Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates.
Antimicrob Agents Chemother
; 44(4): 1100-1, 2000 Apr.
Article
en En
| MEDLINE
| ID: mdl-10722523
ABSTRACT
Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Doxorrubicina
/
Fluconazol
/
Antibióticos Antineoplásicos
/
Antifúngicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos