Cross-reactivity of anti-10kD heat shock protein antibodies in leprosy and tuberculosis patients
Medicina (B.Aires)
; 57(5): 581-6, 1997. graf, tab
Article
en En
| LILACS
| ID: lil-209685
Biblioteca responsable:
BR1.1
RESUMO
The response to recombinant 10-KD heat shock protein (HSP of Mycobacterium leprae (rML10) was evaluated by indirect ELISA in sera from leprosy patients, household contacts, tuberculosis patients and healthy controls a leprosy-endemic area in tne North East of Argentina. Some technical parameters were a analyzed within-assay and between-assay variability, dose-response curves and dectability indexed (specificity and sensitivity) of ELISA applied to measure anti-10kDa antibodies. High levels of these antibodies have already been reported in positive baciloscopy patients; herein we have also demonstrated that tuberculosis patients sera cross-react with this M. leprae antigen. This test seems to have a low sensificity for leporsy detection; it confirms that antibodies against highly conserved HSP antigens are important in the polycional response against mycobacterial epitopes in leprosy as well as in tuberculosis.
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Colección:
01-internacional
Asunto principal:
Tuberculosis
/
Chaperonina 10
/
Lepra
/
Anticuerpos Antibacterianos
/
Mycobacterium leprae
/
Antígenos Bacterianos
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Aged80
/
Humans
Idioma:
En
Revista:
Medicina (B.Aires)
Asunto de la revista:
MEDICINA
Año:
1997
Tipo del documento:
Article