RESUMO
Igaki explores how cell-cell communication directs tissue and tumor development.
Assuntos
Caspase 1 , Proteínas de Drosophila , Proteínas de Membrana , Doenças Neurodegenerativas , Animais , Caspase 1/genética , Caspase 1/história , Caspase 1/metabolismo , Proteínas de Drosophila/genética , Proteínas de Drosophila/história , Proteínas de Drosophila/metabolismo , Drosophila melanogaster , História do Século XX , História do Século XXI , Humanos , Proteínas de Membrana/genética , Proteínas de Membrana/história , Proteínas de Membrana/metabolismo , Doenças Neurodegenerativas/genética , Doenças Neurodegenerativas/história , Doenças Neurodegenerativas/metabolismo , Doenças Neurodegenerativas/patologia , Retratos como AssuntoRESUMO
Recognition of the importance of cell adhesion grew steadily during the twentieth century as it promised answers to fundamental questions in diverse fields that included cell biology, developmental biology, tumorigenesis, immunology and neurobiology. However, the route towards a better understanding of its molecular basis was long and difficult, with many false starts. Major progress was made in the late 1970s to late 1980s with the identification of the major families of adhesion molecules, including integrins and cadherins. This in turn set the stage for the explosive growth in adhesion research over the past 25 years.
Assuntos
Moléculas de Adesão Celular/história , Animais , Adesão Celular/fisiologia , Moléculas de Adesão Celular/fisiologia , Proteínas da Matriz Extracelular/história , Proteínas da Matriz Extracelular/fisiologia , História do Século XX , História do Século XXI , Humanos , Proteínas de Membrana/história , Proteínas de Membrana/fisiologia , CamundongosRESUMO
We dedicate the 2008 Berlin conference and this collection of scientific manuscripts to the memory of our colleague Shoichiro Tsukita. His seminal scientific contributions and impact on the field of tight junctions is substantial. Shoichiro was a professor at Kyoto University and one the world's most influential biologists when he passed away on December 11, 2005 at the age of 52 from complications of pancreatic cancer. He was a pioneer in several areas of cell biology; most particularly he will be remembered as the founding father of the molecular study of tight junctions.
Assuntos
Proteínas de Membrana/história , Junções Íntimas/fisiologia , História do Século XX , História do Século XXI , Japão , Proteínas de Membrana/fisiologia , Junções Íntimas/químicaRESUMO
On December 11, 2005, Shoichiro Tsukita died at the young age of 52, after 14 months of treatment for cancer. Early in his career, Tsukita succeeded in isolating and purifying the adherens junction with his wife Sachiko, an accomplishment that he followed up with an impressive series of discoveries of cell adhesion and cytoskeletal molecules, including what may have been his greatest contribution to the field, the identification of occludin and the claudin family of molecules, which were watershed discoveries in the study of the molecular nature of tight junctions.