Diferença entre os vocábulos bucal e oral na terminologia odontológica e seus significados na língua portuguesa / Difference between oral and oral vocables in dental terminology and their meanings in portuguese language

O objetivo do presente trabalho foi discutir sobre a diferença entre os termos bucal e oral na Odontologia, tendo como respaldo a Língua Portuguesa. A metodologia bibliográfica buscou se ancorar em teóricos da linguagem e da Odontologia para investigar a diferença entre tais palavras. Após leitura de textos que versaram sobre essas vertentes, observamos que a principal diferença residiu na origem das palavras bucca e os, originárias do latim clássico e vulgar, respectivamente, com significados distintos. Todavia, ao migrarem para o português, os falantes escolheram o termo bucca em detrimento de os, o qual ainda hoje é usado ao lado de oral, com sentidos semelhantes. Notamos, ainda, que para os profissionais da saúde seria importante padronizar a terminologia, pois facilitaria a compreensão desses termos para pacientes e profissionais de outras áreas, tais como os tradutores; por outro lado, ficou nítido que, em alguns momentos, a unificação terminológica seria mais difícil, pois os contextos de uso teriam que ser mudados. Por fim, destacamos que estudar estes vocábulos no contexto da Odontologia é importante para que tanto pacientes quanto os profissionais de saúde, ou de áreas similares conheçam a peculiar diferença(AU)

The objective of the present work was to discuss the difference between the terms oral and oral in Dentistry, based on the Portuguese language. The bibliographic methodology sought to anchor in language and dentistry theorists to investigate the difference between such words. After reading texts that dealt with these aspects, we observed that the main difference resided in the origin of the word bucca and os, originating from classical and vulgar Latin, respectively, with different meanings. However, when migrating to Portuguese, the speakers chose the term bucca over os, which is still used alongside oral, with similar meanings. We also noted that for health professionals it would be important to standardize the terminology, as it would facilitate the understanding of these terms for patients and professionals from other areas, such as translators; on the other hand, it was clear that at times, terminological unification would be more difficult, as the contexts of use would have to be changed. Finally, we emphasize that studying these words in the context of Dentistry is important so that both patients and health professionals, or from similar areas, know the peculiar difference(AU)

Risco de exacerbação de asma em adolescentes usuários de dispositivos eletrônicos de liberação de nicotina: uma revisão sistemática e metanálise / Risk of asthma exacerbation in adolescent users of electronic nicotine delivery systems: a systematic review and meta-analysis

Este trabalho tem como objetivo investigar a associação entreo o uso dos cigarros eletrônicos e doenças pulmonares em adolescentes. Foi realizada uma revisão sistemática na base de dados PubMed. Os termos Mesh incluídos na busca foram "Electronic Nicotine Delivery Systems" e "Lung Diseases" e sinônimos no título e abstract, com o filtro de idade "child: birth - 18 years", para buscar artigos relacionados ao uso de cigarros eletrônicos e doenças pulmonares em adolescentes. Os critérios de elegibilidade consistiram em: usuários adolescentes, exposição ao cigarro eletrônico e doença pulmonar como desfecho. Os artigos foram selecionados por uma revisão pareada de maneira independente, primeiramente com a leitura dos títulos e resumos, seguida da leitura integral dos artigos selecionados, os quais foram analisados pela ferramenta New Castle-Ottawa quanto sua qualidade, e receberam entre 5 e 7 estrelas. Os dados encontrados foram extraídos para a realização da metanálise. Inicialmente foram encontrados 61 artigos, sendo seis considerados elegíveis, todos transversais e com aplicação de questionários. Na metanálise foi encontrada uma associação significativa entre o uso de cigarro eletrônico e exacerbação de asma (OR ajustado 1,44; IC 95% 1,17­1,76). Não foram encontrados estudos que avaliassem a associação do cigarro eletrônico e outras doenças pulmonares, incluindo EVALI (E-cigarette or Vaping product use-Associated Lung Injury), em adolescentes. Na metanálise foi encontrada uma associação significativa entre exacerbações de asma e uso de cigarros eletrônicos em adolescentes com asma crônica e nos previamente hígidos.

This study aims to investigate the association between electronic cigarette use and lung disease in adolescents. A systematic review was conducted in PubMed. We used the MeSH terms "Electronic Nicotine Delivery Systems" and "Lung Diseases" as well as synonyms in the title and abstract, with the age filter "child: birth - 18 years" to search for articles related to electronic cigarette use and lung disease in adolescents. The eligibility criteria consisted of adolescent users and exposure to e-cigarettes that resulted in lung disease. The articles were selected by independent assessment, reading first the titles and abstracts, then the full text of the selected articles. The Newcastle-Ottawa Scale was used to assess study quality, and the included studies received between 5 and 7 stars. Finally, the data were extracted for meta-analysis. Initially, 61 articles were found and 6 were considered eligible, all of which were cross-sectional and applied questionnaires. The meta-analysis found a significant association between electronic cigarette use and asthma exacerbation (adjusted OR 1.44 95% CI 1.17 - 1.76). However, no studies evaluated the association with other lung diseases, including electronic cigarette or vaping product use-associated lung injury in adolescents. The metaanalysis revealed a significant association between e-cigarette use and asthma exacerbation among adolescents with chronic asthma, as well as among their previously healthy peers.

Citation analysis of the 100 top-cited articles on the topic of hidradenitis suppurativa since 2013 using Sankey diagrams: Bibliometric analysis.

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, inflammatory and debilitating dermatosis characterized by painful nodules, sinus tracts and abscesses in apocrine gland-bearing areas that predominantly affect women worldwide. New therapeutic interventions based on the clinical manifestations of patients have recently been introduced in numerous articles. However, which countries, journals, subject categories, and articles have the ultimate influence remain unknown. This study aimed to display influential entities in 100 top-cited HS-related articles (T100HS) and investigate whether medical subject headings (i.e., MeSH terms) can be used to predict article citations. METHODS: T100HS data were extracted from PubMed since 2013. Subject categories were classified by MeSH terms using social network analysis. Sankey diagrams were applied to highlight the top 10 influential entities in T100HS from the three aspects of publication, citations, and the composited score using the hT index. The difference in article citations across subject categories and the predictive power of MeSH terms on article citations in T100HS were examined using one-way analysis of variance and regression analysis. RESULTS: The top three countries (the US, Italy, and Spain) accounts for 54% of the T100HS. The T100HS impact factor (IF) is 12.49 (IF = citations/100). Most articles were published in J Am Acad Dermatol (15%; IF = 18.07). Eight subject categories were used. The "methods" was the most frequent MeSH term, followed by "surgery" and "therapeutic use". Saunte et al, from Roskilde Hospital, Denmark, had 149 citations in PubMed for the most cited articles. Sankey diagrams were used to depict the network characteristics of the T100HS. Article citations did not differ by subject category (F(7, 92) = 1.97, P = .067). MeSH terms were evident in the number of article citations predicted (F(1, 98) = 129.1106; P < .001). CONCLUSION: We achieved a breakthrough by displaying the characteristics of the T100HS network on the Sankey diagrams. MeSH terms may be used to classify articles into subject categories and predict T100HS citations. Future studies can apply the Sankey diagram to the bibliometrics of the 100 most-cited articles.

Comparing the similarity and differences in MeSH terms associated with spine-specific journals using the forest plot: A bibliometric analysis.

BACKGROUND: A common concern in the literature is the comparison of the similarities and differences between research journals, as well as the types of research they publish. At present, there are no clear methodologies that can be applied to a given article of interest. When authors use an effective and efficient method to locate journals in similar fields, they benefit greatly. By using the forest plot and major medical subject headings (MeSH terms) of Spine (Phila Pa 1976) compared to Spine J, this study: displays relatively similar journals to the target journal online and identifies the effect of the similarity odds ratio of Spine (Phila Pa 1976) compared to Spine J. METHODS: From the PubMed library, we downloaded 1000 of the most recent top 20 most similar articles related to Spine (Phila Pa 1976) and then plotted the clusters of related journals using social network analysis (SNA). The forest plot was used to compare the differences in MeSH terms for 2 journals (Spine (Phila Pa 1976) and Spine J) based on odds ratios. The heterogeneity of the data was evaluated using the Q statistic and the I-square (I2) index. RESULTS: This study shows that: the journals related to Spine (Phila Pa 1976) can easily be presented on a dashboard via Google Maps; 8 journal clusters were identified using SNA; the 3 most frequently searched MeSH terms are surgery, diagnostic imaging, and methods; and the odds ratios of MeSH terms only show significant differences with the keyword "surgery" between Spine (Phila Pa 1976) and Spine J with homogeneity at I2 = 17.7% (P = .27). CONCLUSIONS: The SNA and forest plot provide a detailed overview of the inter-journal relationships and the target journal using MeSH terms. Based on the findings of this research, readers are provided with knowledge and concept diagrams that can be used in future submissions to related journals.

Predicting the number of citations of polycystic kidney disease with 100 top-cited articles since 2010: Bibliometric analysis.

BACKGROUND: Polycystic kidney disease (PKD) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidneys. Numerous studies on PKD have been published in the literature. However, no such articles used medical subject headings (MeSH terms) to predict the number of article citations. This study aimed to predict the number of article citations using 100 top-cited PKD articles (T100PKDs) and dissect the characteristics of influential authors and affiliated counties since 2010. METHODS: We searched the PubMed Central® (PMC) database and downloaded 100PKDs from 2010. Citation analysis was performed to compare the dominant countries and authors using social network analysis (SNA). MeSh terms were analyzed by referring to their citations in articles and used to predict the number of article citations using its correlation coefficients (CC) to examine the prediction effect. RESULTS: We observed that the top 3 countries and journals in 100PKDs were the US (65%), Netherlands (7%), France (5%), J Am Soc Nephrol (21%), Clin J Am Soc Nephrol (8%), and N Engl J Med (6%); the most cited article (PMID = 23121377 with 473 citations) was authored by Vicente Torres from the US in 2012; and the most influential MeSH terms were drug therapy (3087.2), genetics (2997.83), and therapeutic use (2760.7). MeSH terms were evident in the prediction power of the number of article citations (CC = 0.37; t = 3.92; P < .01, n = 100). CONCLUSIONS: A breakthrough was made by developing a method using MeSH terms to predict the number of article citations based on 100PKDs. MeSH terms are evident in predicting article citations that can be applied to future research, not limited to PKD, as we did in this study.

Scientific production and most researched diseases in the Biological Sciences postgraduate programs in Brazil / Produção científica e doenças mais pesquisadas nos programas de pós-graduação em Ciências Biológicas no Brasil

This macro-level scientometrics study aimed to analyze the similarities and differences in the scientific communication patterns of the Brazilian postgraduate programs (BPPs) belonging to the Biological Sciences II field (BS2), as defined by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Also, it was identified the most researched diseases and it was discussed their relationship with the needs of Brazilian public health considering the burden of disease (Disability-Adjusted Life Year - DALY, Brazil) estimated by the World Health Organization (WHO). Thus, the scientific production of the BS2's sub-areas Biophysics, Biochemistry, Pharmacology, Physiology, and Morphology was evaluated from 2013 to 2016, through considering the citation impact, Impact Factor (Journal Citation Reports), and scientific collaboration. Data collected included formal information provided to CAPES by all BPPs through the Plataforma Sucupira as well as metadata from Web of Science documents. In addition, were employed the standardized Medical Subject Headings (PubMed) for the analysis of researched diseases. We concluded that the patterns of scientific communication in Biophysics, Biochemistry, Pharmacology, Physiology, and Morphology were predominantly different. Thus, there is a need to consider specificities among the five sub-areas in the evaluation process performed by CAPES. Different approaches are revealed by identifying the most frequently researched diseases and explaining the contributions of each sub-area for Brazilian public health.

Este estudo cientométrico de nível macro teve como objetivo analisar as semelhanças e as diferenças nos padrões de comunicação científica dos programas de pós-graduação brasileiros (PPGs) da área de Ciências Biológicas II, avaliados pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Além disso, foram identificadas as doenças mais pesquisadas e foi discutido sua relação com as necessidades de saúde pública brasileira, considerando a carga de doenças (Disability-Adjusted Life Year - DALY, Brasil) estimada pela Organização Mundial da Saúde (OMS). Assim, a produção científica das subáreas Biofísica, Bioquímica, Farmacologia, Fisiologia e Morfologia da área de Ciências Biológicas II foi avaliada de 2013 a 2016, considerando o impacto de citações, o Fator de Impacto (Journal Citation Reports) e a colaboração científica. Os dados coletados incluíram informações declaradas à CAPES por todos os PPGs por meio da Plataforma Sucupira, bem como metadados de documentos da Web of Science. Além disso, foram utilizados os cabeçalhos de Medical Subject Headings (PubMed) para a análise das doenças pesquisadas. Concluímos que os padrões de comunicação científica entre as subáreas Biofísica, Bioquímica, Farmacologia, Fisiologia e Morfologia foram predominantemente diferentes. Assim, é necessário considerar as especificidades entre as cinco subáreas no processo de avaliação realizado pela CAPES. Diferentes abordagens são reveladas a partir da identificação das doenças mais pesquisadas e da explicação das contribuições de cada subárea para a saúde pública brasileira.

Marcadores FGF-23 y Klotho en enfermedad renal crónica y su implicación cardiovascular, una revisión sistemática / FGF-23 and Klotho markers in chronic kidney disease and its cardiovascular implication, a systematic review

La principal causa de mortalidad en enfermedad renal crónica (ERC), en el 80% de pacientes se da por enfermedad cardiovascular asociada, los parámetros bioquímicos clásicos del metabolismo óseomineral aún no logran explicar la progresión patológica por tanto, se ha empezado a estudiar nuevos marcadores con relación al daño cardiovascular, donde se ha encontrado al marcador FGF-23 y su correceptor Klotho, implicados en la génesis del daño cardiovascular y enfermedad óseomineral asociada al fosforo, que en conjunto causan remodelamiento cardiovascular, lo que ha empezado aclarecer aún más esta dinámica fisiopatológica. Esta revision busca conocer la implicación de los marcadores FGF-23 y Klotho en ERC y el riesgo cardiovascular asociado y para ello realizó una revision sistemática de literatura, indagando en bases biomédicas como COCHRANE, Embase, LILACS, Scielo, Pub-Med, EBSCO, Hinari, Sociedades médicas, así como tesauros MeSH propios de esta investigación.

The main cause of mortality in chronic kidney disease (CKD), in 80% of patients, is due to associated cardiovascular disease, the classic biochemical parameters of bone-mineral metabolism will not yet be able to explain the pathological progression, therefore, new markers have begun to be studied in relation to cardiovascular damage, where the marker FGF-23 and its co-receptor Klotho have been found, involved in the genesis of cardiovascular damage and bone-mineral disease associated with phosphorus, which together cause cardiovascular remodeling , which has begun to further clarify this pathophysiological dynamic.This review seeks to know the implication of the FGF-23 and Klotho markers in CKD and the associated cardiovascular risk and for this purpose, a systematic review of the literature was carried out, investigating biomedical bases such as COCHRANE, Embase, LILACS, Scielo, Pub-Med, EBSCO, Hinari, Medical Societies, as well as MeSH thesauri specific to this research.

Dermatoglifia como medio de hallazgo de diabetes mellitus: revisión sistemática / Dermatoglyphics as a means of finding diabetes mellitus: a systematic review

Introducción. La diabetes mellitus (DM) es una de las enfermedades crónicas más comunes, siendo una de las causas principales de mortalidad de la población mun-dial. La dermatoglifia es empleada como instrumento para el hallazgo de ciertos aspectos biológicos en diferentes poblaciones. Objetivo. Reconocer, a partir de una revisión sistemática, la relevancia que tiene la dermatoglifia como medio de hallazgo de diabetes mellitus. Metodología. Revisión de literatura científica en bases de datos como Sciencedi-rect, PubMed, Scopus y BVS, en las cuales se extrajo información después de co-rrer la ecuación de búsqueda con términos MESH. Posteriormente, fueron revisados para incluir aquellos artículos relacionados con DM y dermatoglifia. Para todo el proceso se siguió la metodología PRISMA, evaluando los artículos con la escala de sesgo de Cochrane y el nivel de evidencia y recomendación con escala SIGN. Resultados. Después de una revisión de 475 artículos, se incluyeron ocho artículos, y al ser evaluados fueron clasificados cinco artículos 2+ y tres 2-, con nivel de reco-mendación D. Conclusión. La dermatoglifía es una herramienta útil como medio de detección de la DM. Sin embargo, es necesario realizar estudios de cohortes para demostrarlo en di-ferentes poblaciones, como la colombiana. En ese sentido, se encuentra que el 70% de los artículos revisados demuestran que la predicción de hallazgo de DM es efectiva. Sin embargo, el 30% de las investigaciones dentro de esta revisión no consideran que sea una herramienta lo suficientemente óptima para descubrir la patología en la población.

Introduction. Diabetes mellitus (DM) is one of the most common chronic diseases, be-ing one of the main causes of mortality in the world population. Dermatoglyphics is used as an instrument for the discovery of certain biological aspects in different populations.Objective. To recognize, by doing a systematic review, the relevance of dermato-glyphics as a means of finding diabetes mellitus. Methodology. Review of scientific literature in databases such as Sciencedirect, PubMed, Scopus, and VHL, in which information was extracted after running the search equation with MESH terms. After that, they were revised to include those articles related to DM and dermatoglyphics. For the entire process, the PRISMA methodology was followed, evaluating the articles with the Cochrane bias scale and the level of evidence and recommendation with the SIGN scale. Results. After a review of 475 articles, eight articles were included, and when evalu-ated, five articles were classified as 2+ and three as 2-, with a level D recommendation. Conclusion. Dermatoglyphics is a useful tool as a means of detecting DM. However, it is necessary to carry out cohort studies to demonstrate this in different populations, such as the Colombian population. 70% of the reviewed articles show that the prediction of DM finding is effective. Nevertheless, 30% of the investigations within this review do not consider it to be a sufficiently optimal tool to discover the pathology in the population

Conocimientos, prácticas y estilos de vida durante COVID-19 entre estudiantes universitarios en México: encuesta en línea / Knowledge, practices and lifestyle during COVID-19 among university students in Mexico: online survey

Introducción: la pandemia del síndrome respiratorio agudo grave Sars-CoV-2 causado por un coronavirus que se denominó COVID-19, revolucionado de forma importante los estilos de vida de la población universitaria, la población requiere de conocimientos y tener buenas prácticas para evitar el contagio por medio del autocuidado, los retos y adaptaciones del aprendizaje en un entorno virtual conlleva a formas de vida modificadas relacionadas con un incremento de sedentarismo, estrés y temor al contagio, entre otros. Objetivo: determinar los estilos de vida saludables, conocimientos y prácticas de cuidado por causa de la pandemia de COVID-19 en estudiantes de enfermería de la Universidad de Morelos. Material y métodos: estudio descriptivo, transversal, con participación de 265 estudiantes. Se aplicaron los cuestionarios en línea HPLP-II, valora estilos de vida y cuestionario ex profeso para conocimientos, práctica del cuidado durante la pandemia, durante septiembre a octubre 2020. Resultados: conocimientos: los estudiantes sólo reconocen la sintomatología respiratoria, mencionan que practican sólo algunas de las medidas de seguridad, se obtuvo asociaciones entre conocimientos, práctica y estilos de vida p=<.05. Discusión: estudios en Perú, Colombia, España y México, revelan resultados semejantes y significativos, relacionan calidad de vida y estilos de vida, conocimientos, actitudes y prácticas adecuadas, así como actitudes positivas de estudiantes universitarios ante la COVID-19. Conclusión: la población universitaria es vulnerable al contagio, aún no han dimensionado la magnitud del problema que se vive, cuentan con escasos recursos, los estilos de vida se fragilizan al afectar las dimensiones alimentación, actividad y ejercicio, control del estrés, relaciones interpersonales, entre otras.

Introduction: the severe acute respiratory syndrome Sars-CoV-2 pandemic, caused by a coronavirus called COVID-19, has significantly revolutionized the lifestyles of the university population, it requires knowledge and good practices to avoid contagion through self-care; the challenges and adaptations of learning in a virtual environment lead to modified lifestyles, related to an increase in sedentary lifestyle, stress and fear of contagion, among others. Objective: determine healthy lifestyles, knowledge and care practices due to the Covid-19 pandemic in nursing students at the University of Morelos. Material and methods: descriptive, cross-sectional study, with participation of 265 students. The HPLP-II online questionnaires were applied, asses lifestyles and an exprofessional questionnaire for knowledge, and practice of care during the pandemic, were applied during September to October 2020. Results: knowledge: students only recognize respiratory symptoms; they mention that they practice only some of safety measures, associations were obtained between knowledge, practice and lifestyles, p = <. 05. Discussion: studies in Peru, Colombia, Spain and Mexico reveal similar and significant results; these relate quality of life and lifestyles, knowledge, attitudes and appropriate practices, as well as positive attitudes of university students towards COVID-19. Conclusion: the university population is vulnerable to contagion, it has not yet dimensioned the magnitude of the problem that it is experiencing, it has few resources, and lifestyles are weakened by affecting the dimensions of nutrition, activity and exercise, stress control, interpersonal relationships, among others.

La clave está en las palabras / The key is in the words

¿Cuál es la función de las palabras clave en un artículo científico? ¿Para qué sirven? ¿Son lo mismo que los descriptores? En el pre- sente editorial se responden esas y otras preguntas relacionadas con el uso de las palabras clave, a fin de que los autores de artí- culos científicos las elijan de una mejor manera para guiar a sus potenciales lectores y aumentar la visibilidad de su artículo, lo cual puede incrementar las probabilidades de que sea citado.

What is the role of keywords in a scholarly article? What are they for? Are keywords and descriptors the same? In this editorial those and other questions related to the use of keywords are answered, in order for the authors of scholarly articles to choose them properly so that they can guide their potential readers and increase the visibility of their article, which can lead to its citation.

Using Kano diagrams to display the most cited article types, affiliated countries, authors and MeSH terms on spinal surgery in recent 12 years.

BACKGROUND: Citation analysis has been increasingly applied to assess the quantity and quality of scientific research in various fields worldwide. However, these analyses on spinal surgery do not provide visualization of results. This study aims (1) to evaluate the worldwide research citations and publications on spinal surgery and (2) to provide visual representations using Kano diagrams onto the research analysis for spinal surgeons and researchers. METHODS: Article abstracts published between 2007 and 2018 were downloaded from PubMed Central (PMC) in 5 journals, including Spine, European Spine Journal, The Spine Journal, Journal of Neurosurgery: Spine, and Journal of Spinal Disorders and Techniques. The article types, affiliated countries, authors, and Medical subject headings (MeSH terms) were analyzed by the number of article citations using x-index. Choropleth maps and Kano diagrams were applied to present these results. The trends of MeSH terms over the years were plotted and analyzed. RESULTS: A total of 18,808 publications were extracted from the PMC database, and 17,245 were affiliated to countries/areas. The 12-year impact factor for the five spine journals is 5.758. We observed that (1) the largest number of articles on spinal surgery was from North America (6417, 37.21%). Spine earns the highest x-index (= 82.96). Comparative Study has the highest x-index (= 66.74) among all article types. (2) The United States performed exceptionally in x-indexes (= 56.86 and 44.5) on both analyses done on the total 18,808 and the top 100 most cited articles, respectively. The most influential author whose x-index reaches 15.11 was Simon Dagenais from the US. (3) The most cited MeSH term with an x-index of 23.05 was surgery based on the top 100 most cited articles. The most cited article (PMID = 18164449) was written by Dagenais and his colleagues in 2008. The most productive author was Michael G. Fehlings, whose x-index and the author's impact factor are 13.57(= √(13.16*14)) and 9.86(= 331.57/33.64), respectively. CONCLUSIONS: There was a rapidly increasing scientific productivity in the field of spinal surgery in the past 12 years. The US has extraordinary contributions to the publications. Furthermore, China and Japan have increasing numbers of publications on spinal surgery. This study with Kano diagrams provides an insight into the research for spinal surgeons and researchers.

Prediction of miRNA-disease associations based on Weighted [Formula: see text]-Nearest known neighbors and network consistency projection.

MicroRNAs (miRNA) are a type of non-coding RNA molecules that are effective on the formation and the progression of many different diseases. Various researches have reported that miRNAs play a major role in the prevention, diagnosis, and treatment of complex human diseases. In recent years, researchers have made a tremendous effort to find the potential relationships between miRNAs and diseases. Since the experimental techniques used to find that new miRNA-disease relationships are time-consuming and expensive, many computational techniques have been developed. In this study, Weighted [Formula: see text]-Nearest Known Neighbors and Network Consistency Projection techniques were suggested to predict new miRNA-disease relationships using various types of knowledge such as known miRNA-disease relationships, functional similarity of miRNA, and disease semantic similarity. An average AUC of 0.9037 and 0.9168 were calculated in our method by 5-fold and leave-one-out cross validation, respectively. Case studies of breast, lung, and colon neoplasms were applied to prove the performance of our proposed technique, and the results confirmed the predictive reliability of this method. Therefore, reported experimental results have shown that our proposed method can be used as a reliable computational model to reveal potential relationships between miRNAs and diseases.

Teoría de seres humanos unitarios en el cuidado de la administración de medicamentos / Unitary human beings theory in the care of the administration of medicines / Teoria do ser humano unitário no cuidado da administração de medicamento

La administración de medicamentos es uno de los pilares fundamen-tales en la gestión del cuidado de la enfermería, de ahí la impor-tancia y responsabilidad de su manejo con personas que estén re-cibiendo fármacos especializados por su condición aguda o crítica. Objetivo: Construir un instrumento de valoración con los principios homeodinámicos y el concepto de pandimensionalidad de la teoría de seres humanos unitarios, para la administración de medicamen-tos especializados, como inotrópicos y vasopresores en servicios de UCI y urgencias. Materiales y métodos: Es una investigación cua-litativa con enfoque descriptivo, para conocer la realidad del sujeto de cuidado desde la premisa sobre la relación de la administración de medicamentos y los principios de la teoría de Seres Humanos Unitarios. Resultados: Se construyó un instrumento de valoración desde la perspectiva de la teoría de Rogers. La misma permite al profesional de enfermería evaluar y generar propuestas de cuida-do guiadas al equilibrio armónico de los campos de energía, según propone esta teórica en relación con la administración de medica-mentos. También le facilita al estudiante el identificar las alteracio-nes de los principios de la teoría en relación a los efectos de los medicamentos. Conclusiones: El instrumento permite contemplar los principios homeodinámicos y la pandimensionalidad; además, facilita los procesos de cuidado en la administración de medicamen-tos, que en ocasiones por diferentes causas no se evalúa la respuesta del sujeto de cuidado ante un medicamento, retrasando su evolución ante la enfermedad.

The administration of medications is one of the fundamental pillars in the management of nursing care, hence the importance and responsibility of the management of medications to people who are receiving specialized medicine for their acute or critical condition, that is why this study was proposed The objective: is to build an assessment instrument with the homeodynamic principles and the concept of pandimensionality of the theory of unitary human beings for the administration of specialized drugs such as inotropics and vasopressors in ICU and emergency health services. Materials and methods: qualitative with a descriptive approach, to know the reality of the care subject from the premise of the relationship of the administration of medicines and principles of the theory of Unitary Human Beings, Results: an assessment instrument was built from the pers-pective of Rogers' theory that allows the nursing professional to evaluate and generate proposals for care guided to the harmonic balance of the energy fields proposed by this theory in relation to the administration of medications, also, it allows the student to identify alterations in the prin-ciples of the theory in relation to the effects of medications Conclusions: the instrument allows to contemplate homeodynamic principles and the concept of pandimensionality thus facilitate the process of care for the administration of drugs that sometimes for different reasons does not evaluate the response of the care subject to a drug, delaying the evolution of the subject before the disease.

A administração de medicamentos é um dos eixos fundamentais do cuidado de enfermagem, sendo importante a responsabilidade do seu manejo com pessoas que recebem fármacos espe-cializados pela sua condição aguda ou crítica. Objetivo: Construir um instrumento de avaliação dos princípios homeodinâmicos e o conceito de pandimensionalidade da teoria do ser humanos unitários, para a administração de medicamentos especializados como inotrópicos e vasopres-sores nas UTI e Unidades de Emergência. Materiais e métodos: Pesquisa qualitativa com foco descritivo para conhecer a realidade do sujeito de cuidado sobre a relação da administração de medicamentos e os princípios da teoria do Ser Humano Unitário. Resultados: Construiu-se um instrumento de valoração desde a perspectiva de Rogers, permitindo ao profissional de enferma-gem avaliar e gerar propostas de cuidado guiadas ao equilíbrio harmônico dos campos de energia, segundo a proposta da teoria em relação com a administração de medicamentos. Também lhe fa-cilita ao estudante identificar as alterações dos princípios da teoria em relação com os efeitos dos medicamentos. Conclusões: O instrumento permite contemplar os princípios homeodinâmicos e pandimensionalidade; além disso, facilita os processos de cuidado na administração de medica-mentos que ocasionalmente, por diferentes causas não se avalia a resposta do sujeito de cuidado ante um medicamento, retrasando a sua evolução perante a doença.

New Health Sciences Descriptors to classify and retrieve information on equity / Nuevos Descriptores en Ciencias de la Salud para clasificar y recuperar información sobre equidad

ABSTRACT The Health Sciences Descriptors (DeCS) vocabulary establishes a unique and common language that allows the organization and facilitates the search and retrieval of technical and scientific literature on health available in the information sources of the Virtual Health Library. The DeCS, created by the Latin American and Caribbean Center on Health Sciences Information (BIREME), a specialized center of the Pan American Health Organization/World Health Organization (PAHO/WHO), is the translation and extension of the Medical Subject Headings (MeSH) vocabulary, maintained by the United States National Library of Medicine. BIREME, in coordination with experts from Latin America and the Caribbean, has included in the DeCS the topics of equity, gender, ethnicity and human rights—cross-cutting themes in the programmatic framework of PAHO/WHO technical cooperation—to ensure better retrieval and use of scientific information and evidence related to these topics. The objective of this article is to describe the methodology used during the terminology review of the DeCS and to report the results obtained and the impacts of the terminology expansion in the field of equity, which included the inclusion of 35 new descriptors.

RESUMEN El vocabulario Descriptores en Ciencias de la Salud (DeCS) establece un lenguaje único y común que permite la organización y facilita la búsqueda y recuperación de la literatura técnica y científica en salud disponible en las fuentes de información de la Biblioteca Virtual en Salud. El DeCS, creado por el Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud (BIREME), un centro especializado de la Organización Panamericana de la Salud/Organización Mundial de la Salud (OPS/OMS), es la traducción y la extensión del vocabulario Medical Subject Headings (MeSH), mantenido por la National Library of Medicine de los Estados Unidos. BIREME, en coordinación con expertos de América Latina y el Caribe, ha incluido en el DeCS los temas de equidad, género, etnicidad y derechos humanos —temas transversales en el marco programático de la cooperación técnica de la OPS/OMS— para garantizar una mejor recuperación y uso de la información y evidencia científica relacionadas a estos temas. El objetivo de este artículo es describir el método de revisión terminológica del DeCS e informar los resultados obtenidos y los impactos de la ampliación terminológica en el área de equidad, que comprendió la inclusión de 35 nuevos descriptores.

BioLitMine: Advanced Mining of Biomedical and Biological Literature About Human Genes and Genes from Major Model Organisms.

The accumulation of biological and biomedical literature outpaces the ability of most researchers and clinicians to stay abreast of their own immediate fields, let alone a broader range of topics. Although available search tools support identification of relevant literature, finding relevant and key publications is not always straightforward. For example, important publications might be missed in searches with an official gene name due to gene synonyms. Moreover, ambiguity of gene names can result in retrieval of a large number of irrelevant publications. To address these issues and help researchers and physicians quickly identify relevant publications, we developed BioLitMine, an advanced literature mining tool that takes advantage of the medical subject heading (MeSH) index and gene-to-publication annotations already available for PubMed literature. Using BioLitMine, a user can identify what MeSH terms are represented in the set of publications associated with a given gene of the interest, or start with a term and identify relevant publications. Users can also use the tool to find co-cited genes and a build a literature co-citation network. In addition, BioLitMine can help users build a gene list relevant to a MeSH term, such as a list of genes relevant to "stem cells" or "breast neoplasms." Users can also start with a gene or pathway of interest and identify authors associated with that gene or pathway, a feature that makes it easier to identify experts who might serve as collaborators or reviewers. Altogether, BioLitMine extends the value of PubMed-indexed literature and its existing expert curation by providing a robust and gene-centric approach to retrieval of relevant information.

Glosario para una pandemia: el ABC de los conceptos sobre el coronavirus / Pandemic's glossary: The ABC of coronavirus concepts

Actualmente, el mundo se enfrenta a la pandemia generada por el SARS-CoV-2, infección para la cual no hay medidas farmacológicas de prevención ni tratamiento. Hasta el momento, ha dejado más de 4'880.000 casos confirmados y 322.000 muertes. Se han propuesto diferentes estrategias para el control de la enfermedad que implican la participación de diferentes sectores de la sociedad con acciones guiadas por lineamientos jurídicos y basados en medidas de salud pública, entre ellas, la contención, la mitigación, el aislamiento físico y la cuarentena. Dado que se trata de una situación de dimensión poblacional, la información tiene un papel fundamental; sin embargo, la proliferación de términos nuevos, muchas veces usados erróneamente, causa confusión y desinformación y, en consecuencia, limitan la participación ciudanía. En ese contexto, en el presente documento se hizo una revisión de los términos utilizados en epidemias y pandemias de enfermedades infecciosas, con énfasis en la COVID-19, para facilitar al público general la comprensión de los términos relevantes sobre el comportamiento de los agentes patógenos y de su ciclo epidémico y pandémico, así como los criterios para la adopción de las decisiones pertinentes en salud pública. Se aspira a que el glosario resultante ayude al uso correcto de los términos y a homogenizar la información.

Currently, the world is facing the pandemic generated by SARS-CoV-2. There are no no pharmacological measures for the prevention or treatment of this infection and, so far, it has caused more than 4'880.000 confirmed cases and 322.000 deaths. The different strategies for the control of the disease that have been proposed involve the participation of different actors. Such participation, guided by legal guidelines based on public health measures, include containment, mitigation, physical isolation, and quarantine. As this is a population-based problem, information plays a primary role; however, the many new terms hat have arisen and their misuse confuse and, therefore, misinform thus limiting citizen participation. For this reason, we conducted a review of the terms used in epidemics and pandemics of infectious diseases, particularly COVID-19. We considered and differentiated the relevant terms to facilitate the understanding of pathogen's behavior and epidemic and pandemic cycles, as well as the criteria for public health decision-making for the general public. This glossary should facilitate the use of the terms and standardize the information.

Analysis of research trends in Korean dentistry journals by assigning MeSH to author keywords.

Researchers seek to identify optimal journals for submission based on their studies but tend to rely on journal impact factors or scientific journal rankings. We investigated research trends by selecting high-frequency words from author keywords (AKs), analyzing subject areas, and performing quantitative data analysis of Korean dental journals. Consequently, we suggest a method for choosing journals that fit a specific subject area.We used a corpus of 9 Korean dentistry journals regarded in Korea as quality internationally approved journals. AKs occurring more than 10 times were assigned to Medical Subject Headings (MeSH) terms and subcategories, which were then categorized using the MeSH tree structure. KnowledgeMatrix Plus and VOSviewer were used to analyze network relationships, density, and clustering.The AKs were of 7527 types, 15,960 terms, and formed 54 clusters. The AKs with 10+ occurrence were 199 types, 4289 terms, and formed 9 clusters. Assigning the AKs with 10+ occurrence to MeSH terms led to expanding 732 types of AK terms into 249 types with 9 clusters and 4268 links. Core study areas over the past 10 years were facial asymmetry, a topic under oral surgery and medicine, and orthognathic surgery focused on mandibular fractures, followed by shear bond strength of zirconia. Analyzing 16 MeSH subject categories, we found that the "analytical, diagnostic and therapeutic techniques and equipment" category had the largest distribution of AKs (40.7%). This was followed by "diseases" (21.2%) and "anatomy" (14.90%). The orthognathic surgery cluster was the largest, followed by the shear bond strength cluster. Dental implants is a core area with strong links to high-occurrence words, such as cone-beam computed tomography and mandible, which were distributed in the order of The Journal of Advanced Prosthodontics (37.8%) and Journal of Periodontal & Implant Science (30.6%). Five clusters were closely packed in the center, 2 clusters were formed above the center, 1 cluster was formed below the center, and a cluster on the right was widespread.Cluster analysis using AKs and MeSH may be a good analytic method for researchers to determine expanding research areas and select optimal journals for paper submission.

Development of the Gender, Sex, and Sexual Orientation ontology: Evaluation and workflow.

OBJECTIVE: The study sought to create an integrated vocabulary system that addresses the lack of standardized health terminology in gender and sexual orientation. MATERIALS AND METHODS: We evaluated computational efficiency, coverage, query-based term tagging, randomly selected term tagging, and mappings to existing terminology systems (including ICD (International Classification of Diseases), DSM (Diagnostic and Statistical Manual of Mental Disorders ), SNOMED (Systematized Nomenclature of Medicine), MeSH (Medical Subject Headings), and National Cancer Institute Thesaurus). RESULTS: We published version 2 of the Gender, Sex, and Sexual Orientation (GSSO) ontology with over 10 000 entries with definitions, a readable hierarchy system, and over 14 000 database mappings. Over 70% of terms had no mapping in any other available ontology. DISCUSSION: We created the GSSO and made it publicly available on the National Center for Biomedical Ontology BioPortal and on GitHub. It includes clarifications on over 200 slang terms, 190 pronouns with linked example usages, and over 200 nonbinary and culturally specific gender identities. CONCLUSIONS: Gender and sexual orientation continue to represent crucial areas of medical practice and research with evolving terminology. The GSSO helps address this gap by providing a centralized data resource.

A PubMed Citations Search Study on the Prevalence of Epiphora in the General Adult Population.

PURPOSE: To assess the prevalence of epiphora in the general adult population based on PubMed search citations. METHODS: 1) Electronic PubMed MEDLINE database search (September 13, 2019) with the terms (Medical Subject Headings or MeSH) "prevalence" and "epiphora", 2) "epiphora" and "dry eye", and 3) "prevalence", "epiphora", and "dry eye". Review of all citations from these searches containing the term "epiphora" either in their abstract or title. RESULTS: 1) PubMed search retrieved 2 617 137 citations for "prevalence", 26 135 for "epiphora", and 2554 for "prevalence" AND "epiphora". Within the latter 2554 citations, the word "epiphora" appeared in the abstract or title of only 109 citations (< 5%). None of these 109 citations assessed the prevalence of epiphora in the adult general population as the primary end point. Only one abstract mentioned that out of 125 patients, 7.2% indicated, retrospectively, that they had already had epiphora before cataract surgery. Two large population-based studies addressed the incidence of epiphora, not in adults, but in infants (20%) and children (7.7%). 2) The PubMed search showed 22 487 citations for "dry eye", 30 211 for "epiphora" OR "dry eye", and up to 18 414 joint citations for the terms "epiphora" AND "dry eye". These 18 414 citations were 70 and 82% of the number of MeSH citations for "epiphora" and "dry eye" alone, respectively. Of these 18 414 citations, the word "epiphora" only appeared in 131 citations (< 1%), one of them being an extra report mentioning a 32% incidence of epiphora among postmenopausal women. 3) The search found 2206 citations for "prevalence" AND "epiphora" AND "dry eye", with only 10 of them (< 1%) containing the word "epiphora". CONCLUSIONS: Despite a large number of citations retrieved by PubMed searches, there seems to be a lack of studies on the prevalence of epiphora in the adult general population. There is apparently also a large number of overlapping PubMed citations retrieved for searches with the terms "epiphora" AND "dry eye", although more than 99% of them did not even display the word "epiphora". Although epiphora is considered a common complain, its prevalence in the adult general population deserves to be further assessed.