. The phantom measuring procedure presented in this study provides a practice-oriented realization for quality control of ruthenium-106 ophthalmic applicators in clinical routine The phantom seems capable of performing periodic system tests, as well as controlling the introduction of new applicators delivered by the manufacturer.


Assuntos
Braquiterapia/instrumentação , Braquiterapia/métodos , Neoplasias Oculares/radioterapia , Controle de Qualidade , Radioisótopos de Rutênio/administração & dosagem , Dosimetria Termoluminescente/instrumentação , Imagens de Fantasmas , Dosagem Radioterapêutica , Radioisótopos de Rutênio/uso terapêutico
8.
Radiat Prot Dosimetry ; 187(4): 509-517, 2019 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-31650175

RESUMO

The objective of this paper is to study the effect of consecutive heating of TL elements of a thermoluminescence dosemeter (TLD) card in hot N2 gas-based TLD badge reader. The effect is studied by theoretical simulations of clamped heating profiles of the discs and resulting TL glow curves. The simulated temperature profile accounts for heat transfer to disc from hot gas as well as radiative and convective heat exchanges between the disc and the surrounding. The glow curves are simulated using 10 component glow peak model for CaSO4:Dy using the simulated temperature profile. The shape of the simulated glow curves and trend in total TL signal of the three discs were observed to match closely with the experimental observations when elevated surrounding temperature was considered for simulation. It is concluded that the readout (heating) of adjacent TLD disc affects the surrounding temperature leading to the changes in temperature profile of the next disc.


Assuntos
Sulfato de Cálcio/química , Disprósio/química , Temperatura Alta , Compostos de Lítio/química , Dosimetria Termoluminescente/instrumentação , Dosimetria Termoluminescente/métodos , Humanos , Termodinâmica
9.
Appl Radiat Isot ; 151: 235-241, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31228731

RESUMO

The aim of this paper is to examine the energy and angular responses of thermoluminescent dosimeters containing either MTS-N (LiF:Mg,Ti) or MCP-N (LiF:Mg,Cu,P) detector materials, and of the InLight optically stimulated luminescent dosimeters containing Al2O3:C detectors. Ten radiation qualities, with mean energies ranging from 24 keV to 1.25 MeV, and five angles of incidence, between 0° and 80°, were used for this purpose. The dosimeter response measure of quality were the IEC 62387 requirements. The experimental results show that the MTS-N-based and the InLight dosimeters performed in line with the standard's criteria. On the other hand, the MCP-N-based dosimeters exhibited a pronounced under-response around the energy of 120 keV, which resulted in deviations from the standard's conditions for both the energy and angular responses.


Assuntos
Dosimetria por Luminescência Estimulada Opticamente/instrumentação , Fótons , Dosímetros de Radiação , Dosimetria Termoluminescente/instrumentação , Humanos
10.
Health Phys ; 117(4): 345-352, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31136314

RESUMO

We investigated the main question of whether thermoluminescent dosimeters indicate the correct dose when exposed to magnetic fields from low stray fields up to high magnetic resonance imaging fields inside human magnetic resonance imaging scanners (0.05 T ≤ B ≤ 7 T) during and after irradiation. Medical personnel working in radiology, oncology, or nuclear medicine are regularly monitored with thermoluminescent dosimeters. They might also enter the magnetic field of a magnetic resonance imaging scanner while supervising patients as well as during positron emission tomography-magnetic resonance imaging and magnetic resonance imaging-linac integrated imaging systems and will therefore be exposed to the magnetic fields of magnetic resonance imaging scanners and low stray fields of several millitesla outside of the magnetic resonance imaging scanner, not only before and after, but also during irradiation. Panasonic thermoluminescent dosimetry badges and ring dosimeters for personal monitoring were exposed to magnetic fields originating from a 7 T and a 3 T magnetic resonance imaging scanner as well as neodymium permanent magnets. Four different sealed Cs sources were used in two sets of experiments: (1) magnetically induced fading: irradiated thermoluminescent dosimeters (D ≈ 100 mSv) were exposed to a strong magnetic field (B = 7 T) of a human high-field magnetic resonance imaging scanner after irradiation; no magnetically induced fading (magnetoluminescence) for LiBO:Cu or CaSO:Tm was observed; (2) magnetically induced attenuation: thermoluminescent dosimeters were placed during irradiation in a magnetic field for about 60 h; a significantly reduced dose response was observed for LiBO:Cu-interestingly not at maximum B ≈ 7 T but at B ≈ 0.2 T. This experimental observation is possibly relevant especially for medical and technical personnel in nuclear medicine before and during a magnetic resonance imaging scanning procedure. Follow-up studies need to be made to clarify the kinetics of this effect.


Assuntos
Campos Magnéticos , Medicina Nuclear/normas , Exposição Ocupacional/análise , Dosímetros de Radiação/normas , Radiação Ionizante , Dosimetria Termoluminescente/instrumentação , Dosimetria Termoluminescente/métodos , Relação Dose-Resposta à Radiação , Humanos , Imageamento por Ressonância Magnética , Radiometria
11.
J Cancer Res Ther ; 15(Supplement): S123-S126, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30900633

RESUMO

AIM: By necessity of dosimeters calibration for evaluating delivered dose accuracy to organs out of the radiation field in patients undergoing gamma knife radiosurgery, we calibrated thermoluminescence dosimeters in gamma knife and 60Co instruments, and then, compared both results to investigate when one of these devices was out of reach, can we use one of this instruments instead of the ther. MATERIALS AND METHODS: To individual calibration by 60Co, thermoluminescent dosimeters (TLDs) were placed in a Perspex sheet with conditions of source-skin distance = 80 cm, field size = 10 cm × 10 cm, and dose = 100 cGy. For individual calibration by Gamma knife, TLDs placed in flat Perspex were located in a special sphere and were exposed with conditions of source to axis distance = 40 cm, field size = 18 mm, and dose = 100 cGy, and for group calibration, TLDs were divided into six groups and were exposed with doses of 0-1000 cGy in both devices. RESULTS: According to Fisher's exact test, calculated P = 0.27, so the difference is not significant. CONCLUSIONS: The result showed despite differences in calibration conditions, 60Co unit can be used to calibrate TLD dosimeter for estimating the accuracy of measurement of delivered dose to organs of patients undergoing Gamma Knife 4C radiosurgery treatment.


Assuntos
Dosímetros de Radiação/normas , Radiocirurgia/instrumentação , Dosimetria Termoluminescente/instrumentação , Calibragem , Radioisótopos de Cobalto , Imagens de Fantasmas , Radiometria , Radiocirurgia/normas , Dosagem Radioterapêutica/normas , Água
12.
Phys Med Biol ; 64(8): 08NT04, 2019 04 12.
Artigo em Inglês | MEDLINE | ID: mdl-30840946

RESUMO

Ge-doped silica fibre (GDSF) thermoluminescence dosimeters (TLD) are non-hygroscopic spatially high-resolution radiation sensors with demonstrated potential for radiotherapy dosimetry applications. The INTRABEAM® system with spherical applicators, one of a number of recent electronic brachytherapy sources designed for intraoperative radiotherapy (IORT), presents a representative challenging dosimetry situation, with a low keV photon beam and a desired rapid dose-rate fall-off close-up to the applicator surface. In this study, using the INTRABEAM® system, investigations were made into the potential application of GDSF TLDs for in vivo IORT dosimetry. The GDSFs were calibrated over the respective dose- and depth-range 1 to 20 Gy and 3 to 45 mm from the x-ray probe. The effect of different sizes of spherical applicator on TL response of the fibres was also investigated. The results show the GDSF TLDs to be applicable for IORT dose assessment, with the important incorporated correction for beam quality effects using different spherical applicator sizes. The total uncertainty in use of this type of GDSF for dosimetry has been found to range between 9.5% to 12.4%. Subsequent in vivo measurement of skin dose for three breast patients undergoing IORT were performed, the measured doses being below the tolerance level for acute radiation toxicity.


Assuntos
Dosimetria in Vivo/métodos , Dosímetros de Radiação/normas , Dosimetria Termoluminescente/métodos , Calibragem , Feminino , Humanos , Dosimetria in Vivo/normas , Dosagem Radioterapêutica , Dióxido de Silício/química , Dosimetria Termoluminescente/instrumentação , Dosimetria Termoluminescente/normas
13.
J Cancer Res Ther ; 14(Supplement): S1110-S1116, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30539854

RESUMO

AIM: The aim of this study was to assess the accuracy of electron dose calculations of Prowess Panther treatment planning system (TPS) for abutting photon-electron (PE) technique. In this work, we have assessed the accuracy of electron dose calculations in a simulated internal mammary field because this field is irradiated with electron in PE technique. MATERIALS AND METHODS: In this study, regions of in-field, under electron shield, and outside the internal mammary field were evaluated. Thermoluminescent dosimeter (TLD-700) chips were used within RANDO phantom for dose measurement. Prowess Panther TPS was also applied for dose calculation. Finally, confidence limit values were obtained to quantify the TPS electron dose calculation accuracy of an internal mammary field. RESULTS: The results show that for outside of field and under shield regions, Prowess Panther TPS underestimated the dose compared to the measured doses by TLD-700, whereas for in-field regions, the calculated doses by Prowess Panther TPS compared to the measured doses by TLD-700, for some points are overestimated and other points are underestimated. Finally, the confidence limit values were obtained for various regions of the internal mammary field. Confidence limits for in-field, outside of field, and under shield regions were 54.23, 108.19, and 80.51, respectively. CONCLUSIONS: It is concluded that the accuracy of electron dose calculations of Prowess Panther TPS is not adequate for internal mammary field treatment. Therefore, it is recommended that for fields with electron beams Prowess Panther TPS calculations should not be entirely relied upon.


Assuntos
Neoplasias da Mama/radioterapia , Elétrons/uso terapêutico , Fótons/uso terapêutico , Planejamento da Radioterapia Assistida por Computador/métodos , Dosimetria Termoluminescente/instrumentação , Algoritmos , Feminino , Humanos , Imagens de Fantasmas , Lesões por Radiação/prevenção & controle , Dosagem Radioterapêutica , Planejamento da Radioterapia Assistida por Computador/instrumentação , Dosimetria Termoluminescente/métodos , Tomografia Computadorizada por Raios X
14.
Radiat Prot Dosimetry ; 181(2): 57-99, 2018 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-30239880

RESUMO

CaSO4:Dy is a reliable high-sensitive themoluminescent phosphor useful for low-level and high-level radiation measurements as it exhibits fading free linear dose response with a single glow peak at ~230°C in these dose regions. For large-scale radiation protection dosimetry service, it is embedded in Teflon matrix with varying thicknesses. Extensive studies have been carried out with such CaSO4:Dy Teflon discs in individual and environmental radiation monitoring applications including its capability to measure International Commission on Radiation Units and Measurements operational quantities. The review highlights their development and application in high-energy photon measurements, thin wafers and graphite-loaded Teflon discs for beta-dosimetry, phosphor-filled aluminium discs for high-dose applications, 6LiF-mixed CaSO4:Dy Teflon discs for thermal and albedo or moderated fast neutrons, sulphur-mixed CaSO4:Dy pellets for fast-neutron exposure even in the presence of gamma-rays and polyethylene-mixed CaSO4:Dy discs for fast neutrons.


Assuntos
Sulfato de Cálcio/química , Exposição Ocupacional/análise , Proteção Radiológica/instrumentação , Dosimetria Termoluminescente/instrumentação , Carga Corporal (Radioterapia) , Humanos , Proteção Radiológica/métodos , Dosimetria Termoluminescente/métodos
15.
Appl Radiat Isot ; 141: 176-181, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29673719

RESUMO

In previous work we investigated the real-time radioluminescence (RL) yield of Ge-doped silica fibres and Al2O3 nanodot media, sensing electron- and x-ray energies and intensities at values familiarly obtained in external beam radiotherapy. The observation of an appreciable low-dose sensitivity has given rise to the realisation that there is strong potential for use of RL dosimetry in diagnostic radiology. Herein use has been made of P-doped silica optical fibre, 2 mm diameter, also including a 271 µm cylindrical doped core. With developing needs for versatile x-ray imaging dosimetry, preliminary investigations have been made covering the range of diagnostic x-ray tube potentials 30 kVp to 120 kVp, demonstrating linearity of RL with kVp as well as in terms of the current-time (mAs) product. RL yields also accord with the inverse-square law. Given typical radiographic-examination exposure durations from tens- to a few hundred milliseconds, particular value is found in the ability to record the influence of x-ray generator performance on the growth and decay of beam intensity, from initiation to termination.


Assuntos
Exposição Ocupacional/análise , Exposição à Radiação/análise , Dosimetria Termoluminescente/métodos , Humanos , Exposição Ocupacional/efeitos adversos , Fibras Ópticas , Exposição à Radiação/efeitos adversos , Radiografia/efeitos adversos , Dióxido de Silício , Dosimetria Termoluminescente/instrumentação , Dosimetria Termoluminescente/estatística & dados numéricos
16.
Phys Med Biol ; 63(8): 085017, 2018 04 19.
Artigo em Inglês | MEDLINE | ID: mdl-29509148

RESUMO

Systematic 3D mapping of out-of-field doses induced by a therapeutic proton pencil scanning beam in a 300 × 300 × 600 mm3 water phantom was performed using a set of thermoluminescence detectors (TLDs): MTS-7 (7LiF:Mg,Ti), MTS-6 (6LiF:Mg,Ti), MTS-N (natLiF:Mg,Ti) and TLD-700 (7LiF:Mg,Ti), radiophotoluminescent (RPL) detectors GD-352M and GD-302M, and polyallyldiglycol carbonate (PADC)-based (C12H18O7) track-etched detectors. Neutron and gamma-ray doses, as well as linear energy transfer distributions, were experimentally determined at 200 points within the phantom. In parallel, the Geant4 Monte Carlo code was applied to calculate neutron and gamma radiation spectra at the position of each detector. For the cubic proton target volume of 100 × 100 × 100 mm3 (spread out Bragg peak with a modulation of 100 mm) the scattered photon doses along the main axis of the phantom perpendicular to the primary beam were approximately 0.5 mGy Gy-1 at a distance of 100 mm and 0.02 mGy Gy-1 at 300 mm from the center of the target. For the neutrons, the corresponding values of dose equivalent were found to be ~0.7 and ~0.06 mSv Gy-1, respectively. The measured neutron doses were comparable with the out-of-field neutron doses from a similar experiment with 20 MV x-rays, whereas photon doses for the scanning proton beam were up to three orders of magnitude lower.


Assuntos
Imageamento Tridimensional/métodos , Imagens de Fantasmas , Terapia com Prótons/métodos , Radiometria/métodos , Dosimetria Termoluminescente/métodos , Raios gama , Humanos , Método de Monte Carlo , Nêutrons , Fótons , Prótons , Radioatividade , Cintilografia , Dosagem Radioterapêutica , Planejamento da Radioterapia Assistida por Computador/métodos , Dosimetria Termoluminescente/instrumentação , Água
17.
Appl Radiat Isot ; 137: 73-79, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29587162

RESUMO

TLD-400 (CaF2:Mn) chips were applied for the gamma-ray dose measurement in a PMMA phantom exposed to a BNCT beam because of their very low neutron sensitivity. Since TLD-400 chips possess an adequate amount of Mn activator they have been employed in this work simultaneously for neuron activation measurement. The self-irradiation TL signals owing to the decay of the neutron induced 56Mn activity have been applied for a calibration of the TLD-400 chip in situ, where the activities were measured by an HPGe detector system and the energy deposition per disintegration of 56Mn was calculated by applying a Monte Carlo code. It was accidentally found that the irradiated TLD-400 chips were capable of emitting prominent scintillation lights owing to the induced 56Mn activity, which can easily be recorded by the TLD reader without heating and after a calibration can be used to determine the 56Mn activity.


Assuntos
Terapia por Captura de Nêutron de Boro , Dosimetria Termoluminescente/métodos , Terapia por Captura de Nêutron de Boro/normas , Calibragem , Raios gama , Humanos , Manganês/análise , Manganês/efeitos da radiação , Método de Monte Carlo , Nêutrons , Imagens de Fantasmas , Controle de Qualidade , Radioisótopos/análise , Dosagem Radioterapêutica , Contagem de Cintilação , Dosimetria Termoluminescente/instrumentação , Dosimetria Termoluminescente/estatística & dados numéricos
18.
Radiat Prot Dosimetry ; 181(4): 368-373, 2018 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-29509945

RESUMO

To assess the radiation exposure of the investigator during navigated fusion of nuclear medicine images with ultrasound after application of I-124. Dosimetry with two different types of thermoluminescent detectors (TLD) was performed in 25 patients. The dose rate at the patient's neck was measured with a calibrated dose rate meter (DRM) and served as the standard of reference. The average exposure per investigation at the patient's neck measured by LiF:Mg,Cu,P TLDs (cumulative: 212 µSv), LiF:Mg,Ti TLDs (cumulative: 112 µSv) and DRM (cumulative: 150.3 µSv). The radiation exposure of the hand during navigated fusion of nuclear medicine imaging with 124I and ultrasound with a mean duration of 13 min is low and comparable between different methods. Yearly examinations are not expected to add a relevant cumulative risk.


Assuntos
Mãos/efeitos da radiação , Radioisótopos do Iodo/administração & dosagem , Radioisótopos do Iodo/química , Imagem Multimodal , Pescoço/efeitos da radiação , Exposição Ocupacional/análise , Tomografia por Emissão de Pósitrons , Monitoramento de Radiação/instrumentação , Compostos Radiofarmacêuticos/administração & dosagem , Compostos Radiofarmacêuticos/química , Dosimetria Termoluminescente/instrumentação , Ultrassonografia , Administração Oral , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Exposição à Radiação
19.
Z Med Phys ; 28(2): 96-109, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28807441

RESUMO

PURPOSE: Long-term survivors of cancer who were treated with radiotherapy are at risk of a radiation-induced tumor. Hence, it is important to model the out-of-field dose resulting from a cancer treatment. These models have to be verified with measurements, due to the small size, the high sensitivity to ionizing radiation and the tissue-equivalent composition, LiF thermoluminescence dosimeters (TLD) are well-suited for out-of-field dose measurements. However, the photon energy variation of the stray dose leads to systematic dose errors caused by the variation in response with radiation energy of the TLDs. We present a dosimeter which automatically corrects for the energy variation of the measured photons by combining LiF:Mg,Ti (TLD100) and LiF:Mg,Cu,P (TLD100H) chips. METHODS: The response with radiation energy of TLD100 and TLD100H compared to 60Co was taken from the literature. For the measurement, a TLD100H was placed on top of a TLD100 chip. The dose ratio between the TLD100 and TLD100H, combined with the ratio of the response curves was used to determine the mean energy. With the energy, the individual correction factors for TLD100 and TLD100H could be found. The accuracy in determining the in- and out-of-field dose for a nominal beam energy of 6MV using the double-TLD unit was evaluated by an end-to-end measurement. Furthermore, published Monte Carlo (M.C.) simulations of the mean photon energy for brachytherapy sources, stray radiation of a treatment machine and cone beam CT (CBCT) were compared to the measured mean energies. Finally, the photon energy distribution in an Alderson phantom was measured for different treatment techniques applied with a linear accelerator. Additionally, a treatment plan was measured with a cobalt machine combined with an MRI. RESULTS: For external radiotherapy, the presented double-TLD unit showed a relative type A uncertainty in doses of -1%±2% at the two standard deviation level compared to an ionization chamber. The type A uncertainty in dose was in agreement with the theoretically calculated type B uncertainty. The measured energies for brachytherapy sources, stray radiation of a treatment machine and CBCT imaging were in agreement with M.C. simulations. A shift in energy with increasing distance to the isocenter was noticed for the various treatment plans measured with the Alderson phantom. The calculated type B uncertainties in energy were in line with the experimentally evaluated type A uncertainties. CONCLUSION: The double-TLD unit is able to predict the photon energy of scatter radiation in external radiotherapy, X-ray imagine and brachytherapy sources. For external radiotherapy, the individual energy correction factors enabled a more accurate dose determination compared to conventional TLD measurements.


Assuntos
Modelos Teóricos , Dosimetria Termoluminescente , Humanos , Compostos de Lítio/química , Neoplasias Induzidas por Radiação/prevenção & controle , Dosagem Radioterapêutica/normas , Dosimetria Termoluminescente/instrumentação , Dosimetria Termoluminescente/métodos , Raios X
20.
Radiat Prot Dosimetry ; 178(4): 364-373, 2018 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-28981726

RESUMO

In view of the recommendations of International Commission on Radiological Protection for reduction of the occupational annual dose limit for eye lens from 150 mSv to 20 mSv/y, questions have been raised on the adequacy of monitoring for the quantities Hp(10) and Hp(0.07). As an immediate requirement, in the present situation, where there is no exclusive eye lens dosemeter in India, the existing chest TLD badge was modified to be used as head badge (head dosemeter) by including a strap to enable wearing on the forehead. In order to estimate the eye lens dose in terms of the operational quantity Hp(3), the prevalent algorithm of chest badge was also modified. The modified algorithm was applied to estimate Hp(3) for dosemeters irradiated to various beta and photon radiations including mixtures. The Q values (estimated/delivered dose equivalent) were found to be within ±20% for most of the photon beams.


Assuntos
Algoritmos , Cristalino/efeitos da radiação , Exposição Ocupacional/análise , Exposição à Radiação/análise , Dosimetria Termoluminescente/instrumentação , Calibragem , Humanos , Exposição Ocupacional/prevenção & controle , Exposição à Radiação/prevenção & controle , Proteção Radiológica/normas , Dosimetria Termoluminescente/normas
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