RESUMO
Malignant pleura mesothelioma (MPM) is a rare type of cancer with devastating prognosis, which develops in the pleural cavity from transformed mesothelium. MPM has been directly associated with asbestos exposure however there are aspects of the pathophysiology involved in the translocation of asbestos fibers in the pleura that remain unclear. Here, we propose and discuss that certain proteins secreted by airways symbiotic microbiota create membrane pores to the airway epithelial cells, through which asbestos fibers can penetrate the lung parenchyma and reach the sub-pleural areas. We evaluate this hypothesis using data from the published literature regarding the airways microbiota toxins such as cholesterol-dependent cytolysins (CDCs).
Assuntos
Amianto/toxicidade , Neoplasias Pulmonares/microbiologia , Neoplasias Pulmonares/fisiopatologia , Pulmão/microbiologia , Mesotelioma/microbiologia , Mesotelioma/fisiopatologia , Colesterol/química , Citotoxinas/química , Células Epiteliais/efeitos dos fármacos , Células Epiteliais/microbiologia , Humanos , Pulmão/efeitos dos fármacos , Mesotelioma Maligno , Microbiota , Modelos Biológicos , Pleura/efeitos dos fármacos , Pleura/microbiologia , Neoplasias Pleurais/microbiologia , Neoplasias Pleurais/fisiopatologia , Prognóstico , Streptococcus intermedius , Streptococcus mitis , Streptococcus pneumoniae , Streptococcus pyogenesAssuntos
Klebsiella pneumoniae/enzimologia , beta-Lactamases/biossíntese , Proteínas de Bactérias/biossíntese , Humanos , Infecções por Klebsiella/enzimologia , Infecções por Klebsiella/microbiologia , Klebsiella pneumoniae/genética , Mesotelioma/enzimologia , Mesotelioma/microbiologia , Resistência beta-Lactâmica , beta-Lactamases/genéticaRESUMO
Mesotheliomas are pleural, pericardial, or peritoneal neoplasms frequently associated with asbestos exposure, and it is estimated that over the next twenty years up to 80,000 new cases are expected in the USA alone. We found simian virus 40-like DNA sequences in 29 of 48 mesotheliomas studied (60%) and demonstrated simian virus large-T antigen expression in 13 of 16 specimens. The matching lung samples did not contain simian virus 40-like sequences; however, they contained asbestos. These findings are to our knowledge the first demonstration of a physical link between DNA virus-like sequences and human mesothelioma. We suggest that a simian virus 40-like virus may act independently or as a co-carcinogen with asbestos. Moreover, the selective large T antigen expression by mesothelioma and not by the surrounding pulmonary parenchyma may have both diagnostic and therapeutic implications.
Assuntos
DNA Viral/análise , Mesotelioma/microbiologia , Neoplasias Pleurais/microbiologia , Vírus 40 dos Símios/genética , Adulto , Idoso , Antígenos Transformantes de Poliomavirus/análise , Amianto/efeitos adversos , Sequência de Bases , DNA Viral/química , Feminino , Humanos , Masculino , Mesotelioma/diagnóstico , Mesotelioma/etiologia , Pessoa de Meia-Idade , Dados de Sequência Molecular , Neoplasias Pleurais/diagnóstico , Neoplasias Pleurais/etiologia , Reação em Cadeia da Polimerase , Vírus 40 dos Símios/imunologia , Proteínas Virais/análiseRESUMO
Diffuse mesothelioma with a large pleural effusion was diagnosed nine months after the appearance of herpes zoster in the overlying thoracic segment in a patient presenting with chest pain mimicking post-herpetic neuralgia. Clinical implications of such an association are discussed.