[An investigation of serum soluble interferon receptor levels in patients with renal cell carcinoma].
Nihon Hinyokika Gakkai Zasshi
; 91(5): 514-9, 2000 May.
Article
en Ja
| MEDLINE
| ID: mdl-10853333
ABSTRACT
OBJECTIVE:
Serum soluble interferon alpha/beta receptor (s-IFN-receptor) levels were determined in renal cell carcinoma (RCC) patients to study the clinical significance of the measurement. SUBJECTS ANDMETHODS:
S-IFN-receptor levels were measured in RCC patients (n = 27) and healthy volunteers (n = 22) by enzyme immunoassay technique.RESULTS:
Significantly higher serum s-IFN-receptor levels were observed in RCC patients compared with the healthy volunteers (p < 0.003). The high s-IFN receptor levels in the patients suggested seriousness and mal-prognosis of this disease. The 4-years survival rate of the higher level group (with the mean value of 2.7 +/- 1.7 ng/ml or more) was 53.3%, while the lower level group's rate was 78.7% (Statistical analysis result by Logrank (Mantel-Cox) test; p = 0.4289).CONCLUSION:
Further study in more subjects is required to determine the feasibility of the s-IFN receptor levels as a prognosis marker, since correlation between the prognosis and s-IFN receptor level was not clarified by this study result.
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Colección:
01-internacional
Asunto principal:
Carcinoma de Células Renales
/
Receptores de Interferón
/
Neoplasias Renales
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ja
Revista:
Nihon Hinyokika Gakkai Zasshi
Año:
2000
Tipo del documento:
Article