Expression of perforin and Fas ligand mRNA in the liver of viral hepatitis.
J Clin Immunol
; 20(5): 347-53, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-11051276
ABSTRACT
Cytotoxic T lymphocytes (CTLs) play an important role in the pathogenesis of viral hepatitis. We studied the expression of mRNAs of perforin and Fas ligand (Fas-L) in biopsy specimens from chronic hepatitis B (CHB) (15 cases) and hepatitis C (CHC) patients (13 cases). Both perforin and Fas-L mRNAs were detected in all cases of both CHB and CHC. No messages were detected in the control livers from two cases of fatty liver, a case of Gilbert's syndrome, and a case of Dubin-Johnson syndrome. Semiquantitative analysis revealed a positive correlation between the intensity of perforin and Fas-L mRNAs in both CHB and CHC. In CHB, the intensity of both perforin and Fas-L mRNAs showed a positive correlation with the histological activity and serum alanine aminotransferase level, while the correlation was not apparent in CHC. These results suggest that both perforin and Fas/Fas-L systems are involved in the pathogenesis of liver cell injury of CHB and CHC.
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Colección:
01-internacional
Asunto principal:
Glicoproteínas de Membrana
/
Hepatitis B Crónica
/
Hepatitis C Crónica
Límite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Clin Immunol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón