Beauty and the sharp fangs of the beast: degree of angularity predicts perceived preference and threat.

The evaluation of angular vs. curved forms has a long history in psychology but few of the many studies conducted have examined actual degree of angularity. In two experiments, we present observers with randomly positioned and randomly oriented texture displays of angles viewed within a circular frame. The angle conditions varied from 0° to 180° in 20° increments, covering the entire spectrum of possibilities including acute, obtuse, right, and straight line angles. In Experiment 1, 25 undergraduates rated the perceived beauty of these displays. In Experiment 2, the same stimulus set and procedure were used with 27 participants instead judging perceived threat. Based on the findings in the literature, we predicted that sharper angles would be judged less beautiful and more threatening. The results were mostly confirmed. Acute angles are preferred less but there are also distinct preferences for right angles and straight lines, perhaps due to their greater familiarity in constructed environments. There was a consistent and anticipated finding for threat in the second study: the sharper an angle, the greater its perceived threat. Fear of sharp objects as assessed in a personality questionnaire was found to positively correlate with threat judgements. Future work should look more closely at degree of angularity in embedded object contours and at individual response differences.

Improving Medical Image Decision-Making by Leveraging Metacognitive Processes and Representational Similarity.

Improving the accuracy of medical image interpretation can improve the diagnosis of numerous diseases. We compared different approaches to aggregating repeated decisions about medical images to improve the accuracy of a single decision maker. We tested our algorithms on data from both novices (undergraduates) and experts (medical professionals). Participants viewed images of white blood cells and made decisions about whether the cells were cancerous or not. Each image was shown twice to the participants and their corresponding confidence judgments were collected. The maximum confidence slating (MCS) algorithm leverages metacognitive abilities to consider the more confident response in the pair of responses as the more accurate "final response" (Koriat, 2012), and it has previously been shown to improve accuracy on our task for both novices and experts (Hasan et al., 2021). We compared MCS to similarity-based aggregation (SBA) algorithms where the responses made by the same participant on similar images are pooled together to generate the "final response." We determined similarity by using two different neural networks where one of the networks had been trained on white blood cells and the other had not. We show that SBA improves performance for novices even when the neural network had no specific training on white blood cell images. Using an informative representation (i.e., network trained on white blood cells) allowed one to aggregate over more neighbors and further boosted the performance of novices. However, SBA failed to improve the performance for experts even with the informative representation. This difference in efficacy of the SBA suggests different decision mechanisms for novices and experts.

Incidental disgust does not cause moral condemnation of neutral actions.

Emotivism in moral psychology holds that making moral judgements is at least partly an affective process. Three emotivist hypotheses can be distinguished: the elicitation hypothesis (that moral transgressions elicit emotions); the amplification hypothesis (that disgust amplifies moral judgments); and the moralisation hypothesis (that affect moralises the non-moral). Even though the moralisation hypothesis is the strongest and most radical form of emotivism, it has not been systematically experimentally tested. Most previous studies have used as stimuli morally wrong actions, and thus they cannot answer whether disgust is sufficient to moralise an otherwise neutral action. In Experiment 1 (N = 87) we tested the effect of incidental disgust on morally neutral scenarios, and in Experiment 2 (N = 510) the differential effect of disgust on neutral and wrong scenarios. The results did not support either the moralisation or the amplification hypothesis. Instead, Bayesian analyses provided substantial evidence for the null hypothesis that incidental disgust does not affect moral ratings. The results are in line with a recent meta-analysis suggesting that disgust has no effect on moral ratings.

Neural patterns during anticipation predict emotion regulation success for reappraisal.

The ability to exert control over emotions, termed emotion regulation (ER), is vital for everyday functioning. ER success may be influenced by processes relating to the anticipation (prior to active regulation) and implementation (during active regulation) of ER strategy use. We investigated whether brain activity patterns recorded using electroencephalography (EEG) during the first second of anticipation and implementation of two ER strategies-distraction and reappraisal-were related to regulation success. Participants viewed negative images that evoked disgust and sadness. Before each image was presented, participants were cued to either passively view the image or decrease their emotional responses. ER success scores were calculated from subsequent self-reported disgust and sadness ratings. Using multivariate support vector regression, ER success scores were predicted from spatiotemporal patterns of event-related potentials during the first second of anticipation and implementation phases of each ER strategy. For both sadness and disgust, reappraisal success could be predicted during anticipation, while distraction success could be predicted during implementation. These findings suggest that early anticipatory cognitive processes are a key determinant of reappraisal success, but may not be similarly important for distraction. This may be because reappraisal is more cognitively demanding than distraction, requiring enhanced preparation of mental resources.

The role of metamemory on cognitive complaints in cancer patients.

OBJECTIVE: Although cancer patients frequently report cognitive disturbances, it is commonly asserted a lack of association between cognitive complaints and neuropsychological test performances. Our goal was to better understand the relationships between subjective and objective cognitive scores through a metamemory monitoring assessment. METHODS: Sixty cancer patients currently treated by chemotherapy and/or targeted therapy, and 30 healthy controls (HC) were included. Cognitive complaint was assessed by FACT-cog, QAM and DEX questionnaires. One or more z-scores ≤-1.65 among these three questionnaires defined the presence of cognitive complaints. Objective cognitive performances assessed episodic memory, processing speed and executive functions/working memory (ESR paradigm, TMT, Stroop, n-back). Metamemory was assessed with a Judgment of Learning (JOL) task. RESULTS: Patients with cognitive complaints had significantly more depressive and anxiety symptoms (ps < .004), and lower performances on several cognitive tests (ps < .05) than both patients without complaints and HC. More specifically, analyses of the metamemory scores revealed that HC gave significantly more overestimations ("Yes" judgment and incorrect recall) than patients with cognitive complaints (p = .036). For these patients, JOL scores correlated positively with executive functioning (ps < .01). CONCLUSION: Metamemory monitoring seems to be well-preserved during cancer. What is more, patients make less overestimation than HC, and they do not underestimate their memory. An accurate self-estimation of memory abilities in cancer patients, particularly those with mild cognitive deficits, may play an adaptive function. Our results suggest that the discrepancy frequently reported between cognitive complaints and objective cognitive scores may not be related to metamemory monitoring dysfunction.

Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment.

RATIONALE: 5-methoxy-N,N-dimethyltryptamine is a psychotropic substance found in various plant and animal species and is synthetically produced. 5-methoxy-N,N-dimethyltryptamine is used in naturalistic settings for spiritual exploration, recreation, or to address negative affect and mood problems. However, scientific knowledge on the effects of 5-methoxy-N,N-dimethyltryptamine in humans is scarce. OBJECTIVES: The first objective was to assess the effects of inhalation of vaporized synthetic 5-methoxy-N,N-dimethyltryptamine on neuroendocrine markers. The second objective was to assess effects of the substance on affect and mindfulness. In addition, we assessed whether ratings of subjective measures were associated with changes in stress biomarkers (i.e., cortisol) and immune response (i.e., IL-6, CRP, IL-1ß), as well as the acute psychedelic experience. METHODS: Assessments (baseline, immediately post-session, and 7-day follow-up) were made in 11 participants. Salivary samples were collected at baseline and post-session and analyzed by high-sensitivity enzyme-linked immunosorbent assay (ELISA). RESULTS: 5-methoxy-N,N-dimethyltryptamine significantly increased cortisol levels and decreased IL-6 concentrations in saliva immediately post-session. These changes were not correlated to ratings of mental health or the psychedelic experience. Relative to baseline, ratings of non-judgment significantly increased, and ratings of depression decreased immediately post-session and at follow-up. Ratings of anxiety and stress decreased from baseline to 7-day follow-up. Participant ratings of the psychedelic experience correlated negatively with ratings of affect and positively with ratings of non-judgment. CONCLUSION: Inhalation of vaporized synthetic 5-methoxy-N,N-dimethyltryptamine produced significant changes in inflammatory markers, improved affect, and non-judgment in volunteers. Future research should examine the effect of 5-methoxy-N,N-dimethyltryptamineamine with healthy volunteers in a controlled laboratory setting.

Water supplementation after dehydration improves judgment and decision-making performance.

Previous research has shown that dehydration and water supplementation affect mood and cognitive performance in both adults and children on a variety of tasks that assess memory, attention, executive function, and speeded responses. Given the varied effects of water on cognition, this study explored potential effects of water supplementation, hydration status, and thirst on thinking and decision-making tasks. 29 adult participants undertook a battery of cognitive tests on two separate occasions after having fasted from the previous night. On one occasion, they were offered 500 ml of water to drink prior to testing. Measures of urine osmolality confirmed the group-level effectiveness of the dehydration manipulation. Water supplementation was found to improve performance on tasks measuring cognitive reflection in judgement and decision-making. This increase in performance was associated with differences in tasks implicated in inhibition processes. Drinking water after a 12-h dehydration period increased performance in judgement and decision-making tasks, and this was not explained by differences in subjective thirst or attentiveness.

Co-occurrence and relational information in evaluative learning: A multinomial modeling approach.

Dual-process theories of evaluative learning suggest that evaluative representations can be formed via two functionally distinct mechanisms: automatic formation of associative links between co-occurring events (associative learning) and nonautomatic generation and truth assessment of mental propositions about the relation between stimuli (propositional learning). Single-process propositional theories reject the idea of automatic association formation, attributing all instances of evaluative learning to propositional processes. A central question in the debate between the two theories concerns the mechanisms underlying unqualified effects of stimulus co-occurrence when the relation between the co-occurring stimuli suggests an evaluation that is opposite to the one implied by the observed co-occurrence (e.g., sunscreen prevents skin cancer). Addressing interpretational ambiguities in previous research on the differential impact of co-occurrence and relational information on implicit and explicit measures, the current research used a multinomial modeling approach to investigate the functional properties of the effects of co-occurrence and relational information on a single measure of evaluative responses. Although the moderating effects obtained for relational information are consistent with the predictions of the two theories, the obtained properties of co-occurrence effects pose an explanatory challenge to both dual-process and single-process propositional theories. The findings demonstrate the value of multinomial modeling in providing deeper insights into the functional properties of the effects of co-occurrence and relational information, which impose stronger empirical constraints on extant theories of evaluative learning. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Emotion recognition in objects in patients with neurological disease.

OBJECTIVE: Considerable research indicates that individuals with dementia have deficits in the ability to recognize emotion in other people. The present study examined ability to detect emotional qualities of objects. METHOD: Fifty-two patients with frontotemporal dementia (FTD), 20 patients with Alzheimer's disease (AD), 18 patients awaiting surgery for intractable epilepsy, and 159 healthy controls completed a newly developed test of ability to recognize emotional qualities of art (music and paintings), and pleasantness in simple sensory stimuli (tactile, olfactory, auditory), and to make aesthetic judgments (geometric shapes, room décor). A subset of participants also completed a test of ability to recognize emotions in other people. RESULTS: Patients with FTD showed a marked deficit in ability to recognize the emotions conveyed in art, compared with both healthy individuals and patients with AD (relative to controls, deficits in patients with AD only approached significance). This deficit remained robust after controlling for FTD patients' ability to recognize pleasantness in simple sensory stimuli, make aesthetic judgments, identify odors, and identify emotions in other people. Neither FTD nor AD patients showed deficits in recognizing pleasant sensory stimuli or making aesthetic judgments. Exploratory analysis of patients with epilepsy revealed no deficits in any of these domains. CONCLUSION: Patients with FTD (but not AD) showed a significant, specific deficit in ability to interpret emotional messages in art, echoing FTD-related deficits in recognizing emotions in other people. This finding adds to our understanding of the impact these diseases have on the lives of patients and their caregivers. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

A Distorted Body Schema and Susceptibility to Experiencing Anomalous Somatosensory Sensations in Fibromyalgia Syndrome.

OBJECTIVE: Evidence suggests that there is an association between chronic pain and disruption of the body schema. We tested the hypothesis in fibromyalgia syndrome (FMS). MATERIALS AND METHODS: We investigated distinct perceptual aspects of the body schema both in a sample of patients with FMS and in pain-free controls. Performances on the left/right judgment task were measured; tactile acuity was assessed by using the 2-point discrimination test. Furthermore, we evaluated sensations evoked by tactile stimulation with von Frey filaments to body parts that were experiencing pain. Anomalous sensations elicited by sensory-motor conflict (SMC) were also investigated. RESULTS: Patients with FMS showed inferior performance on the right/left judgment task, both in terms of correct matches (75.38% vs. 89.67%, respectively; P<0.05) and response time (2.58 s vs. 1.89 s, respectively; P<0.05). Effect sizes were large and very large, respectively. Two-point discrimination thresholds were significantly higher (P<0.05) in participants from the FMS sample (mean of 49.71 mm, SD: 12.09 mm) relative to controls (mean of 37.36 mm, SD: 7.81 mm). Nine of 14 participants with FMS, but no control participants, reported referred sensations upon tactile stimulation, including tingling, pins and needles, weight, and cramps. Referral sites included regions both adjacent and remote to stimulated sites. Patients with FMS scored across all items within the administered questionnaire addressing anomalous sensations on the mirror setup (Cohen d=1.04 to 2.42 across all items), and FMS patients perceived pain during the SMC (the required statistical power for it to be statistically significant was 96% and for it to be recognized as a difference of means in pain item). CONCLUSION: Our present findings suggest a disrupted body schema and propensity to experiencing anomalous somatosensory sensations during SMC in people with FMS.

The physiological basis of psychological disgust and moral judgments.

To address ongoing debates about whether feelings of disgust are causally related to moral judgments, we pharmacologically inhibited spontaneous disgust responses to moral infractions and examined effects on moral thinking. Findings demonstrated, first, that the antiemetic ginger (Zingiber officinale), known to inhibit nausea, reduces feelings of disgust toward nonmoral purity-offending stimuli (e.g., bodily fluids), providing the first experimental evidence that disgust is causally rooted in physiological nausea (Study 1). Second, this same physiological experience was causally related to moral thinking: ginger reduced the severity of judgments toward purity-based moral violations (Studies 2 and 4) or eliminated the tendency for people higher in bodily sensation awareness to make harsher moral judgments than those low in this dispositional tendency (Study 3). In all studies, effects were restricted to moderately severe purity-offending stimuli, consistent with preregistered predictions. Together, findings provide the first evidence that psychological disgust can be disrupted by an antiemetic and that doing so has consequences for moral judgments. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

No experimental evidence for emotion-specific gaze cueing in a threat context.

We examined the utility of a gaze cueing paradigm to examine sensitivity to differences among negatively valenced expressions. Participants judged target stimuli (dangerous or safe), the location of which was cued by the gaze direction of a central face. Dawel et al. reported that gaze cueing effects (faster response times on valid vs. invalid trials) were larger when the central face displayed fear than when it displayed happiness. Our aim was to determine whether this effect was specific to fear, to all threat-related expressions (fear, anger), or to all negatively valenced expressions (fear, anger, sadness, disgust) with the aim of using this protocol to study the development of implicit discrimination of negatively valenced expressions. Across five experiments in which we varied the number of models (1 vs. 4), the number of expressions (2 vs. 5), and the country of residence of participants (Canada vs. Australia) we found no evidence that the magnitude of gaze cueing effects is modulated by expression. We discuss our failure to replicate in the context of the broader literature.

Cognitive and personality correlates of trait disgust and their relationship to condemnation of nonpurity moral transgressions.

Past research has found that individuals who are more sensitive to physically disgusting stimuli also condemn moral transgressions more harshly. However, there is debate about whether this condemnation includes transgressions that do not involve impure behaviors. We present a meta-analysis of 6 studies (N = 1082) which suggests that trait disgust is associated with condemnation of nonpurity transgressions. This relationship was primarily explained by sensitivity toward the very core disgust stimuli that those transgressions lack. We next tested whether this relationship might be mediated by a third variable. We found that trait core disgust was associated with higher orderliness, lower deviance sensitivity, and preference for intuitive thinking; these variables also correlated with moral condemnation. Trait disgust was also associated with lower generalized social trust, but trust was not correlated with moral condemnation. Neither trait disgust nor moral condemnation were associated with ethnocentrism. Further, none of these variables mediated the relationship between trait disgust and condemnation. Taken together, our results support a role for trait disgust in moral judgments outside of the purity domain, but leave unexplained its association with condemnation of nonpurity transgressions. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Many moral buttons or just one? Evidence from emotional facial expressions.

We investigated whether moral violations involving harm selectively elicit anger, whereas purity violations selectively elicit disgust, as predicted by the Moral Foundations Theory (MFT). We analysed participants' spontaneous facial expressions as they listened to scenarios depicting moral violations of harm and purity. As predicted by MFT, anger reactions were elicited more frequently by harmful than by impure actions. However, violations of purity elicited more smiling reactions and expressions of anger than of disgust. This effect was found both in a classic set of scenarios and in a new set in which the different kinds of violations were matched on weirdness. Overall, these findings are at odds with predictions derived from MFT and provide support for "monist" accounts that posit harm at the basis of all moral violations. However, we found that smiles were differentially linked to purity violations, which leaves open the possibility of distinct moral modules.

Human chemosignals of disgust facilitate food judgment.

Choosing food is not a trivial decision that people need to make daily, which is often subject to social influences. Here, we studied a human homolog of social transmission of food preference (STFP) as observed in rodents and other animals via chemosignals of body secretions. Human social chemosignals (sweat) produced during a disgust or neutral state among a group of donors were presented to participants undergoing a 2-alternative-forced-choice food healthiness judgment task during functional magnetic resonance imaging (fMRI). Response speed and two key signal detection indices-d' (discrimination sensitivity) and ß (response bias)-converged to indicate that social chemosignals of disgust facilitated food healthiness decisions, in contrast to primary disgust elicitors (disgust odors) that impaired the judgment. fMRI analyses (disgust vs. neutral sweat) revealed that the fusiform face area (FFA), amygdala, and orbitofrontal cortex (OFC) were engaged in processing social chemosignals of disgust during food judgment. Importantly, a double contrast of social signaling across modalities (olfactory vs. visual-facial expressions) indicated that the FFA and OFC exhibited preferential response to social chemosignals of disgust. Together, our findings provide initial evidence for human STFP, where social chemosignals are incorporated into food decisions by engaging social and emotional areas of the brain.

Additional intraoral radiographs may change the judgment regarding the final position of orthodontic mini-implants

ABSTRACT Objective: This study aimed to assess if additional vertical bitewing (VBW) and/or occlusal (OC) radiographs may change initial judgment based only on periapical radiograph (PAR) about the final position of orthodontic mini-implants (OMI). Methods: Subjective and objective analyses were performed. Radiographic images of 26 OMI were divided into four groups: PAR, PAR+VBW, PAR+OC and ALL (PAR+VBW+OC). For subjective analysis, five observers were asked to assess if the position of OMI was favorable to its success, using questionnaires with a four-point scale for responses: 1= definitely not favorable, 2= probably not favorable, 3= probably favorable, or 4= definitely favorable. Each group containing sets of images was presented to them in four different viewing sessions. Objective evaluation compared horizontal distances between OMI tip and the root nearest to the device in PAR and VBW. Results: Most of observers (3 out of 5) changed their initial judgment based on PAR about OMI position when additional radiographs were analyzed. Differences between groups (i.e. PAR vs. PAR+VBW; PAR vs. PAR+OC; and, PARvs.ALL) were statistically significant for these observers. For those that changed their judgment about OMI position, confidence level could significantly increase, decrease or even be maintained, not indicating a pattern. There was no agreement for distances between OMI tip and the root nearest to the device in PAR and VBW. Conclusion: Considering the limitations of the study, it is concluded that additional radiographic images may change the judgement about OMI final position without necessarily increasing the degree of certainty of such judgment.

RESUMO Objetivo: avaliar se a adição de radiografias interproximais verticais (IV) e/ou oclusais (OC) pode alterar o julgamento inicial sobre a posição final dos mini-implantes ortodônticos (MI) baseado somente na radiografia periapical (PA). Métodos: foram realizadas análises subjetivas e objetivas. Imagens radiográficas de 26 regiões contendo MI foram divididas em quatro grupos: PA, PA+IV, PA+OC e TODAS (PA+IV+OC). Na análise subjetiva, cinco observadores foram convidados a avaliar se a posição do MI era favorável para o seu sucesso, utilizando questionários com uma escala de quatro pontos para respostas: 1 = definitivamente não favorável; 2 = provavelmente não favorável; 3 = provavelmente favorável; ou 4 = definitivamente favorável. Cada grupo contendo conjuntos de imagens foi apresentado aos observadores em quatro sessões diferentes. Adicionalmente, uma avaliação objetiva comparou as distâncias horizontais entre a ponta do MI e a raiz dentária mais próxima ao dispositivo na PA e IV. Resultados: a maioria dos observadores (3 de 5) mudou seu julgamento inicial sobre a posição do MI baseado na PA quando radiografias adicionais foram analisadas. Diferenças entre os grupos (ou seja, PA vs PA+IV; PA vs PA+OC; e PAvsTODAS) foram estatisticamente significativas para esses observadores. Para aqueles que mudaram seu julgamento sobre a posição do MI, o nível de confiança das respostas aumentou, diminuiu ou foi mantido, não indicando um padrão. Houve diferença estatisticamente significante entre as distâncias da ponta do MI para a raiz mais próxima ao dispositivo na PA e IV. Conclusão: considerando-se as limitações desse estudo, concluiu-se que imagens radiográficas adicionais podem alterar o julgamento sobre a posição final de MI sem, necessariamente, aumentar o grau de certeza de tal julgamento.

Impact of simulated three-dimensional perception on precision of depth judgements, technical performance and perceived workload in laparoscopy.

BACKGROUND: This study compared precision of depth judgements, technical performance and workload using two-dimensional (2D) and three-dimensional (3D) laparoscopic displays across different viewing distances. It also compared the accuracy of 3D displays with natural viewing, along with the relationship between stereoacuity and 3D laparoscopic performance. METHODS: A counterbalanced within-subjects design with random assignment to testing sequences was used. The system could display 2D or 3D images with the same set-up. A Howard-Dolman apparatus assessed precision of depth judgements, and three laparoscopic tasks (peg transfer, navigation in space and suturing) assessed performance (time to completion). Participants completed tasks in all combinations of two viewing modes (2D, 3D) and two viewing distances (1 m, 3 m). Other measures administered included the National Aeronautics and Space Administration Task Load Index (perceived workload) and the Randot® Stereotest (stereoacuity). RESULTS: Depth judgements were 6·2 times as precise at 1 m and 3·0 times as precise at 3 m using 3D versus 2D displays (P < 0·001). Participants performed all laparoscopic tasks faster in 3D at both 1 and 3 m (P < 0.001), with mean completion times up to 64 per cent shorter for 3D versus 2D displays. Workload was lower for 3D displays (up to 34 per cent) than for 2D displays at both viewing distances (P < 0·001). Greater viewing distance inhibited performance for two laparoscopic tasks, and increased perceived workload for all three (P < 0·001). Higher stereoacuity was associated with shorter completion times for the navigating in space task performed in 3D at 1 m (r = - 0·40, P = 0·001). CONCLUSION: 3D displays offer large improvements over 2D displays in precision of depth judgements, technical performance and perceived workload.

Deciding what is possible and impossible following hippocampal damage in humans.

There is currently much debate about whether the precise role of the hippocampus in scene processing is predominantly constructive, perceptual, or mnemonic. Here, we developed a novel experimental paradigm designed to control for general perceptual and mnemonic demands, thus enabling us to specifically vary the requirement for constructive processing. We tested the ability of patients with selective bilateral hippocampal damage and matched control participants to detect either semantic (e.g., an elephant with butterflies for ears) or constructive (e.g., an endless staircase) violations in realistic images of scenes. Thus, scenes could be semantically or constructively 'possible' or 'impossible'. Importantly, general perceptual and memory requirements were similar for both types of scene. We found that the patients performed comparably to control participants when deciding whether scenes were semantically possible or impossible, but were selectively impaired at judging if scenes were constructively possible or impossible. Post-task debriefing indicated that control participants constructed flexible mental representations of the scenes in order to make constructive judgements, whereas the patients were more constrained and typically focused on specific fragments of the scenes, with little indication of having constructed internal scene models. These results suggest that one contribution the hippocampus makes to scene processing is to construct internal representations of spatially coherent scenes, which may be vital for modelling the world during both perception and memory recall. © 2016 The Authors. Hippocampus Published by Wiley Periodicals, Inc.

Multiple "buy buttons" in the brain: Forecasting chocolate sales at point-of-sale based on functional brain activation using fMRI.

We set out to forecast consumer behaviour in a supermarket based on functional magnetic resonance imaging (fMRI). Data was collected while participants viewed six chocolate bar communications and product pictures before and after each communication. Then self-reports liking judgement were collected. fMRI data was extracted from a priori selected brain regions: nucleus accumbens, medial orbitofrontal cortex, amygdala, hippocampus, inferior frontal gyrus, dorsomedial prefrontal cortex assumed to contribute positively and dorsolateral prefrontal cortex and insula were hypothesized to contribute negatively to sales. The resulting values were rank ordered. After our fMRI-based forecast an instore test was conducted in a supermarket on n=63.617 shoppers. Changes in sales were best forecasted by fMRI signal during communication viewing, second best by a comparison of brain signal during product viewing before and after communication and least by explicit liking judgements. The results demonstrate the feasibility of applying neuroimaging methods in a relatively small sample to correctly forecast sales changes at point-of-sale.

Memory Reactivation Predicts Resistance to Retroactive Interference: Evidence from Multivariate Classification and Pattern Similarity Analyses.

Memory reactivation--the reinstatement of processes and representations engaged when an event is initially experienced--is believed to play an important role in strengthening and updating episodic memory. The present study examines how memory reactivation during a potentially interfering event influences memory for a previously experienced event. Participants underwent fMRI during the encoding phase of an AB/AC interference task in which some words were presented twice in association with two different encoding tasks (AB and AC trials) and other words were presented once (DE trials). The later memory test required retrieval of the encoding tasks associated with each of the study words. Retroactive interference was evident for the AB encoding task and was particularly strong when the AC encoding task was remembered rather than forgotten. We used multivariate classification and pattern similarity analysis (PSA) to measure reactivation of the AB encoding task during AC trials. The results demonstrated that reactivation of generic task information measured with multivariate classification predicted subsequent memory for the AB encoding task regardless of whether interference was strong and weak (trials for which the AC encoding task was remembered or forgotten, respectively). In contrast, reactivation of neural patterns idiosyncratic to a given AB trial measured with PSA only predicted memory when the strength of interference was low. These results suggest that reactivation of features of an initial experience shared across numerous events in the same category, but not features idiosyncratic to a particular event, are important in resisting retroactive interference caused by new learning. SIGNIFICANCE STATEMENT: Reactivating a previously encoded memory is believed to provide an opportunity to strengthen the memory, but also to return the memory to a labile state, making it susceptible to interference. However, there is debate as to how memory reactivation elicited by a potentially interfering event influences subsequent retrieval of the memory. The findings of the current study indicate that reactivating features idiosyncratic to a particular experience during interference only influences subsequent memory when interference is relatively weak. Critically, reactivation of generic contextual information predicts subsequent source memory when retroactive interference is either strong and weak. The results indicate that reactivation of generic information about a prior episode mitigates forgetting due to retroactive interference.