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1.
Radiology ; 297(3): 721-729, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33021894

RESUMO

Background Prophylactic image-guided procedures performed by interventional radiologists for impending pathologic fractures are becoming more pertinent, as patients with metastatic cancer have extended overall survival because of advanced therapies. Purpose To evaluate the efficacy, safety, and palliative durability of collimated-beam CT-guided percutaneous fixation with internal cemented screws (FICS) for impending pathologic fractures of the femoral neck. Materials and Methods This single-institute retrospective study examined all patients with metastatic cancer treated between February 2010 and October 2019 with collimated-beam CT-guided percutaneous FICS procedures for preventive consolidation of impending femoral neck pathologic fractures. The short-term palliative efficacy was assessed through comparison of visual analog scale (VAS) scores before and 1 month after FICS. A review of cross-section imaging and clinic reports identified any procedural complications. Long-term consolidation efficacy was defined as the absence of any screw dislodgement or development of a pathologic fracture at completion of the study. The Wilcoxon test was used for the mean comparison of paired nonparametric variables. Results Sixty-one consecutive patients (mean age, 59 years ± 11 [standard deviation]; 35 women) underwent preventive FICS for consolidation of impending pathologic femoral neck fracture with a mean follow-up of 533 days ± 689. Two patients died of cancer within the first month. Complications were limited to three self-resolving hematomas. The mean VAS score decreased 1 month after FICS from 4.2 ± 3.2 to 1.8 ± 2.0 (P < .001). The long-term consolidation efficacy was 92% (54 of 59 patients), with three of 59 patients (5%) subsequently developing fractures despite FICS and an additional two of 59 patients (3%) with durable FICS undergoing definitive total hip arthroplasty surgery because of local tumor progression. Conclusion Percutaneous fixation with internal cemented screws as performed by the interventional radiologist is a safe nonsurgical treatment that provides an effective palliative result and durable prevention for impending pathologic fractures of the femoral neck. © RSNA, 2020 Online supplemental material is available for this article.


Assuntos
Parafusos Ósseos , Fraturas do Colo Femoral/prevenção & controle , Neoplasias Femorais/secundário , Fixação Interna de Fraturas/métodos , Fraturas Espontâneas/prevenção & controle , Radiografia Intervencionista , Tomografia Computadorizada por Raios X , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
2.
Acta Orthop ; 90(6): 523-529, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31340710

RESUMO

Background and purpose - The Mitch proximal epiphyseal replacement (PER) was developed to preserve proximal femoral bone and minimize femoral neck fracture associated with hip resurfacing arthroplasty (HRA). We studied the survival and risk of revision of HRA compared with cementless metal-on-polyethylene (MoP) total hip arthroplasty (THA) and the survival and risk of revision of the Mitch PER compared with MoP THA.Patients and methods - Using propensity score, we matched 1,057 HRA to 1,057 MoP THA and 202 Mitch PER to 1,010 MoP THA from the Danish Hip Arthroplasty Register. To estimate the relative risk (RR) of revision, we used regression with the pseudo-value approach and treated death as a competing risk.Results - The cumulative incidence for any revision of HRA at 10 years' follow-up was 11% (95% confidence interval [CI] 9.1-13) and 6.4% (CI 5.8-7.0) for MoP THA. The RR of any revision was 1.5 (CI 1.1-2.1) for HRA at 10 years' follow-up. By excluding the ASR components, the RR of revision at 10 years was 1.2 (CI 0.8-1.7). The cumulative incidence of revision was 9.6% (CI 4.2-18) for Mitch PER and 5.4% (CI 5.1-5.7) for MoP THA at 8 years. The RR of revision was 2.0 (CI 0.9-4.3) for Mitch PER at 8 years' follow-up.Interpretation - The HRA had increased risk of revision compared with the MoP THA. When excluding ASR, the HRA group had similar risk of revision compared with MoP THA. The Mitch PER did not have a statistically significant increased risk of revision compared with MoP THA.


Assuntos
Artroplastia de Quadril , Fraturas do Colo Femoral , Osteoartrite do Quadril , Falha de Prótese , Reoperação , Idoso , Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/métodos , Artroplastia de Quadril/mortalidade , Artroplastia de Quadril/estatística & dados numéricos , Dinamarca/epidemiologia , Epífises/cirurgia , Feminino , Fraturas do Colo Femoral/etiologia , Fraturas do Colo Femoral/prevenção & controle , Prótese de Quadril , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/epidemiologia , Osteoartrite do Quadril/cirurgia , Avaliação de Processos e Resultados em Cuidados de Saúde , Desenho de Prótese , Sistema de Registros/estatística & dados numéricos , Reoperação/métodos , Reoperação/estatística & dados numéricos , Medição de Risco , Fatores de Risco
3.
Women Health ; 59(8): 845-853, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-30721115

RESUMO

Coronary artery disease (CAD) and osteoporosis, the two most frequently occurring chronic diseases of aging populations, share many risk factors including lack of estrogen, smoking, and low physical activity. CAD and low bone mineral density (BMD) are strongly associated. Statins, (3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase inhibitors), are used to prevent and treat CAD and have been associated with high BMD. This cross-sectional study examined associations of BMD with statin use and nonuse in elderly women with or without CAD. Multivariate regression analyses were conducted on 185 women aged ≥60 years who were referred between October 2010 and March 2015 to a geriatric osteoporosis clinic in Houston, Texas, for compromised skeletal health. Compared to the control group (without CAD and without statin use), patients with CAD and no statin use were more likely to have lower femoral neck BMD (ß: -0.46, 95% confidence interval: -0.75 to -0.18). The BMD of patients taking statins, regardless of presence of CAD, was similar to that of the control group. Statins may be protective in preventing bone loss in elderly women suffering from CAD. Prospective trials are warranted to determine if continued use of statins in them would help prevent both CAD and bone loss.


Assuntos
Densidade Óssea/efeitos dos fármacos , Doença da Artéria Coronariana/tratamento farmacológico , Fraturas do Colo Femoral/prevenção & controle , Colo do Fêmur/efeitos dos fármacos , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Osteoporose/etiologia , Idoso , Idoso de 80 Anos ou mais , Doença da Artéria Coronariana/epidemiologia , Estudos Transversais , Fêmur/diagnóstico por imagem , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/farmacologia , Pessoa de Meia-Idade , Osteoporose/epidemiologia , Fatores de Proteção , Estudos Retrospectivos
4.
Orthop Surg ; 10(4): 337-342, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30398027

RESUMO

The purpose of this study was to demonstrate the reduced chances of iatrogenic femoral neck fracture while removing the Richard's screw using the dynamic hip screw-femur head conjoint removal technique. This retrospective cohort study analyzed 16 hips operated on with total hip arthroplasty from March 2010 to February 2015. All cases were previously treated with dynamic hip screws (DHS) for proximal femur fractures. The age of the patients ranged from 20 to 75 years. We used uncemented sockets in 15 patients and cemented sockets in 1 patient. We used conical fluted straight stems in 9 cases, ML (Mediolateral) tapered stems in 5 patients and CLS (Cementless Spotorno) stems in 2 patients. The head of the femur was removed together with the attached Richard's screw after taking a neck cut during hip replacement after previous dynamic hip screw fixation. At 2-year follow-up, there was a statistically significant improvement in the Harris hip score: from a mean preoperative score of 35 ± 7.975 to a mean postoperative score of 89.38 ± 4.870 (P < 0.001). Stem sinking and Type AL (Vancouver classification for periprosthetic fracture) periprosthetic fracture in 1 patient with a tapered stem was noted. Good acetabular inclination was achieved in all cases. At 2-year follow-up, all patients were able to carry out their daily activities. This is a novel technique with the advantage of avoiding iatrogenic femoral neck fracture in an osteoporotic bone.


Assuntos
Artroplastia de Quadril/métodos , Parafusos Ósseos/efeitos adversos , Remoção de Dispositivo/métodos , Fraturas do Quadril/cirurgia , Osteoartrite do Quadril/cirurgia , Adulto , Idoso , Artroplastia de Quadril/efeitos adversos , Remoção de Dispositivo/efeitos adversos , Feminino , Fraturas do Colo Femoral/etiologia , Fraturas do Colo Femoral/prevenção & controle , Cabeça do Fêmur/diagnóstico por imagem , Cabeça do Fêmur/cirurgia , Articulação do Quadril/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/diagnóstico por imagem , Osteoartrite do Quadril/etiologia , Radiografia , Recuperação de Função Fisiológica , Estudos Retrospectivos , Adulto Jovem
5.
Bone Joint J ; 100-B(1): 11-19, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29305445

RESUMO

AIMS: Instability remains a challenging problem in both primary and revision total hip arthroplasty (THA). Dual mobility components confer increased stability, but there are concerns about the unique complications associated with these designs, as well as the long-term survivorship. MATERIALS AND METHODS: We performed a systematic review of all English language articles dealing with dual mobility THAs published between 2007 and 2016 in the MEDLINE and Embase electronic databases. A total of 54 articles met inclusion criteria for the final analysis of primary and revision dual mobility THAs and dual mobility THAs used in the treatment of fractures of the femoral neck. We analysed the survivorship and rates of aseptic loosening and of intraprosthetic and extra-articular dislocation. RESULTS: For the 10 783 primary dual mobility THAs, the incidence of aseptic loosening was 1.3% (142 hips); the rate of intraprosthetic dislocation was 1.1% (122 hips) and the incidence of extra-articular dislocation was 0.46% (41 hips). The overall survivorship of the acetabular component and the dual mobility components was 98.0%, with all-cause revision as the endpoint at a mean follow-up of 8.5 years (2 to 16.5). For the 3008 revision dual mobility THAs, the rate of aseptic acetabular loosening was 1.4% (29 hips); the rate of intraprosthetic dislocation was 0.3% (eight hips) and the rate of extra-articular dislocation was 2.2% (67 hips). The survivorship of the acatabular and dual mobility components was 96.6% at a mean of 5.4 years (2 to 8). For the 554 dual mobility THAs which were undertaken in patients with a fracture of the femoral neck, the rate of intraprosthetic dislocation was 0.18% (one hip), the rate of extra-articular dislocation was 2.3% (13 hips) and there was one aseptic loosening. The survivorship was 97.8% at a mean of 1.3 years (0.75 to 2). CONCLUSION: Dual mobility articulations are a viable alternative to traditional bearing surfaces, with low rates of instability and good overall survivorship in primary and revision THAs, and in those undertaken in patients with a fracture of the femoral neck. The incidence of intraprosthetic dislocation is low and limited mainly to earlier designs. High-quality, prospective, comparative studies are needed to evaluate further the use of dual mobility components in THA. Cite this article: Bone Joint J 2018;100-B:11-19.


Assuntos
Artroplastia de Quadril/instrumentação , Prótese de Quadril , Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/métodos , Fraturas do Colo Femoral/etiologia , Fraturas do Colo Femoral/prevenção & controle , Humanos , Instabilidade Articular/etiologia , Instabilidade Articular/prevenção & controle , Desenho de Prótese , Falha de Prótese/etiologia , Reoperação/instrumentação , Resultado do Tratamento
6.
J Bone Miner Res ; 32(8): 1625-1631, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28474780

RESUMO

Daily subcutaneous (SC) injections of the investigational drug abaloparatide-SC (80 mcg) for 18 months significantly decrease the risk of vertebral and nonvertebral fracture compared with placebo in postmenopausal women. We examined the efficacy of abaloparatide-SC as a function of baseline fracture risk, assessed using the FRAX tool. Baseline clinical risk factors (age, body mass index [BMI], prior fracture, glucocorticoid use, rheumatoid arthritis, and smoking) were entered into country-specific FRAX models to calculate the 10-year probability of major osteoporotic fractures, with or without femoral neck bone mineral density (BMD). The interaction between probability of a major osteoporotic fracture and treatment efficacy was examined by a Poisson regression. A total of 821 women randomized to placebo and 824 women to abaloparatide-SC, mean age 69 years in both groups, were followed for up to 2 years. At baseline, the 10-year probability of major osteoporotic fractures (with BMD) ranged from 2.3% to 57.5% (mean 13.2%). Treatment with abaloparatide-SC was associated with a 69% (95% confidence interval [CI] 38-85%) decrease in major osteoporotic fracture (MOF) and a 43% (95% CI 9-64%) decrease in any clinical fracture compared with placebo. For all outcomes, hazard ratios tended to decrease (ie, greater efficacy) with increasing fracture probability. Whereas the interaction approached significance for the outcome of any fracture (p = 0.11), there was no statistically significant interaction for any of the fracture outcomes. Similar results were noted when FRAX probability was computed without BMD. Efficacy of abaloparatide-SC to decrease the risk of major osteoporotic fracture or any clinical fracture in postmenopausal women with low BMD and/or prior fracture appears independent of baseline fracture probability. © 2017 American Society for Bone and Mineral Research.


Assuntos
Índice de Massa Corporal , Densidade Óssea/efeitos dos fármacos , Fraturas do Colo Femoral/prevenção & controle , Colo do Fêmur/metabolismo , Osteoporose Pós-Menopausa/tratamento farmacológico , Proteína Relacionada ao Hormônio Paratireóideo/administração & dosagem , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Método Duplo-Cego , Feminino , Fraturas do Colo Femoral/epidemiologia , Fraturas do Colo Femoral/metabolismo , Humanos , Pessoa de Meia-Idade , Osteoporose Pós-Menopausa/epidemiologia , Osteoporose Pós-Menopausa/metabolismo , Fatores de Risco
7.
Clin Orthop Relat Res ; 474(12): 2633-2640, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27535284

RESUMO

BACKGROUND: Osteochondroplasty of the head-neck region is performed on patients with cam femoroacetabular impingement (FAI) without fully understanding its repercussion on the integrity of the femur. Cam-type FAI can be surgically and reproducibly induced in the ovine femur, which makes it suitable for studying corrective surgery in a consistent way. Finite element models built on quantitative CT (QCT) are computer tools that can be used to predict femoral strength and evaluate the mechanical effect of surgical correction. QUESTIONS/PURPOSES: We asked: (1) What is the effect of a resection of the superolateral aspect of the ovine femoral head-neck junction on failure load? (2) How does the failure load after osteochondroplasty compare with reported forces from activities of daily living in sheep? (3) How do failure loads and failure locations from the computer simulations compare with the experiments? METHODS: Osteochondroplasties (3, 6, 9 mm) were performed on one side of 18 ovine femoral pairs with the contralateral intact side as a control. The 36 femurs were scanned via QCT from which specimen-specific computer models were built. Destructive compression tests then were conducted experimentally using a servohydraulic testing system and numerically via the computer models. Safety factors were calculated as the ratio of the maximal force measured in vivo by telemeterized hip implants during the sheep's walking and running activities to the failure load. The simulated failure loads and failure locations from the computer models were compared with the experimental results. RESULTS: Failure loads were reduced by 5% (95% CI, 2%-8%) for the 3-mm group (p = 0.0089), 10% (95% CI, 6%-14%) for the 6-mm group (p = 0.0015), and 19% (95% CI, 13%-26%) for the 9-mm group (p = 0.0097) compared with the controls. Yet, the weakest specimen still supported more than 2.4 times the peak load during running. Strong correspondence was found between the simulated and experimental failure loads (R2 = 0.83; p < 0.001) and failure locations. CONCLUSIONS: The resistance of ovine femurs to fracture decreased with deeper resections. However, under in vitro testing conditions, the effect on femoral strength remains small even after 9 mm correction, suggesting that femoral head-neck osteochondroplasty could be done safely on the ovine femur. QCT-based finite element models were able to predict weakening of the femur resulting from the osteochondroplasty. CLINICAL RELEVANCE: The ovine femur provides a seemingly safe platform for scientific evaluation of FAI. It also appears that computer models based on preoperative CT scans may have the potential to provide patient-specific guidelines for preventing overcorrection of cam FAI.


Assuntos
Simulação por Computador , Impacto Femoroacetabular/cirurgia , Fraturas do Colo Femoral/prevenção & controle , Cabeça do Fêmur/cirurgia , Colo do Fêmur/cirurgia , Análise de Elementos Finitos , Modelos Biológicos , Procedimentos Ortopédicos , Animais , Fenômenos Biomecânicos , Modelos Animais de Doenças , Feminino , Impacto Femoroacetabular/fisiopatologia , Fraturas do Colo Femoral/etiologia , Fraturas do Colo Femoral/fisiopatologia , Cabeça do Fêmur/diagnóstico por imagem , Cabeça do Fêmur/fisiopatologia , Colo do Fêmur/diagnóstico por imagem , Colo do Fêmur/fisiopatologia , Procedimentos Ortopédicos/efeitos adversos , Osteotomia , Fatores de Risco , Ovinos , Estresse Mecânico , Tomografia de Coerência Óptica , Falha de Tratamento
8.
Proc Inst Mech Eng H ; 230(7): 668-74, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27098752

RESUMO

Peri-prosthetic femoral neck fracture after femoral head resurfacing can be either patient-related or surgical technique-related. The study aimed to develop a patient-specific finite element modelling technique that can reliably predict an optimal implant position and give minimal strain in the peri-prosthetic bone tissue, thereby reducing the risk of peri-prosthetic femoral neck fracture. The subject-specific finite element modelling was integrated with optimization techniques including design of experiments to best possibly position the implant for achieving minimal strain for femoral head resurfacing. Sample space was defined by varying the floating point to find the extremes at which the cylindrical reaming operation actually cuts into the femoral neck causing a notch during hip resurfacing surgery. The study showed that the location of the maximum strain, for all non-notching positions, was on the superior femoral neck, in the peri-prosthetic bone tissue. It demonstrated that varus positioning resulted in a higher strain, while valgus positioning reduced the strain, and further that neutral version had a lower strain.


Assuntos
Artroplastia de Quadril/métodos , Cabeça do Fêmur/cirurgia , Prótese de Quadril , Fenômenos Biomecânicos , Fraturas do Colo Femoral/prevenção & controle , Cabeça do Fêmur/diagnóstico por imagem , Colo do Fêmur/diagnóstico por imagem , Colo do Fêmur/fisiopatologia , Colo do Fêmur/cirurgia , Análise de Elementos Finitos , Humanos , Imageamento Tridimensional , Modelos Anatômicos , Tomografia Computadorizada por Raios X
9.
J Orthop Surg Res ; 8: 44, 2013 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-24289492

RESUMO

BACKGROUND: Osteoporosis is one of the commonest bone diseases in which bone fragility is increased. Over 300,000 patients present to hospitals in the UK with fragility fractures each year, with medical and social care costs - most of which relate to hip fracture care - at around £2 billion. The number of these fractures rises by 2% a year. The 30 days mortality is 10% and 30% at 1 year. The purpose of this study is to review the current practice according to NICE and BOA guidelines of secondary prevention of osteoporosis and to suggest changes to these guidelines. METHODS: Patients over 50 years old admitted as inpatients to our facility with non-neck-of-femur (NOF) fragility fractures in March and September 2008 were studied. Retrospectively (March), looking for risk factors and if treated or not, then prospectively (September), after introducing the new trauma admission sheet. Also cross-sectional study was performed by comparing the services provided for NOF and non-NOF fragility fractures in September. Two-sample t test is used to compare between percentages. RESULTS: Twenty-nine percent of fragility fractures are non-NOF fractures with a mean age of 70 years, while the remaining 71% are NOF fractures with a mean age of 80 years. There is a great difference in the care provided to these patients: non-NOF fragility fractures got less attention for assessment of osteoporosis (25%) and obtained less interest in investigations by medical staff (11%) and, finally, less intentions to treat osteoporosis (35%), compared to NOF fractures in which 35% of cases were assessed, 47% were investigated and 71% were treated for osteoporosis. Twenty-five percent of NOF fracture patients were found to have previous fragility fractures in the preceding years, while only 6% were on osteoporosis treatment before the fracture. CONCLUSION: Osteoporosis (a new epidemic) is the most common disease of the bone and its incidence is rising rapidly as the population ages. Though treatable, it is often left untreated. We believe that treating patients with non-NOF fragility fractures from osteoporosis before proceeding to NOF fractures would improve their quality of life and reduce the burden on hospital services and funding.


Assuntos
Osteoporose/tratamento farmacológico , Fraturas por Osteoporose/prevenção & controle , Absorciometria de Fóton/estatística & dados numéricos , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Conservadores da Densidade Óssea/uso terapêutico , Estudos Transversais , Uso de Medicamentos/estatística & dados numéricos , Feminino , Fraturas do Colo Femoral/etiologia , Fraturas do Colo Femoral/prevenção & controle , Humanos , Masculino , Pessoa de Meia-Idade , Osteoporose/complicações , Osteoporose/diagnóstico , Guias de Prática Clínica como Assunto , Prática Profissional , Estudos Prospectivos , Estudos Retrospectivos , Prevenção Secundária/métodos
10.
Acta Orthop Belg ; 79(4): 470-3, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24205780

RESUMO

Vitamin D is required for calcium homeostasis and bone metabolism. This prospective observational study examined the incidence of vitamin D deficiency amongst patients with a fracture of the femoral neck, and the correlation between pre-admission use of bone-protection medication and vitamin D levels. Vitamin D assays were available in 75 out of 151 patients admitted with a hip fracture in February-March 2012; the assays were performed within one week of admission and surgery. The incidence of suboptimal vitamin D levels was 90% (68/75), with severe deficiency (<15nmol/l) or deficiency (<30nmol/l) seen in 71% (53/75). Only 7 patients were on bone protection medication at the time of admission, and all of them had suboptimal vitamin D levels. This suggests that the prevention is practically inexistent or at best insufficient. According to the literature, vitamin D deficiency is also associated with falls and maybe with outcome of surgery. Current management strategies may not be sufficient to address vitamin D deficiency and are overlooking an important and potentially modifiable risk factor.


Assuntos
Fraturas do Colo Femoral/epidemiologia , Fraturas do Colo Femoral/prevenção & controle , Deficiência de Vitamina D/epidemiologia , Deficiência de Vitamina D/prevenção & controle , Acidentes por Quedas , Idoso , Idoso de 80 Anos ou mais , Alendronato/administração & dosagem , Conservadores da Densidade Óssea/administração & dosagem , Conservadores da Densidade Óssea/uso terapêutico , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Risco
11.
Intern Med J ; 43(1): 38-45, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22931254

RESUMO

BACKGROUND: Recently, the dual-energy X-ray absorptiometry (DXA) diagnostic cut-off (T-score) for Australian Pharmaceutical Benefits Scheme (PBS) supported primary fracture prevention therapy with alendronate for older women (>70 years) has been changed from -3.0 to -2.5. AIM: To examine the impact of the expanded criteria for PBS-supported fracture prevention therapy in older women on case finding and cost. METHODS: One thousand, nine hundred and eighty-three women, median age 76 years, not previously known to have low bone mineral density by DXA or a vertebral fracture underwent DXA scanning and a thoracolumbar X-ray. A woman was considered eligible for fracture prevention therapy if she had a T-score ≤-2.5 at the femoral neck and/or the lumbar vertebrae (two to four) or at least one vertebral fracture of ≥20% deformity. RESULTS: Seven hundred and forty-six women (37.6%) met the new criteria as a case for PBS-subsidised fracture prevention therapy. Four hundred and thirty-one (21.7%) had a T-score ≤-2.5 on DXA compared with 10.6% (n = 210) with a T-score ≤-3.0. Four hundred and eighty-three (24.4%) had at least one vertebral fracture. Only 8.5% (n = 168) had both a T-score ≤-2.5 and a prevalent vertebral fracture. The cost per case found by DXA equated to $460 compared with $398 for screening by thoracolumbar X-ray. CONCLUSIONS: The use of either DXA or X-ray will identify approximately two-thirds of women aged 70 years and over who would be eligible for fracture prevention. The use of X-ray would identify a marginally larger number of women and at lower financial cost but involve substantially greater radiation exposure.


Assuntos
Densidade Óssea , Fraturas Espontâneas/prevenção & controle , Vértebras Lombares/diagnóstico por imagem , Osteoporose Pós-Menopausa/diagnóstico por imagem , Atenção Primária à Saúde/métodos , Fraturas da Coluna Vertebral/prevenção & controle , Vértebras Torácicas/diagnóstico por imagem , Absorciometria de Fóton/economia , Idoso , Idoso de 80 Anos ou mais , Alendronato/uso terapêutico , Austrália/epidemiologia , Conservadores da Densidade Óssea/uso terapêutico , Feminino , Fraturas do Colo Femoral/prevenção & controle , Colo do Fêmur/diagnóstico por imagem , Fraturas Espontâneas/diagnóstico por imagem , Fraturas Espontâneas/economia , Fraturas Espontâneas/etiologia , Humanos , Vértebras Lombares/lesões , Programas de Rastreamento , Osteoporose Pós-Menopausa/tratamento farmacológico , Osteoporose Pós-Menopausa/economia , Osteoporose Pós-Menopausa/epidemiologia , Doses de Radiação , Medição de Risco , Fraturas da Coluna Vertebral/diagnóstico por imagem , Fraturas da Coluna Vertebral/economia , Fraturas da Coluna Vertebral/etiologia , Vértebras Torácicas/lesões
12.
Indian J Pediatr ; 79(5): 667-9, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-21761121

RESUMO

Fibrous dysplasia is an uncommon metabolic bone disease. Medical management is often not rewarding. Index patient, a 15-year-old girl with history of recurrent fractures on trivial trauma was treated with pamidronate. She showed good outcome with symptomatic improvement and no new fractures over 3 year duration of follow up.


Assuntos
Conservadores da Densidade Óssea/uso terapêutico , Difosfonatos/uso terapêutico , Fraturas do Colo Femoral/etiologia , Displasia Fibrosa Poliostótica/tratamento farmacológico , Adolescente , Feminino , Fraturas do Colo Femoral/prevenção & controle , Displasia Fibrosa Poliostótica/complicações , Displasia Fibrosa Poliostótica/diagnóstico , Humanos , Pamidronato
13.
Endocr Regul ; 45(4): 199-204, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22073949

RESUMO

OBJECTIVES: The aim of the study is to evaluate the changes of bone mineral density (BMD), incidence of pathological fractures and to asses the effect of bisphosphonate therapy in prostate cancer patients (PCa) on androgen deprivation therapy (ADT) with the use of LHRH. METHODS: In this prospective study bone mass density (BMD) was assessed by dual x-ray absorptiometry (DXA) in 97 PCa patients and 89 patients of compared group. DXA was examined at baseline and patients in the study group were subjected to ADT. PCa patients with osteoporosis were treated by calcium, vitamin D, and bisphosphonate and the subsequent DXA was made after 10 months. All other PCa patients (non-osteoporotic) had DXA examined every 12-14 months. RESULTS: Patients of the study group had significantly lower baseline L1-L4 and total hip BMD (p=0.028, p=0.022). BMD was significantly lower in L1-L4 and total hip (p=0.004, p<0.001, resp.) after 10-14 months and in L1-L4, femoral neck, and total hip (p=0.001, p=0.037, p< 0.001, resp.) after 20-26 months of ADT. After the treatment for osteoporosis with bisphosphonate a significant increase of BMD (p=0.04) was found in a total of 23 patients. Overall, the incidence of fractures after 20-26 months of ADT was 8.5 %. CONCLUSIONS: Osteopenia is very common in hormone naive PCa patients. There was a significant loss of BMD after 12 months of ADT which was progressive while the patients were on ADT. Bisphosphonate therapy was effective after 20 months of treatment. The incidence of pathological fractures was 7-fold higher in the study group.


Assuntos
Antagonistas de Androgênios/uso terapêutico , Densidade Óssea/efeitos dos fármacos , Doenças Ósseas Metabólicas/tratamento farmacológico , Difosfonatos/uso terapêutico , Fraturas Espontâneas/prevenção & controle , Neoplasias da Próstata/tratamento farmacológico , Absorciometria de Fóton , Idoso , Conservadores da Densidade Óssea/uso terapêutico , Doenças Ósseas Metabólicas/diagnóstico por imagem , Doenças Ósseas Metabólicas/epidemiologia , Cálcio/uso terapêutico , Fraturas do Colo Femoral/diagnóstico por imagem , Fraturas do Colo Femoral/epidemiologia , Fraturas do Colo Femoral/prevenção & controle , Fraturas Espontâneas/diagnóstico por imagem , Fraturas Espontâneas/epidemiologia , Articulação do Quadril/efeitos dos fármacos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Neoplasias da Próstata/epidemiologia , Vitamina D/uso terapêutico , Vitaminas/uso terapêutico
14.
Aging Clin Exp Res ; 23(2 Suppl): 25-7, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21970912

RESUMO

The progressive aging of the population inevitably leads to an increase in all age-related diseases, with osteoporosis arising as a health and social priority. Fragility fractures, resulting by Osteoporosis, may have important consequences such as hospitalizations with long periods of immobility, need of surgery, increased risk of disability and partial or complete loss of autonomy in the ordinary activities of daily life and related economical burden. It is therefore essential to implement immediately a tertiary prevention to reduce the risk of further fractures through a diagnostic-therapeutic evidence-based pathway. So, starting from the fracture, the orthopaedic surgeon is meant to play an essential role in the management of osteoporotic patients, both to reduce the risk of further fractures and improve long-term outcome in these people, thus lowering the health and life quality downward spiral that often results in fractures in the elderly.


Assuntos
Fraturas Ósseas/prevenção & controle , Ortopedia/métodos , Ortopedia/tendências , Osteoporose/terapia , Idoso , Densidade Óssea , Densitometria/métodos , Fraturas do Colo Femoral/prevenção & controle , Humanos , Osteoporose/complicações , Fraturas por Osteoporose/prevenção & controle , Risco , Resultado do Tratamento
15.
Praxis (Bern 1994) ; 100(14): 821-32, 2011 Jul 06.
Artigo em Alemão | MEDLINE | ID: mdl-21732293
16.
Orthop Clin North Am ; 42(2): 207-30, viii, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21435496

RESUMO

This article determines the incidence and cause of the complications commonly associated with metal-on-metal hip resurfacing implants and the proposed methods to prevent these complications. The literature available in PubMed was reviewed. Complication rates after hip resurfacing are low, and the procedure has shown both safety and efficacy in the hands of surgeons trained in specialized centers. Proper surgical technique can further reduce the incidence of femoral neck fracture, component loosening, and abnormal wear of the prosthesis. A more systematic detection of adverse local tissue reactions is needed to provide accurate assessments of their prevalence.


Assuntos
Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/métodos , Cimentação , Fraturas do Colo Femoral/epidemiologia , Fraturas do Colo Femoral/prevenção & controle , Prótese de Quadril , Humanos , Incidência , Osteoartrite do Quadril/terapia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/prevenção & controle , Falha de Prótese , Ajuste de Prótese , Reoperação , Estresse Mecânico
17.
Clin Orthop Relat Res ; 469(6): 1621-6, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20936388

RESUMO

BACKGROUND: Femoral neck fracture in hip resurfacing has been attributed to technical error during femoral head preparation. In the absence of fracture, several radiographic findings have been speculated to increase the risk of femoral component failure. QUESTIONS/PURPOSES: We examined whether (1) the use of navigation to reduce technical errors during femoral head preparation reduces the incidence of femoral neck fractures in the short-term followup period; and (2) alignment of the femoral component with the use of computer navigation reduces the incidence of femoral neck thinning, femoral stem radiolucencies, and stem migration. METHODS: We retrospectively reviewed the first 100 Birmingham Hip Resurfacings performed in 94 prospectively followed patients between October 2005 and November 2007. We examined all radiographs on last followup. Eighty-six patients of the 94 patients had a minimum followup of 2 years (mean, 2.5 years; range, 2-4.1 years). RESULTS: There were no cases of femoral neck notching, varus femoral component alignment, or femoral neck fractures in the series. Neck thinning of greater than 10% was observed in three patients and perimetaphyseal stem lucencies were noted in 10 patients. In three patients, the metaphyseal stem showed varus migration relative to the postoperative stem-shaft angle at latest followup. There was one revision to a total hip arthroplasty for deep sepsis. The overall survivorship at 4 years was 99%. CONCLUSIONS: The use of imageless computer navigation to reduce technical errors in hip resurfacing may reduce the incidence of femoral neck fracture in the short-term. However, neck thinning, stem radiolucencies, and stem migration remain radiographic sequelae of hip resurfacing despite the use of navigation for placement of the femoral component.


Assuntos
Artroplastia de Quadril/métodos , Fraturas do Colo Femoral/prevenção & controle , Cabeça do Fêmur/cirurgia , Prótese de Quadril , Osteoartrite do Quadril/cirurgia , Cirurgia Assistida por Computador/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Artroplastia de Quadril/efeitos adversos , Feminino , Fraturas do Colo Femoral/etiologia , Fraturas do Colo Femoral/cirurgia , Cabeça do Fêmur/diagnóstico por imagem , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Quadril/diagnóstico por imagem , Desenho de Prótese , Radiografia , Estudos Retrospectivos , Fatores de Tempo
18.
Exp Toxicol Pathol ; 63(5): 491-8, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20385473

RESUMO

The aim of this study was to evaluate whether zinc (Zn) supplementation can protect from an enhanced risk of femoral neck fracture due to chronic exposure to cadmium (Cd). For this purpose, biomechanical properties of the neck and bone mineral density (BMD) at the proximal femur of rats receiving Cd (5 or 50mg/l) or/and Zn (30 or 60 mg/l) in drinking water for 6 and 12 months were evaluated. The exposure to 5 and 50mg Cd/l decreased the proximal femur BMD and affected biomechanical properties of the femoral neck. In the rats treated with 5mg Cd/l, weakening of the femoral neck strength was observed after 12 months, whereas at higher exposure--already after 6 months. The supplementation with 30 and 60 mg Zn/l, enhancing its daily intake by 68% and 138%, respectively, compared to the standard diet, had beneficial influence on the femoral neck biomechanical properties during the exposure to Cd, but it had no impact on the proximal femur BMD. Zn administration during the 12-month exposure to 5mg Cd/l totally prevented the weakening of the neck. Zn supplementation during the 6-month treatment with 50mg Cd/l entirely prevented the Cd-induced decrease in the neck fracture strength; however, at the longer exposure to Cd the protective effect of Zn was only partial. The beneficial Zn influence was independent on its dose. The results allow the conclusion that an increase in the daily intake of Zn during moderate and relatively high exposures to Cd can reduce femoral neck susceptibility to fracture. Based on the findings, it seems that enhanced Zn consumption in subjects chronically exposed to Cd may, at least partly, protect from the enhanced risk of femoral neck fracture.


Assuntos
Cloreto de Cádmio/toxicidade , Suplementos Nutricionais , Poluentes Ambientais/toxicidade , Fraturas do Colo Femoral/prevenção & controle , Colo do Fêmur/efeitos dos fármacos , Zinco/uso terapêutico , Animais , Densidade Óssea/efeitos dos fármacos , Cloreto de Cádmio/sangue , Cloreto de Cádmio/farmacocinética , Poluentes Ambientais/farmacocinética , Fraturas do Colo Femoral/metabolismo , Colo do Fêmur/diagnóstico por imagem , Colo do Fêmur/metabolismo , Masculino , Radiografia , Ratos , Ratos Wistar , Risco , Fatores de Tempo , Zinco/administração & dosagem , Zinco/farmacologia
19.
Hip Int ; 20 Suppl 7: S43-7, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20512771

RESUMO

Surgical navigation systems are offered to provide more precise implantation of the femoral component in hip resurfacing (HR), allowing to reduce the risk of malpositioning and of femoral neck fracture and notching. We conducted a retrospective analysis of 30 HR divided into two cohorts and compared the results of a nonnavigated group (15 hips) with those of a navigated group (15 hips). The BrainLAB Computer Navigation System was used in all cases. No notching occurred in either group. The femoral component did not show better positioning in the navigated group, but more outlier cases were observed in the nonnavigated group (7, versus 3 in the navigated group). Although there are no long-term studies showing that surgical navigation increases the survival of HR, the avoidance of outlier values justifies its use, especially during the surgical learning curve, which is a difficult and lengthy one.


Assuntos
Artroplastia de Quadril/métodos , Colo do Fêmur/cirurgia , Prótese de Quadril , Osteoartrite do Quadril/cirurgia , Cirurgia Assistida por Computador/métodos , Adulto , Idoso , Feminino , Fraturas do Colo Femoral/prevenção & controle , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Reoperação , Estudos Retrospectivos , Resultado do Tratamento
20.
Eklem Hastalik Cerrahisi ; 20(3): 143-8, 2009.
Artigo em Turco | MEDLINE | ID: mdl-19958270

RESUMO

OBJECTIVES: We aimed at assessing the visual functions in elderly patients with femoral neck fracture and to compare the results with age-matched controls in this three-year prospective study. PATIENTS AND METHODS: Seventy-one patients with a history of fall related hip fracture (39 females, 32 males; mean age 76.3+/-9.7 years; range 64 to 90 years) and who were diagnosed with femoral neck fracture after direct graphy were treated by means of bipolar partial prosthesis and they were contacted postoperatively or prior to discharge to participate in the study. Visual acuity, depth perception, the presence of cataract in the red reflex were evaluated. A dilated fundus and slit-lamp examination were performed if possible. On completion of the examination, the ophthalmologist documented the causes of any visual impairment found. Control group was comprised of age-matched 40 subjects (22 females, 18 males; mean age 73.2+/-7.6 years; range 62 to 90 years) who applied to ophtalmology clinic for routine examination. RESULTS: The visual acuity was significantly decreased in the patient group as was stereopsis (p<0.05). We found no difference between the study group and the controls when we evaluate the distribution of self reported eye disease and eye disease found on ocular examination. The rate of cases who reported not usually wearing glasses was 35% while it was 5% in the control group. When we evaluate the time since last examination, 38% of cases had not had an eye examination for over four years, as compared with 22.5% of controls. CONCLUSION: This study shows that elderly people should have their eyes tested at least once every two years, refractive errors should be corrected and eye diseases should be treated to decrease the risk of fall-related femoral neck fractures.


Assuntos
Fraturas do Colo Femoral/complicações , Transtornos da Visão/epidemiologia , Testes Visuais , Acidentes por Quedas/prevenção & controle , Idoso , Idoso de 80 Anos ou mais , Percepção de Profundidade , Feminino , Fraturas do Colo Femoral/prevenção & controle , Fraturas do Colo Femoral/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Acuidade Visual
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