Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
Rev. Soc. Bras. Med. Trop
; 53: e20190150, 2020. tab
Article
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| ID: biblio-1057268
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil's Federal District.METHODS:
Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality.RESULTS:
Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%).CONCLUSIONS:
The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Tripanocidas
/
Enfermedad de Chagas
/
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
/
Nitroimidazoles
Tipo de estudio:
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2020
Tipo del documento:
Article
País de afiliación:
Brasil