Similar pregnancy outcomes from fresh and frozen donor oocytes transferred to gestational carriers: a SART database analysis isolating the effects of oocyte vitrification.

PURPOSE: This work aimed to study clinical and neonatal outcomes of embryos derived from frozen compared to fresh donor oocytes in gestational carrier cycles. METHODS: This is a retrospective cohort study using the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database between 2014 and 2015, comprising of 1284 fresh transfer cycles to gestational carrier recipients of embryos resulting from fresh (n = 1119) and vitrified/thawed (n = 165) donor oocytes. Models were adjusted for gestational carrier age, preimplantation genetic testing (PGT-A), number of embryos transferred, multiple gestation, and fetal heart reduction. As our models were part of a larger analysis, intended parent BMI, smoking status, and parity were also adjusted for, but did not influence outcomes in this analysis. RESULTS: There was no significant difference in probability of live birth rates when comparing embryos derived from fresh and frozen donor oocytes in gestational carrier cycles. There were also no significant differences in biochemical pregnancy losses or clinical miscarriage. There were no significant differences noted in low birthweight or high birthweight infants derived from fresh versus frozen donor oocyte after transfer into a gestational carrier. CONCLUSIONS: The analysis of fresh and frozen donor oocytes in gestational carrier cycles provides the opportunity to assess for a possible effect of vitrification on the oocyte by controlling for differences in the uterine environment. We observed no significant differences in live birth, pregnancy loss, low birthweight or high birthweight infants when comparing fresh and frozen donor oocytes in gestational carrier cycles.

La gestación solidaria, oportunidad reproductiva para las familias cubanas / The solidary gestation, reproductive opportunity for Cuban families i: en

La gestación solidaria es una técnica de reproducción humana asistida, destinada a parejas de distinto o igual sexo y a personas solas con alguna causa de infertilidad que les impide concebir el embarazo de manera natural. Al respecto, en el Código de las Familias en Cuba se esclarece que este proceder solo debe realizarse por motivos altruistas y de solidaridad humana, ajenos a cualquier tipo de honorarios. Teniendo en cuenta las consideraciones anteriores, se analizó el tema desde diferentes puntos de vista, con el objetivo de socializar esta práctica como una oportunidad de reproducción para las familias cubanas.

Solidarity gestation is an assisted human reproductive technique intended for different or same sex couples and to single people with some infertility problems which prevent them from conceiving in a natural way. In this respect, the Cuba's Family Code clarifies that this procedure should only be carried out due to altruistic reasons and human solidarity, without any fees. Taking into account the above considerations, the topic was analyzed from different points of view, aimed at socializing this practice as a reproduction opportunity for Cuban families.

subrogación en series: una narrativa sobre la metafísica del embarazo / Surrogacy in Series: A Narrative on the Metaphysics of Pregnancy

Se analizan dos series que, con diferencia de quince años, abordan el tema de la maternidad subrogada: Shameless y Little fires everywhere, con el foco en las cuestiones bioéticas y sociales involucradas en ellas. A partir de los relatos de apego entre la gestante y la persona nacida o por nacer, se pone a prueba el concepto de "metafísica del embarazo", tal como lo trabaja Suki Finn, ofreciendo un escenario novedoso para un tema complejo y controvertido

Two series are analyzed that, with a difference of fifteen years, address the issue of surrogate motherhood: Shameless and Little fires everywhere, with a focus on the bioethical and social issues involved in them. From the stories of attachment between the pregnant woman and the person born or unborn, the concept of "metaphysics of pregnancy" is examined, as Suki Finn works, offering a novel scenario for a complex and controversial issue

Cuando el cuerpo no puede / When the Body can't

En el presente trabajo nos proponemos visibilizar el padecimiento psíquico de las mujeres que atraviesan un cáncer ginecológico y que, además, deben hacer frente a la imposibilidad de gestar como consecuencia de la enfermedad. Y también reflexionar sobre el trabajo del psicólogo en este ámbito. Para cumplir con nuestro objetivo nos valdremos del episodio cinco de la segunda temporada de la serie televisiva estadounidense "New Amsterdam" (S2, E 5), estrenada en el año 2018 en Netflix, la plataforma de streaming estadounidense

In this paper we intend to make visible the psychological suffering of women who go through a gynecological cancer and who, in addition, must face the impossibility of gestating as a result of the disease. And also reflect on the work of the psychologist in this area. To meet our goal, we will use episode five of the second season of the American television series "New Amsterdam" (S2, E 5), premiered in 2018 on Netflix, the American streaming platform

The Long Road to Parenthood: Assisted Reproduction, Surrogacy, and Adoption Among US Surgeons.

OBJECTIVE: We sought to characterize demographics, costs, and workplace support for surgeons using assisted reproductive technology (ART), adoption, and surrogacy to build their families. SUMMARY BACKGROUND DATA: As the surgical workforce diversifies, the needs of surgeons building a family are changing. ART, adoption, and surrogacy may be used with greater frequency among female surgeons who delay childbearing and surgeons in same-sex relationships. Little is known about costs and workplace support for these endeavors. METHODS: An electronic survey was distributed to surgeons through surgical societies and social media. Rates of ART use were compared between partners of male surgeons and female surgeons and multivariate analysis used to assess risk factors. Surgeons using ART, adoption, or surrogacy were asked to describe costs and time off work to pursue these options. RESULTS: Eight hundred and fifty-nine surgeons participated. Compared to male surgeons, female surgeons were more likely to report delaying children due to surgical training (64.9% vs. 43.5%, P < 0.001), have fewer children (1.9 vs. 2.4, p < 0.001), and use ART (25.2% vs. 17.4%, P = 0.035). Compared to non-surgeon partners of male surgeons, female surgeons were older at first pregnancy (33 vs 31 years, P < 0.001) with age > 35 years associated with greater odds of ART use (odds ratio 3.90; 95% confidence interval 2.74-5.55, P < 0.001). One-third of surgeons using ART spent >$40,000; most took minimal time off work for treatments. Forty-five percent of same-sex couples used adoption or surrogacy. 60% of surgeons using adoption or surrogacy spent >$40,000 and most took minimal paid parental leave. CONCLUSIONS: ART, adoption, or surrogacy is costly and lacks strong workplace support in surgery, disproportionately impacting women and same-sex couples. Equitable and inclusive environments supporting all routes to parenthood ensure recruitment and retention of a diverse workforce. Surgical leaders must enact policies and practices to normalize childbearing as part of an early surgical career, including financial support and equitable parental leave for a growing group of surgeons pursuing ART, surrogacy, or adoption to become parents.

Indução da lactação em mulheres nuligestas: relato de experiência / Inducción de la lactancia en mujeres nuligestas: informe de experiencia / Lactation induction in women who never got pregnant: experience report

Resumo Objetivo relatar a experiência de indução da lactação em nuligestas realizada por enfermeira consultora em aleitamento. Método relato de experiência. O processo de indução láctea foi realizado com três mulheres por motivo de gestação em útero de substituição e relacionamento homoafetivo. Resultados todas perceberam o aumento de tamanho e a sensibilidade nas mamas, bem como apresentaram secreção láctea. No entanto, a continuidade da amamentação foi diferenciada entre elas. A primeira não recebeu apoio de profissionais de saúde no contexto de pós-parto hospitalar, nem em casa, e não deu continuidade à amamentação. A segunda recebeu apoio da equipe do hospital e da parceira, amamentando por três meses. A terceira, com o apoio da parceira, amamentou por dois meses, mas interrompeu por sentir-se inibida por familiares. Conclusão e implicações para a prática a técnica de indução é capaz de desencadear a produção láctea. Já o processo de amamentação só se estabeleceu mediante a associação com a rede de apoio, o acolhimento, o incentivo da equipe de saúde e o olhar integral à mulher e sua família. Dessa forma, o cuidado de Enfermagem na indução láctea não deve focar apenas no manejo da indução, mas transcender o aspecto técnico, o que se mostra como fundamental para a proteção, o estabelecimento e a continuidade da amamentação.

Resumen Objetivo reportar la experiencia de inducir la lactancia en nuligestas realizada por una consultora de enfermería en lactancia materna. Método relato de experiencia. El proceso de inducción de la leche se realizó con tres mujeres por embarazo en útero de reemplazo y relación homoafectiva. Resultados todas notaron el aumento de tamaño y la sensibilidad en las mamas, además de presentar secreción de leche. Sin embargo, la continuidad de la lactancia materna se diferencia entre ellos. La primera no recibió apoyo de los profesionales de la salud en el contexto posparto hospitalario, ni en el domicilio, y no continuó con la lactancia. La segunda recibió apoyo del personal del hospital y su pareja, amamantando durante tres meses. La tercera, con el apoyo de su pareja, amamantó durante dos meses, pero la interrumpió porque se sentía inhibida por familiares. Conclusión e implicaciones para la práctica la técnica de inducción es capaz de desencadenar la producción de leche. El proceso de lactancia materna, en cambio, solo se estableció a través de la asociación con la red de apoyo, la acogida, el estímulo del equipo de salud y la mirada integral a la mujer y su familia. Así, el cuidado de Enfermería en la inducción de la leche no debe enfocarse solo en el manejo de la inducción, sino trascender el aspecto técnico, que se muestra fundamental para la protección, el establecimiento y la continuidad de la lactancia materna.

Abstract Objective to report the experience of lactation induction in women who never got pregnant by a lactation consultant nurse. Method experience report. The process of lactation induction was performed with three women due to surrogate pregnancy and homosexual relationships. Results all noticed an increase in the size and sensitivity of the breasts, as well as milk secretion. However, the continuity of breastfeeding was different between them. The first did not receive support from health professionals in the postpartum hospital setting, nor at home, and did not continue breastfeeding. The second received support from the hospital staff and her partner, breastfeeding for three months. The third, with the support of her partner, breastfed for two months, but stopped because she felt inhibited by family members. Conclusion and implications for practice the induction technique is capable of triggering milk production. However, the breastfeeding process was only established through the association with the support network, the reception, the encouragement of the health team, and the comprehensive view of the woman and her family. Thus, nursing care in lactation induction should not focus only on the management of induction, but transcend the technical aspect, which is essential for the protection, establishment, and continuity of breastfeeding.

Gravidez de substituição: ressignificando o adoecimento por câncer / Gestación de sustitución: resignificación de la enfermedad por cáncer / Surrogacy: new meaning for cancer disease

Objetivo: conhecer a vivência da família ampliada quando um de seus membros/casal decide pela gravidez de substituição após diagnóstico e tratamento de câncer ginecológico. Método: estudo de caso de abordagem qualitativa. Participou uma família ampliada de sete pessoas domiciliadas em dois municípios. Os dados foram produzidos pela narrativa de vivências, obtidos por entrevista aberta e submetidos à análise temática. Resultados: a primeira categoria refere-se à união da família para apoiar a familiar que enfrentava um diagnóstico de câncer ginecológico. A segunda discorre sobre sentimentos que representaram o amálgama familiar diante do adoecimento e da decisão pela gravidez de substituição, vitais ao amparo da gestante substituta e mãe biológica. Conclusões: a gravidez de substituição possibilitou que a família ressignificasse o adoecimento e o sentido de família, mobilizada pela solidariedade, altruísmo, empatia e fé.(AU)

Objective: to share experiences of an extended family when one of its members/couple decides for surrogate pregnancy after gynecological cancer's diagnosis and treatment. Method: it is a case study with a qualitative approach. An extended family composed of seven people, residing in two municipalities, participated in the study. Data were produced by the narrative of experiences, obtained by open interviews and submitted to thematic analysis. Results: the first analytical category refers to the union of the family to provide support who faced the diagnosis. The second one is about the feelings that represented the family amalgam face to sickness and the decision for surrogate pregnancy, both vital for the support to the surrogate and the biological mother. Conclusions: the surrogate pregnancy made it possible for the family to resinify the sickness and the sense of the family itself, and had been mobilized by solidarity, altruism, empathy and faith.(AU)

Objetivo: conocer la vivencia de la familia ampliada cuando uno de sus miembros/pareja se decide por gestación de sustitución después del diagnóstico y tratamiento del cáncer ginecológico. Método: estudio de caso cualitativo. Participó una familia de siete personas domiciliadas en dos municipios. Los datos fueron producidos por la narrativa de vivencias, obtenidas por entrevistas abiertas y sometidos a análisis temático. Resultados: la primera categoría se refiere a la unión familiar para apoyar quien enfrenta diagnóstico de cáncer ginecológico. A segunda discurre sobre sentimientos que representan la amalgama familiar delante el proceso de enfermedad y la decisión por el embarazo de sustitución, vitales para el amparo a la embarazada y madre biológica. Conclusiones: el embarazo de reemplazo permitió a la familia replantear la enfermedad y el sentido de familia, movilizados por la solidaridad, el altruismo, la empatía y la fe.

Association of Obstetric and Neonatal Outcomes With Deviation From Guidelines for Gestational Carriers.

OBJECTIVE: To evaluate whether deviation from American Society for Reproductive Medicine (ASRM) safety guidelines for women who are gestational carriers is associated with increased risk of severe obstetric and perinatal morbidity and mortality. METHODS: This is a cross-sectional study of births from gestational carrier pregnancies in Utah from 2009 to 2018 with data collected from birth certificates. Deviations from ASRM guidelines include women aged younger than 21 years or older than 45 years, nulliparity, prior stillbirth, tobacco or percutaneous drug use, more than five prior deliveries, more than three prior cesarean deliveries, major comorbidities, and mental health conditions. The primary outcome was a composite of severe obstetric morbidity and mortality (death within 1 year of delivery; intensive care unit admission; eclampsia; hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome; transfusion; unplanned hysterectomy). Secondary outcomes were cesarean delivery, gestational diabetes mellitus, hypertensive disorders of pregnancy, preterm delivery (analyzed per pregnancy), and a composite neonatal outcome. Associations were analyzed using descriptive statistics and multivariable logistic regression. RESULTS: A total of 361 gestational carrier deliveries of 435 neonates were included in this analysis. Sixteen percent (58/361) of pregnancies did not meet guidelines. Rates of severe obstetric morbidity or mortality did not differ between gestational carrier pregnancies that deviated from guidelines and those that did not (1.7% for both, odds ratio [OR] 1.04, 95% CI 0.12-9.12). Rate of cesarean delivery was higher among pregnancies that deviated from guidelines (36.2% vs 23.4%, OR 1.85, 95% CI 1.02-3.37). Rates of gestational diabetes mellitus and hypertensive disorders of pregnancy did not differ. Preterm delivery was also more common among pregnancies that deviated from guidelines, particularly after controlling for multifetal gestation (36.2% vs 23.4%, adjusted OR 2.16, 95% CI 1.04-4.48). Neonatal complications were significantly more common in pregnancies that did not meet guidelines, even after adjusting for gestational age and multifetal gestation (adjusted OR 3.66, 95% CI 1.44-9.29). CONCLUSION: Nearly one in five gestational carrier pregnancies in this cohort did not meet ASRM guidelines. Deviation from guidelines is associated with increased rate of cesarean delivery, neonatal morbidity, and preterm birth. Future research should focus on the safety of women who are gestational carriers and on why deviation occurs.

Determinants of gestational surrogates' satisfaction in relation to the characteristics of surrogacy cases.

RESEARCH QUESTION: The study undertook an evaluation of the retrospective experiences of gestational surrogates within a Canadian context. DESIGN: Data were collected using an anonymous online survey from June 2016 to February 2017 with participants recruited from the Canadian surrogacy community and the internet. The characteristics of surrogacy arrangements carried out by the participants, factors influencing their surrogacy satisfaction, the impact of surrogacy on their family functioning, and their attitudes towards carrying a pregnancy for different types of intended parents were analysed. RESULTS: A total of 184 gestational surrogates (mean age at surrogacy 32 years, range 21-48 years) who were involved in 287 arrangements completed a study-specific survey. More than three-quarters of these cases involved an agency (225 cases, 78.4%). Most of the intended parents were heterosexual couples (158, 55.1%), followed by same-sex male couples (113, 39.4%). More than one-third of these cases were for non-residents from 15 different countries (n = 108, 37.6%). The two main determinants of surrogates' satisfaction were being a surrogate for domestic intended parents (P < 0.05) and having a viable pregnancy outcome (P < 0.005). Nine out of ten participants were comfortable with carrying a pregnancy for same-sex male couples (93.4%) and cancer survivors (89.6%), yet less than one-third (30.7%) were comfortable with being a surrogate for heterosexual couples at advanced ages of over 50 years. CONCLUSIONS: The findings suggest that many intended parents, including same-sex male couples and non-residents, used Canadian surrogacy services to build their families. A better understanding of the fundamentals contributing to positive experiences would help clinicians develop better practice models to care for the well-being of surrogates.

Structural, immunohistochemical and molecular features of placentas and placental sites after in vitro fertilization with donor eggs (surrogate motherhood).

OBJECTIVE: to identify structural, immunohistochemical and molecular features of placentas and placental sites afterin vitro fertilization (IVF) with donor eggs (surrogate motherhood). STUDY DESIGN: morphological and immunohistochemical studies were performed on placental material obtained after delivery by caesarean section. The study included 26 women patients whose pregnancy resulted from IVF with a donor egg (IVF-SM group). The comparison group included 13 women patients whose pregnancy occurred after IVF with their own eggs (IVF-OE). Immunohistochemistry of biopsy material was performed using mouse antibodies to total cytokeratin (clone AE1/AE3) and murine antibodies to HLA-DR (clone TAL.1B5). Molecular studies were performed on DNA samples isolated from venous blood. HLA-DNA-TEH reagent kits and polymerase chain reaction were used for genotyping the main human histocompatibility complex class II (DQA1, DQB1 and DRB1). RESULTS: Histological examination of placenta in IVF-SM group showed a high incidence of central ischemic infarctions (69% of cases), dissociated cotyledon development (61%), pathological villus immaturity (46%) and massive perivillous fibrin deposition (73%). This group also had a pronounced lymphoplasmacytic deciduitis, which was 2 times higher than in the control group, and an expressed inflammatory process in the placental sites. Remodeling of the spiral arteries was incomplete in more than 40% of cases, and 30% of spiral arteries had no gestational changes. In comparison group, a complete gestational adjustment was found in more than 90% of spiral arteries. A focal lymphohistiocytic infiltration in perivascular regions, and a decrease in the number of multinucleated cells as compared with the control were also observed. For seven female surrogate mothers and their children, allelic polymorphisms of genes of HLA II class were studied. CONCLUSION: Placental material of women from IVF-SM group is characterized by complex immune response in sites of tight contact between maternal and fetal tissues. The immune pathogenesis is associated with an increase in the number of HLA-DR positive cells, defects in remodeling of the spiral arteries, development of areas of chronic inflammation in perivascular regions, and a decrease in the number of multinucleated cells. Genetic incompatibility between alleles of HLA II genes can be a molecular predictor of impaired immune tolerance.

Endometrial preparation for third-party parenting and cryopreserved embryo transfer.

The advent of third party parenting ushered in the era of artificial stimulation of the endometrium. Initially intended only for patients with ovarian failure, exogenous induction of endometrial receptivity was quickly shown to be as good as natural endometrial preparation, with the advantage that the timing of embryo transfer could be controlled. It is perhaps surprising that even though the ovary produces a variety of steroids, that estradiol (E2) and progesterone (P) alone would be needed to achieve optimal receptivity; no other substance has ever been shown to improve on the basic regimen of E2 and P. A variety of routes of administration are available for both E2 and P and physiologic (or supraphysiologic) serum or endometrial tissue levels of both can be achieved. The optimal duration of E2 stimulation and the timing of the onset of P administration continue to be debated, but it appears that imitating the sequence that normally occurs in nature leads to optimal results. The poorly responsive endometrium and cases of recurrent implantation failure remain a challenge, but the clear majority of patients can successfully achieve pregnancy as long as embryos of adequate quality are transferred.

Uterine Factor Infertility: A Clinical Review.

Uterine factor infertility (UFI) may affect up to 1 in 500 reproductive age women. The uterus is an essential component of achieving pregnancy and carrying a pregnancy to term successfully. There are many etiologies of UFI which may be categorized into either congenital or acquired causes. In this review, we discuss the different causes of UFI as well as the treatment options, which now includes uterine transplant.

Gestational surrogacy in the Czech Republic.

BACKGROUND: Gestational surrogacy, is a treatment option for women with certain clearly defined medical problems, usually an absent uterus, to help them have their own genetic children. The aim of our study was to review, evaluate and share our experience and outcomes over the last 13 years of the largest surrogacy program in the Czech republic. METHODS: A total of 75 intended mothers and 82 surrogate mothers participated in this study. A retrospective cohort study was performed. Anonymized data were collected on 130 cycles of gestational surrogate (2004-2017) directly from the Clinic database. RESULTS: We performed 130 in vitro fertilization cycles with gestational surrogacy which involved 73 fresh embryo transfers and 57 frozen embryo transfers. We achieved 57 (43.9%) pregnancies and 42 (32.3%) live births. The rate of multiple pregnancies was only 2.3 %. The most common indication for using was an absent or damaged uterus (65%), followed by medical conditions precluding pregnancy (23%) and repeated in vitro fertilization cycles or pregnancy failure (12%). CONCLUSION: In the 14 years of our experience, we have shown that treatment of young women with specific indications for gestational surrogacy is beneficial, successful and relatively free of complications. However, it is imperative to follow the medical indications for this treatment and specialist recommendations.

Surrogacy and ethics in women with cancer.

Women diagnosed with gynaecological cancer may face unwanted loss of fertility as well as all the other life-changing issues with which cancer and its treatments are associated. The decision to harvest and store gametes has to be made before commencement of treatment, and advances in these techniques have made this successful. Fertility sparing therefore must be discussed and offered at an early stage post diagnosis. Surrogacy is currently an evidence-based method of assisted reproduction, with mainly desirable outcomes for the commissioning mother, surrogate and child, without impacting on the cancer treatment and long-term survival. Surrogacy is therefore ethical as long as the autonomous rights of both the commissioning mother and gestational carrier are equally observed, they both have equal legal protection and due attention is paid to the short- and long-term welfare of any resulting offspring.

Substitution gestation: the family in the discussions of the brazilian written media / Gestación por sustitución: la familia en los discursos de los medios de comunicación escritos brasileños / Gestação de substituição: a família nos discursos da mídia escrita brasileira

ABSTRACT Objective: to understand the different positions of the subject attributed to the family in the substitution gestation process. Method: documentary-type qualitative research, based on Cultural Studies, in the post-structuralism field, based on Michel Foucault's discourse and statement tools. For such, there were analyzed discourses published in the Brazilian written media, between September and December in the year 2016, on subjects who experienced the substitution gestation. Results: The speeches point out that the biological parents should monitor and control gestation. They emphasize that the cares with the baby, especially maternal breastfeeding, must be accompanied by the father and realized by the biological mother. Another point is that such technology makes it possible to experience the position of culturally constituted father and mother for the subjects who wish to have children. The discourses reinforce distinct roles for biological father and mother and surrogate mothers, presented as happy with this family formation. The statements divide, distribute and order the roles of motherhood between the two mothers in order in order to naturalize the substitution gestation. To this end, they reinforce the discourses on maternal breastfeeding and emphasize the medicalization of the female body in the substitution gestation. Conclusion: the substitution gestation was recognized as a distinct conception form, but reinforce that it does not entail another maternity form. The media are concerned with demonstrating the rituals that assist in the constitution of maternal and paternal subjects, in order to teach ways of living this gestation. Therefore, experiencing the substitution gestation is one of the possibilities for constituting a family.

RESUMEN Objetivo: comprender las diferentes posiciones de sujetos atribuidas a la familia en el proceso de gestación por sustitución. Método: estudio cualitativo, tipo documental, con base en los Estudios Culturales, en la vertiente posestructuralista, fundamentada en las herramientas de discurso y anunciado por Michel Foucault. Para ello, se analizaron discursos publicados en los medios de comunicación escritos de Brasil, entre septiembre y diciembre de 2016, respecto a sujetos que vivenciaron la gestación por sustitución. Resultados: los discursos señalan que los padres biológicos deben acompañar y controlar la gestación. Además, se resalta que los cuidados con el bebé, en especial la lactancia materna, deben ser asistidos por el padre y realizados por la madre biológica. Otra cuestión es que tal tecnología permite vivenciar la posición del padre y de la madre, constituidos culturalmente a los sujetos que desean tener hijos. Los discursos refuerzan diferentes roles para el padre y la madre biológicos y las madres por sustitución, presentados como felices con esta formación familiar. Los enunciados dividen, distribuyen y orden los roles de la maternidad entre ambas madres, con el objetivo de naturalizar la gestación por sustitución. Por lo tanto, se refuerzan los discursos sobre la lactancia materna y se enfatiza la medicalización del cuerpo femenino en la gestación por sustitución. Conclusión: la gestación por sustitución fue reconocida como una forma distinta de concebir, pero hacen hincapié en que no conduce a otra forma distinta de la maternidad. Los medios de comunicación se ocupan en demonstrar los rituales que auxilian en la constitución de sujetos maternos y paternos, para enseñar los modos de vivir de esta gestación. Por ende, vivenciar la gestación por sustitución es una de las posibilidades de constituirse una familia.

RESUMO Objetivo: compreender as diferentes posições de sujeito atribuídas à família no processo de gestação de substituição. Método: pesquisa qualitativa, do tipo estudo documental com base nos Estudos Culturais, na vertente pós-estruturalista, fundamentada nas ferramentas de discurso e enunciado de Michel Foucault. Para tanto, foram analisados discursos publicados na mídia escrita brasileira, entre setembro e dezembro no ano de 2016, sobre sujeitos que vivenciaram a gestação de substituição. Resultados: os discursos apontam que os pais biológicos devem acompanhar e controlar a gestação. Destacam que os cuidados com o bebê, especialmente o aleitamento materno, devem ser acompanhados pelo pai e realizados pela mãe biológica. Outro apontamento, é que tal tecnologia possibilita vivenciar a posição de pai e mãe constituídos culturalmente aos sujeitos que desejam ter filhos. Os discursos reforçam papéis distintos para pai e mãe biológicos e mães substitutas, apresentados como felizes com essa formação familiar. Os enunciados dividem, distribuem e ordenam os papéis da maternidade entre as duas mães visando naturalizar a gestação de substituição. Para tanto, reforçam os discursos sobre aleitamento materno e enfatizam a medicalização do corpo feminino na gestação de substituição. Conclusão: os discursos reconhecem a gestação de substituição foi reconhecida como forma distinta de concepção, mas reforçam que não acarreta em outra forma distinta de maternidade. As mídias se ocupam em demonstrar os rituais que auxiliam na constituição de sujeitos maternos e paternos, para ensinar modos de viver essa gestação. Portanto, vivenciar a gestação de substituição é uma das possibilidades de constituir família.

Gestational surrogacy: results of 10 years of experience in the Netherlands.

RESEARCH QUESTION: What are the reproductive and obstetric outcomes of the gestational surrogacy treatment in the Netherlands? DESIGN: This retrospective cohort study reports all data of gestational surrogacy treatment in the VU University Medical Centre over a period of 10 years. Data was collected from 60 intended parents and 63 gestational carriers, including reproductive and obstetric outcomes. RESULTS: All intended mothers had a medical indication for gestational surrogacy and used autologous oocytes, and semen of the intended father. Ninety-three IVF cycles were initiated in 60 intended mothers, with subsequent 184 single embryo transfers in 63 gestational carriers. This resulted in 35 ongoing singleton pregnancies. At least one live birth was achieved for 55.0% of intended couples. Pregnancy was complicated in 20.6% by a hypertensive disorder. Labour was induced in 52.9%, and the Caesarean section rate was 8.8%. None of the pregnancies was complicated by preterm birth. Postpartum haemorrhage (>500 ml) occurred in 23.5%. CONCLUSIONS: This study shows the effective results of the non-commercial gestational surrogacy programme in the Netherlands, in a multidisciplinary team setting. An increased risk for adverse obstetric outcomes in surrogate mothers is noted for hypertensive disorders and post-partum haemorrhage compared with the incidence in non-surrogacy pregnancies.

Estrategia educativa en el reconocimiento de signos de alarma respiratorios por parte de madres comunitarias del programa Familia, Mujer e Infancia del instituto Colombiano de Bienestar Familiar, Colombia / Educational strategy in recognition of signs of respiratory alarm by community mothers of the Family, Women and Children program of the Instituto Colombiano de Bienester Familiar, Colombia

Objetivo: identificar el nivel de conocimiento antes y después de una estrategia educativa en el reconocimiento de signos de alarma respiratorios por parte de madres comunitarias del programa Familia, Mujer e Infancia, del Instituto Colombiano de Bienestar Familiar, entre los meses de junio y julio del 2017. Materiales y Método: cuantitativa, cuasi experimental, con preprueba y posprueba. Estrategia educativa extracurricular, de tipo participativa, dirigida a madres comunitarias del programa Familia Mujer e Infancia en el reconocimiento de los signos de alarma respiratorios. Una Muestra de 33 madres comunitarias pertenecientes a la sede Norte. Se creó una base de datos, analizada en el formato SPSS versión 20, sometida a revisión, validación y consistencia de datos. Los instrumentos de medición, fueron validados en una prueba piloto que contaban con las mismas características de la población de estudio. Resultados: se encontró que existe una diferencia significativa después de aplicar la estrategia educativa, el nivel de conocimiento fue medido a través de un cuestionario que evalúa el nivel de conocimiento en signos de alarma respiratorios, encontrando una diferencia de media de 2,03 entre la preprueba y el posprueba, un intervalo de confianza del 95% (0,81- 3,92) y un valor de P 0,004. Conclusiones: los programas educativos en salud se convierten en la estrategia perfecta para minimizar complicaciones asociadas al desconocimiento de las buenas prácticas de cuidado en el individuo, especialmente cuando el cuidado se desarrolla en población de la primera infancia..(AU)

Objective: to identify the level of knowledge before and after an educational strategy in the recognition of respiratory alarm signs by community mothers of the Family, Women and Children program of the Colombian Family Welfare Institute, between June and July. 2017. Materials and Method: quantitative, quasi-experimental, with pretest and posttest. Extracurricular educational strategy, of a participatory type, aimed at community mothers of the FAMI program in the recognition of respiratory alarm signs. A sample of 33 community mothers belonging to the North headquarters. A database was created, analyzed in the SPSS version 20 format, subject to review, validation and data consistency. The measurement instruments were validated in a pilot test that had the same characteristics of the study population. Results: it was found that there is a significant difference after applying the educational strategy, the level of knowledge was measured through a questionnaire that evaluates the level of knowledge in respiratory alarm signs, finding an average difference of 2.03 between the pretest and the posttest, a confidence interval of 95% (0.81- 3.92) and a value of P 0.004. Conclusions: health education programs become the perfect strategy to minimize complications associated with ignorance of good care practices in the individual, especially when care is developed in the early childhood population..(AU)

What to do when good-quality embryos repeatedly fail to implant.

Recurrent implantation failure (RIF) is very distressing for couples and frustrating for their clinicians who seek to find a solution. RIF is defined as the failure to achieve a clinical pregnancy following the transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman of age below 40 years. An agreed local protocol regarding how couples with RIF should be further investigated and managed should be in place. Ovarian function should be assessed by measuring antral follicle count, FSH, and AMH. Chromosomal testing of the couple is advised to exclude genetic abnormalities that may lead to RIF. Various uterine pathologies including fibroids, endometrial polyps, congenital anomalies, and intrauterine adhesions should be excluded by ultrasonography and hysteroscopy. Hydrosalpinges are a recognized cause of implantation failure and should be excluded by hysterosalpingogram, and if necessary, laparoscopy should be performed to confirm or refute the diagnosis. Consideration should be given to preimplantation genetic screening (PGS) and the adoption of a "freeze-all" protocol. Treatment offered should be evidence based, aimed at improving embryo quality or endometrial receptivity. Gamete donation or surrogacy may be necessary if there is no realistic chance of success with further IVF attempts.

Long-term outcomes in cancer patients who did or did not pursue fertility preservation.

OBJECTIVE: To compare long-term outcomes of cancer patients who pursued fertility preservation (FP) with those who did not and compare random-start (RS) and menstrual cycle-specific (CS) protocols for FP. DESIGN: Retrospective cohort. SETTING: Single urban academic institution. PATIENT(S): Oncology patients who contacted the FP patient navigator, 2005-2015. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Time to cancer treatment, disease-free survival, and reproductive outcomes in FP versus no-FP patients and cycle outcomes for RS versus CS protocols. Data were analyzed by χ2 and logistic regression. RESULT(S): Of 497 patients who met the inclusion criteria, 41% elected FP. The median number of days to cancer treatment was 33 and 19 days in the FP and no-FP groups, respectively. There was no difference in cancer recurrence or mortality. There were no differences in stimulation parameters, outcomes, or days to next cancer treatment in RS versus CS protocols. Twenty-one patients returned to use cryopreserved specimens, resulting in 16 live births. Eight of 21 returning patients used a gestational carrier. Thirteen FP (6.4%) and 16 no-FP (5.5%) patients experienced a spontaneous pregnancy. CONCLUSION(S): FP is both safe and efficacious for eligible cancer patients. Only 10% of patients returned to use cryopreserved specimens, and almost half used a gestational carrier, suggesting the need for further research into reproductive decision-making in cancer survivors.