Health-related quality of life and psychological well-being in men with benign prostatic hyperplasia: An integrative review.

AIM: This integrative review aims to summarize the evidence regarding the health-related quality of life, psychological well-being, and the relevant influencing factors in men with benign prostatic hyperplasia. METHODS: An integrative published work review was adopted. Articles published in English from 2002 to 2014 that addressed the variables of health-related quality of life, psychological well-being, or the relevant influencing factors in men with benign prostatic hyperplasia were included. RESULTS: Of the 4708 articles retrieved, 16 were deemed relevant. Analysis of the published work suggests that benign prostatic hyperplasia has a negative impact on health-related quality of life, citing two major predictive factors: lower urinary tract symptoms and medical management. The psychological well-being of men with benign prostatic hyperplasia remains inconclusive as very limited studies have been conducted to investigate this aspect in these men. Limited studies collectively investigate the relationship among concepts such as health-related quality of life, psychological well-being, and sociodemographic and clinical factors related to benign prostatic hyperplasia. CONCLUSION: This review highlights the need to conduct further study on health-related quality of life and the psychological well-being of patients with benign prostatic hyperplasia, especially in an Asian context. Such efforts promote patient-centric care and improve patient satisfaction through incorporating the concept of health-related quality of life into clinical practices.

High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue.

While Trichomonas vaginalis, a protozoan parasite, is a well-investigated pathogen in the female population, there is little awareness of its significance in the male uro-genital tract. The presence of T. vaginalis in the prostate gland has only been scarcely investigated and has never been attested in conditions other than clinical prostatitis. Still, by some authors, this organ is regarded as ecologic niche for T. vaginalis. Since normal prostate tissue of sufficient quality is hard to come by, we investigated samples from 86 patients (mean age 68.7 ± 7.6 years) suffering from benign prostatic hyperplasia (BPH), a medical condition currently ranked as noninfectious, but characterized by chronic inflammatory tissue infiltrates of unknown etiology. Applying two different PCR protocols and sequence analysis of the respective amplicons, we detected T. vaginalis DNA in 29/86 (34%) BPH tissue samples, whereas in only 2/86 (2.3%) cases T. vaginalis grew in culture. Detection of T. vaginalis DNA correlated significantly (P < 0.01) with elevated peripheral blood monocytic cell counts, appearing along with protozoan infections. Given the unexpected high prevalence of T. vaginalis in BPH tissue of a nonselected, elderly study population from Austria, further epidemiological studies have to confirm this finding. Potential interactions of T. vaginalis in its prostatic habitat may be investigated with respect to their possible contribution to the inflammatory pathogenesis of BPH, since inflammatory cytokines have been shown to sustain prostatic hyperplastic growth.

Prostatic paracoccidioidomycosis: differential diagnosis of prostate cancer.

Symptomatic prostatic paracoccidioidomycosis (PCM) is a very rare condition; however, it may express as a typical benign prostatic hyperplasia or a simulating prostatic adenocarcinoma. This case report presents PCM mimicking prostatic adenocarcinoma. The purpose of this paper is to call the general physician's attention to this important differential diagnosis.

Prostatic paracoccidioidomycosis: differential diagnosis of prostate cancer

Symptomatic prostatic paracoccidioidomycosis (PCM) is a very rare condition; however, it may express as a typical benign prostatic hyperplasia or a simulating prostatic adenocarcinoma. This case report presents PCM mimicking prostatic adenocarcinoma. The purpose of this paper is to call the general physician's attention to this important differential diagnosis.