RESUMO
OBJECTIVE: To review the use of gentian violet in dermatology. DESIGN: A comprehensive literature search on gentian violet in dermatology practice was performed through PubMed. RESULTS: Gentian violet is effective in treating methicillin-resistant Staphylococcus aureus-colonized skin lesions; mean number of days for complete eradication was 9.1 days. Gentian violet is almost as effective as ketoconazole and more effective than nystatin in the treatment of oral thrush in AIDS patients. In an in vitro study on cutaneous T cell lymphoma cell lines, there was no difference between nitrogen mustard and gentian violet in stimulating apoptosis. When comparing gentian violet to silver sulfadiazine dressings in healing burn wounds, the gentian violet treatment group reported less pain, fewer febrile episodes, and decreased bacterial growth compared to control. In atopic dermatitis subjects, gentian violet decreased Staphylococcus aureus colonization and improved disease severity in lesional skin compared to non-lesional skin. CONCLUSION: Studies have investigated gentian violet's antibacterial, antifungal, antiviral, antiparasitic, anti-angiogenic, antitumor, and wound healing properties. Gentian violet is a low cost and well-tolerated topical agent with the potential for widespread applications in dermatology.
Assuntos
Anti-Infecciosos Locais/uso terapêutico , Violeta Genciana/uso terapêutico , Dermatopatias/tratamento farmacológico , Administração Tópica , Anti-Infecciosos Locais/efeitos adversos , Anti-Infecciosos Locais/farmacologia , Dermatologia , Violeta Genciana/efeitos adversos , Violeta Genciana/farmacologia , HumanosRESUMO
This case involved a 75-year-old female with left-eye epiretinal membrane (ERM) and cataract who developed serious eye disorders during vitreous surgery due to methylrosaniline chloride (MRC) being mistakenly injected and applied to the retina instead of Brilliant Blue G during internal limiting membrane staining. Once realized, MRC was washed out with intraocular infusion solution, and ERM surgery was successfully completed. Postoperatively, a Descemet's fold and corneal edema, marked reduction in corneal endothelial cell density, and inner retina damage and visual field defect extending from the macula toward the temporal side were observed. MRC was found highly toxic to eye tissues. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:1010-1015.].
Assuntos
Edema da Córnea/induzido quimicamente , Violeta Genciana/efeitos adversos , Complicações Intraoperatórias/induzido quimicamente , Doenças do Nervo Óptico/induzido quimicamente , Retina/efeitos dos fármacos , Escotoma/induzido quimicamente , Vitrectomia/efeitos adversos , Idoso , Anti-Infecciosos Locais/administração & dosagem , Anti-Infecciosos Locais/efeitos adversos , Edema da Córnea/diagnóstico , Membrana Epirretiniana/cirurgia , Feminino , Violeta Genciana/administração & dosagem , Humanos , Injeções Intraoculares/efeitos adversos , Complicações Intraoperatórias/diagnóstico , Doenças do Nervo Óptico/diagnóstico , Retina/patologia , Escotoma/diagnóstico , Tomografia de Coerência Óptica/métodosRESUMO
BACKGROUND: Sterile surgical marker pens are commonly used in cartilage repair surgery to aid in the placement of periosteal patches or collagen membranes in autologous chondrocyte implantation. PURPOSE: To investigate the effects that methylene blue and crystal violet marker pen ink have on human chondrocytes when cultured on collagen membranes in vitro. STUDY DESIGN: Controlled laboratory study. METHODS: Human chondrocytes were applied to Chondro-Gide collagen membranes at a volume of 12 million cells. In the first experiment, 2 sterile marker pens, one containing methylene blue and the other crystal violet inks, were used to mark membranes immediately before the addition of cells. In the second experiment, the same marker pens marked the membranes after 7 days of cell culture. In each experiment, 3 groups of membrane were tested for each pen. Group A consisted of no ink mark, group B had only the uppermost "smooth" layer marked, and group C had the lower "porous" layer marked. All membranes were then cultured in standard growth media for 24 hours. Cell viability was assessed at 24 hours on all membranes using a live/dead-cell viability assay. Cell viability was quantified with florescent microscopy with mean percentage of live cells in each marker pen group compared with control membranes using the Student t test (P < .05). RESULTS: Control membranes (group A) with no ink showed cell viability approaching 100%. A statistically significant reduction in cell viability with both methylene blue (23.1%; P < .0001) and crystal violet (18.9%; P < .0001) was found adjacent to the ink mark on the smooth side (group B) and on the porous side remote from the ink (group C) in both experiments (<30%; P < .0001). A reduction in cell viability was noted on the smooth side remote from the ink mark but did not reach statistical significance. Marked cell death was seen with both dyes (<15%; P < .0001) adjacent to the ink on the porous side. CONCLUSION: Chondrocyte viability is significantly reduced when cells are cultured in vitro on collagen membranes marked with methylene blue and crystal violet pen ink. CLINICAL RELEVANCE: Surgeons should be aware of the potential negative effect of marker pens in cell-based therapies.
Assuntos
Condrócitos/efeitos dos fármacos , Corantes/efeitos adversos , Violeta Genciana/efeitos adversos , Azul de Metileno/efeitos adversos , Animais , Contagem de Células , Sobrevivência Celular , Células Cultivadas , Colágeno Tipo I , Colágeno Tipo III , Humanos , Membranas Artificiais , SuínosAssuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Violeta Genciana/uso terapêutico , Leucoplasia Pilosa/tratamento farmacológico , Animais , Estudos de Coortes , Modelos Animais de Doenças , Violeta Genciana/efeitos adversos , Humanos , Leucoplasia Pilosa/diagnóstico , Camundongos , Medição de Risco , Sensibilidade e EspecificidadeRESUMO
Basic Violet 3, Basic Violet 1, and Basic Violet 4 are triphenylmethane dyes that function as direct (nonoxidative) hair colorants. No current uses or use concentrations in cosmetics are reported. The term Gentian Violet is used synonymously with Basic Violet 1 and Basic Violet 3, although the chemical structures of these 2 dyes are not the same. The Cosmetic Ingredient Review Expert Panel noted that Basic Violet 1, 3, and 4 contain quaternary ammonium ions, and therefore the rate of penetration across the epidermis is expected to be slow. The panel concluded that because of the carcinogenic potential of these dyes, insufficient data exist to support the safety of Basic Violet 1, 3, and 4 in cosmetic formulation. Dermal absorption data and a risk assessment are needed to complete this safety assessment.
Assuntos
Violeta Genciana/efeitos adversos , Tinturas para Cabelo/efeitos adversos , Corantes de Rosanilina/efeitos adversos , Animais , Sobrevivência Celular/efeitos dos fármacos , Cosméticos , Oftalmopatias/induzido quimicamente , Oftalmopatias/patologia , Feminino , Violeta Genciana/análise , Violeta Genciana/química , Violeta Genciana/toxicidade , Tinturas para Cabelo/análise , Tinturas para Cabelo/química , Tinturas para Cabelo/toxicidade , Humanos , Irritantes/toxicidade , Gravidez , Reprodução/efeitos dos fármacos , Corantes de Rosanilina/análise , Corantes de Rosanilina/química , Corantes de Rosanilina/toxicidade , Segurança , Dermatopatias/induzido quimicamente , Teratogênicos/toxicidade , Doenças da Bexiga Urinária/induzido quimicamenteRESUMO
OBJECTIVE: Radiotherapy-induced moist desquamation is a significant problem but there is a paucity of randomised data on which to base treatment decisions. The current prospective randomised trial compared gentian violet (GV) to a hydrogel dressing in this context. METHOD: Thirty patients undergoing radiotherapy to the head and neck region or breast who had developed moist desquamation in the radiotherapy field were randomised to treatment with 0.5% aqueous gentian violet (GV) (n=16) or a hydrogel dressing (n=14). The area of desquamation was regularly measured until healing or withdrawal from the study. RESULTS: The likelihood of healing with the hydrogel was greater than GV with a hazard ratio for healing of 7.95 (95% CI 2.20-28.68; p=0.002). The median time to healing for hydrogel was 12 days but had not been reached for GV by 30 days. Over the first 14 days the median'area under curve' of moist desquamation for GV was 82.6 cm2 (range 31.8-320.7 cm2) and that for hydrogel 20.0 cm2 (range 3.8-301.0 cm2) (difference significant at p=0.003). Ten of 16 patients treated with GV withdrew from the study (due to stinging in five and failure to heal in five) compared with two of the 14 treated with hydrogel (difference significant at p=0.021). CONCLUSION: Hydrogel dressings are more likely to heal radiotherapy-induced moist desquamation and are better tolerated than GV.
Assuntos
Anti-Infecciosos Locais/uso terapêutico , Curativos Hidrocoloides , Violeta Genciana/uso terapêutico , Radiodermite/prevenção & controle , Idoso , Anti-Infecciosos Locais/efeitos adversos , Neoplasias da Mama/radioterapia , Pesquisa em Enfermagem Clínica , Feminino , Violeta Genciana/efeitos adversos , Neoplasias de Cabeça e Pescoço/radioterapia , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação em Enfermagem , Modelos de Riscos Proporcionais , Estudos Prospectivos , Radiodermite/etiologia , Radiodermite/patologia , Dosagem Radioterapêutica , Higiene da Pele/efeitos adversos , Higiene da Pele/métodos , Higiene da Pele/enfermagem , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do Tratamento , CicatrizaçãoRESUMO
Shoulder arthroscopy is used widely to treat a variety of shoulder pathologies. These include various diagnostic and stabilization procedures such as Bankart repair, treating SLAP lesions, capsular plication, and rotator cuff repair. Sutures are commonly used, particularly in stabilization procedures, with or without the use of suture anchors. Suture management is one of the prerequisites for a successful arthroscopic stabilization procedure. We describe a simple method of aiding suture management. In cases using the suture anchor, the preloaded suture is firstly removed from the anchor, and approximately half the length of the suture is stained with methylene blue. The suture is then reinserted into the same suture anchor. The suture anchor is used in the usual manner. During shoulder arthroscopy, one end of the suture is pulled, if necessary, to determine the direction of the thread, which is readily shown by the methylene blue. This simple maneuver helps the surgeon identify the desired direction of the thread and avoid the common problems of pulling out the suture and twisting the sutures.
Assuntos
Artroscopia/métodos , Corantes , Azul de Metileno , Articulação do Ombro/cirurgia , Técnicas de Sutura , Suturas , Contraindicações , Violeta Genciana/efeitos adversos , Humanos , Complicações Intraoperatórias/prevenção & controle , Técnicas de Sutura/instrumentaçãoRESUMO
Chemical cystitis due to intravesical instillation of gentian violet or crystal violet is rare and all of the reported cases have been in adults using undiluted solution, which resulted in long-term sequelae. This is a case report on a 16-month-old boy with hemorrhagic cystitis after the instillation of diluted gentian violet into the bladder to rule out bladder injury during inguinal herniorrhaphy. Although he was completely recovered with conservative therapy, gentian violet, even when diluted, should not be used on the urinary tract.
Assuntos
Cistite/induzido quimicamente , Cistite/terapia , Violeta Genciana/administração & dosagem , Violeta Genciana/efeitos adversos , Hemorragia/induzido quimicamente , Hemorragia/terapia , Doenças da Bexiga Urinária/induzido quimicamente , Doenças da Bexiga Urinária/terapia , Administração Intravesical , Humanos , Lactente , MasculinoRESUMO
Two patients developed chondrolysis following injection of 0.4% aqueous gentian violet into the glenohumeral joint to visualize a rotator cuff tear during surgery. In both cases, conventional radiographs revealed joint space narrowing 10-12 months after surgery. Histological examination of the humeral heads revealed loss of the articular cartilage.
Assuntos
Anti-Infecciosos Locais/efeitos adversos , Cartilagem Articular/efeitos dos fármacos , Corantes/efeitos adversos , Violeta Genciana/efeitos adversos , Lesões do Manguito Rotador , Adulto , Feminino , Humanos , Masculino , Ruptura/diagnósticoAssuntos
Traumatismos em Atletas/diagnóstico , Doenças das Cartilagens/induzido quimicamente , Cartilagem Articular , Violeta Genciana/efeitos adversos , Dor/induzido quimicamente , Corantes de Rosanilina/efeitos adversos , Lesões do Manguito Rotador , Adulto , Traumatismos em Atletas/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , RupturaRESUMO
We describe a patient who developed superficial necrosis of the glans penis from irritation after topical treatment with 1% gentian violet. The foregoing condition resolved after withdrawal of treatment. A differential diagnosis (sexually transmitted diseases, epidermoid carcinoma, etc.) is warranted on finding this type of lesion in the glans penis.
Assuntos
Toxidermias/etiologia , Violeta Genciana/efeitos adversos , Pênis/patologia , Adulto , Toxidermias/patologia , Violeta Genciana/uso terapêutico , Humanos , Masculino , Necrose , Fimose/tratamento farmacológicoRESUMO
The instillation of diluted Bonney's blue into the bladder during gynaecological operations has been quite common practice over the last 50 years. Bonney's blue is composed of a 1:1 mixture of brilliant green and crystal violet dissolved in ethanol (90%) or industrial methylated spirit. Before insertion into the bladder this solution must be diluted with water to a 0.5% solution. Failure to do this will result in a severe inflammatory reaction within the bladder. The degree of resultant damage depends upon the duration of exposure. Persistent pain is a feature of this condition, although the other symptoms (frequency and urgency) may settle in time. Two cases of chemical cystitis resulting from the use of undiluted Bonney's blue are described to illustrate the possible consequences. Both patients were awarded 6-figure sums as compensation.
Assuntos
Cistite/induzido quimicamente , Violeta Genciana/efeitos adversos , Compostos de Amônio Quaternário/efeitos adversos , Administração Intravesical , Adulto , Combinação de Medicamentos/administração & dosagem , Combinação de Medicamentos/efeitos adversos , Feminino , Violeta Genciana/administração & dosagem , Humanos , Compostos de Amônio Quaternário/administração & dosagemRESUMO
From April 1 to October 31, 1985, postoperative surgical-wound infections due to rapidly growing mycobacteria developed in eight patients undergoing cosmetic plastic surgery performed by one surgeon. All infections followed either face-lift or augmentation-mammoplasty procedures performed in the surgeon's office; no infections occurred after surgical procedures performed at the hospital or after other surgical procedures performed at the office. An epidemiologic investigation implicated a gentian violet skin-marking solution as the source of the infections (P less than 0.001). Among patients exposed to the gentian violet, infection was significantly more likely to develop in those undergoing a face lift or augmentation mammoplasty than in those undergoing blepharoplasty (P less than 0.001). Additional risk factors for infection included the postoperative use of antibiotics and glucocorticoids. Mycobacterium chelonae, subspecies abscessus, was isolated from the gentian violet stock used by the surgeon and from five of the eight patients. Additional studies showed that the same organism was present in the gentian violet stock at the pharmacy that supplied the agent to the surgeon. After a sterile skin-marking agent was substituted for the contaminated agent, no further cases occurred.