RESUMO
PURPOSE: Limitations of existing techniques for clampless proximal anastomosis (CPA) in coronary artery bypass grafting include air emboli and excessive bleeding. This study evaluated the safety and performance of a new device for performing CPA. DESCRIPTION: The device includes a temporary adjustable sealing element that is connected by a catheter to a handle that controls its opening and closure. An aortic punch is mounted on the catheter and activated by a detachable handle. EVALUATION: Six adult female swine underwent partial coronary artery bypass grafting that included construction of a CPA using autologous arterial or venous conduits. During anastomosis construction, good sealing was achieved in all cases, and a blower was not needed in 4 of 6 animals. In the first 2 cases, the blower was intermittently used in 14 % of the entire anastomosis construction time. A mean flow rate of 140.0 ± 52.9 mL/min was measured for the arterial grafts and 666.7 ± 230.9 mL/min for the venous grafts. CONCLUSIONS: The VIOLA device (Vascular Graft Solutions, Tel Aviv, Israel) is safe and associated with good hemostasis and minimal use of a blower during CPA construction in a swine model.
Assuntos
Ponte de Artéria Coronária/instrumentação , Anastomose Cirúrgica/métodos , Animais , Ponte de Artéria Coronária/métodos , Desenho de Equipamento , Feminino , SuínosRESUMO
BACKGROUND: The timing for heart surgery following cerebral embolization after cardiac valve vegetation is vital to postoperative recovery being uneventful, additionally Covid-19 may negatively affect the outcome. Minimally invasive methods and upgraded surgical instruments maximize the benefits of surgery also in complex cardiac revision cases with substantial perioperative risk. CASE PRESENTATION: A 68 y.o. patient, 10 years after previous sternotomy for OPCAB was referred to cardiac surgery on the 10th postoperative day after neurosurgical intervention for intracerebral bleeding with suspected mitral valve endocarditis. Mitral valve vegetation, tricuspid valve insufficiency and coronary stenosis were diagnosed and treated by minimally invasive revision cardiac surgery on the 14th postoperative day after neurosurgery. CONCLUSION: The present clinical case demonstrates for the first time that the minimally invasive approach via right anterior mini-thoracotomy can be safely used for concomitant complex mitral valve reconstruction, tricuspid valve repair and aorto-coronary bypass surgery, even as a revision procedure in the presence of florid endocarditis after recent neurosurgical intervention. The Covid-19 pandemic and prophylactic patient isolation slow down the efficacy of pulmonary weaning and mobilisation and prolong the need for ICU treatment, without adversely affecting long-term outcome.
Assuntos
Ponte de Artéria Coronária/métodos , Estenose Coronária/cirurgia , Endocardite/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Valva Mitral/cirurgia , Insuficiência da Valva Tricúspide/cirurgia , Cirurgia Vídeoassistida/métodos , Idoso , COVID-19/epidemiologia , Ponte de Artéria Coronária/efeitos adversos , Ponte de Artéria Coronária/instrumentação , Humanos , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos/efeitos adversos , Procedimentos Cirúrgicos Minimamente Invasivos/instrumentação , Pandemias , Complicações Pós-Operatórias , Reoperação , SARS-CoV-2 , Toracotomia/efeitos adversos , Toracotomia/instrumentação , Toracotomia/métodos , Cirurgia Vídeoassistida/efeitos adversosRESUMO
Importance: Cell therapy may be helpful for cardiac disease but has been fraught with poor cell retention and survival after transplantation. Objective: To determine whether cell-laden hydrogel treatment is safe and feasible for patients with chronic ischemic heart disease (CIHD). Design, Setting, and Participants: This randomized, double-blind clinical trial was conducted between March 1, 2016, and August 31, 2019, at a single hospital in Nanjing, China. Among 115 eligible patients with CIHD, 50 patients with left ventricular ejection fraction of 45% or less were selected to receive elective coronary artery bypass grafting (CABG) and additionally randomized to cell-plus-collagen treatment (collagen/cell group), cell treatment alone (cell group), or a control group. Sixty-five patients were excluded because of severe comorbidities or unwillingness to participate. Forty-four participants (88%) completed the study. The last patient completed 12 months of follow-up in August 2019. Analyses were prespecified and included all patients with available data. Interventions: During CABG, patients in the collagen/cell group were treated with human umbilical cord-derived mesenchymal stromal cell (hUC-MSC)-laden collagen hydrogel intramyocardial injection, and the cell group was treated with hUC-MSCs alone. Patients in the control group underwent CABG alone. Main Outcomes and Measures: The primary outcome was safety of the cell-laden collagen hydrogel assessed by the incidence of serious adverse events. The secondary end point was the efficacy of treatment, according to cardiovascular magnetic resonance imaging-based left ventricular ejection fraction and infarct size. Results: Fifty patients (mean [SD] age, 62.6 [8.3] years; 38 men [76%]) were enrolled, of whom 18 were randomized to the collagen/cell group, 17 to the cell group, and 15 to the control group. Patient characteristics did not differ among groups at baseline. For the primary end point, no significant differences in serious adverse events, myocardial damage markers, and renal or liver function were observed among all groups after treatment; the collagen/cell and cell groups each had 1 case of hospitalization because of heart failure, and no serious adverse events were seen in the control group. At 12 months after treatment, the mean infarct size percentage change was -3.1% (95% CI, -6.20% to -0.02%; P = .05) in the collagen/cell group, 5.19% (-1.85% to 12.22%, P = .35) in the cell group, and 8.59% (-3.06% to 20.25%, P = .21) in the control group. Conclusions and Relevance: This study provides, to our knowledge, the first clinical evidence that the use of collagen hydrogel is safe and feasible for cell delivery. These findings provide a basis for larger clinical studies. Trial Registration: ClinicalTrials.gov Identifier: NCT02635464.
Assuntos
Colágeno/uso terapêutico , Ponte de Artéria Coronária/instrumentação , Células-Tronco Mesenquimais , Isquemia Miocárdica/cirurgia , Idoso , China , Colágeno/farmacologia , Ponte de Artéria Coronária/métodos , Ponte de Artéria Coronária/estatística & dados numéricos , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/complicações , Resultado do TratamentoRESUMO
BACKGROUND: Cardiopulmonary bypass (CPB) induces a systemic inflammatory response (SIRS) and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory response. The purpose of this study was to compare the vascular reactivity of the internal thoracic arteries (ITAs) due to the inflammatory response between patients undergoing coronary artery bypass grafting (CABG) under CPB with a roller pump or with a centrifugal pump. METHODS: Eighty elective male patients undergoing CABG were selected using one or two internal thoracic arteries under CPB with a roller pump (RP group) or centrifugal pump (CFP group). ITA samples were collected before starting CPB (Time 1) and before the last coronary anastomosis during aortic cross clamping (Time 2). The primary endpoint was the endothelium-dependent relaxation of ITAs investigated using wire-myography. The secondary endpoint was the parietal inflammatory response of arteries defined by the measurements of superoxide levels, leukocytes and lymphocytes rate and gene expression of inflammatory proteins using. Terminal complement complex activation (SC5b-9) and neutrophil activation (elastase) analysis were performed on arterial blood at the same times. RESULTS: Exposure time of ITAs to the pump flow was respectively 43.3 minutes in the RP group and 45.7 minutes in the CFP group. Acetylcholine-dependent relaxation was conserved in the two groups whatever the time. Gene expression of C3 and C4a in the artery wall decreased from Time 1 to Time 2. No oxidative stress was observed in the graft. There was no difference between the groups concerning the leukocytes and lymphocytes rate. SC5b-9 and elastase increased between Time 1 and Time 2. CONCLUSION: Endothelium-dependent relaxation of the internal thoracic arteries was preserved during CPB whatever the type of pump used. The inflammatory response observed in the blood was not found in the graft wall within this time frame. TRIAL REGISTRATION: Name of trial study protocol: IPITA Registration number (ClinicalTrials.gov): NCT04168853.
Assuntos
Ponte Cardiopulmonar/instrumentação , Ponte de Artéria Coronária/métodos , Coração Auxiliar/efeitos adversos , Artéria Torácica Interna/cirurgia , Complicações Pós-Operatórias/etiologia , Idoso , Idoso de 80 Anos ou mais , Ponte Cardiopulmonar/efeitos adversos , Ponte Cardiopulmonar/métodos , Ponte de Artéria Coronária/efeitos adversos , Ponte de Artéria Coronária/instrumentação , Endotélio Vascular/metabolismo , Endotélio Vascular/fisiologia , Feminino , Humanos , Elastase de Leucócito/metabolismo , Masculino , Pessoa de Meia-Idade , Estresse Oxidativo , Complicações Pós-Operatórias/epidemiologia , Transplantes/fisiologia , Transplantes/cirurgia , Vasoconstrição , VasodilataçãoRESUMO
PURPOSE: We developed a heart positioner, the Tentacles NEO, specifically designed for minimally invasive coronary artery bypass grafting (MICS-CABG). DESCRIPTION: The device has 3 flexible suction tubes, with a suction cup at the tip of each tube. The suction tubes can be detached from the device body, allowing them to be manipulated in any direction through a small incision around the small thoracotomy. When the device displaces the heart, the suction cup moves behind the chest wall and does not crowd the operative field. EVALUATION: Although the sideways suction force of the new device was as strong as that of the original device, Tentacles, the longitudinal and perpendicular force exerted was approximately 80% of the original device. Nevertheless, the new device could safely and favorably displace the heart in a pig model and even during off-pump CABG via sternotomy. During MICS-CABG, the device was able to displace the heart without crowding the operative field. CONCLUSIONS: The new heart positioner, Tentacles NEO, is a useful and practical heart positioner suitable for MICS-CABG.
Assuntos
Ponte de Artéria Coronária/instrumentação , Procedimentos Cirúrgicos Minimamente Invasivos/instrumentação , Animais , Ponte de Artéria Coronária/métodos , Desenho de Equipamento , Humanos , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Sucção , SuínosAssuntos
Ponte de Artéria Coronária/instrumentação , Doença da Artéria Coronariana/cirurgia , Procedimentos Cirúrgicos Robóticos/métodos , Anastomose Cirúrgica/instrumentação , Ponte Cardiopulmonar/instrumentação , Contraindicações , Ponte de Artéria Coronária/métodos , Ponte de Artéria Coronária sem Circulação Extracorpórea/instrumentação , Humanos , Tempo de Internação/estatística & dados numéricos , Artéria Torácica Interna/transplante , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Procedimentos Cirúrgicos Minimamente Invasivos/estatística & dados numéricos , Ventilação Monopulmonar/métodos , Avaliação de Resultados em Cuidados de Saúde , Posicionamento do Paciente/métodos , Seleção de Pacientes , Pesos e Medidas/instrumentaçãoRESUMO
Transoesophageal and epicardial echocardiography are indispensible intraoperative imaging modalities to guide paediatric heart disease surgeries and influence surgical decision-making. A less well-described role of intraoperative imaging is its utility in evaluating coronary artery patency and flow. Focused two-dimensional, colour, and spectral Doppler imaging of the coronary arteries should be performed during surgeries involving coronary manipulation or re-implantation, or in cases where there is unexpected ventricular dysfunction or electrographic signs concerning for ischaemia. Intraoperative imaging allows for any anatomical issues to be detected and addressed promptly in the operating room. Imaging of the coronary arteries should identify unobstructed coronary ostia and proximal course without kinking, angulation, narrowing, or significant calibre change to suggest stenosis or extrinsic compression from neighbouring structures. The aim of this review is to highlight the usefulness of transoesophageal and epicardial echocardiography in evaluating coronary artery patency and flow, provide a how-to guide for optimal imaging, and to introduce a practical guideline to achieve best clinical practice.
Assuntos
Ponte de Artéria Coronária/métodos , Vasos Coronários/diagnóstico por imagem , Ecocardiografia Transesofagiana , Monitorização Intraoperatória , Angiografia por Tomografia Computadorizada , Ponte de Artéria Coronária/instrumentação , Cardiopatias Congênitas/cirurgia , Cardiopatias/cirurgia , Humanos , Imageamento TridimensionalRESUMO
OBJECTIVE: To compare the results of polytetrafluoroethylene (PTFE) and great saphenous vein (GSV) bypass after resection of a degenerative aneurysm of the carotid artery. METHODS: From January 1994 to November 2017, 37 patients (27 men) with a mean age of 58 years (range, 39-82 years) with a degenerative aneurysm of the carotid artery (median diameter, 28 mm; range, 19-42 mm), underwent resection of the aneurysm followed by a bypass with either a GSV (n = 10) or a PTFE prosthesis (n = 27). Although 31 patients were asymptomatic, 6 patients were symptomatic: transient ischemic attack (n = 4), minor stroke (n = 1), and compression of the hypoglossal nerve (n = 1). The preoperative workup included duplex ultrasound examination of the arteries to the head, and angiography or computed tomography angiography. All patients were operated under general anesthesia and six were intubated through the nose. Sixteen patients were monitored through transcutaneous oximetry. No shunt was used in this series. In 10 patients receiving a PTFE graft, the external carotid artery was implanted in the prosthesis. Mean follow-up was 16.9 ± 2 years (95% confidence interval, 14.5-19.3 years). Primary end points were the 30-day combined stroke/death rate, graft infection, late graft patency, and late stroke-free survival. Secondary end points were cranial nerve injury and length of postoperative hospital stay. RESULTS: Postoperative mortality was nil in both groups. One postoperative stroke was observed in the PTFE group, whereas none occurred in the GSV group (P = .84). No graft infection was observed in either group. At 10 years, survival in the GSV group was 80 ± 12%, and survival in the PTFE group was 76 ± 8% (log-rank [Mantel-Cox], P = .85). In the GSV group, graft patency at 7 and 10 years was 85 ± 13%. In the PTFE group B, graft patency was 100% (log-rank [Mantel-Cox], P = .12). No late stroke was observed. Two transient cranial nerve injuries were observed in the GSV group (20%) and two in the PTFE group (8%) (P = .97). Length of hospital stay was comparable in both groups (GSV group, 6 days; PTFE group, 5 days; P = .12). CONCLUSIONS: This study suggests that, after resection of a degenerative aneurysm of the carotid artery, bypass with a PTFE prosthesis gives comparable results to those obtained with the GSV. We recommend sparing the GSV and instead using a PTFE prosthesis in patients with a degenerative aneurysm of the carotid artery.
Assuntos
Aneurisma/cirurgia , Implante de Prótese Vascular/métodos , Doenças das Artérias Carótidas/cirurgia , Ponte de Artéria Coronária/métodos , Complicações Pós-Operatórias/epidemiologia , Idoso , Aneurisma/mortalidade , Prótese Vascular/efeitos adversos , Implante de Prótese Vascular/efeitos adversos , Implante de Prótese Vascular/instrumentação , Doenças das Artérias Carótidas/mortalidade , Ponte de Artéria Coronária/efeitos adversos , Ponte de Artéria Coronária/instrumentação , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Politetrafluoretileno/efeitos adversos , Complicações Pós-Operatórias/etiologia , Veia Safena/transplante , Resultado do Tratamento , Grau de Desobstrução VascularRESUMO
OBJECTIVE: There is a high prevalence of concomitant coronary artery disease (CAD) and aortic stenosis (AS), and these conditions can be treated with a variety of invasive and/or percutaneous approaches. The aim of this study is to demonstrate the feasibility, efficacy, and safety of a staged transcatheter aortic valve replacement (TAVR) after a hybrid minimally invasive direct coronary artery bypass surgery (MIDCAB) to treat combined complex CAD and AS. METHODS: Six patients with concomitant CAD and severe AS underwent staged treatment of their CAD with MIDCAB and TAVR. All patients had significant complex left main or left anterior descending artery (LAD) stenosis deemed to be not amenable to percutaneous coronary intervention (PCI). RESULTS: The average syntax score was 22±8 and the Society of Thoracic Surgeons score for surgical AVR was 8±3%. All patients underwent a single vessel MIDCAB for revascularization of the LAD (three patients required additional PCI for non-LAD disease). Two patients had pre-TAVR balloon aortic valvuloplasty and one patient also required treatment of severe mitral valve regurgitation with percutaneous edge-to-edge repair (the MitraClip). There was no intraprocedural or hospital mortality. No neurological deficits or vascular complications were recorded. CONCLUSIONS: A hybrid staged approach for combined complex CAD and severe AS with MIDCAB, PCI, and TAVR is a valid option in high-risk patients. The order and timing of these procedures must be tailored to the patient's clinical symptoms, stability, and severity of disease.
Assuntos
Estenose da Valva Aórtica/cirurgia , Ponte de Artéria Coronária/instrumentação , Doença da Artéria Coronariana/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Substituição da Valva Aórtica Transcateter/métodos , Idoso , Idoso de 80 Anos ou mais , Estenose da Valva Aórtica/complicações , Doença da Artéria Coronariana/complicações , Estudos de Viabilidade , Humanos , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos/tendências , Intervenção Coronária Percutânea/métodos , Procedimentos Cirúrgicos Robóticos/métodos , Segurança , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Metal allergy is an uncommon problem during surgery. Among them, titanium allergy is said to be rare, but can lead to serious complications, such as palmoplantar pustulosis (PPP). A 69-year-old woman was admitted to our hospital with a chief complaint of chest pain. Coronary angiography showed severe coronary artery disease that required coronary artery bypass grafting (CABG). The patient had a history of orthopedic surgery for left distal radius fracture 2 years previously, which resulted in inflammation on the left arm and PPP. We suspected titanium allergy based on results of skin patch tests and use of titanium alloy in the previous orthopedic operation. The patient underwent CABG without use of permanent metallic material. As a result, her PPP disappeared. In this rare case, it is difficult to identify the exact cause of the improvement in PPP; thus, further studies are required to clarify the mechanism of remission.
Assuntos
Placas Ósseas/efeitos adversos , Ponte Cardiopulmonar , Ponte de Artéria Coronária , Doença da Artéria Coronariana/cirurgia , Hipersensibilidade/etiologia , Psoríase/induzido quimicamente , Titânio/efeitos adversos , Idoso , Ponte Cardiopulmonar/instrumentação , Ponte de Artéria Coronária/instrumentação , Doença da Artéria Coronariana/diagnóstico por imagem , Feminino , Humanos , Hipersensibilidade/diagnóstico , Desenho de Prótese , Psoríase/diagnóstico , Resultado do TratamentoRESUMO
An ongoing debate exists over the role of percutaneous coronary intervention and coronary artery bypass grafting for revascularization in patients with multivessel or left main disease. Despite improvements in stent technology, bypass surgery still provides the best long-term results in the majority of patients. The present review focuses on randomized controlled trials and a meta-analysis published over the last 4 years.
Assuntos
Ponte de Artéria Coronária , Doença da Artéria Coronariana/terapia , Intervenção Coronária Percutânea , Tomada de Decisão Clínica , Ponte de Artéria Coronária/efeitos adversos , Ponte de Artéria Coronária/instrumentação , Ponte de Artéria Coronária/mortalidade , Doença da Artéria Coronariana/diagnóstico por imagem , Doença da Artéria Coronariana/mortalidade , Medicina Baseada em Evidências , Humanos , Metanálise como Assunto , Seleção de Pacientes , Intervenção Coronária Percutânea/efeitos adversos , Intervenção Coronária Percutânea/mortalidade , Ensaios Clínicos Controlados Aleatórios como Assunto , Medição de Risco , Fatores de Risco , Stents , Resultado do TratamentoRESUMO
Coronary artery bypass grafting offers patients a better long-term prognosis than catheter intervention, but it carries a higher risk of perioperative stroke. To reduce cerebral complications associated with proximal anastomosis, preprocedural epiaortic ultrasound assessment, avoidance of aortic clamping, and the use of an anastomosis assist device are useful. For multivessel bypass across two regions, piggyback anastomosis, which stacks the proximal anastomoses of the two grafts, reduces aortic invasion because this technique requires only one proximal anastomosis. In addition, this method uses only one device, which helps to reduce costs. The Heartstring is considered among the least invasive of the various anastomosis assist devices. However, its removal is irreversible, and once the sutures are cut, repair without aortic clamping is difficult. We have developed a safe method for performing a piggyback anastomosis using a single Heartstring device. This cost-effective technique produces a safe piggyback anastomosis with minimal invasiveness to the aorta.
Assuntos
Ponte de Artéria Coronária/instrumentação , Idoso , Anastomose Cirúrgica/métodos , Aorta/cirurgia , Constrição , Feminino , Humanos , Masculino , Veia Safena/transplante , Acidente Vascular Cerebral/etiologia , Instrumentos Cirúrgicos , Técnicas de SuturaRESUMO
OBJECTIVE: Intra-aortic balloon pump (IABP) is one of the most commonly used mechanical circulatory assist devices for high-risk patients undergoing cardiac surgery. In an effort to validate previously reported clinical outcomes, we describe the preoperative characteristics and outcomes of patients who underwent prophylactic IABP in high-risk patients undergoing coronary artery bypass grafting (CABG). DESIGN: A prospective observational study. METHODS: From 2005 to 2017, 471 patients underwent either isolated or combined CABG at our institution. Of those, 393 patients underwent isolated CABG and were included for the analysis. Eighty-five patients (22%) were considered high-risk and underwent prophylactic IABP, with subsequent review of surgical morbidity and mortality rates. RESULTS: The 30-day postoperative mortality (prophylactic IABP group vs non prophylactic IABP group: 0% vs 1.6%, p = 0.589) and major adverse cardiac or cerebrovascular events (5.9% vs 3.3%, p = 0.333) were not significantly different between the two groups. Prolonged mechanical ventilation (>72 hours) (12.5% vs 4.2%, p = 0.014) occurred more frequently in the prophylactic IABP group. CONCLUSIONS: No IABP-related complications were noted, emphasizing that the use of prophylactic IABP in high-risk patients undergoing CABG is an acceptable option.
Assuntos
Ponte de Artéria Coronária/instrumentação , Balão Intra-Aórtico , Adulto , Feminino , Humanos , Masculino , Isquemia Miocárdica/cirurgia , Período Pré-Operatório , Risco , Resultado do TratamentoRESUMO
The aim of our study was to compare early and long-term outcome of patients undergoing either on-pump or off-pump coronary artery bypass grafting with special focus on impairment of renal function. Five hundred ninety-three consecutive patients undergoing coronary artery bypass grafting were retrospectively analyzed. They were assigned either to on-pump (n = 281) or to off-pump (n = 312) group. Early and long-term outcomes were analyzed with special focus on renal function. Basic demographics and preoperative characteristics did not differ between groups (p>0.05) as well as postoperative renal parameters (p>0.05). Postoperative odds ratios (OR) of off-pump group in comparison to on-pump group were higher without reaching significance in terms of incidence of gastrointestinal complications and pneumonia (OR = 2.23 and 1.61, respectively) as well as hazard ratios (HR) on long-term follow-up for mortality and incidence of myocardial infarction (HR = 1.50 and 2.29, respectively). Kaplan-Meier estimation analysis also revealed similar results for both groups in terms of mid- and long-term survival (Breslow p = 0.062 and Log-Rank p = 0.064, respectively) and for incidence of myocardial infarction (Breslow p = 0.102 and Log-Rank p = 0.103, respectively). Our study suggests that use or not use of coronary artery bypass did not influence postoperative renal function. Odds of early outcomes were similar in both groups as well as incidence of myocardial infarction and mortality in long-term follow-up.
Assuntos
Ponte de Artéria Coronária/métodos , Máquina Coração-Pulmão/efeitos adversos , Nefropatias/epidemiologia , Rim/fisiologia , Complicações Pós-Operatórias/epidemiologia , Idoso , Ponte de Artéria Coronária/efeitos adversos , Ponte de Artéria Coronária/instrumentação , Feminino , Gastroenteropatias/epidemiologia , Gastroenteropatias/etiologia , Humanos , Nefropatias/etiologia , Masculino , Pessoa de Meia-Idade , Pneumonia/epidemiologia , Pneumonia/etiologia , Complicações Pós-Operatórias/etiologiaRESUMO
AIM: To analyze own experience of coronary artery bypass grafting (CABG) using microsurgical technique and operating microscope. MATERIAL AND METHODS: There were 100 patients with coronary artery disease who underwent CABG in the Petrovsky Russian Research Center for Surgery for the period from April 2017 to December 2018. Mean age of patients was 59.7 ± 8.9 years. Triple-vessel disease was noted in 83 (83%) patients, two-vessel - in 17 (17%) patients. Stenosis of left main coronary artery was observed in 34 (34%) patients. On-pump myocardial revascularization using microsurgical technique was performed in all patients. RESULTS: A total of 360 distal anastomoses with coronary arteries were formed in 100 patients using surgical microscope. Revascularization index was 3.6 ± 0.8, mean CPB time - 104 ± 24 min, aoric cross-clamping time - 72 ± 16 min. In-hospital mortality was absent. There were no cases of resternotomy for bleeding, infectious complications of postoperative wounds. One (1%) patient had intraoperative myocardial infarction. CONCLUSION: CABG using microsurgical technique and operating microscope may be appropriate in patients with multiple-vessel coronary lesion and small diameter of coronary arteries.
Assuntos
Ponte de Artéria Coronária/métodos , Doença da Artéria Coronariana/cirurgia , Idoso , Ponte de Artéria Coronária/instrumentação , Estenose Coronária , Humanos , Microcirurgia/instrumentação , Pessoa de Meia-IdadeRESUMO
Microsurgical approach implies a special technique of operation under operating microscope with the use of special tools and ultra-thin atraumatic sutures. This method may be used in coronary artery bypass surgery in order to improve conventional technique, its quality and outcomes. The report summarizes information about technical features, capabilities and results of microsurgical coronary artery bypass grafting. The problem of popularizing microsurgical technologies in coronary bypass surgery is also discussed.
Assuntos
Ponte de Artéria Coronária/métodos , Microcirurgia/métodos , Ponte de Artéria Coronária/instrumentação , Humanos , Microcirurgia/instrumentação , SuturasRESUMO
Design strategies for small diameter vascular grafts are converging toward native-inspired tissue engineered grafts. A new automated technology is presented that combines a dip-spinning methodology for depositioning concentric cell-laden hydrogel layers, with an adapted solution blow spinning (SBS) device for intercalated placement of aligned reinforcement nanofibres. This additive manufacture approach allows the assembly of bio-inspired structural configurations of concentric cell patterns with fibres at specific angles and wavy arrangements. The middle and outer layers were tuned to structurally mimic the media and adventitia layers of native arteries, enabling the fabrication of small bore grafts that exhibit the J-shape mechanical response and compliance of human coronary arteries. This scalable automated system can fabricate cellularized multilayer grafts within 30 min. Grafts were evaluated by hemocompatibility studies and a preliminary in vivo carotid rabbit model. The dip-spinning-SBS technology generates constructs with native mechanical properties and cell-derived biological activities, critical for clinical bypass applications.
Assuntos
Bioprótese , Prótese Vascular , Vasos Coronários/anatomia & histologia , Engenharia Tecidual/métodos , Animais , Implante de Prótese Vascular/instrumentação , Implante de Prótese Vascular/métodos , Ponte de Artéria Coronária/instrumentação , Ponte de Artéria Coronária/métodos , Feminino , Células Endoteliais da Veia Umbilical Humana , Humanos , Hidrogéis/química , Teste de Materiais/métodos , Modelos Animais , Coelhos , Resistência à TraçãoAssuntos
Antibacterianos/efeitos adversos , Hemangiossarcoma/diagnóstico , Melanose/diagnóstico , Minociclina/efeitos adversos , Neoplasias Cutâneas/diagnóstico , Administração Oral , Angina Pectoris/cirurgia , Antibacterianos/administração & dosagem , Ponte de Artéria Coronária/efeitos adversos , Ponte de Artéria Coronária/instrumentação , Diagnóstico Diferencial , Face , Hemangiossarcoma/patologia , Humanos , Masculino , Melanose/induzido quimicamente , Melanose/patologia , Pessoa de Meia-Idade , Minociclina/administração & dosagem , Infecções Relacionadas à Prótese/tratamento farmacológico , Infecções Relacionadas à Prótese/etiologia , Pele/patologia , Neoplasias Cutâneas/patologiaRESUMO
OBJECTIVES: The intermediate-term all-cause mortality rate of real-world patients with multivessel disease (MVD) treated with percutaneous coronary intervention (PCI) with new-generation drug-eluting stents or coronary artery bypass grafting (CABG) remains unknown. We sought to compare the intermediate-term all-cause mortality rates of real-world patients with MVD including left main stem disease, treated with CABG or PCI. METHODS: All consecutive all-comer patients with MVD undergoing CABG or PCI with second/third generation drug-eluting stents from 2007 to 2015 in Harefield Hospital, UK were included in this study. The revascularization modality was based on heart team discussions. Primary outcome was all-cause mortality. Mean follow-up of the study was 3.3 years. Cox regression analysis and propensity matching were used. RESULTS: Of 6383 patients with MVD, 4230 underwent CABG, whereas 2153 had PCI with new-generation stents. In the CABG group, the mean age was 66.4 ± 10 years, whereas in the PCI group it was 65.3 ± 12.1 years (P < 0.001). Fewer female patients with MVD were treated with CABG than were treated with PCI (18.5% vs 20.5%; P = 0.026). There was a higher 5-year estimated survival rate among patients having CABG (88% vs 78.3%; Plog-rank < 0.001). The adjusted hazard ratio (HR) for PCI over CABG was 1.74 [95% confidence interval (CI) 1.41-2.16; P < 0.001]. A total of 653 patients having CABG and 653 having PCI were included in the propensity-matched groups. At mean follow-up, PCI was associated with a higher adjusted HR for all-cause mortality (2.18, 95% CI 1.54-3.1; P < 0.001). CONCLUSIONS: In this contemporary cohort of real-world patients with MVD, CABG was associated with increased intermediate-term survival compared to PCI with new-generation drug-eluting stents.
Assuntos
Ponte de Artéria Coronária , Doença da Artéria Coronariana , Intervenção Coronária Percutânea , Idoso , Ponte de Artéria Coronária/efeitos adversos , Ponte de Artéria Coronária/instrumentação , Ponte de Artéria Coronária/mortalidade , Doença da Artéria Coronariana/epidemiologia , Doença da Artéria Coronariana/mortalidade , Doença da Artéria Coronariana/cirurgia , Stents Farmacológicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Intervenção Coronária Percutânea/efeitos adversos , Intervenção Coronária Percutânea/instrumentação , Intervenção Coronária Percutânea/mortalidade , Estudos RetrospectivosRESUMO
The world experience of coronary artery bypass surgery using an operating microscope is reviewed in the article. Important role of operating microscope and microsurgical techniques for coronary anastomoses formation is shown. High optical magnification provided by operating microscope directly affects the quality of surgical technique and accuracy of coronary anastomoses suturing that affects postoperative graft patency. Thus, the use of operating microscope can affect the results of coronary artery bypass surgery, as shown in several reports.