Mismatch repair defects in cancer.
Curr Opin Genet Dev
; 10(2): 157-61, 2000 Apr.
Article
en En
| MEDLINE
| ID: mdl-10753784
ABSTRACT
Post-replicative mismatch repair in humans utilises the hMSH2, hMSH6, hMSH3, hMLH1 and hPMS2 genes and possibly the newly identified hMLH3 gene. Recently, a link has been established between hMSH6 mutations and 'atypical' hereditary non-polyposis colon cancer (HNPCC) with an increased incidence of endometrial cancers. To satisfy the need for a diagnostic test capable of differentiating between pathogenic mutations and polymorphisms, several functional assays that fulfil these criteria have been described. These should allow for better diagnosis of HNPCC.
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Colección:
01-internacional
Asunto principal:
Neoplasias Colorrectales Hereditarias sin Poliposis
/
Disparidad de Par Base
/
Reparación del ADN
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
2000
Tipo del documento:
Article