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1.
Colorectal Dis ; 26(5): 1047-1052, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38566354

RESUMO

AIM: Total neoadjuvant therapy (TNT) for locally advanced rectal cancer (LARC) is rapidly spreading. The robotic surgical techniques to approach lateral invasion, such as that of the pelvic plexus, have not yet been established. In this technical note, we present a video illustrating a surgical technique for lateral invasion using our novel technique and discuss its pitfalls. METHOD: We present the case of a 65-year-old man with LARC. Robotic surgery was performed after TNT using the da Vinci Xi Surgical System (Intuitive Surgical Inc., Sunnyvale, CA, USA). The surgical procedure was as follows: (1) D3 lymph node dissection around the inferior mesenteric artery using a medial-to-lateral approach; (2) rectal mobilization; (3) dissection of the ureterohypogastric fascia and ureter; and (4) combined resection of the hypogastric nerve and pelvic plexus. The key surgical point for sidewall invasion is the resection extent. Dividing the resection extent into three areas is important: zone A, which contains the pelvic plexus and is closest to the tumour; zone B, which contains the iliac vessels; and zone C, the most lateral zone, which contains the obturator nerves. This allows organ and function preservation by resecting only the smallest organ that truly requires R0 resection. RESULTS: The operating time was 333 min, console time was 232 min, and blood loss was 0 mL. The circumferential resection margin was 10 mm, and an R0 resection was achieved. CONCLUSION: We introduced a novel approach for robotic surgery after TNT for LARC with sidewall invasion. This technique can be performed safely and may help standardize 'beyond total mesorectal excision'.


Assuntos
Terapia Neoadjuvante , Invasividade Neoplásica , Neoplasias Retais , Procedimentos Cirúrgicos Robóticos , Humanos , Neoplasias Retais/cirurgia , Neoplasias Retais/patologia , Masculino , Terapia Neoadjuvante/métodos , Idoso , Procedimentos Cirúrgicos Robóticos/métodos , Reto/cirurgia , Protectomia/métodos , Excisão de Linfonodo/métodos , Plexo Hipogástrico/cirurgia
2.
Fertil Steril ; 118(5): 992-994, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36171149

RESUMO

OBJECTIVE: Although dLPE is not overly rare, isolation of the autonomic nerves from dLPE cannot always be guaranteed. In patients with endometriosis lesions that are embedded in the deep parametrium, nerve-sparing techniques are no longer considered feasible, except for those with unilateral involvement. However, even one-sided radical parametrectomy may actually lead to bladder dysfunction, which seriously affects the quality of life. Therefore, the objective is to demonstrate the anatomical and technical highlights of nerve-sparing laparoscopic surgery for deep lateral parametrial endometriosis (dLPE). DESIGN: Stepwise demonstration of this method with a narrated video footage. SETTING: An urban general hospital. PATIENT(S): A 38-year-old woman, para 1, presented with a 5-year history of severe chronic pelvic and gluteal pain, all of which were resistant to pharmacotherapy. The patient showed no neurological disorders, such as bladder dysfunction. Magnetic resonance imaging revealed right ovarian endometrioma and hydrosalpinx with dLPE reaching the lateral pelvic wall. Based on the dermatome involved, we suspected that the main lesion causing gluteal pain was located around the second and third sacral roots. INTERVENTION(S): Laparoscopic excision of dLPE with a pelvic autonomic nerve-sparing technique, decompression of somatic nerves and preservation of all branches of the internal iliac vessels. Assessment of preserved tissue perfusion using indocyanine green. The procedure was performed using 8 steps, as follows: step 1, adhesiolysis and adnexal surgery; step 2, complete ureterolysis; step 3, identification and dissection of the hypogastric nerve and inferior hypogastric plexus with development of the pararectal space; step 4, dissection of the internal iliac vessels; step 5, identification and dissection of the sacral roots S2-S4 and the pelvic splanchnic nerves; step 6, complete removal of dLPE; step 7, hemostasis and assessment of tissue perfusion using indocyanine green; and step 8, application of barrier agents to prevent adhesion. Dissection of the pelvic nerves before dLPE excision revealed the relationship between the lesions and pelvic innervation, thereby reducing the risk of nerve injury, whether by minimizing the risk of neuropraxia or by allowing as many nerve fibers as possible to be spared in patients with some invasion of the pelvic nerve system. We considered even partial preservation of these nerves as beneficial to the resumption of pelvic organ functions. The step-by-step technique should help perform each stage of the surgery in a logical sequence, ensuring easy and safe completion of the procedure. MAIN OUTCOME MEASURE(S): Relief from severe pain, avoidance of postoperative morbidity (including intermittent self-catheterization). RESULT(S): The patient developed no perioperative complications, including postoperative bladder, rectal, or sexual dysfunctions. Pain was completely resolved. CONCLUSION(S): Nerve-sparing surgery is technically safe and feasible for selected patients with dLPE. Suitably tailored treatment should be provided for each individual based on both latest scientific evidence and life planning for the patient.


Assuntos
Endometriose , Laparoscopia , Feminino , Humanos , Adulto , Endometriose/diagnóstico por imagem , Endometriose/cirurgia , Verde de Indocianina , Qualidade de Vida , Plexo Hipogástrico/cirurgia , Plexo Hipogástrico/lesões , Plexo Hipogástrico/patologia , Laparoscopia/efeitos adversos , Laparoscopia/métodos , Dor/etiologia
4.
Minerva Urol Nephrol ; 73(3): 283-291, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33439578

RESUMO

INTRODUCTION: We provide a systematic analysis of nerve-sparing surgery (NSS) to assess and summarize the risks and benefits of NSS in high-risk prostate cancer (PCa). EVIDENCE ACQUISITION: We have undertaken a systematic search of original articles using 3 databases: Medline/PubMed, Scopus, and Web of Science. Original articles in English containing outcomes of nerve-sparing radical prostatectomy (RP) for high-risk PCa were included. The primary outcomes were oncological results: the rate of positive surgical margins and biochemical relapse. The secondary outcomes were functional results: erectile function (EF) and urinary continence. EVIDENCE SYNTHESIS: The rate of positive surgical margins differed considerably, from zero to 47%. The majority of authors found no correlation between NSS and a positive surgical margin rate. The rate of biochemical relapse ranged from 9.3% to 61%. Most of the articles lacked data on odds ratio (OR) for positive margin and biochemical relapse. The presented results showed no effect of nerve sparing (NS) on positive margin (OR=0.81, 0.6-1.09) or biochemical relapse (hazard ratio [HR]=0.93, 0.52-1.64). A strong association between NSS and potency rate was observed. Without NSS, between 0% and 42% of patients were potent, with unilateral 79-80%, with bilateral - up to 90-100%. Urinary continence was not strongly associated with NSS and was relatively good in both patients with and without NSS. CONCLUSIONS: NSS may provide benefits for patients with urinary continence and significantly improves EF in high-risk patients. Moreover, it is not associated with an increased risk of relapse in short- and middle-term follow-up. However, the advantages of using such a surgical technique are unclear.


Assuntos
Plexo Hipogástrico/cirurgia , Plexo Lombossacral/cirurgia , Próstata/inervação , Prostatectomia/métodos , Neoplasias da Próstata/cirurgia , Humanos , Masculino , Margens de Excisão , Recidiva Local de Neoplasia/epidemiologia , Recidiva Local de Neoplasia/etiologia , Recidiva Local de Neoplasia/prevenção & controle , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Próstata/patologia , Próstata/cirurgia , Neoplasias da Próstata/complicações , Neoplasias da Próstata/patologia , Resultado do Tratamento
5.
J Minim Invasive Gynecol ; 28(2): 170-171, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-32526383

RESUMO

OBJECTIVE: To show technical highlights of a nerve-sparing laparoscopic eradication of deep endometriosis (DE) with posterior compartment peritonectomy. DESIGN: Demonstration of the technique with narrated video footage. SETTING: An urban general hospital. A systematic review and meta-analysis has suggested significant advantages of the nerve-sparing technique when considering the relative risk of persistent urinary retention in the treatment of DE [1]. In addition, a recent article has suggested that complete excision of DE with posterior compartment peritonectomy could be the surgical treatment of choice to decrease postoperative pain, improve fertility rate, and prevent future recurrence [2]. However, in DE, nerve-sparing procedures are even more challenging than oncologic radical procedures because the pathology resembles both ovarian/rectal cancer in terms of visceral involvement and advanced cervical cancer in terms of wide parametrial infiltration through the pelvic wall. INTERVENTIONS: The video highlights the anatomic and technical aspects of a fertility- and nerve-sparing surgery in DE with posterior compartment peritonectomy. After adhesiolysis and ovarian surgery, we developed retroperitoneal space at the level of promontory. The hypogastric nerve consists of the upper edge of the pelvic plexus, therefore the autonomic nerves were separated in a "nerve plane" by sharp interfascial dissection of the loose connective tissue layers both above (between the fascia propria of the rectum and the prehypogastric nerve fascia) and below (between the prehypogastric nerve fascia and the presacral fascia) the hypogastric nerve [3,4]. As a result of these dissections, the autonomic nerves in the pelvis were separated like a sheet with surrounding fascia. We then completely resected all DE lesions including peritoneal endometriosis while avoiding injury to the nerve plane. In a small number of our experiences, none of the patients (n = 51) required clean intermittent self-catheterization after this procedure. CONCLUSION: Fertility- and nerve-sparing laparoscopic eradication of DE with total posterior compartment peritonectomy is a feasible technique and may provide both curability of DE and functional preservation. Our nerve-sparing technique can reproducibly simplify this complex procedure.


Assuntos
Endometriose/cirurgia , Preservação da Fertilidade/métodos , Plexo Hipogástrico/cirurgia , Enteropatias/cirurgia , Laparoscopia/métodos , Tratamentos com Preservação do Órgão/métodos , Doenças Peritoneais/cirurgia , Dissecação/métodos , Endometriose/patologia , Feminino , Humanos , Plexo Hipogástrico/lesões , Plexo Hipogástrico/patologia , Enteropatias/patologia , Pelve/inervação , Pelve/patologia , Pelve/cirurgia , Traumatismos dos Nervos Periféricos/prevenção & controle , Doenças Peritoneais/patologia , Peritônio/inervação , Peritônio/patologia , Peritônio/cirurgia , Reto/inervação , Reto/patologia , Reto/cirurgia
6.
Urology ; 149: 24-29, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33279610

RESUMO

OBJECTIVE: To evaluate the specific contribution of ilioinguinal (II) and iliohypogastric (IH) nerve injury and referred pain to interstitial cystitis/bladder pain syndrome and patient-reported chronic pelvic pain, and to enumerate the effects of II and IH nerve resection on the pain and voiding symptoms in patients with IC/BPS. MATERIALS AND METHODS: This was a prospective cohort study of 8 patients with ICS/BPS who had prior abdominal surgery. All patients received diagnostic image guided T12/L1 nerve blocks, followed by II and IH nerve resections. Validated O'Leary-Sant ICS symptom indices (OSPI) and pelvic pain and urgency/frequency patient symptoms scale (PUF) scores were collected at specified intervals pre- and post-operatively. RESULTS: Median scores at pre-operative (OSPI 13.9, PUF 20.4) and 1 week time points (OSPI 5.9, PUF 11), as well as differences between pre-operative and 10 month time points (OSPI 3.7, PUF 6) were all statistically significant (P = .008 and .009 at 1 week, and .007 and .008 at 10 months, for OSPI and PUF respectively). The mean difference in score from pre-operative to longest follow-up as measured by the OSPI was -14.4 (P < .001) and by PUF -10.3 (P < .001). All time points registered demonstrated improvement in pain scores. There were no surgical complications or adverse events. CONCLUSION: II and IH nerve resection may be an effective and durable treatment option for those with prior abdominal surgery who have referred interstitial cystitis/bladder pain syndrome pain from these injured nerves.


Assuntos
Cistite Intersticial/etiologia , Plexo Hipogástrico/cirurgia , Dor Referida/cirurgia , Traumatismos dos Nervos Periféricos/cirurgia , Doenças da Bexiga Urinária/cirurgia , Adulto , Idoso , Dor Crônica/etiologia , Dor Crônica/cirurgia , Feminino , Manobra de Heimlich , Humanos , Plexo Hipogástrico/lesões , Masculino , Pessoa de Meia-Idade , Bloqueio Nervoso/métodos , Dor Referida/etiologia , Dor Pélvica/etiologia , Dor Pélvica/cirurgia , Traumatismos dos Nervos Periféricos/complicações , Estudos Prospectivos , Bexiga Urinária/inervação , Doenças da Bexiga Urinária/etiologia , Transtornos Urinários/etiologia , Transtornos Urinários/cirurgia , Adulto Jovem
7.
J Minim Invasive Gynecol ; 28(3): 387, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-32673647

RESUMO

OBJECTIVE: To demonstrate identification and dissection of the pelvic autonomic nerves in gynecologic surgery. DESIGN: Identification on the right and left pelvic pelvises, dissection and preservation of the inferior hypogastric plexus in deep endometriosis, and dissection and preservation of the pelvic autonomic nerves in radical hysterectomy. SETTING: Academic center. INTERVENTIONS: Robotic excision of the pelvic peritoneum, excision of deep endometriosis in the uterosacral ligaments, and radical hysterectomy. CONCLUSION: Pelvic autonomic nerves are easy to identify with the magnification provided with an endoscopic camera. They should be dissected and preserved whenever possible because of their important function.


Assuntos
Procedimentos Cirúrgicos em Ginecologia/métodos , Tratamentos com Preservação do Órgão/métodos , Pelve/inervação , Traumatismos dos Nervos Periféricos/prevenção & controle , Dissecação , Endometriose/patologia , Endometriose/cirurgia , Feminino , Humanos , Plexo Hipogástrico/lesões , Plexo Hipogástrico/cirurgia , Histerectomia/métodos , Ligamentos/lesões , Ligamentos/inervação , Ligamentos/cirurgia , Pelve/cirurgia , Doenças Peritoneais/patologia , Doenças Peritoneais/cirurgia , Peritônio/inervação , Peritônio/cirurgia , Útero/inervação , Útero/cirurgia
9.
J Minim Invasive Gynecol ; 27(4): 813-814, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31386912

RESUMO

OBJECTIVE: Excisional techniques used to surgically treat deep infiltrating endometriosis (DIE) can result in inadvertent damage to the autonomic nervous system of the pelvis, leading to urinary, anorectal, and sexual dysfunction [1-4]. This educational video illustrates the autonomic neuroanatomy of the pelvis, identifying the predictable location of the hypogastric nerve in relation to other pelvic landmarks, and demonstrates a surgical technique for sparing the hypogastric nerve and inferior hypogastric plexus. DESIGN: Using didactic schematics and medical drawings, we discuss and illustrate the autonomic neuroanatomy of the pelvis. With annotated laparoscopic footage, we demonstrate a stepwise approach for identifying, dissecting, and preserving the hypogastric nerve during pelvic surgery. SETTING: Tertiary care academic hospitals: Mount Sinai Hospital in Toronto, Ontario, Canada, and S. Orsola Hospital in Bologna, Italy. INTERVENTIONS: Radical excision of DIE with adequate identification and sparing of the hypogastric nerve and inferior hypogastric plexus bilaterally was performed, following an overview of pelvic neuroanatomy. The superior hypogastric plexus was described and the hypogastric nerve, the most superficial and readily identifiable component of the inferior hypogastric plexus, was identified and used as a landmark to preserve autonomic bundles in the pelvis. The following steps, illustrated with laparoscopic footage, describe a surgical technique developed to identify and preserve the hypogastric nerve and the deeper inferior hypogastric plexus without the need for more extensive pelvic dissection to the level of the sacral nerve roots: (1) transperitoneal identification of the hypogastric nerve, with a pulling maneuver for confirmation; (2) opening of the retroperitoneum at the level of the pelvic brim and retroperitoneal identification of the ureter; (3) medial dissection and identification of the hypogastric nerve; and (4) lateralization of the hypogastric nerve, allowing for safe resection of DIE. CONCLUSION: The hypogastric nerve follows a predictable course and can be identified, dissected, and spared during pelvic surgery, making it an important landmark for the preservation of pelvic autonomic innervation.


Assuntos
Endometriose/cirurgia , Procedimentos Cirúrgicos em Ginecologia/métodos , Plexo Hipogástrico/cirurgia , Enteropatias/cirurgia , Laparoscopia/métodos , Doenças Peritoneais/cirurgia , Dissecação/educação , Dissecação/métodos , Endometriose/patologia , Feminino , Procedimentos Cirúrgicos em Ginecologia/educação , Humanos , Plexo Hipogástrico/diagnóstico por imagem , Plexo Hipogástrico/patologia , Enteropatias/patologia , Itália , Laparoscopia/educação , Ontário , Órgãos em Risco/diagnóstico por imagem , Órgãos em Risco/patologia , Órgãos em Risco/cirurgia , Pelve/diagnóstico por imagem , Pelve/inervação , Pelve/patologia , Pelve/cirurgia , Doenças Peritoneais/patologia
10.
Pain Med ; 21(6): 1255-1262, 2020 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-31343689

RESUMO

OBJECTIVE: Cancer-related abdominal and pelvic pain syndromes can be debilitating and difficult to treat. The objective of this study was to evaluate the efficacy of superior hypogastric plexus blockade or neurolysis (SHPN) for the treatment of cancer-related pelvic pain. DESIGN: Retrospective study. SETTING: MD Anderson Cancer Center, Houston, Texas. METHODS: We enrolled 46 patients with cancer-related pelvic pain who underwent SHPN. A numeric rating scale (NRS) was used for pain intensity, and symptom burden was evaluated using the Edmonton Symptom Assessment System at baseline, visit 1 (within one month), and visit 2 (within one to six months). RESULTS: Forty-six patients who received SHPN showed a significant reduction in pain score from 6.9 to 5.6 at visit 1 (P = 0.01). Thirty of the 46 patients continued to complete visit 2 follow-up, and the NRS score was consistently lower at 4.5 at visit 2 (P < 0.0001), with anxiety and appetite improved significantly. There was no significant change in the morphine equivalent dose at visits 1 and 2. The efficacy of the block was not influenced by patients' age, gender, type of cancer, cancer stage, regimen of chemotherapy and/or radiation therapy, diagnostic block, approach or laterality of procedure, or type or amount of neurolytic agent. Nonsmokers with high baseline pain scores were more likely to have improved treatment outcomes from SHPN at short-term follow-up. Adverse effects with SHPN were mild and well tolerated. CONCLUSIONS: SHPN was an effective and relatively safe procedure for pain associated with pelvic malignancies. There is a need for larger prospective trials.


Assuntos
Neoplasias , Bloqueio Nervoso , Humanos , Plexo Hipogástrico/cirurgia , Dor Pélvica/etiologia , Dor Pélvica/terapia , Estudos Prospectivos , Estudos Retrospectivos , Texas
11.
J Minim Invasive Gynecol ; 27(2): 263-264, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31518711

RESUMO

OBJECTIVE: To show technical highlights of a nerve-sparing laparoscopic eradication of deep infiltrating endometriosis with rectal and parametrial resection according to the Negrar method. DESIGN: Stepwise demonstration of the technique with narrated video footage. SETTING: Tertiary care endometriosis unit. Bowel endometriosis accounts for about 12% of the total cases of endometriosis. Most frequently, rectal infiltration also means parametrial infiltration from the widespread infiltrating disease. Its removal with inadequate anatomical surgical knowledge may lead to severe damage to visceral pelvic innervation, causing bladder, rectal, and sexual function impairments and lasting lifelong. Nerve-sparing techniques, which are the heritage of onco-gynecologic surgery, have been described to have lower post-operative bladder, rectal, and sexual dysfunctions than classical approaches. INTERVENTIONS: Laparoscopic excision of deep infiltrating endometriosis was performed by following the nerve-sparing Negrar technique in 6 steps: step 0-adhesiolysis, ovarian surgery, and removal of the involved peritoneal tissues; step 1-opening of pre-sacral space, development of avascular spaces, and identification and preservation of pelvic sympathetic fibers of the inferior mesenteric plexus, superior hypogastric plexus, upper hypogastric nerves, and lumbosacral sympathetic trunk and ganglia; step 2-dissection of parametrial planes, isolation of ureteral course, lateral parametrectomy, and preservation of sympathetic fibers of postero-lateral parametrium and lower mesorectum (the lower hypogastric nerves and proximal part of the inferior hypogastric plexus or pelvic plexus); step 3-posterior parametrectomy, deep uterine vein identification, and preservation of the parasympathetic pelvic splanchnic nerves and the cranial and middle part of the mixed inferior hypogastric plexus in caudad posterior parametrium and lower mesorectal planes; step 4-preserving the caudad part of the inferior hypogastric plexus in postero-lateral parametrial ligaments; step 5-preserving the caudad part of the inferior hypogastric plexus in paravaginal planes; and step 6-rectal resection and colorectal anastomosis. CONCLUSION: As shown in this case, the laparoscopic nerve-sparing complete excision of endometriosis is a feasible and reproducible technique in expert hands and, as reported in the literature, offers good results in terms of bladder morbidity reduction with higher satisfaction than the classical technique.


Assuntos
Endometriose/cirurgia , Procedimentos Cirúrgicos em Ginecologia/métodos , Plexo Hipogástrico , Laparoscopia/métodos , Tratamentos com Preservação do Órgão/métodos , Doenças Peritoneais/cirurgia , Anastomose Cirúrgica , Dissecação , Endometriose/patologia , Feminino , Humanos , Plexo Hipogástrico/patologia , Plexo Hipogástrico/cirurgia , Pelve/inervação , Pelve/cirurgia , Doenças Peritoneais/patologia , Peritônio/inervação , Peritônio/patologia , Peritônio/cirurgia , Reto/inervação , Reto/patologia , Reto/cirurgia , Indução de Remissão
12.
Sci Rep ; 9(1): 13260, 2019 09 13.
Artigo em Inglês | MEDLINE | ID: mdl-31519975

RESUMO

Waterjet dissection of the inferior hypogastric plexus (IHP) resulted in a more rapid return of normal urodynamics than blunt dissection (control group) in patients who received laparoscopic nerve-sparing radical hysterectomy (NSRH) in a randomized controlled study. However, the definite reasons for these results were unknown. This subgroup analysis compared the neural areas and impairment in the IHP uterine branches harvested during NSRH as an alternative to the IHP vesical branches between the waterjet and control groups. This study included samples from 30 eligible patients in each group of the trial NCT03020238. At least one specimen from each side of the IHP uterine branches was resected. The tissues were scanned, images were captured, and the neural component areas were calculated using the image segmentation method. Immunohistochemical staining was used to evaluate neural impairment. The control and waterjet groups had similar areas of whole tissues sent for evaluation. However, the control group had significantly fewer areas (median 272158 versus 200439 µm2, p = 0.044) and a lower percentage (median 4.9% versus 3.0%, p = 0.011) of neural tissues. No significant changes in immunohistochemical staining were found between the two groups. For patients with residual urine ≤100 and >100 ml at 14 days after NSRH (42 and 18 patients, respectively), there were significantly different percentages of neural tissues in the resected samples (p < 0.001). Hence, Due to the accurate identification of IHP during NSRH, the waterjet dissection technique achieved better urodynamic results.


Assuntos
Plexo Hipogástrico/patologia , Histerectomia/métodos , Tratamentos com Preservação do Órgão/métodos , Nervos Periféricos/cirurgia , Bexiga Urinária/cirurgia , Neoplasias do Colo do Útero/cirurgia , Estudos de Casos e Controles , Feminino , Humanos , Plexo Hipogástrico/lesões , Plexo Hipogástrico/cirurgia , Bexiga Urinária/inervação , Urodinâmica , Neoplasias do Colo do Útero/patologia
13.
Int J Gynecol Cancer ; 29(7): 1203-1208, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31326949

RESUMO

AIM: The primary objective of this review was to study and analyze techniques of nerve-sparing radical hysterectomy so as to be able to characterize and elucidate intricate steps for the dissection of each component of the pelvic autonomic nerve plexuses during nerve-sparing radical hysterectomy. METHODS: This review was based on a five-step study design that included searching for relevant publications, selecting publications by applying inclusion and exclusion criteria, quality assessment of the identified studies, data extraction, and data synthesis. RESULTS: There are numerous differences in the published literature concerning nerve-sparing radical hysterectomy including variations in techniques and surgical approaches. Techniques that claim to be nerve-sparing by staying above the dissection level of the hypogastric nerves do not highlight the pelvic splanchnic nerve, do not take into account the intra-operative patient position, nor the fact that the bladder branches leave the inferior hypogastric plexus in a ventrocranial direction, and the fact that inferior hypogastric plexus will be drawn cranially with the vaginal walls (if this is not recognized and isolated earlier) above the level of hypogastric nerves by drawing the uterus cranially during the operation. CONCLUSIONS: The optimal nerve-sparing radical hysterectomy technique has to be radical (type C1) and must describe surgical steps to highlight all three components of the pelvic autonomic nervous system (hypogastric nerves, pelvic splanchnic nerves, and the bladder branches of the inferior hypogastric plexus). Recognizing the pelvic splanchnic nerves in the caudal parametrium and the isolation of the bladder branches of the inferior hypogastic plexus requires meticulous preparation of the caudal part of the ventral parametrium.


Assuntos
Histerectomia/métodos , Feminino , Humanos , Plexo Hipogástrico/cirurgia , Pelve/inervação , Pelve/cirurgia , Nervos Esplâncnicos/cirurgia , Bexiga Urinária/inervação
14.
Ann Surg Oncol ; 26(5): 1560-1568, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30759291

RESUMO

BACKGROUND: Little data exist about the impact of dissection methods on bladder function during nerve-sparing radical hysterectomy (NSRH). This randomized controlled trial compared the urodynamic and survival outcomes of different methods dissecting the inferior hypogastric plexus (IHP) during laparoscopic NSRH. METHODS: Eligible patients presenting with stage IB cervical cancer from 9 May 2013 to 27 October 2015 were randomized at a ratio of 1:1 and subjected to waterjet (study group) or traditional blunt (control group) dissection of the IHP for laparoscopic type C radical hysterectomy. Participants were subjected to urodynamic evaluations before and after NSRH. The primary measurement was the proportion of patients with residual urine (RU) ≤ 100 ml, while secondary measurements included urodynamic parameters, disease-free survival (DFS), and overall survival (OS). RESULTS: In total, 191 women met the inclusion criteria, and 160 patients were included in the final analysis, with 80 randomized to each group. At 14 days after NSRH, the study group had more patients with RU ≤ 100 ml than the control group (82.5% vs. 62.5%, p = 0.005). The study group had similar urodynamic outcomes of preoperative and postoperative tests. Comparison with the study group and preoperative tests revealed the control group had significant bladder function impairment at 4 months after NSRH. After a median follow-up of 33 months, the dissection methods had no significant impact on DFS or OS. CONCLUSIONS: Waterjet dissection of the IHP in laparoscopic NSRH resulted in a more rapid return of normal urodynamics without compromising survival outcome. ClinicalTrials.gov Identifiers NCT03015376 (PUMCH-OBGYN-2013), NCT03291236 (SOCM-1).


Assuntos
Plexo Hipogástrico/cirurgia , Histerectomia/mortalidade , Laparoscopia/mortalidade , Tratamentos com Preservação do Órgão/métodos , Bexiga Urinária/cirurgia , Urodinâmica , Neoplasias do Colo do Útero/mortalidade , Adenocarcinoma/mortalidade , Adenocarcinoma/patologia , Adenocarcinoma/cirurgia , Adulto , Idoso , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Estudos de Casos e Controles , Feminino , Seguimentos , Humanos , Plexo Hipogástrico/patologia , Pessoa de Meia-Idade , Prognóstico , Bexiga Urinária/patologia , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/cirurgia
16.
Pain Physician ; 21(4): E341-E345, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-30045600

RESUMO

BACKGROUND: A superior hypogastric plexus block is difficult to perform and hampered by bony structures of the iliac crest and transverse process of L5. OBJECTIVE: We report on a fluoroscopically guided posterolateral transdiscal technique for superior hypogastric plexus neurolysis using a single needle. STUDY DESIGN: A technical note describing interventional procedures. SETTING: The neurosurgery department of a cancer hospital. METHODS: The patient was placed in the prone position with a pillow beneath the iliac crest to facilitate opening of the intervertebral disc. The entry point for the needle was 7-8 cm to the left of the midline of the L45 level. The spinal needle was slightly advanced caudally toward the L5-S1 disc and at a 40° angle from the vertical plane. Using lateral fluoroscopic control, the needle was advanced beneath the inferior aspect of the facet joint. After entering the disc, the needle was then advanced until it passed the anterior annulus fibrosus of the L5S1 disc. After verifying adequate position using contrast, 3 mL of 75% ethanol was injected for neurolysis. RESULTS: During the follow-up, the patient reported reduction of pain in the lower abdomen and quality of life was significantly improved. LIMITATIONS: Sample size; no placebo control. CONCLUSION: Although different approaches exist, we prefer the posterolateral transdiscal approach for superior hypogastric plexus block and neurolysis using a single needle. This technique is a valuable alternative. KEY WORDS: Superior hypogastric plexus neurolysis, transdiscal approach, cancer pain.


Assuntos
Plexo Hipogástrico/cirurgia , Bloqueio Nervoso/métodos , Manejo da Dor/métodos , Idoso , Dor do Câncer/complicações , Dor do Câncer/cirurgia , Feminino , Fluoroscopia , Humanos , Agulhas , Bloqueio Nervoso/instrumentação , Medição da Dor/métodos , Dor Pélvica/etiologia , Dor Pélvica/cirurgia , Radiografia Intervencionista/métodos
17.
J Minim Invasive Gynecol ; 25(7): 1144-1145, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29432901

RESUMO

STUDY OBJECTIVE: To show the feasibility and safety of nerve-preserving laparoscopic radical hysterectomy (type C1 Querleu-Morrow Classification [1]) for the treatment of early cervical cancer. DESIGN: A surgical video article (Canadian Task Force classification III). SETTING: A university hospital (University Hospital of Barcelona, Barcelona, Spain). PATIENTS: Nerve-preserving radical hysterectomy is performed in a patient with Fédération Internationale de Gynécologie et d'Obstétrique stage 1B1 cervical cancer with deep stromal invasion. INTERVENTIONS: Three steps are fundamental for the removal of the cérvix with a safe oncologic margin and preservation of the pelvic autonomic nerves [2]. 1. Step 1: for the correct preservation of the pelvic splanchnic nerves (ventral roots from spinal nerves S2-S4) and the inferior hypogastric plexus during the section of the paracervix, it is essential to identify the deep uterine vein. This vein will correspond with the inferior limit of the dissection. 2. Step 2: during the dissection of the uterosacral ligament and after dissecting the Okabayashi space, the inferior hypogastric nerve is isolated. This nerve runs 2 cm parallel below the uterosacral ligament in the peritoneal leaf of the broad ligament. 3. Step 3: during the section of the vesicouterine ligament, the lateral side must be preserved because it includes the medial and inferior vesical veins that drain to the deep uterine vein. CONCLUSION: Nerve-sparing laparoscopic radical hysterectomy is an attractive surgical approach for early-stage cervical cancer. Direct visualization of the pelvic autonomic nervous system (sympathetic and parasympathetic branches) innervating the bladder and rectum makes the nerve-sparing approach a safe and feasible procedure.


Assuntos
Plexo Hipogástrico/cirurgia , Histerectomia/efeitos adversos , Laparoscopia/efeitos adversos , Tratamentos com Preservação do Órgão/métodos , Traumatismos do Sistema Nervoso/prevenção & controle , Ligamento Largo/cirurgia , Dissecação/métodos , Estudos de Viabilidade , Feminino , Humanos , Plexo Hipogástrico/lesões , Histerectomia/métodos , Laparoscopia/métodos , Pelve/cirurgia , Raízes Nervosas Espinhais/cirurgia , Nervos Esplâncnicos/lesões , Bexiga Urinária/inervação , Neoplasias do Colo do Útero/cirurgia
18.
Pain Pract ; 18(3): 314-321, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-28520297

RESUMO

INTRODUCTION: Superior hypogastric plexus block (SHGPB) is technically difficult, and an accurate procedure is required to avoid potential complications. We attempted to determine the reference angles for fluoroscopy-assisted SHGPB and to establish a predictor as a guide to select the optimal approach between the classic posterior approach and transdiscal approach. METHODS: Abdominopelvic computed tomography (CT) scans from 268 patients diagnosed with pelvic malignancies were examined. The oblique and axial angles needed for the fluoroscope were measured both for posterior and transdiscal approaches by simulating the needle trajectory on CT imaging. We developed an SHGPB index defined by the ratio (%) of the interposterior iliac border distance to the L5 body transverse diameter, which represents the relative transverse diameter of the bony pelvis. We evaluated whether it can help select the optimal approach for the SHGPB between the posterior and transdiscal approaches. RESULTS: Males had a significantly smaller angle than females (right oblique angle for posterior approach, males 14 [range 12 to 17] degrees vs. females 19 [range 16 to 23] degrees; P < 0.001). An SHGPB index of < 150 was an independent predictor for failure of the classic posterior approach (odds ratio 31.3, 95% confidence interval 5.1 to 104.7). CONCLUSIONS: The optimal right oblique angle of fluoroscopy for the posterior approach is 13° to 15° in males and 19° to 20° in females. The transdiscal approach may be favored over the posterior approach when the bony pelvis is narrow relative to the target vertebral body, which can be measured by the SHGPB index being < 150.


Assuntos
Bloqueio Nervoso Autônomo/métodos , Plexo Hipogástrico/diagnóstico por imagem , Plexo Hipogástrico/cirurgia , Radiografia Intervencionista/métodos , Adulto , Idoso , Feminino , Fluoroscopia , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência , Estudos Retrospectivos
19.
J Minim Invasive Gynecol ; 24(6): 940-945, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28552655

RESUMO

STUDY OBJECTIVE: To evaluate safety, feasibility, and long-term clinical effects of adding laparoscopic pelvic plexus ablation to uterine-sparing procedures (uterine artery occlusion and partial adenomyomectomy) for adenomyosis. DESIGN: A prospective controlled study (Canadian Task Force classification II-1). SETTING: A teaching hospital. PATIENTS: A total of 112 patients with symptomatic adenomyosis were eligible for uterine-sparing laparoscopy. INTERVENTIONS: Laparoscopic pelvic plexus ablation, uterine artery occlusion, and partial adenomyomectomy. MEASUREMENTS AND MAIN RESULTS: After the exclusion of patients with malignant tumors or those lost to follow-up, 102 women underwent laparoscopic uterine artery occlusion and partial adenomyomectomy; 50 of these patients also had laparoscopic uterine pelvic plexus ablation (group A) with the remaining 52 patients serving as the control group (group B). Other than operative time (107.0 ± 15.4 vs 98.9 ± 20.2 minutes, p = .02), there were no statistical differences regarding other operative parameters between groups A and B. Relief of severe dysmenorrhea (Visual Analogue Scale score ≥ 7) at 36 months was higher in group A than in group B (100% vs 76.9%, p < .01). No patient suffered constipation or uroschesis in either group. CONCLUSION: Adding laparoscopic uterine pelvic plexus ablation to laparoscopic uterine artery occlusion and partial adenomyomectomy was more effective in relieving dysmenorrhea.


Assuntos
Adenomiose/cirurgia , Plexo Hipogástrico/cirurgia , Laparoscopia/métodos , Tratamentos com Preservação do Órgão/métodos , Embolização da Artéria Uterina/métodos , Miomectomia Uterina/métodos , Adenomiose/complicações , Adulto , Dismenorreia/etiologia , Dismenorreia/cirurgia , Estudos de Viabilidade , Feminino , Preservação da Fertilidade/métodos , Humanos , Pessoa de Meia-Idade , Duração da Cirurgia , Artéria Uterina/cirurgia , Útero/cirurgia
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