Assuntos
Doença de Crohn , Granulomatose Orofacial , Adulto , Doença de Crohn/complicações , Doença de Crohn/tratamento farmacológico , Granulomatose Orofacial/induzido quimicamente , Granulomatose Orofacial/tratamento farmacológico , Humanos , Intestinos , Recidiva , Inibidores do Fator de Necrose Tumoral/efeitos adversosAssuntos
Monoterpenos Cicloexânicos/efeitos adversos , Hipersensibilidade a Drogas/etiologia , Granulomatose Orofacial/induzido quimicamente , Hipersensibilidade Tardia/induzido quimicamente , Doenças Labiais/induzido quimicamente , Criança , Hipersensibilidade a Drogas/diagnóstico , Granulomatose Orofacial/diagnóstico , Humanos , Hipersensibilidade Tardia/diagnóstico , Doenças Labiais/diagnósticoAssuntos
Amálgama Dentário/efeitos adversos , Granulomatose Orofacial/induzido quimicamente , Hipersensibilidade Tardia/etiologia , Índio/efeitos adversos , Doenças Labiais/induzido quimicamente , Granulomatose Orofacial/patologia , Humanos , Hipersensibilidade Tardia/patologia , Doenças Labiais/patologia , Testes do EmplastroRESUMO
Orofacial granulomatosis is a clinicopathologic entity characterized by chronic swelling of the lip and possible soft tissues in the orofacial region owing to granulomatous inflammation of unknown cause. We present 3 cases of orofacial granulomatosis associated with allergic contact dermatitis to dental materials. Previous treatment with corticosteroids did not have any therapeutic effect. Patch testing revealed a positive reaction to several allergens, including dental amalgam and mercury in 2 cases. A lymphocyte transformation test modified for metals was used to evaluate lymphocyte reactivity. After the removal of the suspected allergens, all patients experienced recovery within 1 month, with the exception of the lip swelling, which gradually subsided over several months.
Assuntos
Amálgama Dentário/efeitos adversos , Granulomatose Orofacial/induzido quimicamente , Hipersensibilidade Tardia/etiologia , Doenças Labiais/induzido quimicamente , Mercúrio/efeitos adversos , Adulto , Feminino , Granulomatose Orofacial/patologia , Granulomatose Orofacial/terapia , Humanos , Hipersensibilidade Tardia/patologia , Hipersensibilidade Tardia/terapia , Doenças Labiais/patologia , Doenças Labiais/terapia , Pessoa de Meia-Idade , Testes do Emplastro , Resultado do Tratamento , Adulto JovemRESUMO
OBJECTIVES: It has been reported that clinical changes due to hypersensitivity reactions to various foods, preservatives, and oral hygiene products may be consistent with the characteristic signs of orofacial granulomatosis (OFG). The objective of this study was to examine 37 well-documented cases of cinnamon-induced contact stomatitis for clinical and histological features consistent with a diagnosis of OFG. STUDY DESIGN: We reviewed the records of the 37 cases to screen them for the clinical and histopathologic features of OFG. RESULTS: Twelve patients showed clinical characteristics of OFG. The most commonly affected site was the gingiva. Focal non-caseating, epitheloid granulomas were observed in four histologic specimens. Multinucleated giant cells were observed in an additional four cases. CONCLUSIONS: Although OFG may have multiple etiologies, it is clear that, in some instances, a hypersensitivity reaction to cinnamon products can elicit lesions consistent with OFG.
Assuntos
Cinnamomum zeylanicum/efeitos adversos , Granulomatose Orofacial/induzido quimicamente , Estomatite/induzido quimicamente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The etiology, diagnosis and treatment of childhood granulomatous periorificial dermatitis (GPD) are highly controversial. Some authors underline the similarities between GPD and perioral dermatitis and consider both as part of a spectrum while other authors regard GPD as a distinctive condition. Clinically GPD is a papulo-pustular periorificial disease of the face which histopathologically shows a granulomatous perifollicular infiltrate. Because of its granulomatous pattern, GPD also has been related to cutaneous sarcoidosis. The clinical course is benign and self-limited. Topical steroids are regarded as either the main cause or a worsening factor. While topical treatment is occasionally effective, systemic antibiotic therapy of GPD is usually recommended. We report a "typical" case of GPD and review the literature to discuss the difficulties in its diagnosis and treatment.