[Anti-NMDA-receptor encephalitis: a new axis-III disorder in the differential diagnosis of childhood disintegrative disorder, early onset schizophrenia and late onset autism]. / Anti-NMDA-receptorencefalitis: een nieuwe as III-stoornis in de differentiaaldiagnose van desintegratiestoornis van de kinderleeftijd, vroeg optredende schizofrenie en laat optredend autisme.

Childhood disintegrative disorder (CDD), early onset schizophrenia (EOS), and late onset autism (LOA) often follow a similar course: initially, development is normal, then there is a sudden neuropsychiatric deterioration of social interaction and communication skills, which is combined with a decline in intelligence and reduction in daily activities. A 9-year-old boy was admitted to the paediatric ward with acute onset of secondary epileptic seizures. It was not long until the boy's symptoms resembled that of patients with cdd, eos and loa. Intensive tests led to the diagnosis of anti-NMDA-receptor encephalitis. Anti-NMDA-receptor encephalitis should be regarded as a possible organic cause underlying the syndromal presentation of CDD, EOS and LOA.

[Is periodic psychosis in adolescence a disease of its own? The differential diagnosis of psychomotor psychoses in childhood and adolescence]. / Ist die periodische Psychose der Adoleszenz ein eigenständiges Krankheitsbild? Ein Beitrag zur differenzierten Diagnostik psychomotorischer Psychosen im Kindes- und Jugendalter.

A historically orientated analysis of a disease that must be seen in connection with menstruation is made on the basis of literature on periodical psychoses in adolescence, which are described as nosologically separate disturbances. This relation turns out to be by no means obligatory, and this also applies to the homogeneity of the disease. Psychomotor disturbances of psychopathological importance are described by means of ideally typical cases of disease and presented with a differentiated diagnosis. Psychoses occurring during different periods in childhood and adolescence, do not show any sex-specific differences and no absolute dependence in accordance with the menstruation rhythm, but are mostly connected with a hereditary and also a perinatal strain in childhood. In their acute and long-term progress the psychomotoric disturbances allow a differentiated prognosis and therefore a therapeutic explanation. They can be classified in accordance with the Wernicke-Kleist-Leonhard classification schema as motility psychosis and periodic catatonia. With this in mind, the positive-negative dichotomy of schizophrenic disturbances in childhood and adolescence should be carefully reconsidered.

[Genetic classification of clinical forms of childhood schizophrenia]. / Geneticheskaia sistematika klinicheskikh form detskoi shizofrenii.

In an analysis of 225 families of probands with different forms of the course of children's schizophrenia, a hypothesis on the degree of their genetical similarity (or dissimilarity) was tested. Malignant and slow progredient form of children schizophrenia showed major genetical similarity (correlation coefficient 1.0) with the recurrent schizophrenia occupying a separate position having no common genetical predisposition factors with nuclear forms of schizophrenia. Paroxysmal progredient schizophrenia displayed a distinct genetical relation to any other form (genetical correlation coefficient ranging in 0.5-0.7).