Frequency of Comfort Care and Palliative Care Consultation after ST-Elevation Myocardial Infarction.

INTRODUCTION: ST-elevation myocardial infarction (STEMI) remains a leading cause of death despite advances in revascularization and post-STEMI care. Especially for patients with a poor prognosis, there is increasing emphasis on comfort-focused care. METHODS: We conducted a single-center retrospective cohort study of patients with STEMI at a large tertiary care academic medical center, abstracting patient-level data, causes of death, and use of palliative care consultation from the medical records. We sought to investigate the frequency of comfort-focused approaches and palliative care consultation after STEMI. RESULTS: A total of 536 patients presented with or were transferred with STEMI from January 2010 to July 2018, of whom 61/536 (11.4%) died during index hospitalization. Among those who underwent percutaneous intervention (PCI), the in-hospital mortality rate was 6.8%. Median (IQR) and time to death was two (0-6) days. Among those who died, 25/61 (41%) were treated with mechanical circulatory support (MCS). A total of 25/61 (41%) patients died following transition to a comfort-focused approach. Rate of MCS utilization during hospitalization was higher in the group that was ultimately transitioned to comfort-focused measures than the group who received full treatment measures. Palliative care was consulted in the case of 6/61 (9.8%) patients. Median time to consultation was 5 (1-7) days and time to death was 6.5 (2-28) days. DISCUSSION: Transition to comfort-focused care before death after STEMI is common, particularly in those with cardiogenic shock and/or treated with MCS, highlighting the critical status of such patients. Although increasingly employed in recent years, palliative care consults remain rare and are often employed late in the hospitalization.

Making heart-lung machines work in India: Imports, indigenous innovation and the challenge of replicating cardiac surgery in Bombay, 1952-1962.

In 1962, surgeons at two hospitals in Bombay used heart-lung machines to perform open-heart surgery. The devices that made this work possible had been developed in Minneapolis in 1955 and commercialized by 1957. However, restrictions on currency exchange and foreign imports made it difficult for surgeons in India to acquire this new technology. The two surgeons, Kersi Dastur and PK Sen, pursued different strategies to acquire the ideas, equipment, and tacit knowledge needed to make open-heart surgery work. While Dastur tapped Parsi networks that linked him to local manufacturing expertise, Sen took advantage of opportunities offered by the Rockefeller Foundation to access international training and medical device companies. Each experienced steep learning curves as they pursued the know-how needed to use the machines successfully in dogs and then patients. The establishment of open-heart surgery in India required the investment of substantial labor and resources. Specific local, national, and transnational interests motivated the efforts. Heart-lung machines, for instance, took on new meanings amid the nationalist politics of independent India: Even as surgeons sought imported machines, they and their allies assigned considerable value to 'indigenous' innovation. The confluence of the many interests that made Sen and Dastur's work possible facilitated the uneasy co-existence of conflicting judgments about the success or failure of this medical innovation.

[The Role of Extracorporeal Ventricular Assist Device is Changing in the Era of Implantable Ventricular Assist Device].

In the era of implantable ventricular assist device (VAD), the role of extracorporeal VAD is changing. The extracorporeal VAD was ever the mainstream of treatment for severe heart failure. Now, it is mainly applied to patients with severe cardiogenic shock. Recently the centrifugal pump available for cardiopulmonary bypass system has been often used as the extracorporeal VAD because of its simplicity of management. Although the implantable VAD plays the pivotal role for bridge to transplantation since its clinical introduction in 2011, the extracorporeal VAD still has the important role for end-stage heart failure and cardiogenic shock. We have experienced 47 cases of the extracorporeal VAD until now. Here, based on our experience, we describe the "past and present" role of the extracorporeal VAD and mention the future aspect of the extracorporeal VAD.

[Development of cardiovascular surgery]. / Zur Entwicklung der kardiovaskulären Chirurgie.

On the occasion of the 80th anniversary of the journal "Der Chirurg" (The Surgeon) this article summarizes the development of cardiac surgery. Beginning from the first cardiac suture in 1897 by Ludwig Wilhelm Carl Rehn, through the first catheter investigation of the heart by Werner Forssmann in 1923 to the year 2008 when nearly 100,000 cardiac interventions were carried out in Germany and of these some 90,000 using a heart-lung machine. The article describes the founding of the German Society for Thorax, Heart and Vascular Surgery in the year 1971 and the reintegration in the German Society for Surgery, stemming from efforts for the unification of the structure of further education (common trunk). The motto for this process, which was actively supported by both societies, was "Independence when necessary, cooperation when possible".

[Heart operations for heart tumors in Germany--results of 1996 survey]. / Herzoperationen wegen Herztumoren in Deutschland--Ergebnisse einer Umfrage für das Jahr 1996.

In the Federal Republic of Germany, no data existed regarding the frequency of open heart surgery for excision of cardiac neoplasms. Therefore, a standard questionnaire concerning heart tumors was sent to all 77 German heart centers performing cardiac surgery. Data from 65 of the 77 heart centers (= 84%) are finally available: 187 patients were operated upon for myxomas, only 44 upon for non-myxomatous cardiac tumors (28 of them with malignant primary or secondary lesions of the heart). In 1996, 0.32% (231/72,763) of all surgical procedures using a heart-lung machine (registered 72,763 of 87,372 total) were aimed at excision of heart tumors. Based on surgical data, the incidence of solely the primary tumors of the heart in Germany is at least 3 per million population per year (253 tumors/81.814 million inhabitants). Even if small tumors are asymptomatic and remain undetected, today, the majority of primary tumors of the heart will be revealed by echocardiography, computer tomography, and magnetic resonance imaging, and these patients are usually referred to operation. Thus, in Germany, about 0.3% of operations using a heart-lung machine were performed for cardiac tumors-among these, myxomas are clearly predominant.

Recent advances in multivessel coronary grafting without cardiopulmonary bypass.

BACKGROUND: Coronary artery bypass grafting (CABG) without the heart lung machine has been possible for easily accessible targets such as the anterior descending or proximal right coronary. Until now technical difficulty in reaching lateral and inferior wall targets imposed significant barriers to multivessel off-pump grafting. To expand the potential for off-pump CABG the authors have devised new exposure and stabilization techniques suitable for all target vessels. In this report we relate our experience with these new techniques and demonstrate that multivessel coronary bypass can be safely performed without cardiopulmonary bypass (CPB). METHODS: From February 8, 1993 to December 16, 1997 a total of 280 patients underwent myocardial revascularization on the beating heart via median sternotomy. Until May 20, 1997 only patients with high preoperative risk factors for CPB were considered for this approach (Group A; N = 122). After this date any patients with favorable anatomy were included (Group B; N = 158) and were subsequently compared with patients operated on using CPB during the same time interval (Group C; N = 114). In Group B patients lateral and/or inferior wall targets were exposed by means of 4 cloth slings (2 through the transverse sinus and 2 behind the inferior vena cava) and by positioning the patients in Trendelenburg with rightward rotation of the table. Regional stabilization of the target artery was obtained with a commercial stabilizing foot plate. RESULTS: Thirty day hospital mortality was only 2 patients (1.6%) in Group A, 3 patients (1.9%) in Group B, and 3 patients (2.6%) in Group C (NS). Postoperative complications were low in both Group A and B. When Group B was compared with a similar cohort in whom CPB was used (Group C), there were statistically significant improvements in ICU and hospital stay demonstrated when CPB was not used (16.8+/-10.7 vs 26.3+/-38.6 hours respectively; p = 0.007, and 4.1+/-1.5 vs 5.5+/-2.4 days respectively, p<0.001). Angiographic followup was available for 78 patients in Groups A and B with a global patency rate (all grafts) of 98.6%, including a patency rate of 96.7% for 60 grafts to obtuse marginal branches of the circumflex). CONCLUSIONS: Multivessel CABG without CPB is possible with results similar to those obtained with pump-oxygenator support using simple exposure and stabilization techniques.

An intraluminal shunt for off-pump coronary artery bypass grafting. Report of 501 consecutive cases and review of the technique.

BACKGROUND: Clinical or subclinical manifestations of coronary ischemia may occur when the target vessel is temporarily occluded during revascularization of the beating unsupported heart. Laboratory evidence has shown that even when the surface electrocardiogram is normal, action potential duration, conduction velocity, and regional electrocardiogram patterns change during clamping of the target coronary artery. In addition, local trauma to the endothelium and/or adjacent atherosclerotic plaque by encircling snares or mechanical clamps can lead to plaque disruption and late stenosis in the native vessel. METHODS: The authors report their experience with a continuous series of patients undergoing coronary grafting on the beating heart using an intraluminal shunt. This simple device maintains distal perfusion and prevents ischemia while at the same time protects the anastomosis from potential suturing errors. The shunt also keeps blood from obscuring the operators vision and thus makes snares and clamps unneccesary. Smooth unhindered removal of the shunt immediately confirms patency of the finished anastomosis. RESULTS: Off-pump coronary grafting was performed in 501 consecutive patients utilizing an intraluminal shunt. Three hundred and seventy three men (74.5%) and 128 women ranging from 34 to 92 years old (mean 60.4 years) underwent a total of 196 internal mammary artery and 596 saphenous vein grafts (1.58 grafts per patient) from November 1983 to December 1996 at the Santa Casa de São Paulo Hospital and Hospital Samaritano. Mean shunting time was 14 minutes per anastomosis. Thirty day hospital mortality was 1.39% (7 patients) and all deaths were from non-cardiac causes. Perioperative myocardial infarction occurred in 7 other patients (1.39%) all of whom survived. CONCLUSIONS: In selected cases coronary grafts can be safely constructed on the beating heart without ischemia using a simple and inexpensive intraluminal shunt. The device is easily inserted and removed without damage to the native coronary. In a large series of patients, operative mortality and morbidity were lower than with conventional heart-lung support and cardioplegic arrest.