Epstein-Barr virus meningoencephalitis with a lymphoma-like response in an immunocompetent host.
Ann Neurol
; 45(5): 659-62, 1999 May.
Article
en En
| MEDLINE
| ID: mdl-10319890
ABSTRACT
We report the clinical and neuropathological findings in an immunocompetent 19-year-old patient with a fatal acute Epstein-Barr virus (EBV) meningoencephalitis and a lymphoma-like B-lymphocyte response. Our results suggest that an immunotoxic rather than direct viral neuronal invasion mediates brain damage in EBV encephalitis and rule out primary central nervous system lymphoma (PCNSL) in our patient. We discuss immunosuppression as a therapeutic option, because present strategies mainly consist of symptomatic therapy due to unclear pathogenesis and nonavailability of effective antiviral agents.
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Colección:
01-internacional
Asunto principal:
Inmunocompetencia
/
Mononucleosis Infecciosa
/
Linfoma
/
Meningoencefalitis
Límite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Ann Neurol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Alemania