Temporal bone findings in multiple endocrine neoplasia type 2B.
Eur Arch Otorhinolaryngol
; 257(5): 273-5, 2000.
Article
en En
| MEDLINE
| ID: mdl-10923942
ABSTRACT
To our knowledge, present case is the first published report of temporal bone findings in multiple endocrine neoplasia type 2B (MEN-2B). We describe a 43-year-old Japanese man with medullary thyroid carcinoma (MTC), pheochromocytoma, mucosal neuroma and a Marfanoid body habitus. The collateral adrenal tumors and MTC were removed surgically. However, 14 years after surgery, the MTC and pheochromocytoma recurred and the patient died of intracranial hemorrhage due to hypertension. During the autopsy, metastatic MTC was detected in the liver, lungs, kidneys, pancreas and cervical lymph nodes. Recurrent pheochromocytoma was present in the right kidney. Mucosal neuromas were found in the tongue, gastrointestinal tract and vesical nerve plexus. The following histopathological findings were seen in both temporal bones metastatic MTC was found as well as neuromas and the cochlear aqueduct was widely patent.
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Colección:
01-internacional
Asunto principal:
Neoplasias Craneales
/
Hueso Temporal
/
Neoplasia Endocrina Múltiple Tipo 2b
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Eur Arch Otorhinolaryngol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón