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1.
Med Phys ; 51(6): 4423-4433, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38695760

RESUMO

BACKGROUND: The newly available ZAP-X stereotactic radiosurgical system is designed for the treatment of intracranial lesions, with several unique features that include a self-shielding, gyroscopic gantry, wheel collimation, non-orthogonal kV imaging, short source-axis distance, and low-energy megavoltage beam. Systematic characterization of its radiation as well as other properties is imperative to ensure its safe and effective clinical application. PURPOSE: To accurately determine the radiation output of the ZAP-X with a special focus on the smaller diameter cones and an aim to provide useful recommendations on quantification of small field dosimetry. METHODS: Six different types of detectors were used to measure relative output factors at field sizes ranging from 4 to 25 mm, including the PTW microSilicon and microdiamond diodes, Exradin W2 plastic scintillator, Exradin A16 and A1SL ionization chambers, and the alanine dosimeter. The 25 mm cone served as the reference field size. Absolute dose was determined with both TG-51-based dosimetry using a calibrated PTW Semiflex ion chamber and measurements using alanine dosimeters. RESULTS: The average radiation output factors (maximum deviation from the average) measured with the microDiamond, microSilicon, and W2 detectors were: for the 4 mm cone, 0.741 (1.0%); for the 5 mm cone: 0.817 (1.0%); for the 7.5 mm cone: 0.908 (1.0%); for the 10 mm cone: 0.946 (0.4%); for the 12.5 mm cone: 0.964 (0.2%); for the 15 mm cone: 0.976 (0.1%); for the 20 mm cone: 0.990 (0.1%). For field sizes larger than 10 mm, the A1SL and A16 micro-chambers also yielded consistent output factors within 1.5% of those obtained using the microSilicon, microdiamond, and W2 detectors. The absolute dose measurement obtained with alanine was within 1.2%, consistent with combined uncertainties, compared to the PTW Semiflex chamber for the 25 mm reference cone. CONCLUSION: For field sizes less than 10 mm, the microSilicon diode, microDiamond detector, and W2 scintillator are suitable devices for accurate small field dosimetry of the ZAP-X system. For larger fields, the A1SL and A16 micro-chambers can also be used. Furthermore, alanine dosimetry can be an accurate verification of reference and absolute dose typically measured with ion chambers. Use of multiple suitable detectors and uncertainty analyses were recommended for reliable determination of small field radiation outputs.


Assuntos
Radiometria , Radiocirurgia , Radiocirurgia/instrumentação , Radiometria/instrumentação , Proteção Radiológica/instrumentação , Padrões de Referência
2.
Radiat Prot Dosimetry ; 200(8): 745-754, 2024 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-38702838

RESUMO

This study analysed the occupational dose in Korean pressurized heavy-water reactors (PHWRs) and identified tasks involving high radiation exposure. The average individual dose was sufficiently low to be below the annual effective dose limit for radiation workers and is even lower than the dose limit for the general public. However, some workers received relatively higher doses than others. Furthermore, most PHWR workers are exposed to radiation during planned maintenance periods. In this study, the radiation dose was normalized (radiation dose per unit time) to determine the high-radiation-exposure tasks in Korean PHWRs. Consequently, end-fitting lapping, delayed neutron tube work and fuel channel fixed-end change tasks were identified as high-radiation-exposure tasks in Korean PHWRs. If appropriate radiation protection measures are prioritized for the identified high-dose exposure tasks, optimization of radiological protection will be effectively achieved by reducing the dose that is relatively higher than the average.


Assuntos
Exposição Ocupacional , Doses de Radiação , Monitoramento de Radiação , Exposição Ocupacional/análise , Exposição Ocupacional/prevenção & controle , Humanos , República da Coreia , Monitoramento de Radiação/métodos , Monitoramento de Radiação/instrumentação , Proteção Radiológica/instrumentação , Exposição à Radiação/análise , Reatores Nucleares , Água
4.
Sci Rep ; 14(1): 10719, 2024 05 10.
Artigo em Inglês | MEDLINE | ID: mdl-38729975

RESUMO

The shielding parameters can vary depending on the geometrical structure of the linear accelerators (LINAC), treatment techniques, and beam energies. Recently, the introduction of O-ring type linear accelerators is increasing. The objective of this study is to evaluate the shielding parameters of new type of linac using a dedicated program developed by us named ORSE (O-ring type Radiation therapy equipment Shielding Evaluation). The shielding evaluation was conducted for a total of four treatment rooms including Elekta Unity, Varian Halcyon, and Accuray Tomotherapy. The developed program possesses the capability to calculate transmitted dose, maximum treatable patient capacity, and shielding wall thickness based on patient data. The doses were measured for five days using glass dosimeters to compare with the results of program. The IMRT factors and use factors obtained from patient data showed differences of up to 65.0% and 33.8%, respectively, compared to safety management report. The shielding evaluation conducted in each treatment room showed that the transmitted dose at every location was below 1% of the dose limit. The results of program and measurements showed a maximum difference of 0.003 mSv/week in transmitted dose. The ORSE program allows for the shielding evaluation results to the clinical environment of each institution based on patient data.


Assuntos
Aceleradores de Partículas , Proteção Radiológica , Aceleradores de Partículas/instrumentação , Proteção Radiológica/instrumentação , Proteção Radiológica/métodos , Humanos , Radioterapia de Intensidade Modulada/métodos , Doses de Radiação
5.
Life Sci Space Res (Amst) ; 41: 119-126, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38670638

RESUMO

The risk posed by prolonged exposure to space radiation represents a significant obstacle to long-duration human space exploration. Of the ion species present in the galactic cosmic ray spectrum, relativistic protons are the most abundant and as such are a relevant point of interest with regard to the radiation protection of space crews involved in future long-term missions to the Moon, Mars, and beyond. This work compared the shielding effectiveness of a number of standard and composite materials relevant to the design and development of future spacecraft or planetary surface habitats. Absorbed dose was measured using Al2O3:C optically stimulated luminescence dosimeters behind shielding targets of varying composition and depth using the 1 GeV nominal energy proton beam available at the NASA Space Radiation Laboratory at the Brookhaven National Laboratory in New York. Absorbed dose scored from computer simulations performed using the multi-purpose Monte Carlo radiation transport code FLUKA agrees well with measurements obtained via the shielding experiments. All shielding materials tested and modeled in this study were unable to reduce absorbed dose below that measured by the (unshielded) front detector, even after depths as large as 30 g/cm2. These results could be noteworthy given the broad range of proton energies present in the galactic cosmic ray spectrum, and the potential health and safety hazard such space radiation could represent to future human space exploration.


Assuntos
Radiação Cósmica , Método de Monte Carlo , Prótons , Proteção Radiológica , Voo Espacial , Proteção Radiológica/instrumentação , Proteção Radiológica/métodos , Humanos , Radiação Cósmica/efeitos adversos , Doses de Radiação , Astronave , Simulação por Computador
6.
Cardiovasc Revasc Med ; 64: 70-75, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38538447

RESUMO

OBJECTIVES: This study evaluated the efficacy of a novel comprehensive shield designed to minimize radiation exposure (RE) to Physicians performing coronary and structural heart procedures. BACKGROUND: The Protego™ radiation shielding system (Image Diagnostics Inc., Fitchburg, Ma) is designed to provide comprehensive protection from RE and has been State certified sufficient to allow operators to perform procedures without orthopedically burdensome lead aprons. METHODS: This single center two-group cohort study assessed the efficacy of this shield in a large number of cardiac procedures (coronary and structural), comparing operator RE compared to standard protection methods (personal lead apparel and "drop down" shield). RESULTS: The Protego™ system reduced operator RE by 99 % compared to Standard Protection. RE was significantly lower at both "Head" level by thyroid median dose 0.0 (0.0, 0,0) vs 5.7 (2.9, 8.2) µSv (p < 0.001), as well as waist dose 0.0 (0.0, 0.0) vs 10.0 (5.0, 16.6) µSv (p < 0.001). "Zero" Total RE was documented by Raysafe™ in 64 % (n = 32) of TAVR cases and 73.2 % (n = 183) of the coronary cases utilizing Protego™. In contrast, standard protection did not achieve "Zero" exposure in a single case. These dramatic differences in RE were achieved despite higher fluoroscopy times in the Protego™ arm (11.9 ± 8.6 vs 14.3 ± 12.5 min, p = 0.015). Per case procedural exposure measured by Dose Area Product was higher in the Protego™ group compared to standard protection (115.4 ± 139.2 vs 74.9 ± 69.3, p < 0.001). CONCLUSION: The Protego™ shield provides total body RE protection for operators performing both coronary and structural heart procedures. This shield allows procedural performance without the need for personal lead aprons and has potential to reduce catheterization laboratory occupational health hazards.


Assuntos
Exposição Ocupacional , Saúde Ocupacional , Doses de Radiação , Exposição à Radiação , Proteção Radiológica , Radiografia Intervencionista , Humanos , Exposição Ocupacional/prevenção & controle , Exposição Ocupacional/efeitos adversos , Exposição à Radiação/prevenção & controle , Exposição à Radiação/efeitos adversos , Proteção Radiológica/instrumentação , Radiografia Intervencionista/efeitos adversos , Radiografia Intervencionista/normas , Fatores de Risco , Medição de Risco , Lesões por Radiação/prevenção & controle , Lesões por Radiação/etiologia , Desenho de Equipamento , Cateterismo Cardíaco/efeitos adversos , Cateterismo Cardíaco/instrumentação , Masculino , Monitoramento de Radiação , Feminino
7.
Ir J Med Sci ; 193(3): 1461-1466, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38349509

RESUMO

BACKGROUND: Implantable central venous port systems are widely used in oncology. We upgraded our fluoroscopy machines, and all anesthetists completed two training courses focusing on the risks of ionizing radiation for patients and health workers. AIMS: This study aimed to evaluate the impact of upgrading the machines and the radiation-protection training on ionizing radiation exposure during venous port system implantation. METHODS: We retrospectively analyzed consecutive venous port implantations between 2019 and 2022. The older fluoroscopy machines were replaced by two new machines. A first training session about health worker radioprotection was organized. The medical staff completed a second training course focused on protecting patients from ionizing radiation. We defined four distinct time intervals (TI): venous port implantations performed with the old equipment, the new fluoroscopy machines, after the first training course, and after the second training course. The air kerma-area product (KAP) was compared between these four TI and fluoroscopy times and the number of exposures only with the new machines. RESULTS: We analyzed 2587 procedures. A 93% decrease in the median KAP between the first and last TI was noted (median KAP = 323.0 mGy.cm2 vs. 24.0 mGy.cm2, p < 0.0001). A decrease in the KAP was observed for each of the 11 anesthetists. We also noted a significant decrease in the time of fluoroscopy and the number of exposures. CONCLUSIONS: Upgrading the fluoroscopy equipment and completing two dedicated training courses allowed for a drastic decrease patient exposure to ionizing radiation during venous access port implantation by non-radiologist practitioners.


Assuntos
Doses de Radiação , Proteção Radiológica , Humanos , Estudos Retrospectivos , Fluoroscopia , Proteção Radiológica/instrumentação , Proteção Radiológica/métodos , Cateterismo Venoso Central/métodos , Cateterismo Venoso Central/instrumentação , Feminino , Masculino , Exposição Ocupacional/prevenção & controle , Exposição à Radiação/prevenção & controle , Pessoa de Meia-Idade
8.
Odovtos (En línea) ; 24(2)ago. 2022.
Artigo em Espanhol | LILACS, SaludCR | ID: biblio-1386591

RESUMO

Resumen En las últimas dos décadas ha aumentado el uso de equipos portátiles de rayos X intraorales, los cuales son estabilizados por el operador. Si bien todos los equipos radiográficos presentan un riesgo inherente por el uso de radiación ionizante, el uso indebido de los equipos portátiles puede aumentar la exposición del operador. Se recomienda el uso de los equipos portátiles en un trípode o activados desde un área protegida. Sin embargo, en casos altamente justificados para su uso sin estos aditamentos, se debe seguir recomendaciones para disminuir la exposición del operador. Debido a que la radioprotección es fundamental al trabajar con rayos X, se debe favorecer el uso de equipos radiográficos dentales fijos sobre los equipos portátiles, ya que estos proporcionan una menor dosis de radiación al operador.


Abstract In the last two decades, the use of portable intraoral X-ray devices, stabilized by the operator, has increased. While all radiographic devices present an inherent risk from ionizing radiation, improper use of portable devices can increase operator exposure. Use of portable devices on a tripod or powered from a protected area is recommended. However, in highly justified cases, for using without these accessories, recommendations should be followed to reduce operator exposure. Because radioprotection is essential when using X-rays, fixed dental radiographic devices should be favored over portable equipment since the first provides a lower radiation dose to the operator.


Assuntos
Proteção Radiológica/instrumentação , Radiografia Dentária , Aplicativos Móveis
9.
Medicine (Baltimore) ; 101(4): e28744, 2022 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-35089250

RESUMO

ABSTRACT: Transarterial chemoembolization is the standard treatment option for intermediate-stage hepatocellular carcinoma (HCC). However, during the interventional procedure, occupational radiation protection is compromised. The use of real-time radiation dosimetry could provide instantaneous radiation doses. This study aimed to evaluate the occupational dose of the medical staff using a real-time radiation dosimeter during transarterial chemoembolization (TACE) for HCC, and to investigate factors affecting the radiation exposure dose.This retrospective observational study included 70 patients (mean age: 66 years; age range: 38-88 years; male: female = 59: 11) who underwent TACE using real-time radiation dosimetry systems between August 2018 and February 2019. Radiation exposure doses of operators, assistants, and technicians were evaluated. Patients' clinical, imaging, and procedural information was analyzed.The mean dose-area product (DAP) and fluoroscopy time during TACE were 66.72 ±â€Š55.14 Gycm2 and 12.03 ±â€Š5.95 minutes, respectively. The mean radiation exposure doses were 24.8 ±â€Š19.5, 2.0 ±â€Š2.2, and 1.65 ±â€Š2.0 µSv for operators, assistants, and technicians, respectively. The radiation exposure of the operators was significantly higher than that of the assistants or technicians (P < .001). The perpendicular position of the adjustable upper-body lead protector (AULP) on the table was one factor reducing in the radiation exposure of the assistants (P < .001) and technicians (P = .040). The DAP was a risk factor for the radiation exposure of the operators (P = .003) and technicians (P < .001).Occupational doses during TACE are affected by DAP and AULP positioning. Placing the AULP in the perpendicular position during fluoroscopy could be a simple and effective way to reduce the radiation exposure of the staff. As the occupational dose influencing factors vary by region or institution, further study is needed.


Assuntos
Carcinoma Hepatocelular/terapia , Quimioembolização Terapêutica , Fluoroscopia/efeitos adversos , Neoplasias Hepáticas/terapia , Exposição Ocupacional , Exposição à Radiação , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Pessoal de Saúde , Humanos , Fígado/efeitos da radiação , Masculino , Pessoa de Meia-Idade , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/prevenção & controle , Doses de Radiação , Exposição à Radiação/efeitos adversos , Exposição à Radiação/prevenção & controle , Lesões por Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Radiometria
10.
Biomed Res Int ; 2021: 9985714, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34671681

RESUMO

BACKGROUND: Radiation using conventional X-ray is associated with exposure of radiosensitive organs and typically requires the use of protection. This study is aimed at evaluating the use of bismuth shielding for radiation protection in pediatric pelvic radiography. The effects of the anteroposterior and lateral bismuth shielding were verified by direct measurements at the anatomical position of the gonads. METHODS: Radiation doses were measured using optically stimulated luminescence dosimeters (OSLD) and CIRS ATOM Dosimetry Verification Phantoms. Gonad radiographs were acquired using different shields of varying material (lead, bismuth) and thickness and were compared with radiographs obtained without shielding to examine the effects on image quality and optimal reduction of radiation dose. All images were evaluated separately by three pediatric orthopedic practitioners. RESULTS: Results showed that conventional lead gonadal shielding reduces radiation doses by 67.45%, whereas dose reduction using one layer of bismuth shielding is 76.38%. The use of two layers of bismuth shielding reduces the dose by 84.01%. Using three and four layers of bismuth shielding reduces dose by 97.33% and 99.34%, respectively. Progressively lower radiation doses can be achieved by increasing the number of bismuth layers. Images obtained using both one and two layers of bismuth shielding provided adequate diagnostic information, but those obtained using three or four layers of bismuth shielding were inadequate for diagnosis. CONCLUSIONS: Bismuth shielding reduces radiation dose exposure providing appropriate protection for children undergoing pelvic radiography. The bismuth shielding material is lighter than lead, making pediatric patients more comfortable and less apt to move, thereby avoiding repeat radiography.


Assuntos
Bismuto/química , Pelve/efeitos da radiação , Proteção Radiológica/métodos , Criança , Humanos , Imagens de Fantasmas , Doses de Radiação , Exposição à Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Tomografia Computadorizada por Raios X , Raios X
11.
PLoS One ; 16(9): e0257638, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34534258

RESUMO

Some concepts in nuclear radiation physics are abstract and intellectually demanding. In the present paper, an "MCHP platform" (MCHP was an acronym for Monte Carlo simulations + Human Phantoms) was proposed to provide assistance to the students through visualization. The platform involved Monte Carlo simulations of interactions between ionizing radiations and the Oak Ridge National Laboratory (ORNL) adult male human phantom. As an example to demonstrate the benefits of the proposed MCHP platform, the present paper investigated the variation of the absorbed photon dose per photon from a 137Cs source in three selected organs, namely, brain, spine and thyroid of an adult male for concrete and lead shields with varying thicknesses. The results were interesting but not readily comprehensible without direct visualization. Graphical visualization snapshots as well as video clips of real time interactions between the photons and the human phantom were presented for the involved cases, and the results were explained with the help of such snapshots and video clips. It is envisaged that, if the platform is found useful and effective by the readers, the readers can also propose examples to be gradually added onto this platform in future, with the ultimate goal of enhancing students' understanding and learning the concepts in an undergraduate nuclear radiation physics course or a related course.


Assuntos
Método de Monte Carlo , Física Nuclear/educação , Proteção Radiológica/métodos , Encéfalo/efeitos da radiação , Radioisótopos de Césio/química , Corpo Humano , Humanos , Fótons , Proteção Radiológica/instrumentação , Radiação Ionizante , Radiometria , Estudantes
12.
J Radiat Res ; 62(5): 918-925, 2021 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-34350969

RESUMO

Total body irradiation (TBI) with ovarian shielding is expected to preserve fertility among hematopoietic stem cell transplant (HSCT) patients with myeloablative TBI-based regimens. However, the radiation dose to the ovaries that preserves ovarian function in TBI remains poorly understood. Furthermore, it is uncertain whether the dose to the shielded organs is associated with relapse risk. Here, we retrospectively evaluated the relationship between fertility and the dose to the ovaries, and between relapse risk and the dose to the pelvic bones. A total of 20 patients (median age, 23 years) with standard-risk hematologic diseases were included. Median follow-up duration was 31.9 months. The TBI prescribed dose was 12 Gy in six fractions for three days. Patients' ovaries were shielded with cylinder-type lead blocks. The dose-volume parameters (D98% and Dmean) in the ovaries and the pelvic bones were extracted from the dose-volume histogram (DVH). The mean ovary Dmean for all patients was 2.4 Gy, and 18 patients recovered menstruation (90%). The mean ovary Dmean for patients with menstrual recovery and without recovery were 2.4 Gy and 2.4 Gy, respectively, with no significant difference (P = 0.998). Hematological relapse was observed in five patients. The mean pelvis Dmean and pelvis D98% for relapse and non-relapse patients were 11.6 Gy and 11.7 Gy and 5.6 Gy and 5.3 Gy, respectively. Both parameters showed no significant difference (P = 0.827, 0.807). In conclusion, TBI with ovarian shielding reduced the radiation dose to the ovaries to 2.4 Gy, and preserved fertility without increasing the risk of relapse.


Assuntos
Preservação da Fertilidade/métodos , Órgãos em Risco/efeitos da radiação , Ovário/efeitos da radiação , Ossos Pélvicos/efeitos da radiação , Lesões por Radiação/etiologia , Proteção Radiológica/métodos , Condicionamento Pré-Transplante/efeitos adversos , Irradiação Corporal Total/efeitos adversos , Adolescente , Adulto , Anemia Aplástica/terapia , Feminino , Preservação da Fertilidade/instrumentação , Seguimentos , Transplante de Células-Tronco Hematopoéticas , Humanos , Leucemia/terapia , Menstruação/efeitos da radiação , Agonistas Mieloablativos/administração & dosagem , Síndromes Mielodisplásicas/terapia , Lesões por Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Recuperação de Função Fisiológica , Recidiva , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
13.
Sci Rep ; 11(1): 14559, 2021 07 15.
Artigo em Inglês | MEDLINE | ID: mdl-34267293

RESUMO

We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour model with 2 and 8 Gy absorbed doses. The lead shielding was fabricated into a cuboid shape with a canal on the top and a hole on the vertical side for the beam path. Respective deliveries doses of 28 and 75 Gy from gamma-cell were used to achieve 2 and 8 Gy absorbed doses at the tumour sites.


Assuntos
Neoplasias Experimentais/radioterapia , Proteção Radiológica/instrumentação , Proteção Radiológica/métodos , Animais , Desenho de Equipamento , Feminino , Dosimetria Fotográfica/métodos , Raios gama , Chumbo , Camundongos Endogâmicos BALB C , Dosagem Radioterapêutica
14.
J Bone Joint Surg Am ; 103(17): 1646-1651, 2021 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-34255759

RESUMO

BACKGROUND: Standard lead aprons and vests do not adequately shield the most common breast cancer site, the upper outer quadrant (UOQ), from intraoperative radiation. The purpose of the present study was to determine if lead sleeves, wings, and/or axillary supplements decreased intraoperative radiation exposure of the UOQ of the breast. METHODS: An anthropomorphic torso phantom (simulating the female surgeon) was placed adjacent to a standard operating room table. Dosimeters were placed bilaterally over the UOQ of the breast. Scatter radiation dose equivalent rates (mrem/hr) were measured during continuous fluoroscopy of a pelvic phantom (simulating the patient). Five protection configurations (no lead; lead vest; and vest with sleeves, wings, and axillary supplements), 2 surgeon positions (facing the table and perpendicular to the table), and 2 C-arm positions (anteroposterior and cross-table lateral projection) were tested. The t test was utilized with a Bonferroni correction for multiple t tests. RESULTS: Lead sleeves and axillary supplements decreased intraoperative radiation exposure to the UOQ of the breast when compared with a well-fitted standard lead vest alone (p < 0.01) across all surgeon and C-arm positions. The addition of wings decreased radiation exposure to a lesser extent than sleeves or axillary supplements, and the difference when compared with the lead vest alone did not reach significance (p = 0.29). Breast radiation exposure in the C-arm cross-table lateral projection was highest across all testing. CONCLUSIONS: The UOQ of the breast is not adequately protected by standard lead vests alone or vests with the addition of wings. Axillary supplements and sleeves improved protection of the breast. CLINICAL RELEVANCE: Modifications of lead protective vests may improve intraoperative breast radiation protection.


Assuntos
Mama/efeitos da radiação , Exposição Ocupacional/prevenção & controle , Cirurgiões Ortopédicos , Roupa de Proteção , Exposição à Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Feminino , Fluoroscopia , Humanos , Período Intraoperatório , Imagens de Fantasmas , Médicas , Proteção Radiológica/métodos
15.
Adv Sci (Weinh) ; 8(12): 2100510, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34194950

RESUMO

Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D-printed GI radioprotective devices composed of high-Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (p < 0.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost-effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation.


Assuntos
Trato Gastrointestinal/efeitos da radiação , Neoplasias Bucais/radioterapia , Impressão Tridimensional , Lesões por Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Proteção Radiológica/métodos , Animais , Modelos Animais de Doenças , Trato Gastrointestinal/diagnóstico por imagem , Humanos , Mucosa/diagnóstico por imagem , Mucosa/efeitos da radiação , Órgãos em Risco , Ratos , Ratos Sprague-Dawley , Suínos , Tomografia Computadorizada por Raios X
16.
Radiat Oncol ; 16(1): 109, 2021 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-34120633

RESUMO

BACKGROUND: The present study aimed to propose a new foetal shielding device for pregnant cancer patients to reduce the foetal dose associated with treatment techniques using multiple gantry angles, such as intensity-modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT). METHODS: Three shielding structures were designed to minimise the scattered and leaked radiation from various gantry angles and radiation scattering within the patient. The base-plate part that can be placed on the treatment couch was designed to reduce the scattered and leaked radiation generated at gantry angles located near 180°. A body shielding part that can cover the lower chest and abdomen was designed, and a neck-shielding structure was added to reduce the internal and external radiation scattering from the treatment area. Evaluation plans were generated to assess the foetal dose reduction by the foetal shielding device in terms of the shielding material thickness, distance from the field edge, and shielding component using the flattened 6 MV photon beam (6MV) and flattening filter-free 6 MV photon beam (6MV-FFF). In addition, the effectiveness of the foetal shielding device was evaluated in a pregnant brain tumour patient. RESULTS: The shielding material consisting of three parts was placed on frames composed of four arch shapes with a vertical curved structure, connection bar at the top position, and base plate. Each shielding part resulted in reductions in the radiation dose according to the treatment technique, as the thickness of the shielding material increased and the foetal dose decreased. In addition, a foetal dose reduction of approximately 50% was confirmed at 50 cm from the field edge by using the designed shielding device in most delivery techniques. In patients, the newly designed shielding structures can effectively eliminate up to about 49% of the foetal dose generated from various gantry angles used in VMAT or IMRT. CONCLUSIONS: We designed a foetal shielding device consisting of three parts to effectively reduce the dose delivered to the foetus, and evaluated the device with various treatment techniques for a pregnant patient with brain tumour. The foetal shielding device shielded the scattered/leaked radiation from the treatment machine, and also effectively reduced internal scattering from the treatment area in the patient.


Assuntos
Neoplasias Encefálicas/radioterapia , Feto/efeitos da radiação , Imagens de Fantasmas , Complicações Neoplásicas na Gravidez/prevenção & controle , Lesões por Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Planejamento da Radioterapia Assistida por Computador/métodos , Desenho de Equipamento , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Órgãos em Risco/efeitos da radiação , Gravidez , Dosagem Radioterapêutica , Radioterapia de Intensidade Modulada/métodos , Espalhamento de Radiação , Tomografia Computadorizada por Raios X/métodos
17.
Medicine (Baltimore) ; 100(25): e26277, 2021 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-34160391

RESUMO

BACKGROUND: Radiosensitivity in the breasts increases the risk of carcinogenesis from exposure to the ionizing radiation of computed tomography (CT) administered in the course of medical attention. Bismuth shielding techniques have been used to reduce radiation, but image noise increased, degrading image quality. PURPOSE: The aim of this study was to investigate how the use of iterative reconstruction (IR) combined with bismuth shielding influences image quality. MATERIALS AND METHODS: Women aged at least 20 years with body mass indexes <28 were recruited and randomly assigned to 1 of 3 CT scanning protocols without shielding, with a bismuth breast shield before the scout view, or with a bismuth breast shield after the scout view. All obtained images were reconstructed using an IR algorithm. To evaluate radiation dose, 2 Gafchromic films were placed over the clothes, 1 near each nipple. RESULTS: Average dose reduction was significant (27.99%, P < .05) when bismuth shielding was applied after the scout view. Using the contrast-to-noise ratio, the image quality was found to be superior when the IR algorithm was applied. Using quantitative evaluations by 2 radiologists applying a 4-point Likert scale, significant differences in image quality were not found among the 3 protocols. CONCLUSION: Bismuth breast shields, particularly when used after acquiring scout images, are effective at reducing radiation dose without undermining the diagnostic value of the images when the IR technique is applied.


Assuntos
Bismuto , Mama/diagnóstico por imagem , Equipamentos de Proteção , Proteção Radiológica/instrumentação , Tomografia Computadorizada por Raios X/efeitos adversos , Adulto , Artefatos , Mama/efeitos da radiação , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Estudos Prospectivos , Doses de Radiação , Tolerância a Radiação
18.
Radiol Oncol ; 55(3): 333-340, 2021 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-33991470

RESUMO

BACKGROUND: Breast intraoperative electron radiation therapy (B-IOERT) can be used in clinical practice both as elective irradiation (partial breast irradiation - APBI) in low risk breast cancer patients, and as an anticipated boost. The procedure generally includes the use of a shielding disk between the residual breast and the pectoralis fascia for the protection of the tissues underneath the target volume. The aim of the study was to evaluate the role of intraoperative ultrasound (IOUS) in improving the quality of B-IOERT. PATIENTS AND METHODS: B-IOERT was introduced in Trieste in 2012 and its technique was improved in 2014 with IOUS. Both, needle and IOUS were used to measure target thickness and the latter was used even to check the correct position of the shielding disk. The primary endpoint of the study was the evaluation of the effectiveness of IOUS in reducing the risk of a disk misalignment related to B-IOERT and the secondary endpoint was the analysis of acute and late toxicity, by comparing two groups of patients treated with IOERT as a boost, either measured with IOUS and needle (Group 1) or with needle alone (Group 2). Acute and late toxicity were evaluated by validated scoring systems. RESULTS: From the institutional patients who were treated between June 2012 and October 2019, 109 were eligible for this study (corresponding to 110 cases, as one patients underwent bilateral conservative surgery and bilateral B-IOERT). Of these, 38 were allocated to group 1 and 72 to group 2. The target thickness measured with the IOUS probe and with the needle were similar (mean difference of 0.1 mm, p = 0.38). The percentage of patients in which the shield was perfectly aligned after IOUS introduction increased from 23% to more than 70%. Moreover, patients treated after IOUS guidance had less acute toxicity (36.8% vs. 48.6%, p = 0.33) from radiation therapy, which reached no statistical significance. Late toxicity turned out to be similar regardless of the use of IOUS guidance: 39.5% vs. 37.5% (p = 0.99). CONCLUSIONS: IOUS showed to be accurate in measuring the target depth and decrease the misalignment between collimator and disk. Furthermore there was an absolute decrease in acute toxicity, even though not statistically significant, in the group of women who underwent B-IOERT with IOUS guidance.


Assuntos
Neoplasias da Mama/radioterapia , Cuidados Intraoperatórios/métodos , Lesões por Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Ultrassonografia de Intervenção/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/cirurgia , Elétrons/uso terapêutico , Feminino , Dosimetria Fotográfica/métodos , Humanos , Cuidados Intraoperatórios/instrumentação , Pessoa de Meia-Idade , Estudos Retrospectivos
19.
Cardiovasc Intervent Radiol ; 44(8): 1260-1265, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33987693

RESUMO

PURPOSE: This work was designed to study the effectiveness of radiation protection caps in lowering the dose to the brain and the eye lens during fluoroscopically guided interventions. MATERIALS AND METHODS: Two types of radiation protection caps were examined with regards to their capacity to lower the radiation dose. One cap is equipped with lateral flaps, the other one is not. These caps were fitted to the head of an anthropomorphic Alderson-Rando (A.-R.) phantom. The phantom was positioned aside an angiographic table simulating the position of the first operator during a peripheral arterial intervention. One of the brain slices and both eyes of the A.-R. phantom were equipped with thermoluminescence dosimeters (TLDs). RESULTS: The analysis of the data showed that the cap without lateral flaps reduced the dose to the brain by 11,5-27,5 percent depending on the position within the brain. The cap with lateral protection flaps achieved a shielding effect between 44,7 and 78,9 percent. When evaluating the dose to the eye, we did see an increase of dose reduction from 63,3 to 66,5 percent in the left eye and from 45,8 to 46,8 percent in the right eye for the cap without lateral protection. When wearing the cap with lateral protection we observed an increase of dose reduction from 63,4 to 67,2 percent in the left eye and from 45,8 to 50,0 percent in the right eye. CONCLUSION: Radiation protection caps can be an effective tool to reduce the dose to the brain and the eyes.


Assuntos
Encéfalo/diagnóstico por imagem , Cristalino/diagnóstico por imagem , Doses de Radiação , Proteção Radiológica/instrumentação , Proteção Radiológica/métodos , Radiografia Intervencionista/métodos , Fluoroscopia , Humanos , Imagens de Fantasmas , Dosimetria Termoluminescente
20.
Thyroid ; 31(9): 1291-1296, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33849309

RESUMO

Background: In 2013, the American Thyroid Association (ATA) issued a "Policy Statement on Thyroid Shielding During Diagnostic Medical and Dental Radiology." The recently updated National Council on Radiation Protection and Measurement Radiation Protection in Dentistry and Oral and Maxillofacial Imaging (NCRP Report No. 177) prompts this review of progress related to patient thyroid shielding since the ATA statement was published. Summary: Relevant publications appearing since the ATA statement were identified by querying PubMed for "thyroid and dental and (collar or shielding)" and substituting specific dental radiographic procedures in the search. The search was expanded by reviewing the cited papers in the PubMed-retrieved papers and by use of the Web of Science to retrieve papers citing the PubMed retrieved publications. Although many quantitative studies have appeared reflective of current dental radiographic instrumentation and practice, much more can be done to foster minimizing radiation to the thyroid. Conclusions: We list seven areas that should be pursued. Among them are harmonizing guidelines for the use of thyroid collars based on the recent studies and a comprehensive survey of current dental radiological practice patterns.


Assuntos
Equipamentos de Proteção , Exposição à Radiação/efeitos adversos , Exposição à Radiação/prevenção & controle , Lesões por Radiação/prevenção & controle , Proteção Radiológica/instrumentação , Radiografia Dentária/efeitos adversos , Glândula Tireoide/efeitos da radiação , Desenho de Equipamento , Humanos , Chumbo , Guias de Prática Clínica como Assunto , Equipamentos de Proteção/normas , Doses de Radiação , Lesões por Radiação/etiologia , Proteção Radiológica/normas , Radiografia Dentária/normas , Medição de Risco , Fatores de Risco
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