RESUMO
OBJECTIVES: Differentiation of iris and ciliary body lesions as benign or malignant and cystic or solid is important. The aim of this study was to compare anterior segment swept-source optical coherence tomography (AS SS-OCT) and ultrasound biomicroscopy (UBM) findings in iris and ciliary body tumors. RESEARCH DESIGN AND METHODS: Forty-two eyes of 38 cases with iris and ciliary body tumors imaged with UBM and AS SS-OCT between September 2018 and September 2023 were evaluated retrospectively. RESULTS: Of 42 eyes, 14 had melanoma, 14 iris pigment epithelial (IPE) cysts, 7 nevi, 3 Lisch nodules, 2 iris stromal cysts, 1 pars plana cysts, and 1 iris mammillations. An equivalent (100%) visualization of the anterior tumor margin was obtained with both techniques. Compared to AS SS-OCT, UBM was superior for posterior margin visualization in melanocytic tumors and IPE cysts. Bland-Altman plots demonstrated good agreement between UBM and AS SS-OCT for melanocytic tumors < 2.5 mm in base diameter and < 2 mm in thickness. CONCLUSIONS: Although, UBM is the gold standard for ciliary body and iridociliary tumors. AS SS-OCT should be considered as an excellent alternative to UBM, especially in minimally elevated iris lesions.
Assuntos
Corpo Ciliar , Microscopia Acústica , Tomografia de Coerência Óptica , Humanos , Tomografia de Coerência Óptica/métodos , Microscopia Acústica/métodos , Corpo Ciliar/diagnóstico por imagem , Corpo Ciliar/patologia , Masculino , Feminino , Pessoa de Meia-Idade , Adulto , Estudos Retrospectivos , Idoso , Neoplasias Uveais/diagnóstico por imagem , Neoplasias Uveais/patologia , Segmento Anterior do Olho/diagnóstico por imagem , Segmento Anterior do Olho/patologia , Neoplasias da Íris/diagnóstico por imagem , Adulto Jovem , Doenças da Íris/diagnóstico por imagem , Iris/diagnóstico por imagem , Iris/patologia , AdolescenteRESUMO
INTRODUCTION: Magnetic resonance imaging (MRI) has demonstrated high levels of tissue contrast, accuracy and reproducibility in evaluating posterior uveal melanoma. Owing to smaller size, the role of MRI in detecting and characterising iris melanoma has not yet been explored. AIMS: To develop a protocol to image iris melanoma and describe the MRI characteristics of histopathological-confirmed iris melanoma. MATERIALS AND METHODS: An optimised MRI protocol, using a 3T MRI scanner and a 32-channel head coil, was developed to image iris tumours. A prospective, single-centre, 12-month study was conducted on all patients with lesions suspicious for iris melanoma. All patients were offered an MRI scan in addition to the standardised clinical procedures. Image quality comparison was made with existing clinical investigations. Iris melanoma characteristics on MRI are described. RESULTS: A successful optimised MRI scan protocol was developed that was able to detect and characterise iris melanoma. One normal participant and five patients with subsequent histopathological-confirmed iris melanoma (n = 6) were recruited. Four patients completed the full MRI sequence. All iris melanoma were detected on at least one T1- or T2-weighted images. When compared to the vitreous, all iris melanomas demonstrated hyper-intensity on T1-weighted images and hypo-intensity on T2-weighted images. On T1-mapping, T1-values of iris melanoma demonstrated an inverse relationship with the degree of tumour pigmentation. CONCLUSIONS: This study highlights an optimised, easily reproducible MRI scan protocol to image iris melanoma. Numerous MR imaging characteristics of iris melanoma are reported for the first time and a potential non-invasive tumour biomarker is described.
Assuntos
Neoplasias da Íris , Imageamento por Ressonância Magnética , Melanoma , Neoplasias Uveais , Humanos , Melanoma/diagnóstico por imagem , Melanoma/patologia , Estudos Prospectivos , Imageamento por Ressonância Magnética/métodos , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/patologia , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Reprodutibilidade dos Testes , AdultoAssuntos
Doenças da Córnea/diagnóstico por imagem , Traumatismos Oculares/diagnóstico por imagem , Hérnia/diagnóstico por imagem , Doenças da Íris/diagnóstico por imagem , Neoplasias da Íris/diagnóstico por imagem , Iris/lesões , Diagnóstico Diferencial , Gonioscopia , Humanos , Masculino , Microscopia com Lâmpada de Fenda , Tomografia de Coerência Óptica , Adulto JovemRESUMO
BACKGROUND: Gastric cancer has a wide spectrum of clinical features, imaging manifestations, and pathology. Punctate calcifications in gastric cancer are infrequent but are usually found in mucinous adenocarcinoma. However, there have only been a few autopsy case reports describing the correlation between the radiology and pathology findings of calcified mucinous adenocarcinoma of the stomach. We present an autopsy case of mucinous gastric adenocarcinoma with iris metastases as the initial symptom. CASE PRESENTATION: A 74-year-old Japanese woman presented with blurred vision. Her treating ophthalmologist diagnosed acute iritis with secondary glaucoma. The histopathological and immunohistochemical features of a trabeculectomy specimen favored metastatic carcinoma, most likely of gastrointestinal tract origin. Esophagogastroduodenoscopy revealed multiple irregularly shaped ulcerative lesions, multiple erosions, and thickened folds in the corpus of her stomach. Histologic examination of a gastric tissue specimen obtained by endoscopic biopsy revealed poorly differentiated carcinoma with signet ring cell features. Computed tomography revealed a tumor with multiple punctate calcifications in the thickened gastric wall with diffuse low attenuation and multiple lymph node metastases, including the para-aortic lymph nodes, and peritoneal dissemination. She was diagnosed with stage IV gastric cancer (T4N3M1) and underwent seven cycles of 5-weekly TS-1, a novel oral fluoropyrimidine derivative, plus cisplatin therapy. Serial follow-up computed tomography revealed successive increases in the gastric wall calcifications. Her disease stabilized, but she died of aspiration pneumonia 8 months after the first visit. Autopsy tissue specimens had miliary, punctate calcifications present in abundant extracellular mucin pools in the submucosa, corresponding to the thickened low-attenuating middle layer on computed tomography. The final diagnosis was mucinous gastric adenocarcinoma because mucinous adenocarcinoma is diagnosed when more than half of the tumor area contains extracellular mucin pools. CONCLUSIONS: We report the pathology and computed tomography imaging characteristics of a case of calcified mucinous adenocarcinoma of the stomach metastatic to the iris, including findings at autopsy. Metastatic carcinomas in the iris originating in the stomach are exceedingly rare. Multiple punctate calcifications were present in pools of extracellular mucin, a diagnostic clue for mucinous adenocarcinoma. Possible mechanisms underlying scattered punctuate calcifications in gastric mucinous adenocarcinoma warrant further investigation.
Assuntos
Adenocarcinoma Mucinoso/patologia , Calcinose/patologia , Neoplasias da Íris/secundário , Iris/patologia , Neoplasias Gástricas/patologia , Transtornos da Visão/diagnóstico por imagem , Adenocarcinoma Mucinoso/diagnóstico por imagem , Adenocarcinoma Mucinoso/tratamento farmacológico , Idoso , Calcinose/diagnóstico por imagem , Evolução Fatal , Feminino , Humanos , Iris/diagnóstico por imagem , Neoplasias da Íris/diagnóstico por imagem , Neoplasias Gástricas/diagnóstico por imagem , Neoplasias Gástricas/tratamento farmacológico , Tomografia Computadorizada por Raios X , Transtornos da Visão/etiologia , Transtornos da Visão/patologiaAssuntos
Adenocarcinoma de Pulmão/secundário , Neoplasias da Íris/secundário , Neoplasias Pulmonares/diagnóstico , Adenocarcinoma de Pulmão/diagnóstico , Adenocarcinoma de Pulmão/diagnóstico por imagem , Evolução Fatal , Humanos , Neoplasias da Íris/diagnóstico por imagem , Neoplasias Pulmonares/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Neoplasias Peritoneais/secundário , Tomografia de Coerência Óptica , Tomografia Computadorizada por Raios X , Uveíte Anterior/etiologiaRESUMO
Extraocular infantile hemangiomas have been shown to respond to oral and topical beta blockers, while there is little literature regarding the management of intraocular infantile hemangiomas with beta blockers. This case report discusses the management of an iris hemangioma with topical timolol, a treatment previously unreported in the literature.
Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Hemangioma Capilar/tratamento farmacológico , Neoplasias da Íris/tratamento farmacológico , Síndromes Neoplásicas Hereditárias/tratamento farmacológico , Timolol/uso terapêutico , Administração Oftálmica , Antagonistas Adrenérgicos beta/administração & dosagem , Feminino , Hemangioma Capilar/diagnóstico por imagem , Humanos , Lactente , Neoplasias da Íris/diagnóstico por imagem , Imageamento por Ressonância Magnética , Microscopia Acústica , Síndromes Neoplásicas Hereditárias/diagnóstico por imagem , Timolol/administração & dosagemRESUMO
Abstract We report the case of a 31-year-old woman who presented with a nine-month history of blurred vision in her left eye. Slit-lamp examination and optical coherence tomography showed four cystic masses hanging at the pupillary margin of the left eye. Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser photocoagulation was used to rupture the wall (cystotomy), drain the cyst content and shrink the remnants of the pigment epithelium, using laser parameters at the lowest effective levels. The patient's best corrected visual acuity improved significantly after treatment. Despite the increase of pigment at anterior chamber angle, no complication was observed during 6 months of follow up. This is the first report to describe frequency-doubled Nd:YAG laser (532 nm) photocoagulation as a therapeutic option for patients with symptomatic primary IPE cysts at pupillary margin.
Resumo Relatamos o caso de uma mulher de 31 anos com queixa de visão turva no olho esquerdo. Exame em lâmpada de fenda e tomografia de coerência óptica mostraram quatro lesões císticas nas margens da pupila esquerda. O laser do tipo Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) de dupla-frequência foi o tratamento de escolha para romper a parede (cistotomia), drenar o conteúdo do cisto e encolher os remanescentes do epitélio de pigmentar utilizando os menores parâmetros efetivos. Após o tratamento do olho comprometido, sua acuidade visual melhorou consideravelmente. Apesar do aumento da pigmentação no ângulo da câmara anterior, nenhuma complicação foi observada durante 6 meses de acompanhamento. Este é o primeiro relato que descreve o laser de Nd:YAG de dupla frequência (532 nm) como uma opção terapêutica para pacientes com cistos irianos primários do epitélio pigmentar sintomáticos na margem pupilar.
Assuntos
Humanos , Feminino , Adulto , Neoplasias da Íris/cirurgia , Fotocoagulação a Laser/métodos , Cistos/cirurgia , Lasers de Estado Sólido/uso terapêutico , Neoplasias da Íris/diagnóstico por imagem , Cistos/diagnóstico por imagem , Tomografia de Coerência Óptica , Microscopia com Lâmpada de FendaRESUMO
PURPOSE: To report a case of solitary iris plasmacytoma successfully treated with ruthenium plaque radiotherapy. METHODS: A 44-year-old white woman presented with pain in the right eye and raised intraocular pressure. Her medical history included breast cancer treated 11 years earlier with lumpectomy, lymph node clearance, chemotherapy, and radiotherapy. On examination, the right iris had a tan-colored mass with crystalline deposits visible on the mass surface and on the corneal endothelium. The fundus and left eye were normal. An anterior segment ultrasound scan showed a mass with mixed internal echogenicity and internal blood flow. RESULTS: An iris biopsy showed an infiltrate of plasma cells. Immunohistochemistry for kappa and lambda light chains demonstrated lambda light chain restriction. Systemic hematologic investigations including complete blood count, serum paraproteins, bone marrow biopsy, and full-body magnetic resonance image were normal. The monoclonal plasma cell infiltrate was consistent with a solitary iris plasmacytoma. The mass was treated with ruthenium plaque radiotherapy. After 4 years of follow-up, the mass remained regressed, and no systemic myeloma has developed. CONCLUSIONS: Iris plasmacytoma is rare and should prompt systemic evaluation to rule out multiple myeloma. Solitary iris plasmacytoma can be successfully treated with plaque radiotherapy.
Assuntos
Câmara Anterior/patologia , Neoplasias da Íris/patologia , Plasmocitoma/patologia , Adulto , Biópsia , Braquiterapia , Feminino , Gonioscopia , Humanos , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/radioterapia , Imageamento por Ressonância Magnética , Plasmocitoma/diagnóstico por imagem , Plasmocitoma/radioterapia , Radioisótopos de Rutênio/uso terapêuticoAssuntos
Neoplasias da Íris/diagnóstico por imagem , Melanoma Amelanótico/diagnóstico por imagem , Adulto , Biomarcadores Tumorais/análise , Biópsia , Braquiterapia , Feminino , Gonioscopia , Humanos , Neoplasias da Íris/radioterapia , Melanoma Amelanótico/radioterapia , Microscopia Acústica , Microscopia com Lâmpada de FendaRESUMO
ABSTRACT Ocular metastasis is relatively uncommon, with a reported incidence of approximately 8%, according to the results of autopsy evaluation. The majority of ocular metastases are located within the choroid, while metastatic tumors affecting the iris are rare. Metastatic tumors may manifest as stromal nodules or ill-defined iris thickening, or they may present with nonspecific features such as pain, iridocyclitis, and hyphema. Here, we describe three patients with iris metastasis and discuss the diagnostic challenges and unusual findings associated with these cases.
RESUMO A maioria das metástases oculares do câncer sistêmico são encontrados na coroide. As metástases para a íris são incomuns, podendo se manifestar como nódulo estromal, espessamento de íris de limites mal definidos ou como uma iridociclite ou hifema. Relatamos 3 pacientes com lesão de íris e história pregressa de câncer sistêmico. Enfatizamos a dificuldade no diagnóstico e raridade dessas lesões comparando com relatos anteriores.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Carcinoma/secundário , Neoplasias da Íris/secundário , Neoplasias da Mama/patologia , Carcinoma/terapia , Carcinoma/diagnóstico por imagem , Adenocarcinoma/patologia , Neoplasias da Íris/terapia , Neoplasias da Íris/diagnóstico por imagem , Evolução Fatal , Neoplasias Renais/patologiaRESUMO
Ocular metastasis is relatively uncommon, with a reported incidence of approximately 8%, according to the results of autopsy evaluation. The majority of ocular metastases are located within the choroid, while metastatic tumors affecting the iris are rare. Metastatic tumors may manifest as stromal nodules or ill-defined iris thickening, or they may present with nonspecific features such as pain, iridocyclitis, and hyphema. Here, we describe three patients with iris metastasis and discuss the diagnostic challenges and unusual findings associated with these cases.
Assuntos
Carcinoma/secundário , Neoplasias da Íris/secundário , Adenocarcinoma/patologia , Adulto , Neoplasias da Mama/patologia , Carcinoma/diagnóstico por imagem , Carcinoma/terapia , Evolução Fatal , Feminino , Humanos , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/terapia , Neoplasias Renais/patologia , Masculino , Pessoa de Meia-IdadeRESUMO
PURPOSE: To describe an unusual case of pediatric iris melanocytoma with pigment dispersion glaucoma that resolved after resection of the primary tumor. METHODS: Retrospective case review of the clinical record, ultrasonographic images, and histopathology. RESULTS: A 6-year-old Asian girl, with a dark iris tumor, pigment dispersion, and secondary glaucoma, was initially treated with topical antiglaucoma medication and observation. Rapid growth prompted biopsy, revealing melanocytoma. As the tumor continued to grow, excision of the primary tumor was performed. Surgery proved curative in that the pigment dispersion slowly reabsorbed and her glaucoma resolved. CONCLUSIONS: In this case, rapid growth did not indicate malignant transformation. Initial observation for growth and judiciously timed surgical intervention prevented progression, loss of vision, and potentially the loss of the eye.
Assuntos
Glaucoma de Ângulo Aberto/etiologia , Neoplasias da Íris/patologia , Nevo Pigmentado/patologia , Criança , Feminino , Humanos , Iridectomia , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/cirurgia , Nevo Pigmentado/diagnóstico por imagem , Nevo Pigmentado/cirurgia , Estudos Retrospectivos , UltrassonografiaRESUMO
CASE REPORT: We present a case of plateau iris and glaucoma due to multiple unilateral iridociliary cysts. The patient was treated with iridotomy Nd: YAG laser and 360° iridoplasty, without achieving pressure control. Phacoemulsification improved the hypertension. Dynamic gonioscopy and OCT of the anterior chamber was also performed before and after treatment. DISCUSSION: Iridociliary cysts are a benign condition that can cause iris plateau configuration, and can produce a difficult to treat ocular hypertension. Cystotomy, peripheral iridoplasty, and other treatments have been proposed.
Assuntos
Corpo Ciliar/patologia , Cistos/complicações , Glaucoma de Ângulo Fechado/etiologia , Neoplasias da Íris/complicações , Iris/patologia , Neoplasias Primárias Múltiplas/complicações , Neoplasias Uveais/complicações , Corpo Ciliar/diagnóstico por imagem , Corpo Ciliar/cirurgia , Cistos/cirurgia , Feminino , Humanos , Iris/cirurgia , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/cirurgia , Terapia a Laser , Lasers de Estado Sólido , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/diagnóstico por imagem , Neoplasias Primárias Múltiplas/cirurgia , Facoemulsificação , Tomografia de Coerência Óptica , Neoplasias Uveais/diagnóstico por imagem , Neoplasias Uveais/cirurgiaAssuntos
Anticorpos Monoclonais Murinos/uso terapêutico , Antineoplásicos/uso terapêutico , Neoplasias da Íris/tratamento farmacológico , Linfoma de Zona Marginal Tipo Células B/tratamento farmacológico , Antígenos CD20/imunologia , Humanos , Injeções Intralesionais , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/patologia , Linfoma de Zona Marginal Tipo Células B/diagnóstico por imagem , Linfoma de Zona Marginal Tipo Células B/patologia , Masculino , Microscopia Acústica , Pessoa de Meia-Idade , RituximabRESUMO
PURPOSE: A case of a teenage girl with tapioca melanoma of the iris is presented. This case is unusual, as the patient did not have heterochromia and did not present with elevated intraocular pressure. CASE REPORT: A 14-year-old female patient presented with an amelanotic, multinodular, multifocal lesion of the right iris. Pathology confirmed a diagnosis of tapioca melanoma using immunohistologic staining. The patient underwent enucleation of her right eye and has been free of metastatic disease 3 years later. CONCLUSIONS: Tapioca melanoma of the iris must be included among the other differential diagnoses when examining patients with amelanotic iris lesions, even when iris heterochromia is not clearly evident.
Assuntos
Doenças da Íris/patologia , Neoplasias da Íris/patologia , Melanoma Amelanótico/patologia , Transtornos da Pigmentação/patologia , Adolescente , Enucleação Ocular , Feminino , Humanos , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/cirurgia , Melanoma Amelanótico/diagnóstico por imagem , Melanoma Amelanótico/cirurgia , UltrassonografiaRESUMO
Iris metastasis is one of the rare forms of ocular metastasis. Lung and breast cancers represent more than two thirds of the primary tumor sites in such patients. We here present the F-FDG PET/CT findings in a 60-year-old male patient with small cell lung cancer where metastasis to iris was incidentally discovered on PET/CT.
Assuntos
Fluordesoxiglucose F18 , Achados Incidentais , Neoplasias da Íris/secundário , Neoplasias Pulmonares/diagnóstico por imagem , Tomografia por Emissão de Pósitrons , Carcinoma de Pequenas Células do Pulmão/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Humanos , Neoplasias da Íris/diagnóstico por imagem , Masculino , Pessoa de Meia-IdadeRESUMO
PURPOSE: To evaluate the outcomes of iris melanoma managed with plaque radiotherapy on the basis of the initial presence or absence of glaucoma. DESIGN: Retrospective, comparative case series. PARTICIPANTS: A total of 144 patients. INTERVENTION: Custom-designed iodine-125 plaque radiotherapy delivering planned 8000 cGy to melanoma apex using transcorneal application. MAIN OUTCOME MEASURES: Tumor control and treatment-related complications. RESULTS: Of 144 patients with iris melanoma, glaucoma was present at the initial visit in 58 (40%). Causes of elevated intraocular pressure included angle infiltration by melanoma in 50 patients (86%), angle neovascularization in 4 patients (7%), and hyphema in 4 patients (7%). At presentation, the eyes displaying iris melanoma with glaucoma (vs. without glaucoma) were statistically more likely to display angle tumor (66% vs. 43%), with minimal thickness (1.9 vs. 2.9 mm), and melanoma seeding in iris stroma (7 vs. 3 clock hours) and angle (5 vs. 2 clock hours). Plaque radiotherapy was performed in all cases. Kaplan-Meier estimates at 7 years post-treatment revealed no statistical differences in outcomes of local recurrence (14% vs. 15%), enucleation (14% vs. 11%), or metastasis (2% vs. 0%) comparing eyes with and without glaucoma. Of the entire group, multivariate analysis for factors predictive of recurrence included partial (vs. complete) anterior segment irradiation and postradiotherapy glaucoma. Factors related to enucleation included diabetes mellitus, poor initial visual acuity, higher radiation dose to tumor apex, and tumor recurrence. There were no factors predictive of metastasis. CONCLUSIONS: Iodine-125 plaque radiotherapy provides adequate tumor control for iris melanoma with a low metastatic potential of 1% at 7 years. Iris melanoma with secondary glaucoma showed a statistically significant greater likelihood of flat tumor with iris and angle seeding and no difference in outcomes compared with eyes without glaucoma. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Assuntos
Braquiterapia , Glaucoma/etiologia , Radioisótopos do Iodo/uso terapêutico , Neoplasias da Íris/radioterapia , Melanoma/radioterapia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Segmento Anterior do Olho/diagnóstico por imagem , Segmento Anterior do Olho/patologia , Criança , Feminino , Glaucoma/diagnóstico por imagem , Humanos , Pressão Intraocular/fisiologia , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/patologia , Masculino , Melanoma/diagnóstico por imagem , Melanoma/patologia , Microscopia Acústica , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Resultado do Tratamento , Acuidade Visual/fisiologia , Adulto JovemRESUMO
BACKGROUND: To describe the clinical and histopathological features of lymphomas involving the iris. DESIGN: Retrospective, descriptive study. PARTICIPANTS: Fourteen eyes of 13 patients. METHODS: Review of medical records. MAIN OUTCOME MEASURES: Clinical and histopathological findings. RESULTS: Median patient age was 58 years (range, 25-76 years). Seven patients had known systemic lymphoma of which five were of large B-cell type. Symptoms included blurred vision (8/14), eye redness (3/14) and eye pain (2/14). Four eyes had secondary elevated intraocular pressure. Anterior segment findings included anterior chamber cells (14/14 eyes), keratic precipitates (11/14 eyes), congestion of conjunctival/episcleral blood vessels (9/14), hyphaema (7/14), conjunctival/anterior epibulbar lymphoma (6/14), tumour-induced pseudohypopyon (4/14) and corneal oedema (3/14). Of 12 eyes with adequate view of iris details, clinically detectable iris thickening or visible mass was noted in all (12/12). There was concomitant involvement of ciliary body (8/14), choroid (5/14) and orbit (2/14). All patients had biopsy of conjunctiva, episclera, iris or ciliary body, confirming the diagnosis of lymphoma. Histopathological or cytopathological evaluation of iris or ciliary body showed high-grade lymphoma in 9/11 eyes in which it was performed. Five patients did not have long-term follow up and, of the other eight patients, three died from complications of systemic lymphoma during follow up ranging from 1 to 44 months. CONCLUSION: Lymphomatous involvement of the iris should be considered in the differential diagnosis of corticosteroid-resistant uveitis in middle-aged and elderly patients. Iris lymphoma tends to be high grade and usually develops in patients with known aggressive systemic lymphoma.
Assuntos
Neoplasias da Íris/patologia , Linfoma de Células B/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antineoplásicos/uso terapêutico , Biópsia , Terapia Combinada , Feminino , Humanos , Pressão Intraocular/fisiologia , Neoplasias da Íris/diagnóstico por imagem , Neoplasias da Íris/terapia , Linfoma de Células B/diagnóstico por imagem , Linfoma de Células B/terapia , Masculino , Microscopia Acústica , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Oftalmológicos , Radioterapia , Estudos Retrospectivos , Acuidade Visual/fisiologiaRESUMO
We described a patient with bilateral iris metastases resulted from prostatic cancer. Slit lamp and ultrasonography examination of the both eye demonstrated tumor of the iris, as an amelanotic vascular mass located on the superior temporal quadrant. On open biopsy revealed undifferentiated tissue that stained strongly positive for prostate carcinoma, confirming the diagnosis of metastasis prostate adenocarcinoma. Early diagnostic procedures are essential for the causal therapy of prostate carcinoma as the primary neoplasm.