Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 35
Filtrar
1.
J Vet Sci ; 25(1): e16, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38311329

RESUMO

This report aims to describe a case of tumor-like lymphoplasmacytic conjunctivitis in a 7-year-old spayed-female Pomeranian. On complete ophthalmic examination, a mass with papillary projections was noted on the bulbar surface of the right third eyelid. Debulking of the mass was performed while preserving as much of the third eyelid as possible. On the histopathological examination, the mass was diagnosed as lymphoplasmacytic conjunctivitis with mild epithelial hyperplasia. Although a slight regrowth of the mass was noted 3 weeks after surgery, intralesional injection of triamcinolone acetonide led to its disappearance. There was no further recurrence after 5 months.


Assuntos
Conjuntivite , Doenças do Cão , Neoplasias , Cães , Feminino , Animais , Membrana Nictitante/cirurgia , Triancinolona Acetonida , Neoplasias/veterinária , Conjuntivite/diagnóstico , Conjuntivite/tratamento farmacológico , Conjuntivite/veterinária , Injeções Intralesionais/veterinária , Doenças do Cão/diagnóstico , Doenças do Cão/tratamento farmacológico , Doenças do Cão/cirurgia
2.
Vet Surg ; 51(8): 1265-1272, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-35730789

RESUMO

OBJECTIVE: To describe the use and outcome of sclerotherapy with intralesional doxycycline foam in a horse with a mandibular aneurysmal bone cyst. STUDY DESIGN: Case report. ANIMALS: Client-owned 1 year old Standardbred filly. METHODS: The horse presented for progressive mandibular swelling. A 10 mg/mL doxycycline foam was prepared for intralesional injection. Three doses were injected into the lesion under computed tomographic guidance at 6 and 15 weeks after initial treatment. Volume reduction was monitored after each treatment with 3D volumetric rendering and region of interest segmentation using commercially available software. RESULTS: The volume of the lesion decreased from 458.7455 cm3 before treatment, to 363.3101 cm3 at 6 weeks, 273.5855 cm3 at 15 weeks, and 247.2316 cm3 6 months later, resulting in a total reduction of 54% of the initial volume. Bone formation was noted in the lesion. No adverse effects related to doxycycline foam injections were noted. The mandibular swelling was resolved after treatment. CONCLUSION: Intralesional doxycycline sclerotherapy was shown to be efficacious in reducing the volume of the aneurysmal bone cyst in the horse presented in this report. There was complete resolution of mandibular swelling with no side effects related to the intralesional injections.


Assuntos
Cistos Ósseos Aneurismáticos , Doenças dos Cavalos , Cavalos , Feminino , Animais , Escleroterapia/veterinária , Escleroterapia/efeitos adversos , Escleroterapia/métodos , Cistos Ósseos Aneurismáticos/tratamento farmacológico , Cistos Ósseos Aneurismáticos/etiologia , Cistos Ósseos Aneurismáticos/veterinária , Doxiciclina/uso terapêutico , Resultado do Tratamento , Injeções Intralesionais/veterinária , Doenças dos Cavalos/etiologia
3.
Open Vet J ; 12(2): 192-196, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35603061

RESUMO

Background: Benign esophageal strictures arise from various etiologies, mostly severe esophagitis. Although endoscopic balloon dilation is still the first-line therapy, refractory or recurrent strictures do occur and remain a challenge to the endoluminal treatment. The aim of this report was to communicate a recurrent esophageal stricture resolution in a cat treated with balloon dilatation and steroid injections in Ciudad de Buenos Aires, Argentina. Case Description: A 1-year-old spayed mix-breed female cat was consulted to the Veterinary Endoscopy Service for recurring regurgitation after two previous esophageal dilations. The cat had received doxycycline for Mycoplasma spp. infection and 20 days after the treatment consulted for dysphagia and regurgitation. Upper esophagogastroscopy (UGE) was performed with an Olympus CV-160 8.7 mm diameter endoscope; an annular 7 mm stricture was observed 3 cm caudal to the cranial esophagus sphincter. Three balloon dilatations procedures were performed with a Boston Scientific Controlled Radial Expansion (CRE) balloon 8-10-12 mm of 1 minute each. Because of ongoing clinical signs, another UGE was performed 15 days from the first procedure: a 3 mm stricture was encountered, balloon dilatation was repeated with 6-10-12 mm diameter, and a four-quadrant triamcinolone was injected in the submucosa. Clinically, the cat could eat with no alterations until day 20, where it started with mild dysphagia. Another UGE was performed, and the known stricture conserved a 11 mm diameter and balloon dilatation 12-15-16.5 mm with triamcinolone injection was repeated 30 days after the previous procedure. The cat could eat kibbles with no clinical signs in an 11-month follow-up. Conclusion: The alternative to triamcinolone injection after balloon dilatation presented in this clinical report was successful and it could be a therapeutic option for recurrent esophageal strictures in cats as it is in human medicine.


Assuntos
Doenças do Gato , Transtornos de Deglutição , Estenose Esofágica , Animais , Doenças do Gato/tratamento farmacológico , Gatos , Constrição Patológica/complicações , Constrição Patológica/tratamento farmacológico , Constrição Patológica/veterinária , Transtornos de Deglutição/tratamento farmacológico , Transtornos de Deglutição/etiologia , Transtornos de Deglutição/veterinária , Dilatação/efeitos adversos , Dilatação/métodos , Dilatação/veterinária , Estenose Esofágica/complicações , Estenose Esofágica/veterinária , Esofagoscopia/efeitos adversos , Esofagoscopia/veterinária , Feminino , Injeções Intralesionais/veterinária , Esteroides , Triancinolona/uso terapêutico
4.
J Vet Intern Med ; 35(1): 451-455, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33350511

RESUMO

BACKGROUND: Tigilanol tiglate (TT) is a novel small molecule approved by the European Medicines Agency for intratumoral treatment of mast cell tumors (MCTs) in dogs. In a randomized controlled clinical efficacy and safety study in the United States, 85 of 116 dogs that received a single TT injection achieved complete response (CR) of the treated MCT by day 28. OBJECTIVE: To evaluate the durability of the TT treatment response achieved at day 28 in the U.S. study by assessing MCT recurrence at the treatment site 6 and 12 months after TT administration. ANIMALS: Eighty-five dogs previously treated with TT. METHODS: Dogs that achieved CR at day 28 were assessed retrospectively for the presence or absence of MCT at the treatment site using records from clinical visits and telephone interviews with owners. Dogs unavailable at an assessment time were considered lost-to-follow-up and data for their last assessment used in the final analysis. RESULTS: By 12 months after TT treatment, 64 dogs remained evaluable, with 21 unavailable. Of evaluable patients, 57 (89%) remained tumor free at the treatment site and 7 (11%) had developed recurrence. All recurrences occurred within the first 6 months, predominantly (5/7, 71%) within the first 12 weeks. CONCLUSIONS AND CLINICAL IMPORTANCE: Tigilanol tiglate provided a durable long-term local response for the treatment of MCT in dogs.


Assuntos
Doenças do Cão , Mastócitos , Animais , Doenças do Cão/tratamento farmacológico , Cães , Injeções Intralesionais/veterinária , Recidiva Local de Neoplasia/tratamento farmacológico , Recidiva Local de Neoplasia/veterinária , Estudos Retrospectivos
5.
J Vet Med Sci ; 81(11): 1632-1635, 2019 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-31645510

RESUMO

An African penguin (Spheniscus demersus) presented with a large peri-cloacal mass. The mass was diagnosed as a pyogranuloma histologically, with multifocal to coalescing inflammatory responses in the subcutis and keratinized simple stratified squamous epithelium overlying the surface. The patient was prescribed 125 mg/kg oral clavulanic acid/amoxycillin twice a day and 20 mg/kg oral terbinafine once a day for 14 days, but there was no change in the size of the mass 4 days after therapy, so a decision was made to administer 1 mg/kg of intralesional methylprednisolone. Fourteen days later, the mass resolved with no further recurrence. This case demonstrated that intralesional methylprednisolone used with antibiotic and antifungals was effective in resolving a peri-cloacal pyogranuloma and without any side effects.


Assuntos
Doenças das Aves/tratamento farmacológico , Granuloma/veterinária , Metilprednisolona/uso terapêutico , Spheniscidae , Combinação Amoxicilina e Clavulanato de Potássio/uso terapêutico , Animais , Animais de Zoológico , Antibacterianos/uso terapêutico , Antifúngicos/uso terapêutico , Doenças das Aves/microbiologia , Granuloma/tratamento farmacológico , Granuloma/microbiologia , Injeções Intralesionais/veterinária , Masculino , Metilprednisolona/administração & dosagem , Terbinafina/uso terapêutico
6.
J Am Vet Med Assoc ; 252(1): 84-91, 2018 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-29244608

RESUMO

OBJECTIVE To evaluate the safety and efficacy of intralesional triamcinolone administration, as a sole or adjuvant treatment, in dogs with mast cell tumors. DESIGN Retrospective case series ANIMALS 23 dogs with mast cell tumors. PROCEDURES Medical records of dogs treated for a confirmed diagnosis of a mast cell tumor between 2005 and 2011 were reviewed. Patients with a confirmed diagnosis and measurable disease (tumor longest dimension ≥ 0.5 cm) that had received ≥ 1 intralesional treatment with triamcinolone, regardless of prior, concurrent, or adjuvant treatments, were eligible for inclusion. Data collected included patient characteristics, results of cytologic and histologic testing and tumor staging, triamcinolone dosage, treatment response, and adverse events. RESULTS 23 dogs with 24 tumors were included. Tumors were treated by means of intralesional triamcinolone administration alone (n = 5), intralesional triamcinolone administration with concurrent oral administration of glucocorticoids (6), and intralesional triamcinolone administration with concurrent cytotoxic chemotherapy, with or without oral administration of corticosteroids and radiation therapy (13). Of 5 dogs treated with intralesional triamcinolone administration alone, 1 achieved a complete response, 3 achieved a partial response, and 1 maintained stable disease. The response rate for all 24 tumors (23 dogs) was 67% (16/24), including 4 with a complete response and 12 with a partial response. The median time to progression was 63 days (range, 6 to 447 days). Three dogs experienced adverse events (local hemorrhage [n = 1]; suspected gastrointestinal ulceration [2]). CONCLUSIONS AND CLINICAL RELEVANCE Intralesional triamcinolone administration may be well tolerated and effective for treatment of nonresectable mast cell tumors in dogs.


Assuntos
Anti-Inflamatórios/uso terapêutico , Doenças do Cão/tratamento farmacológico , Mastocitoma Cutâneo/veterinária , Recidiva Local de Neoplasia/veterinária , Neoplasias Cutâneas/veterinária , Triancinolona/uso terapêutico , Animais , Anti-Inflamatórios/administração & dosagem , Cães , Feminino , Injeções Intralesionais/veterinária , Masculino , Mastocitoma Cutâneo/tratamento farmacológico , Prontuários Médicos , Recidiva Local de Neoplasia/tratamento farmacológico , Estadiamento de Neoplasias/veterinária , Estudos Retrospectivos , Neoplasias Cutâneas/tratamento farmacológico , Resultado do Tratamento , Triancinolona/administração & dosagem
7.
J Am Vet Med Assoc ; 248(5): 532-7, 2016 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-26885596

RESUMO

CASE DESCRIPTION A 5-year-old castrated male Maltese was evaluated for intermittent clinical signs of muscle cramping and abnormal movements of the skin of the right pelvic limb at the site where an infiltrative lipoma had twice been resected. After the second surgery, the surgical field was treated with radiation therapy (RT). The clinical signs developed approximately 14 months after completion of RT. CLINICAL FINDINGS When clinical signs were present, the right biceps femoris and semitendinosus muscles in the area that received RT were firm and had frequently visible contractions, and the skin overlying those muscles had episodic vermiform movements. Electromyography of those muscles revealed abnormal spontaneous activity with characteristics consistent with myokymic discharges and neuromyotonia. Magnetic resonance imaging of the affected leg revealed no evidence of tumor regrowth. The myokymia and neuromyotonia were considered secondary to RT. TREATMENT AND OUTCOME 4 U of Clostridium botulinum toxin type A (BoNT-A) neurotoxin complex was injected into the affected muscles at each of 6 sites twice during a 24-hour period (ie, 48 U of BoNT-A were administered). The clinical signs were completely resolved 10 days after BoNT-A treatment and were controlled by repeated BoNT-A treatment every 3 to 4 months for > 1 year. CLINICAL RELEVANCE To our knowledge, this is the first report of myokymia and neuromyotonia secondary to RT in a dog. For the dog of this report, injection of BoNT-A into the affected muscles was safe, effective, and easy to perform.


Assuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Doenças do Cão/tratamento farmacológico , Síndrome de Isaacs/veterinária , Mioquimia/veterinária , Fármacos Neuromusculares/uso terapêutico , Lesões por Radiação/veterinária , Animais , Toxinas Botulínicas Tipo A/administração & dosagem , Doenças do Cão/etiologia , Cães , Eletromiografia/veterinária , Injeções Intralesionais/veterinária , Injeções Intramusculares/veterinária , Síndrome de Isaacs/tratamento farmacológico , Síndrome de Isaacs/etiologia , Masculino , Mioquimia/tratamento farmacológico , Mioquimia/etiologia , Fármacos Neuromusculares/administração & dosagem , Lesões por Radiação/tratamento farmacológico
8.
J Am Vet Med Assoc ; 247(7): 771-7, 2015 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-26383753

RESUMO

OBJECTIVE: To describe outcomes for dogs with primary hyperparathyroidism following treatment with percutaneous ultrasound-guided ethanol ablation of presumed functional parathyroid nodules. DESIGN: Retrospective case series. ANIMALS: 24 dogs with primary hyperparathyroidism that underwent 27 ultrasound-guided ethanol ablation procedures of presumed functional parathyroid nodules identified by cervical ultrasonography. PROCEDURES: Dogs were anesthetized for each procedure. For each nodule, 95% ethanol was injected into the center with ultrasound guidance (volume injected calculated on the basis of ultrasonographic measurements). The interval from treatment to resolution of hypercalcemia, complications, and follow-up clinicopathologic data were recorded. RESULTS: 5 procedures involved simultaneous treatment of 2 nodules. Three dogs underwent a second treatment because of initial treatment failure or development of another nodule. Hypercalcemia resolved after 23 of 27 (85%) procedures. In those 23 treatments, 22 (96%) had resolution of hypercalcemia within 72 hours after treatment. Hypocalcemia was detected in 6 different dogs at 2 (1 dog), 7 (3 dogs), 14 (1 dog), and 21 (1 dog) days after treatment; 5 of these dogs had mild transient hypocalcemia and 1 developed clinical signs requiring calcium supplementation. Although there were no periprocedural adverse effects, 2 dogs had delayed adverse effects; the overall rate of complications (including delayed adverse events and clinical hypocalcemia) was 11.1%. Long-term follow-up data indicated sustained normocalcemia in 17 of 19 dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that percutaneous ultrasound-guided ethanol ablation of functional parathyroid nodules may be an effective treatment for primary hyperparathyroidism of dogs, with short duration of anesthesia, minimal complications, and low risk for hypocalcemia.


Assuntos
Técnicas de Ablação/veterinária , Doenças do Cão/terapia , Etanol/farmacologia , Hiperparatireoidismo/veterinária , Neoplasias das Paratireoides/veterinária , Animais , Cães , Feminino , Hiperparatireoidismo/terapia , Injeções Intralesionais/veterinária , Masculino , Neoplasias das Paratireoides/terapia , Estudos Retrospectivos , Resultado do Tratamento
9.
Aust Vet J ; 91(3): 102-7, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23438462

RESUMO

OBJECTIVE: To evaluate the racing performance of horses that underwent ultrasound-guided intralesional injection of autologous bone marrow aspirate for treatment of selected forelimb suspensory ligament (body or branch) core lesions. DESIGN: Retrospective cohort study of 13 Standardbred and 17 Thoroughbred race horses. METHODS: Autologous bone marrow aspirated from the sternebrae was injected, under ultrasound guidance, into suspensory ligament core lesions (body or branch). Racing records were reviewed for a comparison of performance before and after surgery. RESULTS: Of the 13 Standardbreds, 9 (69%) had one or more starts within the follow-up period and 9 (69%) had five or more starts. Of the 17 Thoroughbreds, 15 (88%) had one or more starts within the follow-up period and 12 (71%) had five or more starts. Eight Standardbred horses had at least one start both before and after surgery. Earnings per start did not differ significantly between the three starts immediately after surgery compared with the three starts immediately prior to surgery. Thirteen Thoroughbred horses had at least one start both before and after surgery. Earnings per start were less for the three starts immediately after surgery compared with the three starts immediately prior to surgery. CONCLUSIONS AND CLINICAL RELEVANCE: A horse with a core lesion in the branch or body of the suspensory ligament has a good prognosis for return to racing after treatment with intralesional injection of bone marrow aspirate.


Assuntos
Transplante de Medula Óssea/veterinária , Doenças dos Cavalos/terapia , Inflamação/veterinária , Ligamentos/patologia , Esportes , Animais , Transplante de Medula Óssea/diagnóstico por imagem , Estudos de Coortes , Feminino , Membro Anterior , Cavalos , Inflamação/terapia , Injeções Intralesionais/veterinária , Coxeadura Animal , Masculino , Estudos Retrospectivos , Resultado do Tratamento , Ultrassonografia
10.
J Zoo Wildl Med ; 44(4): 1059-62, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24450069

RESUMO

A 14-yr-old male puma (Puma concolor) was presented to the veterinary staff of the National Zoo in Malaysia for an auricular mass. Squamous cell carcinoma was diagnosed by histologic examination of a biopsy. Systemic administration of chemotherapy using vincristine (0.5 mg/m2 i.v. q. 7 days for six treatments) and prednisolone (2 mg/kg i.m. q. 72 hr x 7 days) caused side effects of vomiting, weight loss, and alopecia and did not improve the size or appearance of the tumor. Intralesional vincristine injections (0.2 mg q. 7 days for two treatments) and prednisolone (2 mg/kg i.m. q. 72 hr x 15 days) were administered, resulting in complete tumor regression after 14 days of treatment.


Assuntos
Antineoplásicos/uso terapêutico , Carcinoma de Células Escamosas/veterinária , Puma , Neoplasias Cutâneas/veterinária , Vincristina/uso terapêutico , Animais , Antineoplásicos/administração & dosagem , Carcinoma de Células Escamosas/tratamento farmacológico , Injeções Intralesionais/veterinária , Masculino , Neoplasias Cutâneas/tratamento farmacológico , Vincristina/administração & dosagem
11.
J Feline Med Surg ; 14(10): 751-4, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22628268

RESUMO

A spayed 14-year-old female domestic shorthair cat presented with a squamous cell carcinoma of the nasal planum and was treated with intralesional chemotherapy. During nasal infiltrations with cisplatin mixed with the cat's own serum, a new carcinomatous lesion developed at the medial canthus of the right eye, which was also treated using intralesional chemotherapy. Two months after the treatment course, the cat developed a new mass at the site of the eyelid chemotherapy, which was diagnosed as a soft tissue sarcoma. At the owner's request, the tumour was marginally excised, but it recurred after 10 months. No lung or lymph node metastases were evident at the time of euthanasia. The histotype of the tumour, the coincidence with injections and the histological description make the hypothesis of an injection-site sarcoma likely. To the authors' knowledge, this is the first case of an injection-site sarcoma at the site of a cisplatin injection.


Assuntos
Carcinoma de Células Escamosas/veterinária , Doenças do Gato/tratamento farmacológico , Neoplasias Palpebrais/veterinária , Injeções Intralesionais/efeitos adversos , Segunda Neoplasia Primária/veterinária , Neoplasias Nasais/veterinária , Sarcoma/veterinária , Animais , Antineoplásicos/administração & dosagem , Carcinoma de Células Escamosas/tratamento farmacológico , Gatos , Cisplatino/administração & dosagem , Neoplasias Palpebrais/etiologia , Neoplasias Palpebrais/cirurgia , Feminino , Injeções Intralesionais/veterinária , Terapia Neoadjuvante/veterinária , Recidiva Local de Neoplasia/cirurgia , Recidiva Local de Neoplasia/veterinária , Segunda Neoplasia Primária/etiologia , Segunda Neoplasia Primária/cirurgia , Neoplasias Nasais/tratamento farmacológico , Sarcoma/etiologia , Sarcoma/cirurgia , Resultado do Tratamento
12.
J Feline Med Surg ; 12(8): 663-5, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20605101

RESUMO

A 4-year-old castrated male domestic shorthair presented for 1 week of constipation and tenesmus. A rectal stricture had been diagnosed 8 months prior at the time of adoption and the cat had been successfully managed with stool softeners until presentation. A complete diagnostic work-up failed to reveal an underlying etiology for the stricture and colonoscopy was performed. Endoscopic biopsies of the stricture revealed benign non-specific inflammatory changes. Balloon dilation of the rectal stricture was performed during the initial colonoscopy and 3 and 9 days later. Triamcinolone acetonide was injected into the stricture site with endoscopic guidance during the third dilation procedure. The patient has been monitored for over 27 months; follow-up indicates no signs of tenesmus and repeated rectal examinations reveal no stricture recurrence. This case report demonstrates that endoscopic balloon dilation with intralesional steroid injection represented a minimally invasive and effective option for the treatment of a benign rectal stricture in this cat, and deserves further prospective investigation.


Assuntos
Doenças do Gato/terapia , Cateterismo/veterinária , Glucocorticoides/uso terapêutico , Doenças Retais/veterinária , Triancinolona Acetonida/uso terapêutico , Animais , Doenças do Gato/tratamento farmacológico , Doenças do Gato/patologia , Cateterismo/métodos , Gatos , Constrição Patológica/tratamento farmacológico , Constrição Patológica/patologia , Constrição Patológica/terapia , Constrição Patológica/veterinária , Injeções Intralesionais/veterinária , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos/veterinária , Doenças Retais/tratamento farmacológico , Doenças Retais/patologia , Doenças Retais/terapia , Resultado do Tratamento
13.
Vet Comp Oncol ; 8(2): 81-6, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20579320

RESUMO

Acanthomatous ameloblastoma (AA) is a benign gingival tumour that often invades bone. This retrospective study evaluated the efficacy of intralesional (IL) bleomycin as a treatment for AA. Six dogs received weekly or bimonthly IL bleomycin injections (dose range, 10-20 U m(-2)). A seventh dog presented with advanced, nonresectable AA was treated palliatively. One to sixteen treatments were administered (median, 5). Six of the seven dogs had a complete response within 4 months from initial IL injection (median, 1.5 months), whereas the palliative case had approximately 25% decrease in tumour volume 14 days from initial injection. Local recurrence was not observed during the study period, with a median follow-up time of 842 days. Adverse effects were limited to wound formation with bone exposure (n = 4), mild tissue reactions (n = 3), local swelling (n = 2) and local infection (n = 1). The conclusions of this study show IL bleomycin is an effective treatment for canines with AA.


Assuntos
Ameloblastoma/veterinária , Antibióticos Antineoplásicos/uso terapêutico , Bleomicina/uso terapêutico , Doenças do Cão/tratamento farmacológico , Neoplasias Gengivais/veterinária , Ameloblastoma/tratamento farmacológico , Animais , Antibióticos Antineoplásicos/administração & dosagem , Antibióticos Antineoplásicos/efeitos adversos , Bleomicina/administração & dosagem , Bleomicina/efeitos adversos , Cães , Feminino , Neoplasias Gengivais/tratamento farmacológico , Injeções Intralesionais/veterinária , Masculino , Estudos Retrospectivos , Resultado do Tratamento
16.
J Feline Med Surg ; 11(8): 720-3, 2009 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19553150

RESUMO

The present report concerns a case of sporotrichosis in a 3-year-old male crossbred cat. After 9 months of oral itraconazole (20mg/kg) therapy, all skin lesions had resolved with the exception of a single nodular lesion located on the bridge of the nose. Therefore, a combined therapy that included intralesional (IL) amphotericin B (1mg/kg) was started. The lesion resolved completely after three weekly administrations of IL amphotericin B, given in concert with oral itraconazole. The cat remains well 1 year after discontinuing therapy, with no signs of recurrence.


Assuntos
Anfotericina B/administração & dosagem , Antifúngicos/administração & dosagem , Doenças do Gato/tratamento farmacológico , Esporotricose/veterinária , Animais , Brasil , Doenças do Gato/microbiologia , Gatos , Injeções Intralesionais/veterinária , Masculino , Doenças Nasais/tratamento farmacológico , Doenças Nasais/microbiologia , Doenças Nasais/veterinária , Esporotricose/tratamento farmacológico , Resultado do Tratamento
17.
J Vet Med Sci ; 70(12): 1295-300, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19122394

RESUMO

Effects of the collagen oligopeptide (COP) were examined by its repeat injection into the inflammatory rabbit Achilles tendon (Tendo calcaneus communis), in which tenositis was induced by injection of bacterial collagenase. COP was evaluated 5 times over a period of 3 weeks to 1 month after injection of collagenase. At 1 month after treatment, the therapeutic effect of COP was evaluated by examining the structure of collagen fibrils, amount and components of glycosaminoglycans (GAGs) and matrix metalloproteinases (MMPs), and compared with the saline injection, control, and normal groups. The Achilles tendon of rabbit in the control group (no COP injection) and saline injection group showed a notable increase in the number of fine collagen fibrils, a change in GAG composition and increase in the amount of pro-MMP-2, indicating the weakening of the tendon. In contrast, the size distribution of collagen fibrils, GAG composition and the amount of pro-MMP-2 was similar to those in the normal group. These results suggest that COP injection promotes healing processes of the tendon injury.


Assuntos
Colágeno/uso terapêutico , Peptídeos/uso terapêutico , Tendinopatia/tratamento farmacológico , Tendão do Calcâneo/patologia , Animais , Colágeno/administração & dosagem , Colagenases/efeitos adversos , Modelos Animais de Doenças , Glicosaminoglicanos/química , Glicosaminoglicanos/metabolismo , Injeções Intralesionais/veterinária , Masculino , Peptídeos/administração & dosagem , Coelhos , Tendinopatia/induzido quimicamente , Tendinopatia/patologia
18.
Vet Res Commun ; 30(4): 379-91, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16502106

RESUMO

An in vitro and in vivo study was conducted to show the effect of dipeptide methyl ester on the protoscolices of Echinococcus granulosus and in naturally infected sheep. Easily punctured cysts were located by ultrasonography. A PAIR and PAI method were performed by the injection of dipeptide methyl ester into these cysts at a final concentration of 110 mmol/L. Follow-up was conducted monthly by ultrasonography. After injection of the compound, the sheep were sacrificed at different times from 6 to 17 weeks. The size and the morphological aspect of treated cysts were noted. Samples were collected for histology and electron microscopy. In conclusion, these studies revealed significant and rapid detachment of the membrane of the treated cyst and alteration of the inner membrane in less than 5 min after injection of the drug, confirming the effect of the compound on the laminated layer of the parasite.


Assuntos
Anti-Helmínticos/administração & dosagem , Anti-Helmínticos/uso terapêutico , Dipeptídeos/administração & dosagem , Dipeptídeos/uso terapêutico , Equinococose Hepática/veterinária , Doenças dos Ovinos/terapia , Animais , Cistos/ultraestrutura , Relação Dose-Resposta a Droga , Equinococose Hepática/tratamento farmacológico , Equinococose Hepática/patologia , Equinococose Hepática/terapia , Echinococcus granulosus/efeitos dos fármacos , Injeções Intralesionais/métodos , Injeções Intralesionais/veterinária , Ovinos , Doenças dos Ovinos/tratamento farmacológico
19.
In Vivo ; 19(4): 761-7, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15999546

RESUMO

Healing sarcoids were followed in 18 horses which had taken part in previous clinical studies on a total of 29 horses suffering from either primary or recurrent sarcoids, treated with bio-immunotherapy. In the present study, attention was paid to changes observed in these fibroblastic skin tumours during their regression. The tumours were surgically debulked leaving the base in the skin. The horses were immunized according to bio-immunotherapy at 2- to 4-week intervals with an autogenous vaccine made from the excised part of the tumour until the base had visibly regressed. Healing was followed by inspections and serial biopsies from the base, studied under light microscope. Visibly normal epithelisation developed first at the margin of the base, progressing gradually to the centre. The mean rate of epithelisation was approximately equal to normal horse skin. Most of the histopathological features typical of equine sarcoid diminished significantly in the follow-up biopsies, when the first signs of visibly normal epithelisation were observed. The changes were more evident among the primary than the recurrent tumours. No leucocyte infiltration, lysis or apoptosis were found during the regression. Bio-immunotherapy seems to simulate a spontaneous healing process.


Assuntos
Vacinas Anticâncer/uso terapêutico , Doenças dos Cavalos/patologia , Recidiva Local de Neoplasia/veterinária , Sarcoma/veterinária , Neoplasias Cutâneas/veterinária , Vacinação/veterinária , Animais , Intervalo Livre de Doença , Doenças dos Cavalos/terapia , Cavalos , Injeções Intralesionais/veterinária , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/terapia , Sarcoma/patologia , Sarcoma/terapia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/terapia , Vacinação/métodos
20.
Vet Ophthalmol ; 7(3): 141-6, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15091319

RESUMO

A periocular nodular sarcoid of the right upper and lower eyelids was diagnosed in an 11-year-old Thoroughbred mare. Computed tomography scan revealed the extent of the tumor. The mass was surgically debulked under general anesthesia, and the affected periocular region was injected intralesionally with Bacillus of Calmette and Guerin (BCG). An emulsion of cell wall fractions was used, which has been modified to reduce the toxic and allergic effect, but retain the antitumor activity. In total, five injections were performed at 2-week intervals. At follow-up 7 months after the last BCG injection, the tumor was completely resolved. Two years after the last treatment, the horse remains tumor-free.


Assuntos
Neoplasias Palpebrais/veterinária , Doenças dos Cavalos/diagnóstico , Sarcoidose/veterinária , Animais , Vacina BCG/administração & dosagem , Diagnóstico Diferencial , Neoplasias Palpebrais/diagnóstico , Feminino , Doenças dos Cavalos/diagnóstico por imagem , Doenças dos Cavalos/patologia , Doenças dos Cavalos/terapia , Cavalos , Injeções Intralesionais/veterinária , Sarcoidose/diagnóstico , Tomografia Computadorizada por Raios X/veterinária
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA