Key Points for Curbing Cardiopulmonary Bypass Inflammation
Acta cir. bras
; 31(supl.1): 45-52, 2016. tab, graf
Article
en En
| LILACS
| ID: lil-779763
Biblioteca responsable:
BR1.1
ABSTRACT
PURPOSE:
Cardiopulmonary bypass (CPB) procedures are thought to activate systemic inflammatory reaction syndrome (SIRS). Strategies to curb systemic inflammation have been previously described. However, none of them is adequate, since "curbing" the extent of the inflammatory response requires a multimodal approach. The aim of the present mini-review is to discuss the main key points about the main principles in cardiopulmonary bypass curbing inflammation.METHODS:
No systematic literature search (MEDLINE) and extracted data from the accumulated experience of the authors. The preconceived idea of an association between severe inflammation and coagulation disorders is reviewed. Also, some fundamental concepts, CPB inflammatory biomarkers, the vasoplegic syndrome and the need forindividual CPB protocols for children, diabetes and old patients, are discussed.CONCLUSION:
The ways in which surgical technique (atraumatic vein harvest, biocompatibility and shear resistance of the circuit, monitoring, minimizing organ ischemia, minimal cross-clamping trauma, and blood management) are thought to curb SIRS induced by CPB and affect positively the patient outcome.Improved patient outcomes are strongly associated with these modalities of care, more than single or combinatorial drug strategies (aprotinin, tranexamic acid, pentoxifylline) or CPB modalities (minicircuits, heparin-coated circuits, retrograde autologous prime).Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Puente Cardiopulmonar
/
Síndrome de Respuesta Inflamatoria Sistémica
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2016
Tipo del documento:
Article
País de afiliación:
Brasil