Outbreak of laboratory-acquired Brucella abortus in Brazil: a case report

Human brucellosis is an occupational disease affecting workers in slaughterhouses, butcher shops and the milk and dairy product industry as well as individuals who work in clinical or research laboratories. We report the first outbreak of a Brucella abortus infection in a Brazilian laboratory and compare the data obtained with reports available in the literature. Exposure was a result of damage to a biological safety cabinet and failure of the unidirectional airflow ventilation system. An epidemiological investigation identified 3 seroconverted individuals, 1 of whom had clinical manifestations and laboratory results compatible with infection at the time of exposure (n=11; attack rate=9.1%).

Infeccao humana adquirida em laboratorio causada pelo virus SPH 114202 (Arenavirus: familia Arenaviridae): aspectos clinicos e laboratoriais / Laboratory acquired infection by the virus SP H 114202 (Arenavirus : Arenaviridae) : clinical and laboratory findings

Sao descritos os achados clinico-laboratoriais da infeccao acidental pelo virus SP H 114202 (Arenavirus, familia Arenaviridae), um virus novo causador de febre hemorragica humana. O paciente, tecnico de laboratorio, apresentou quadro febril por 13 dias. A doenca cursou com febre elevada (39ºC) diaria, cefaleia, calefrios e mialgias por 8 dias. A partir do 3§ dia surgiram nauseas, vomitos alimentares e anorexia e no 10§ dia, epigastralgia, diarreia e gengivorragia....

Primary cutaneous coccidioidomycosis: a review of the literature and a report of a new case.

A 31-year-old woman working in the laboratory with the mycelial phase of Coccidioides immitis developed a firm, raised, erythematous lesion on the left index finger. A biopsy specimen of the lesion grew a white mold that proved to be C immitis. A sinus tract communicating with the lesion and extending into the proximal phalanx developed. The expressed pus was positive for the tissue form of C immitis by potassium hydroxide and periodic acid-Schiff stains and fluorescent-antibody techniques. The sinus tract was irrigated with an aqueous solution of amphotericin B (Fungizone). The tract closed and the lesion decreased in size. Healing was completed in ten weeks. Primary cutaneous disease must be distinguished from disseminated disease with cutaneous manifestations. In the majority of cases, primary disease heals spontaneously whereas disseminated disease usually requires systemic treatment with amphotericin B.